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Hormones and Hormonomimetic Compounds in the Etiology of Cancer

  • Chapter
Carcinogenic Hormones

Abstract

Hormones, particularly those produced by the gonads, and their synthetic analogs have been the subject of controversy concerning their roles in the process of carcinogenesis. Experimental evidence, dating from 1916 [118] (Table 1), that estrogens can be potent carcinogens was overlooked or lightly dismissed by many because of a prevalent belief that the body should be able to metabolize these physiologic compounds without toxic effects. The relevance of animal experiments to the human cancer problem was also questioned. During the past four decades, a variety of naturally occurring and synthetic estrogens, progestins, and androgens have been manufactured and prescribed in ever-increasing amounts for replacement, treatment of cancer, prevention of abortion, suppression of lactation, contraception, and other purposes without adequate attention to their carcinogenic potential.

I am indebted to Drs. Harold L. Stewart, Heramn F. Kraybill, and Erwun P. Vollmer for their helpful comments and suggestions.

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  1. Carolyn H. Lingeman
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  1. Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, MD, 20014, USA

    Carolyn H. Lingeman M.D.

  2. Department of Environmental and Drug Induced Pathology, Armed Forces Institute of Pathology, Washington, DC, 20306, USA

    Carolyn H. Lingeman M.D.

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Lingeman, C.H. (1979). Hormones and Hormonomimetic Compounds in the Etiology of Cancer. In: Lingeman, C.H. (eds) Carcinogenic Hormones. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 66. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81267-5_1

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