Adjuvant Therapy of Operable Primary Osteosarcoma-Cancer and Leukemia Group B Experience
The major therapeutic approach to primary osteogenic sarcoma has, for many years, been radical surgery. Despite differences in pretherapeutic work-up, surgical techniques, and demography, the overall survival rates in the review of Friedman and Carter was 19.7% (253 of 1286 patients) . The range was fairly small, 16%–23% in the series published. Radiologic evidence of pulmonary metastases occurs at a median of 8.5 months after potentially curative amputation . The patient usually dies within 6 months from the onset of detectable pulmonary metastases .
KeywordsPulmonary Metastasis Protocol Deviation Leukemia Group Protocol Adherence Primary Osteogenic Sarcoma
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