Radiochemotherapy of Postoperative Minimal Residual Disease in Neuroblastoma

  • J. M. Zucker
  • E. Margulis
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 68)


Two-year survival of neuroblastoma patients has not been substantially improved in the last 20 years, either in localized and regional disease or in metastatic tumors (Tab. 1) [1, 16, 19, 23]. As in other tumors of childhood the anatomic extent of the disease is the main prognostic factor (Fig. 1), but host-tumor interrelations seem to be much more decisive in neuroblastoma [7] than the ability of chemotherapeutic agents to eradicate microscopic foci of metastatic deposits as they do in Wilm’s tumor and soft-tissue sarcoma. Thus, guidelines for treatment of postoperative minimal residual disease have been found in supervision of the urinary level of the biochemical markers of neuroblastoma by serial assays [14] and in the reappraisal of the various factors influencing survival [1, 4, 6, 9, 12, 23]. Age at diagnosis is the most prominent of these factors (Fig. 2), and infants under 1 year of age have a surprisingly good prognosis compared to children of 1 year or more, whether disease is localized or widespread.


Minimal Residual Disease Actuarial Survival Neuroblastoma Patient Anatomic Extent Main Prognostic Factor 
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© Springer-Verlag Berlin · Heidelberg 1979

Authors and Affiliations

  • J. M. Zucker
  • E. Margulis

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