Preliminary Clinical Study of Aclacinomycin A
Aclacinomycin A (ACM), a new anthracycline antitumor antibiotic, was isolated in 1974 from a culture of Streptomyces galiaeus MA144-MI by Dr. Umezawa et al. in Japan . The structure of ACM is characterized by an ethyl group at position C-13, methyloxy-carbonyl group at C-10, and rhodosamine, 2-deoxyfucose, and cinerulose at position C-7 (Fig. 1).
KeywordsCardiac Toxicity Bronchogenic Carcinoma Nitrogen Mustard Bone Marrow Depression Preliminary Clinical Study
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