The Efficiency of Oxidative Phosphorylation

  • J. W. Stucki
Part of the Colloquium der Gesellschaft für Biologische Chemie book series (MOSBACH, volume 29)


In many experimental studies with incubated mitochondria it appeared that atstate 4, i.e., in the presence of oxygen and oxidizable substrates but in the absence of added ADP, oxidative phosphorylation behaved almost like a system at thermodynamic equilibrium. This conclusion was based exclusively on the comparison of the measured ∆G values of the driving reaction (oxidation) and the driven reaction (phosphorylation) with their known equilibrium values. From this it was then assumed that the efficiency of mitochondrial energy transductions, notably oxidative phosphorylation, can be treated within the framework of classical equilibrium thermodynamics. Consequently, oxidative phosphorylation at state 4 appeared to operate with an efficiency of almost 100%. Furthermore, it was tacitly assumed that this thermodynamic treatment of oxidative phosphorylation can be extended to mitochondria incubated in the presence of ADP, i.e., under state 3 conditions. Consequently oxidative phosphorylation was assumed to operate with nearly 100% efficiency also at state 3.


Oxidative Phosphorylation Entropy Production Flow Ratio Impedance Match Optimal Efficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Ernster, L., Nordenbrand, K.: In: Dynamics of Energy Transducing Membranes. Ernster, L., Estabrook, R.W., Slater, E.C. (eds.) . Amsterdam: Elsevier Scientific Publ. Co., 1974, Vol. 13, p. 283Google Scholar
  2. 2.
    Rottenberg, H., Caplan, S.R., Essig, A.: In: Membranes and Ion Transport. Bittar, E.E. (ed.). London: Wiley-Interscience, 1970, Vol. 1, p. 165Google Scholar
  3. 3.
    Caplan, S.R.: In: Current Topics in Bioenergetics. Sanadi, D.R. (ed.). New York: Academic Press, 1971, Vol. 4, p. 1Google Scholar
  4. 4.
    Stucki, J.W.: Eur. J. Biochem. 68, 551 (1976)PubMedCrossRefGoogle Scholar
  5. 5.
    Carafoli, E., Rossi, C.S., Lehninger, A.L.: Biochem. Biophys. Res. Commun. 19, 609 (1965)CrossRefGoogle Scholar
  6. 6.
    Lehninger, A.L., Carafoli, E., Rossi, C.S.: Adv. Enzymol. 29, 259 (1967)PubMedGoogle Scholar
  7. 7.
    Stucki, J.W., Ineichen, E.A.: Eur. J. Biochem. 48, 365 (1974)PubMedCrossRefGoogle Scholar
  8. 8.
    Stucki, J.W., Walter, P.: Eur. J. Biochem. 30, 60 (1972)PubMedCrossRefGoogle Scholar
  9. 9.
    Prigogine, I.: Introduction to Thermodynamics of Irreversible Processes. New York: Interscience, 1967Google Scholar
  10. 10.
    Katchalsky, A., Curran, P.F.: Nonequilibrium Thermodynamics in Biophysics. Cambridge, Massachusetts: Harvard UniversicyPress, 1965Google Scholar
  11. 11.
    Kedem, O., Caplan, S.R.: Trans. Faraday Soc. 61, 1897 (1965)CrossRefGoogle Scholar
  12. 12.
    Stucki, J.W.: Progr. Biophys. Mol. Biol., 33, 99 (1978)CrossRefGoogle Scholar
  13. 13.
    Nicolis, G., Prigogine, I.: Self-Organization in Nonequilibrium Systems. New York: John Wiley, 1977Google Scholar
  14. 14.
    Glansdorff, P., Prigogine, I.: Thermodynamic Theory of Structure, Stability and Fluctuations. New York: John Wiley, 1971Google Scholar
  15. 15.
    Rottenberg, H.: In: Progress in Surface and Membrane Science. Danielli, J.F., Cadenhead, A., Rosenberg, M.D. (eds.). New York: Academic Press, 1978, in pressGoogle Scholar
  16. 16.
    Owen, Ch.S., Wilson, D.F.: Arch. Biochem. Biophys. 161, 581 (1974)PubMedCrossRefGoogle Scholar
  17. 17.
    Erecinska, M., Veech, R.L., Wilson, D.F.: Arch. Biochem. Biophys. 160, 412 (1974)PubMedCrossRefGoogle Scholar
  18. 18.
    Caplan, S.R., Essig, A.: Proc. Natl. Acad. Sci. U.S.A. 64, 211 (1969)PubMedCrossRefGoogle Scholar
  19. 19.
    Chance, B., Williams, G.R.: Adv. Enzymol. 17, 92 (1956)Google Scholar
  20. 20.
    Davis, E.J., Lumeng, L.: J. Biol. Chem. 250, 2275 (1975)Google Scholar
  21. 21.
    Atkinson, D.E.: Biochemistry 7, 4030 (1968)PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • J. W. Stucki

There are no affiliations available

Personalised recommendations