Abstract
Nuclear medicine is the application of radionuclides to the investigation and treatment of disease. In its widest form, the speciality of nuclear medicine is thus involved in the management and treatment of patients with thyroid cancer at all stages. For the purpose of this review, however, the discussion will be restricted to the investigation of thyroid cancer before and after treatment; the subject of radioiodine therapy will be dealt with elsewhere. There are two distinct applications, which will be dealt with separately: (1) Preoperative diagnosis, which is usually the investigation of the solitary thyroid nodule; (2) Postoperative assessment of residual functioning thyroid tissue and detection of residual or recurrent functioning tumour, including metastatic deposits.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Alderson PO, Sumner HW, Siegel BA (1976) The single palpable thyroid nodule. Cancer 37: 258–265
Arnold J, Pinsky, S, Ryo UY, Frohman L, Schneider A, Favus M, Stachura M, Arnold M, Colman M (1975) 99mTc Pertechnetate thyroid scintigraphy in patients predisposed to thyroid neoplasm by prior radiotherapy to the head and neck. Radiology 115: 653–657
Beierwaltes WH (1978) The treatment of thyroid carcinoma with radioactive iodine. Semin Nucl Med 8: 79–94
Bekerman C, Gottschalk A, Hoffer PB (1974) Optimal time for 131I total body imaging to detect metastatic thyroid carcinoma. J Nucl Med Allied Sci 15: 477
Bonte FJ, McConnell RW (1973) Pulmonary metastases from differentiated thyroid carcinoma demonstrable only by nuclear imaging. Radiology 107: 585–590
Cowan RI (1976) Thyroid imaging with radionuclides. South-eastern chapter, Society of nuclear medicine, Atlanta Georgia, continuing education lectures. A review of nuclear medicine, part I, pp 2. 1–2. 15
Edmonds CJ, Smith T, Barnaby CF (1970) Follow-up of thyroid carcinoma by whole body counting. Br J Radiol 43: 868–875
Edmonds CJ, Hyes S, Kermode JC, Thompson BD (1977) Measurement of serum TSH and thyroid hormones in the management of treatment of thyroid cyarcinoma with radioiodine. Br J Radiol 50: 799–807
Fukuchi M, Tachibana K, Kuwata K, Nishikawa A, Hyodo K, Okamoto E, Nagai K (1978) Thallium-201 imaging in a thyroid carcinoma — Appearance of a lymph node metastasis. J Nucl Med Allied Sci 19: 195–196
Galvan G (1977) Thin needle aspiration biopsy and cytological examination of hypofunctional `cold’ thyroid nodules in routine clinical work. Clin Nucl Med 2: 413–421
Gardet P, Parmentier C, Gerard-Marchant R, L’heritier C, Caillou B, Cukersztein W, Tubiana M (1977) Differentiated cancers of the thyroid: Course after treatment with special reference to frequency and chronology of the first relapse for 470 treated patients. Ann Radiol (Paris) 20: 831–840
Goolden AWG, Glass BA, Silvester DJ (1968) The choice of a radioactive isotope for the investigation of thyroid disorders. Br J Radiol 41: 20–25
Graze K, Spiler IJ, Tashjian AH, Melvin KEW, Cevvi-Skinner G, Gagel RF, Miller HH, Wolfe HJ, De Lellis RA, Leape L, Feldman ZT, Reichlin S (1978) Natural history of familial medullary thyroid carcinoma. Effect of a program for early diagnosis. N Engl J Med 299: 980–985
Hamburger JI (1969) Diuretic augmentation of 131I uptake in inoperable thyroid cancer. N Engl J Med 280: 1091–1094
Henk JM, Kirkman S, Owen GM (1972) Whole body scanning and 131I therapy in the management of thyroid carcinoma. Br J Radiol 45: 369–376
Hershman JM, Edwards CL (1972) Serum Thyrotropin (TSH) levels after thyroid ablation compared with TSH levels after exogenous bovine TSH; Implications for 131I treatment of thyroid carcinoma. J Clin Endocrinol Metab 34: 814–818
Hurley PJ, Strauss HW, Pavoni P, Langan JK, Wagner HN Jr (1971) The scintillation camera with pinhole collimator in thyroid imaging. Radiology 101: 133
Kaplan WD, Holman BL, Selenkow HA, Davis MA, Holmes RA, Isitman AT, Chandler HL (1974) 67Ga-Citrate and the non-functioning thyroid nodule. J Nucl Med Allied Sci 15: 424–427
Karelitz JR, Richards JB (1975) Necessity of oblique views in evaluating the functional status of a thyroid nodule. J Nucl Med Allied Sci 15: 782–785
Koutras DA, Pandos PG, Sfontouris J, Koukoulomati-Speritza A, Psarras A, Malamos (1976) Thyroid scanning with Gallium-67 and Cesium-131. J Nucl Med Allied Sci 17: 268–271
Kristhnamurthy GT (1978) Human reaction to bovine TSH. J Nucl Med Allied Sci 19: 284–286
Krishnamurthy GT, Bland WH (1972) Diagnostic and therapeutic implications of long term radioisotope scanning in the management of thyroid cancer. J Nucl Med Allied Sci 13: 924–927
