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Organization of the Mitochondrial Respiratory Chain

  • Conference paper
Energy Conservation in Biological Membranes

Part of the book series: Colloquium der Gesellschaft für Biologische Chemie ((MOSBACH,volume 29))

Abstract

In mitochondria, the machinery for oxidative phosphorylation is contained in the inner membrane, which is composed of approximately 70% protein and 30% lipid. Systematic fractionation of inner membrane preparations from bovine heart mitochondria showed in 1961 that the mitochondrial electron transport system could be fragmented into four protein-lipid enzyme systems with the following catalytic properties:

  1. I.

    NADH:ubiquinone oxidoreductase

  2. II.

    Succinate:ubiquinone oxidoreductase

  3. III.

    Reduced ubiquinone:ferricytochrome c oxidoreductase

  4. IV.

    Ferrocytochrome c:oxygen oxidoreductase

The work of this laboratory was supported by grants USPHS AM 08126 and NSF PCM7601378 A01 to Y.H.

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Authors
  1. Y. Hatefi
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  2. Y. M. Galante
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Editor information

Editors and Affiliations

  1. Institut für Klinische Biochemie und Physiologische Chemie, Medizinische Hochschule Hannover, Karl-Wiechert-Allee 9, 3000, Hannover 61, Germany

    Günter Schäfer

  2. Institut für Physiologische Chemie, Physikalische Biochemie und Zellbiologie, Universität München, Goethestraße 33, 8000, München 2, Germany

    Martin Klingenberg

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Hatefi, Y., Galante, Y.M. (1978). Organization of the Mitochondrial Respiratory Chain. In: Schäfer, G., Klingenberg, M. (eds) Energy Conservation in Biological Membranes. Colloquium der Gesellschaft für Biologische Chemie, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81287-3_2

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  • DOI: https://doi.org/10.1007/978-3-642-81287-3_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81289-7

  • Online ISBN: 978-3-642-81287-3

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