Abstract
Polypeptide elongation takes place by repeated cycles composed of three sequential steps: EF-Tu (or EF-1)-dependent aminoacyl-tRNA binding [step (d)], ribosome-cata1yzed peptide bond formation [step (e)] and EF-G (or EF-2)-dependent translocation [step (f)]. Besides the initiation complex formed in step (c2), two molecules of GTP, the specific aminoacyl-tRNA and the elongation factors (EF-Ts, EF-Tu and EF-G in bacteria; EF-1 and EF-2 in eukaryotes) are required in the first elongation cycle.
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© 1979 Springer-Verlag Berlin · Heidelberg
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Vázquez, D. (1979). Elongation. In: Inhibitors of Protein Biosynthesis. Molecular Biology Biochemistry and Biophysics, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81309-2_3
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DOI: https://doi.org/10.1007/978-3-642-81309-2_3
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-81311-5
Online ISBN: 978-3-642-81309-2
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