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Regulation of Proteinase Acitvity

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Biological Functions of Proteinases

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Abstract

Proteolytic enzymes were among the first known enzymes. At the beginning of this century biologists became aware of the involvement of these enzymes in biological control mechanisms. Evidently these early investigators were primarily concerned with enzymes such as trypsin achieving extensive digestion of their protein substrates. Later the extra- and intra-cellular location of proteolytic enzymes was stated and in more recent years the fundamental role of limited proteolysis achieving the activation or modification of a substrate molecule, enabling it to take its place in a reaction cascade, became more and more the center of interest in many laboratories. Obviously there are too many control mechanisms in intra- and extracellular proteolysis to be reviewed here, and this paper will only describe the control of some proteolytic activities in mammalian plasma by eight of the actually known antiproteases. These inhibitors interfere mainly with the proteolytic activities of clotting components, of those enzymes controlling blood pressure and those achieving fibrinolysis. But we have also to take into account the complement system and the proteases liberated by blood cells, namely platelets and leukocytes, as these latter enzymes are able to activate or destroy factors belonging to the before-mentioned systems.

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  1. Centre National de Transfusion Sanguine, 33, avenue des Tropiques, Orsay, France

    M. Steinbuch

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  1. M. Steinbuch
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  1. Biochemisches Institut, Albert-Ludwigs-Universität, Hermann-Herder-Straße 7, 7800, Freiburg, Germany

    Helmut Holzer

  2. Lehrstuhl für Biochemie Fakultät für Chemie, Universität Bielefeld, Universitätsstraße, 4800, Bielefeld, Germany

    Harald Tschesche

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© 1979 Springer-Verlag Berlin Heidelberg

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Steinbuch, M. (1979). Regulation of Proteinase Acitvity. In: Holzer, H., Tschesche, H. (eds) Biological Functions of Proteinases. Colloquium der Gesellschaft für Biologische Chemie 26.–28. April 1979 in Mosbach/Baden, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81395-5_19

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  • DOI: https://doi.org/10.1007/978-3-642-81395-5_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81397-9

  • Online ISBN: 978-3-642-81395-5

  • eBook Packages: Springer Book Archive

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