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Adjuvant Therapy in the Management of Osteosarcoma: Need for Critical Reassessment

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Book cover Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease II

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 68))

Abstract

Until about 8 years ago, the prognosis for patients with osteosarcomas used to be extremely bad [3, 9, 14] in spite of the fact that the control of the primary tumor is usually achieved. As about 90% of these tumors arise in the long bones of the limbs, ablative surgery can usually be performed as a radical procedure and local recurrences are fairly rare. In some centers, mainly in France, radiotherapy is used as an alternative. As osteosarcomas are rather radioresistant tumors, very high radiation doses are necessary. Even though such treatment regimens sometimes lead to complications in the normal tissues, some local recurrences still do occur. However, both the sequelae and the tumor regrowth can usually be managed without great difficulty with ablative surgery. Although this policy is much more complicated and requires intensive follow-up of the patient, the possibility to preserve the limb in a fraction of the patients merits serious consideration.

“I suppose it was only one more indication of a human being’s capacity for self-deception, our baseless optimism that is so much more appalling than our despair.” Graham Greene, 1938

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Authors
  1. K. Breur
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  2. E. van der Schueren
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Editor information

Editors and Affiliations

  1. Istituto Nazionale dei Tumori, Via Venezian 1, I-20133, Milano, Italy

    Gianni Bonadonna

  2. Institut de Cancérologie et d’Immunogénétique, Hôpital Paul-Brousse, 14-16, Avenue Paul-Vaillant-Couturier, F-94800, Villejuif, France

    Georges Mathé

  3. University of Arizona Cancer Center, 1501 North Campbell Ave., Tucson, Arizona, 85724, USA

    Sydney E. Salmon

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© 1979 Springer-Verlag Berlin · Heidelberg

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Breur, K., van der Schueren, E. (1979). Adjuvant Therapy in the Management of Osteosarcoma: Need for Critical Reassessment. In: Bonadonna, G., Mathé, G., Salmon, S.E. (eds) Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease II. Recent Results in Cancer Research, vol 68. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81332-0_2

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  • DOI: https://doi.org/10.1007/978-3-642-81332-0_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81334-4

  • Online ISBN: 978-3-642-81332-0

  • eBook Packages: Springer Book Archive

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