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Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease II pp 363–366Cite as

Results of a Nonrandomized Trial in Malignant Melanoma Patients (Clark’s Stages III–V) Treated by Post-Surgical Chemoimmunotherapy

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Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 68))

Abstract

Malignant melanoma is a poor prognosis disease when centered in the trunk region and whenever node infiltration has occurred [7, 14]. For this reason, we initiated in 1972 a nonrandomized study of complementary chemoimmunotherapy treatment following radical surgery. Chemoimmunotherapy was modulated according to postchemotherapeutic observations concerning immunologic restoration and overshoot phenomena [8, 12]. This therapeutic practice has subsequently been confirmed experimentally.

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Reference

  1. Beretta, G.: Controlled study for prolonged chemotherapy, immunotherapy and chemotherapy plus immunotherapy as an adjuvant to surgery in stage I–II malignant melanoma: preliminary report. In: Immunotherapy of cancer: present status of trials in man. Terry, W. D., Windhorst, D. (eds.), p. 19. New York: Raven Press 1978.

    Google Scholar 

  2. Caraux, J., Serrou, B.: The binding of autologous erythrocytes by human lymphocytes. Biomedicine (in press) (1978).

    Google Scholar 

  3. Caraux, J., Thierry, C., Serrou, B.: Human autologous rosettes. II. Prognostic significance of variations in autologous rosette forming cells in the peripheral blood of cancer patients. J.N.C.I. (in press) (1978).

    Google Scholar 

  4. Cunningham, T. J., Schoenfeld, D., Nathanson, L., Wolter, J., Patterson, W. B., Cohen, M. H.: A controlled study of adjuvant therapy in patients with stage I and II malignant melanoma. In: Immunotherapy of cancer: present status of trials in man. Terry, W. D., Windhorst, D. (eds.), p. 19. New York: Raven Press 1978.

    Google Scholar 

  5. Eilber, F. R., Morton, D. L., Holmes, E. C., Sparks, F. C., Ramming, K. P.: Adjuvant immunotherapy with B.C.G. in treatment of regional lymph-node metastases from malignant melanoma. N. Engl. J. Med. 294, 237–240 (1976).

    Article  PubMed  CAS  Google Scholar 

  6. Gauci, L., Caraux, J., Thierry, C., Pujol, H., Serrou, B.: Modifications of the immune status induced in malignant melanoma patients by chemo-immunotherapy and immunotherapy. In: Human lymphocyte differentiation. Its application to cancer. Serrou, B., Rosenfeld, C. (eds.). New York: North-Holland 1978 (in press).

    Google Scholar 

  7. Gupta, T. K. D.: Results of treatment of 269 patients with primary cutaneous melanoma: a five-year prospective study. Ann. Surg. 186, 201–209 (1977).

    Article  PubMed  CAS  Google Scholar 

  8. Hersh, E. M., Whitecar, J. P., McCredie, K. B., Bodey, G. P., Freireich, E. J.: Immunocompetence, immunosuppression and prognosis in acute leukemia. N. Engl. J. Med. 1211, 285–291 (1971).

    Google Scholar 

  9. Jewell, W. R., Thomas, J. H., Sterchi, J. M., Morse, P. A., Humphrey, L. J.: Critical analysis of treatment of stage II and stage III melanoma patients with immunotherapy. Ann. Surg. 183, 543–548 (1976).

    Article  PubMed  CAS  Google Scholar 

  10. Morton, D. L., Holmes, E. C., Eilber, F. R., Sparks, F., Ramming, K. P.: Adjuvant immunotherapy of malignant melanoma: preliminary results of a randomized trial in patients with lymph node metastases. In: Immunotherapy of cancer: present status of trials in man. Terry, W. D., Windhorst, D. (eds.), p. 57. New York: Raven Press 1978.

    Google Scholar 

  11. Pinsky, C. M., Hirshaut, Y., Wanebo, H. J., Hilal, E. Y., Fortner, J. G., Mike, V., Schottenfeld, D., Oettgen, H. F.: Surgical adjuvant immunotherapy with B.C.G. in patients with malignant melanoma: results of a prospective randomized trial. In: Immunotherapy of cancer: present status of trials in man. Terry, W. D., Windhorst, D. (eds.), p. 27. New York: Raven Press 1978.

    Google Scholar 

  12. Serrou, B., Dubois, J. B.: Immunological overshoot phenomenon following cancer chemotherapy: significance in prognosis evaluation of solid tumors. Biomedicine 23, 41–45 (1975).

    PubMed  CAS  Google Scholar 

  13. Serrou, B., Caraux, J., Domas, J., Grenier, J., Thierry, C., Pujol, H.: Value of some immunological parameters to evaluate the prognosis of melanoma patients treated by chemo-immunotherapy Proc. ASCO 19, 349 (Abs. C-170) (1978).

    Google Scholar 

  14. Veronesi, U., Cascinelli, N., Preda, F.: Prognosis of malignant melanoma according to regional metastases. Am. J. Roentgenol. 111, 301–309 (1971).

    CAS  Google Scholar 

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Authors
  1. B. Serrou
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  2. H. Pujol
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  3. J. Domas
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  4. L. Gauci
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Editor information

Editors and Affiliations

  1. Istituto Nazionale dei Tumori, Via Venezian 1, I-20133, Milano, Italy

    Gianni Bonadonna

  2. Institut de Cancérologie et d’Immunogénétique, Hôpital Paul-Brousse, 14-16, Avenue Paul-Vaillant-Couturier, F-94800, Villejuif, France

    Georges Mathé

  3. University of Arizona Cancer Center, 1501 North Campbell Ave., Tucson, Arizona, 85724, USA

    Sydney E. Salmon

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© 1979 Springer-Verlag Berlin · Heidelberg

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Serrou, B., Pujol, H., Domas, J., Gauci, L. (1979). Results of a Nonrandomized Trial in Malignant Melanoma Patients (Clark’s Stages III–V) Treated by Post-Surgical Chemoimmunotherapy. In: Bonadonna, G., Mathé, G., Salmon, S.E. (eds) Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease II. Recent Results in Cancer Research, vol 68. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81332-0_54

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  • DOI: https://doi.org/10.1007/978-3-642-81332-0_54

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81334-4

  • Online ISBN: 978-3-642-81332-0

  • eBook Packages: Springer Book Archive

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