Blood Coagulation

  • E. W. Davie
  • K. Fujikawa
  • K. Kurachi
Conference paper
Part of the Colloquium der Gesellschaft für Biologische Chemie 26.–28. April 1979 in Mosbach/Baden book series (MOSBACH, volume 30)


Fibrin formation in the test tube results from the interaction of a large number of proteins which are present in plasma in precursor or inactive forms (for a detailed review, see (1)). These proteins include fibrinogen, factor XIII, prothrombin, factor V, factor X, factor VIII, factor IX, factor XI, factor XII, prekallikrein, and high molecular weight kininogen. The clotting process is initiated when the plasma comes in contact with a surface, such as glass or kaolin. Under these conditions, factor XIIa is formed (Fig.1). In recent years, factor XII, prekallikrein, and high molecular weight kininogen have been extensively purified and their interactions during these initial phases of clotting have been studied.


Light Chain Substrate Binding Pocket High Molecular Weight Kininogen Active Site Serine Bovine Factor 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1979

Authors and Affiliations

  • E. W. Davie
  • K. Fujikawa
  • K. Kurachi
    • 1
  1. 1.Department of BiochemistryUniversity of WashingtonSeattleUSA

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