Fibrin formation in the test tube results from the interaction of a large number of proteins which are present in plasma in precursor or inactive forms (for a detailed review, see (1)). These proteins include fibrinogen, factor XIII, prothrombin, factor V, factor X, factor VIII, factor IX, factor XI, factor XII, prekallikrein, and high molecular weight kininogen. The clotting process is initiated when the plasma comes in contact with a surface, such as glass or kaolin. Under these conditions, factor XIIa is formed (Fig.1). In recent years, factor XII, prekallikrein, and high molecular weight kininogen have been extensively purified and their interactions during these initial phases of clotting have been studied.
KeywordsLight Chain Substrate Binding Pocket High Molecular Weight Kininogen Active Site Serine Bovine Factor
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