T Cell Disorders in Primary Immunodeficiency Diseases

  • Thomas A. Waldmann
  • Samuel Broder


During the past decade knowledge of the events of cellular maturation and of regulatory cellular interactions involved in the normal immune response has expanded rapidly as a result of the interplay between studies of patients with primary immunodeficiency diseases and basic laboratory studies in animal systems. Progress in our understanding of disorders of T cell function in immunodeficiency diseases has been facilitated by advances in a number of areas including: 1) The demonstration that T cells are not a homogeneous population but encompass subpopulations of lymphocytes with different and at times opposing functions; 2) The identification of unique cell surface determinants on mouse T cells and more recently on human T cells that appear as these cells mature and differentiate. In many cases T cell subpopulations with different functional capabilities bear different surface determinants; 3) The development of in vitro techniques to assess the functional behavior of isolated subpopulations of T cells and for the evaluation of T cell function in man.


Ataxia Telangiectasia Severe Combine Immunodeficiency Primary Immunodeficiency Disease Cell Disorder DiGeorge Syndrome 
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© Springer-Verlag Berlin Heidelberg 1979

Authors and Affiliations

  • Thomas A. Waldmann
    • 1
  • Samuel Broder
    • 1
  1. 1.Metabolism Branch, National Cancer InstituteNational Institutes of HealthBethesdaUSA

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