Abstract
The review of accumulated experience with adult brain tumors indicates a potential efficiency of chemotherapy when associated with surgery and radiotherapy [2]. Some drugs show their abilities to improve the clinical course of resected or partially resectable or nonresectable malignant gliomas in adult patients [4, 6]. Successively vincristine [1], BCNU, CCNU, and more recently VM-26 and procarbazine have been introduced into therapeutic trials [1–5, 12, 14, 15, 16]. Even the potent nitrosources remain merely a palliative form of therapy. Some recent results obtained in animal tumor model systems indicate that some combinations of drugs appear more effective than drugs used alone. This same approach may increase the mean life span of patients with gliomas [7, 9]. We may anticipate that the failure of brain tumor therapy requires research directed at the discovery of additional active drugs and, for the present, attempts to potentiate the activity of nitrosoureas with a rational combination of drugs [8, 13]. The aim of this study was to compare the best sequence of chemotherapy and to determine the best point for the administration of radiotherapy associated with chemotherapy.
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Armentrout, S. A., Foltz, E., Vermund, H., Otis, P. T.: Comparison of postoperative irradiation alone and in combinations with BCNU (NSC 409, 962) in the management of malignant gliomas. Cancer Chemother. Rep. 58, 841–844 (1974).
Bloom, H. J. G.: Combined modality therapy for intracranial tumors. Cancer 35, 111–120 (1975).
Fewer, D., Wilson, C. B., Boldrey, E. B., Enot, K. J.: Phase II study of 1 (2-chloroethyl) 3 cyclohexyl-1-Nitrosourea(CCNU-NSC 79037) in treatment of brain tumors. Cancer Chemother. Rep. 56, 421–427 (1972).
Goldsmith, M. A., Carter, St K.: Glioblastoma multiforme. A review of therapy. Cancer Treat. Rev. 1, 153–156 (1974).
Lassman, L., Pearce, G. W., Gang, J.: Sensitivity of intracranial glioblastoma to vincristine sulfate. Lancet 1965 I, 296-297.
Levin, V. A., Wilson, Ch. B.: Chemotherapy. The agents in current use. Semin. Oncol. 2, 63–67 (1975).
Levin, V. A., Wilson, Ch. B.: Correlations between experimental chemotherapy in the murine glioma and effectiveness of clinical therapy regimens. Cancer Chemother. Pharmacol. 1, 41–48 (1978).
Levin, V. A., Wilson, Ch. B.: Nitrosourea for primary malignant gliomas. Cancer Treat. Rep. 60, 719–724 (1976).
Pouillart, P., Palangie, T., Poisson, M., Huguenin, P., Morin, P.: Chimiothérapie cytolytique appliquée au traitement des gliomes malins hémisphériques de l’adulte: bases théoriques. Vie Médicale (in press) (1978).
Pouillart, P., Mathe, G., Poisson, M., Buge, A., Huguenin, P., Gautier, H., Morin, P., Hoang Thy Huong, T., Lheritier, J., Parrot, R.: Essai de traitement des glioblastomes de l’adulte et des métastases cérébrales par l’association d’Adriamycine, de VM 26 et de C.C.N.U. Résultats d’un essai de type II. Nouv. Presse Méd. 25, 1571–1576 (1976).
Pouillart, P., Mathe, G., Hoang Thy Huong, T., Lheritier, J., Poisson, M., Huguenin, P., Gautier, H., Morin, P., Parrot, R.: Treatment of malignant gliomas and brain métastases in adults with a combination of Adriamycin, VM 26 and C.C.N.U. Results of a phase II trial. Cancer 38, 1909–1916 (1976).
Rosenblum, M. L., Reynolds, A. F., Smith, K. A., Rumack, B. H., Walcker, D.: Chloroethyl-cyclohexyl-nitrosourea (CCNU) in the treatment of malignant brain tumors. J. Neurol. Surg. 39, 306–324 (1973).
Shapiro, W. R.: Malignant brain tumor chemotherapy. Part II. Clin. Bull. 3, 58–62 (1973).
Sklansky, B. D., Mann-Kaplan, R. S., Reynolds, A. F., Rosenblum, M. L., Walker, M. D.: 4′dimethyl-epipodophylotoxin-D-thenylidene glucoside (PT 6) in the treatment of malignant intracranial neoplasms. Cancer 33, 460–467 (1974).
Vasantha-Kumar, A. R., Renaudin, J., Wilson, Ch. B., Boldrey, Ed. B., Jean-Enot, K., Levin, V. A.: Procarbazine hydrochloride in the treatment of brain tumors. Phase II study. J. Neurol. Surg. 40, 365–371 (1974).
Walker, M. D., Hurwitz, B. S.: BCNU (1,3 bis-(2-chloroethyl)-1 nitrosourea-NSC 409962) in the treatment of malignant brain tumors. Cancer Chemother. Rep. 4, 263–273 (1970).
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Pouillart, P. et al. (1979). Treatment of Adult Malignant Gliomas. In: Bonadonna, G., Mathé, G., Salmon, S.E. (eds) Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease II. Recent Results in Cancer Research, vol 68. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81332-0_60
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DOI: https://doi.org/10.1007/978-3-642-81332-0_60
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