Abstract
Ectopic hormone secretion was first demonstrated by MEADOR et al. [8] in 1962 in patients with Cushing’s syndrome due to ACTH production by nonpituitary tumors. Since this discovery almost all the known peptide hormones have now been reported to be ectopically produced by a variety of tumors (Table 1). This new concept has lead to major developments in endocrinology, particularly in the field of peptide hormone biosynthesis. On the other hand, it has stimulated the search for a new class of tumor markers (hormone markers) with potential usefulness in cancer detection, localization, and therapeutic evaluation.
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Bertagna, X.Y. et al. (1979). Ectopic Production of ACTH, Lipotropin, and β-Endorphin by Human Cancer Cells. Structurally Related Tumor Markers. In: Bonadonna, G., Mathé, G., Salmon, S.E. (eds) Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease I. Recent Results in Cancer Research, vol 67. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81320-7_3
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DOI: https://doi.org/10.1007/978-3-642-81320-7_3
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