Hyperacute Form of Experimental Autoimmune Uveo-Retinitis in Lewis Rats; Electron Microscopic Study

  • Y. de Kozak
  • B. Thillaye
  • G. Renard
  • J. P. Faure
Conference paper
Part of the Current Research in Ophthalmic Electron Microscopy book series (CR OPHTHALMIC, volume 2)


One systemic injection of retinal tissue or extract mixed with Freund’s complete adjuvant induces uveo-retinitis in several animal species: guinea pig [6], rabbit [5,7], monkey [4] and rat [8]. Rod outer segments may be used as the pathogenic antigenic preparation [1,3,9]. This study reports on the conditions of induction of experimental autoimmune uveo-retinitis (EAU) in rats (susceptible strains of rats, optimal doses of antigen and adjuvant) and the histopathological features of the lesions in the early stages of the disease.

In several species one systemic injection of retinal tissue or extract mixed with Freund’s complete adjuvant induces an ocular inflammatory disease, whose main features are an inflammatory infiltration of the uvea and a destruction of the external layers of the retina. With adequate doses of guinea pig retinal extract and adjuvant, the disease was induced in all cases in albino rats of the Lewis strain. The vascular and tissular lesions, and the infiltrates with a predominance of PMN’s and basophils seem to be the result of immune complexe deposition.


Retinal Pigment Epithelium Ciliary Body Pertussis Vaccine Visual Cell Immune Complexe Deposition 
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  1. 1.
    de Kozak, Y., Usui, M., Faure, J.P.: Uvéo-rétinite auto-immune expérimentale. Ultrastructure des lésions chorio-rétiniennes induites chez le cobaye par immunisation contre les articles externes de rétine bovine. Arch. Ophtal. (Paris), 36, 231–248 (1976)Google Scholar
  2. 2.
    McMaster, P.R.B., Wong, V.G., Owens, J.D.: The propensy of different strains of guinea pigs to develop experimental autoimmune uveitis. Mod. Probl. Ophthal., 16, 62–71 (1976)Google Scholar
  3. 3.
    Meyers, R.L., Pettit, T.H.: Pathogenesis of experimental allergic uveitis induced by retinal rod outer segments and pigment epithelium. J. Immunol., 114, 1269–1274 (1975)PubMedGoogle Scholar
  4. 4.
    Sallmann, L. Von, Meyers, R., Stone, S., Lerner, E.: Retinal and uveal inflammation in monkeys following inoculation with homologous retinal antigen. Arch. Ophthal., 81, 381–392 (1969)Google Scholar
  5. 5.
    Tilgner, S., Hempel, E., Meyer, W., Schroder, K.D.: Experimentelle allergische Chorioretinitis bei Kaninchen durch Immunisierung mit homologer Retina in Adjuvans. II. Histologische Untersuchungen. Albrecht v. Graefes Arch. klin. exp. Ophthal., 181, 285–298 (1974)CrossRefGoogle Scholar
  6. 6.
    Wacker, W.B., Barbee, J.Y., Macdonald, R. Jr.: Experimental allergic uveitis. III. Manifestations produced in the guinea pig by immunization with homologous retina. Invest. Ophthal., 8, 381–392 (1969)Google Scholar
  7. 7.
    Wacker, W.B., Lipton, M.M.: Experimental allergic uveitis. I. Production in the guinea pig and rabbit by immunization with retina in adjuvant. J. Immunol., 101, 151–156 (1968)PubMedGoogle Scholar
  8. 8.
    Wacker, W.B., Kalsow, C.M.: Autoimmune uveo-retinitis in the rat sensitized with retina photoreceptor cell antigen. Int. Arch. Allergy, 45, 582–592 (1973)PubMedCrossRefGoogle Scholar
  9. 9.
    Wong, V.G., Green, W.R., Kuwabara, T., Mc Master, P.R.B., Cameron, T.P.: Homologous retinal outer segment immunization in primates. Arch. Ophthal. 93, 509–513 (1975)PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1978

Authors and Affiliations

  • Y. de Kozak
    • 1
  • B. Thillaye
    • 1
  • G. Renard
    • 1
  • J. P. Faure
    • 1
  1. 1.Centre de Recherche d’Ophtalmologie, Hôtel-DieuParis Cedex 04France

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