Preliminary Clinical Study of Aclacinomycin A
Aclacinomycin A (ACM), a new anthracycline antitumor antibiotic, was isolated in 1974 from a culture of Streptomyces galiaeus MA144-MI by Dr. Umezawa et al. in Japan . The structure of ACM is characterized by an ethyl group at position C-13, methyloxy-carbonyl group at C-10, and rhodosamine, 2-deoxyfucose, and cinerulose at position C-7 (Fig. 1).
KeywordsToxicity Lymphoma Cobalt Bilirubin Streptomyces
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- 1.Furue, H., et al.: Clinical experience with aclacinomycin A. Cancer Chemother. 4, 75 (1977)Google Scholar
- 2.Oki, T., et al.: Production of nineteen anthracyclic compounds by Streptomyces galilaeus MA 144-M1. J. Antibiot. (Tokyo) 30, 683 (1977)Google Scholar
- 3.Umezawa, H., et al: New antitumor antibiotics, aclacinomycin A and B. J. Antibiot. (Tokyo). 28, 830 (1975)Google Scholar