The term hypercoagulability describes the phenomenon of increased clottability of the blood in vivo. The latter is caused by continuous procoagulant stimulation of the coagulation system followed by the generation of thrombin.


Platelet Factor Soluble Fibrin Thrombotic Tendency Increase Platelet Reactivity Spontaneous Platelet Aggregation 
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  1. 1.
    Bagge, L., Björk, J., Saldeen, T., Wallin, R.: Purification of a fibrinolysis inhibitor in serum from post-traumatic patients. Thromb. Haemostas. 39, 97–108 (1978)Google Scholar
  2. 2.
    Brass, L. F., Faile, D., Bensusan, H. B.: Direct measurement of the platelet: collagen interaction by affinity-chromatography on collagen/Sepharose. J. Lab. Clin. Med. 87, 525–532 (1976)PubMedGoogle Scholar
  3. 3.
    Breddin, K., Grun, H., Krzywanek, H. J., Schremmer, W. P.: On the measurement of spontaneous platelet aggregation. Thromb. Haemostas. 35, 669–676 (1976)Google Scholar
  4. 4.
    Fletcher, A. P., Alkjaersig, N., O’Brien, J., Tulevski, V. G.: Blood hypercoagulability and thrombosis. Trans. Assoc. Am. Physicians 83, 159–162 (1970)PubMedGoogle Scholar
  5. 5.
    Gazzard, B. G., Lewis, M. L., Ash, G.: Coagulation factor concentrates in the treatment of the haemorrhagic diathesis in fulminant hepatic failure. Gut 15, 993–997 (1974)PubMedCrossRefGoogle Scholar
  6. 6.
    Godal, H. C., Abildgaard, U.: Gelation of soluble fibrin in plasma by ethanol. Scand. J. Haematol. 3, 342–350 (1966)Google Scholar
  7. 7.
    Graeff, H., Hugo, R. von, Hafter, R.: In vivo formation of soluble fibrinmonomer complexes in human plasma. Thromb. Res. 3, 342–350 (1973)CrossRefGoogle Scholar
  8. 8.
    Heene, D. L., Matthias, F. R.: Adsorption of fibrinogen derivatives on insolubilized fibrinogen and fibrinmonomer. Thromb. Res. 2, 137–148 (1973)CrossRefGoogle Scholar
  9. 9.
    Joist, H.: In vivo methods for the detection of increased platelet function. In: Prostaglandine und Plättchenfunktion. Breddin, K. (ed.), pp. 93–103. Stuttgart, New York: Schattauer 1978Google Scholar
  10. 10.
    Lechner, K., Thaler, E., Niessner, H.: Antithrombin III deficiency and tendency to thrombosis. Wien. Klin. Wochenschr. 89, 215–222 (1977)PubMedGoogle Scholar
  11. 11.
    Mueller, V. P., Largo, R., Straub, P. W.: A sensitive latex agglutination method for the detection of soluble fibrin in plasma. Blut 35, 465–479 (1977)CrossRefGoogle Scholar
  12. 12.
    Müller-Berghaus, G., Lasch, H.-G.: Microcirculatory disturbances induced by generalized intravascular coagulation. In: Handbuch der experimentellen Pharmakologie, Bd. XVI/3: Heart and circulation. Schmier, J., Eichler, O. (eds.), pp. 429–514. Berlin, Heidelberg, New York: Springer 1975Google Scholar
  13. 13.
    Nilsson, I. M., Isacson, S.: New aspcects of the pathogenesis of thromboembolism. Prog. Surg. 11, 46–68 (1973)PubMedGoogle Scholar
  14. 14.
    Semeraro, N., Vermylen, J.: Evidence that washed human platelets possess factor X activator activity. Br. J. Haematol. 36, 107–115 (1977)PubMedCrossRefGoogle Scholar
  15. 15.
    Ten Cate, J. W., Vos, J., Costerhuis, H.: Spontaneous platelet aggregation in cerebrovascular disease. Thromb. Haemostas. 39, 223–229 (1978)Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1979

Authors and Affiliations

  • D. L. Heene
    • 1
  1. 1.I. Medizinische Klinik der Fakultät für klinische MedizinUniversität HeidelbergMannheimGermany

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