Lahey FH (1953) Preoperative diagnosis of carcinoma of the thyroid in surgery of the thyroid. Surg Clin North Am 33: 781–792
Livadas D, Psarras A, Koutras DA (1976) Malignant cold thyroid nodules in hyperthyroidism. Br J Surg 63: 726–728
Lo Gerfo P, Stillman T, Colacchio D, Feind C (1977) Serum Thyroglobulin and recurrent thyroid cancer. Lancet 1: 881–882
Ma M, Ong GB (1975) Cystic thyroid nodules. Br J Surg 62: 205
Maisey MN, Moses DC, Hurley PJ, Wagner HN Jr (1963) Improved methods for thyroid scanning. JAMA 223: 761–763
Massin JP, Plauchon C, Perez R (1977) Comparison of 99mTc-Pertechnetate and 131I in scanning of thyroid nodules. Clin Nucl Med 2: 324–333
Meybier H, Claussen C, Nievergelt J, Wahl R (1978) Computerised tomography in retrosternal goitre and cold thyroid nodules. Abstract of the 9th annual meeting of the European Thyroid Association, Berlin. Ann Endocrinol (Paris) 39: (5) A 18
Miskin M, Rosen IB, Walfish PG (1973) B-mode ultrasonography in the assessment of thyroid gland lesions. Ann Intern Med 79: 505–510
National Cancer Institute (1976) U.S. Department of health, education and welfare: Irradiation-related thyroid cancer. Information for Physicians. DHEW Publication No (N1H) 77–1120, Washington
Ng Tang Fui S, Maisey MN (to be published) Radionuclide thyroid scanning. Hospital Update
Patton JA, Hollifield JN, Brill AB, Lee GS, Patton DD (1976) Differentiation between malignant and benign solitary thyroid nodules by fluorescent scanning. J Nucl Med Allied Sci 17: 17–21
Perlmutter M, Slater SL (1956) Which nodular goitres should be removed? N Engl J Med 255: 65–71
Pochin EE (1971) Radioiodine therapy of thyroid cancer. Semin Nucl Med 1: 503–515
Preisman RA, Halpern S (1978) Detection of metastatic thyroid carcinoma after the administration of a therapeutic dose of 131I-Iodine. Eur J Nucl Med 3: 69–70
Psarras A, Papadopoulos SN, Livadas D, Pharmakiolis AD, Koutras DA (1972) The single thyroid nodule. Br J Surg 59: 545–548
Ryo UY, Arnold J, Colman M, Arnold M, Favus M, Frohman L, Schneider A, Stachura M, Pinsky S (1976) Thyroid scintigram. Sensitivity with Sodium Pertechnetate Tc99m and gamma camera with pinhole collimator. JAMA 235: 1235–1238
Stahl TJ, Shapiro B (1973) Use of human thyrotropin radioimmunoassay in management of patients with thyroid carcinoma. J Nucl Med Allied Sci 14: 900–902
Tadros TG (1978) Fluorescent excitation analysis in clinical and endocrinological investigations. Ph. D. dissertation University of London
Thomas SR, Maxon HR, Kereiakes JG, Saenger EL (1977) Quantitative external counting techniques enabling improved diagnostic and therapeutic decisions in patients with well differentiated thyroid cancer. Radiology 122: 731–737
Turner JE, Weir GJ (1972) Pulmonary metastases from thyroid carcinoma detectable only by 131I scan. Treatment and response. J Nucl Med Allied Sci 13: 852–855
Herle AJ van, Uller RP, Matthews NL, Brown J (1973) Radioimmunoassay for measurement of thyroglobulin in human serum. J Clin Invest 52: 1320–1327
Herle AJ van, Uller RP (1975) Elevated serum thyroglobulin. A marker for metastases in differentiated thyroid carcinoma. J Clin Invest 56: 272–277
Wang CA, Vickery AL, Maloof F (1976) The role of needle biopsy in evaluating solitary cold thyroid nodules. In: Robbins J, Braverman L (eds) Thyroid research. Proceedings of the seventh International Thyroid Conference. Excerpta Medica, Amsterdam Oxford, American Elsevier, New York, pp 568–570
Weinstein MB, Ashkar FS, Caron CD (1971) 75Se Selenomethionine as a scanning agent for the differential diagnosis of the cold thyroid nodule. Semin Nucl Med 1: 390–396
Wellman HN, Anger RT Jr (1971) Radioiodine dosimetry and the use of radioiodines other than 131I in thyroid diagnosis. Semin Nucl Med 1: 356–378
Wolfstein RS (1978) Enigma of the hyperfunctioning thyroid carcinoma resolved. J Nucl Med Allied Sci 19: 441–442
Woolfender JM, Waxman AD, Wolfstein RS, Siemsen JK (1975) Scintigraphic evaluation of liver metastases from thyroid carcinoma. J Nucl Med 16: 669–671
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Maisey, M.N., Ng Tang Fui, S. (1980). Nuclear Medicine in the Assessment of Thyroid Cancer. In: Duncan, W. (eds) Thyroid Cancer. Recent Results in Cancer Research, vol 73. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81325-2_8
Download citation
DOI: https://doi.org/10.1007/978-3-642-81325-2_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-81327-6
Online ISBN: 978-3-642-81325-2
eBook Packages: Springer Book Archive