Radiochemotherapy of Postoperative Minimal Residual Disease in Neuroblastoma

  • J. M. Zucker
  • E. Margulis
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 68)

Abstract

Two-year survival of neuroblastoma patients has not been substantially improved in the last 20 years, either in localized and regional disease or in metastatic tumors (Tab. 1) [1, 16, 19, 23]. As in other tumors of childhood the anatomic extent of the disease is the main prognostic factor (Fig. 1), but host-tumor interrelations seem to be much more decisive in neuroblastoma [7] than the ability of chemotherapeutic agents to eradicate microscopic foci of metastatic deposits as they do in Wilm’s tumor and soft-tissue sarcoma. Thus, guidelines for treatment of postoperative minimal residual disease have been found in supervision of the urinary level of the biochemical markers of neuroblastoma by serial assays [14] and in the reappraisal of the various factors influencing survival [1, 4, 6, 9, 12, 23]. Age at diagnosis is the most prominent of these factors (Fig. 2), and infants under 1 year of age have a surprisingly good prognosis compared to children of 1 year or more, whether disease is localized or widespread.

Keywords

Sarcoma Cyclophosphamide Catecholamine Neuroblastoma Vincristine 

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Reference

  1. 1.
    Breslow, N., McCann, B.: Statistical estimation of prognosis for children with neuroblastoma. Cancer Res. 31, 2098–2103 (1971).PubMedGoogle Scholar
  2. 2.
    D’Angio, G. J.: Radiotherapy of children with neuroblastoma. J. Pediatr. Surg. 3, 110–113 (1968).PubMedCrossRefGoogle Scholar
  3. 3.
    Donaldson, S., Jundt, S., Ricour, C., Sarrazin, D., Lemerle, J., Schweisguth, O.: Radiation enteritis in children. A retrospective review, clinicopathologic correlation, and dietary management. Cancer. 35, 1167–1178 (1975).PubMedCrossRefGoogle Scholar
  4. 4.
    Evans, A. E., D’Angio, G. J., Randolph, J.: A proposed staging for children with neuroblastoma. Cancer 27, 374–378 (1971).PubMedCrossRefGoogle Scholar
  5. 5.
    Evans, A. E., Albo, V., D’Angio, G. J., Finklestein, J. Z., Leiken, S., Santulli, T., Weiner, J.: Cyclophosphamide treatment of patients with localized and regional neuroblastoma. A randomized study. Cancer 38, 655–660 (1976).PubMedCrossRefGoogle Scholar
  6. 6.
    Evans, A. E., Albo, V., D’Angio, G. J., Finklestein, J. Z., Leiken, S., Santulli, T., Einer, J.: Factors influencing survival of children with non metastatic neuroblastoma. Cancer 38, 661–666 (1976).PubMedCrossRefGoogle Scholar
  7. 7.
    Evans, A. E., Gerson, J. G., Schnaufer, L.: Spontaneous regression of neuroblastoma. J. Natl. Cancer Inst. 44, 49–54 (1976).Google Scholar
  8. 8.
    Filler, R. M., Traggis, D. G., Jaffe, N., Vawter, G. F.: Favorable outlook for children with mediastinal neuroblastoma. J. Pediatr. Surg. 7, 136 (1972).PubMedCrossRefGoogle Scholar
  9. 9.
    Hassenbusch, S., Kaiser, H., White, J. J.: Prognostic factors in neuroblastic tumors. J. Pediatr. Surg. II, 287–297 (1976).CrossRefGoogle Scholar
  10. 10.
    Hayes, F. A., Mauer, A. M.: Cell kinetics and chemotherapy in neuroblastoma. J. Natl. Cancer Inst. 57, 697–699 (1976).PubMedGoogle Scholar
  11. 11.
    Helson, L., Helson, C., Peterson, R. F., Dass, K.: A rationale for the treatment of metastatic neuroblastoma. J. Natl. Cancer Inst. 57, 727–729 (1976).PubMedGoogle Scholar
  12. 12.
    Koop, C. E., Johnson, D. G.: Neuroblastoma. An assessment of therapy in reference to staging. J. Pediatr. Surg. 6, 595–600 (1971).PubMedCrossRefGoogle Scholar
  13. 13.
    Koop, C. E., Schnaufer, L.: The management of abdominal neuroblastoma. Cancer 35, 905–909 (1975).PubMedCrossRefGoogle Scholar
  14. 14.
    Labrosse, E. H., Comoy, E., Bohuon, C., Zucker, J. M., Schweisguth, O.: Catecholamine metabolism in neuroblastoma. J. Natl. Cancer Inst. 57, 633–638 (1976).PubMedGoogle Scholar
  15. 15.
    Labrosse, E. H., Belehradek, K., Barski, G.: Cytotoxicity of oxydation products from L-dopa. Specificity for neuroblastoma cells in culture. Proceedings of the Society for Experimental Biology and Medicine (to be published). (1978).Google Scholar
  16. 16.
    Leikin, S., Evans, A., Heyn, R., Newton, W.: The impact of chemotherapy on advanced neuroblastoma. Survival of patients diagnosed in 1956, 1961, and 1966–1968 in children’s cancer study group A. J. Pediatr. 84, 131–134 (1974).PubMedCrossRefGoogle Scholar
  17. 17.
    Leikin, S., Bernstein, I., Evans, A. E., Finklestein, J., Hittle, R., Klemperer, M.: Use of combination Adriamycin and DTIC in children with advanced stage in neuroblastoma. Cancer Chemother. Rep. 59, 1015–1018 (1975).PubMedGoogle Scholar
  18. 18.
    Stella, J. G., Schweisguth, O., Schlienger, M.: Neuroblastoma. A study of 144 cases treated in the Institut Gustave Roussy over a period of 7 years. Am. J. Roentgenol. 108, 324–332 (1970).Google Scholar
  19. 19.
    Sutow, W., Gehan, E., Heyn, R., Kung, F. H., Miller, R. W., Murphy, M. L., Traggis, D. G.: Comparison of survival curves, 1956 versus 1962, in children with Wilm’s tumor and neuroblastoma. Pediatrics 45, 800–811 (1970).PubMedGoogle Scholar
  20. 20.
    Tefft, M., Wittenborg, M. H.: Radiotherapeutic management of neuroblastoma in childhood. JAMA 205, 159–166 (1968).PubMedCrossRefGoogle Scholar
  21. 21.
    Zucker, J. M.: Retrospective study of 462 neuroblastomas treated between 1950 and 1970. Maandschr. Kindergeneesk. 42, 369–385 (1974).Google Scholar
  22. 22.
    Zucker, J. M., Mercier, J. C.: Chimiothérapie lourde dans le neuroblastome. Premiers résultats chez 40 enfants porteurs d’une forme métastatique. Arch. Fr. Pediatr. 33, 555–567 (1976).PubMedGoogle Scholar
  23. 23.
    Zucker, J. M., Hesse, C.: Prognostic factors in neuroblastoma. Proceedings of the International Symposium on Neuroblastoma: Biological Bases and Therapeutic Perspectives. Genova, 8–9 July 1977 (to be published) (1978).Google Scholar

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© Springer-Verlag Berlin · Heidelberg 1979

Authors and Affiliations

  • J. M. Zucker
  • E. Margulis

There are no affiliations available

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