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Transport of Ions in Liver Cells

  • M. Claret
Part of the Membrane Transport in Biology book series (MEMBRANE, volume 4)

Abstract

The general characteristics of ionic distribution in hepatocytes are similar to those in other cells. Potassium concentration is higher and sodium and chloride concentrations are lower than in plasma, and most of the evidence suggests that the fundamental processes implicated in this distribution are the same as in other tissues. The membranes of hepatocytes, however, exhibit unique biophysical properties, especially with regard to the passive permeabilities, facilitated diffusion, and the electrogenic activity of the sodium pump. The characteristics of these different transport processes will be described in the present chapter, with a particular emphasis on potassium, sodium, chloride and calcium ions, since these have been studied most intensively.

Keywords

Cation Transport Liver Slice Sodium Pump Coupling Ratio Liver Cell Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ahmed, K., JudahJ. D.: Biochim. biophys. Acta 57, 245 (1962).PubMedGoogle Scholar
  2. Bakkeren, J. A. J. M., Bonitng, S. L.: Biochim. biophys. Acta 150, 460 (1968).PubMedGoogle Scholar
  3. Baker, P. F., Blaustein, M. P., Keynes, R. D., Manil, J., Shaw, J. I., Steinhardt, R. A.: J. Physiol. 200, 459 (1969).PubMedGoogle Scholar
  4. Barnabei, O., Leghissa, G., Tomasi, V.: Biochim. biophys. Acta 362, 316 (1974).PubMedGoogle Scholar
  5. Baur, H., Kasperek, S., Pfaff, E.: Hoppe-Seyler’s Z. Physiol. Chem. 356, 827 (1975).PubMedGoogle Scholar
  6. Beigelman, P. M., Coraboeuf, E., Guilbault, P.: Life Sci. 3, 1343 (1964).PubMedGoogle Scholar
  7. Beigelman, P. M., Schlosser, G. H.: Biochem. Med. 3, 73 (1969).Google Scholar
  8. Beigelman, P. M., Thomas, L. J.: J. Membrane Biol. 8, 181 (1972).Google Scholar
  9. Biederman, M.: Acta biol. med. germ. 21, 827 (1968).Google Scholar
  10. Bonting, S. L.: In: Membrane Ion Transport. (E. E. Bittar, Ed.). London: Wiley-Interscience 1970, p. 257.Google Scholar
  11. Boyer, J. L., Reno, D.: Biochim. biophys. Acta 401, 59 (1975).PubMedGoogle Scholar
  12. Bristow, D. A., Kerly, M.: J. Physiol. 170, 318 (1964).PubMedGoogle Scholar
  13. Caille, J. P., Schanne, O. F.: Canad. J. Physiol. Pharmacol. 50, 416 (1972).Google Scholar
  14. Cascarano, J., Seidman, I.: Biochim. biophys. Acta 100, 301 (1965).PubMedGoogle Scholar
  15. Carafoli, E.: J. gen. Physiol. 50, 1849 (1967).PubMedGoogle Scholar
  16. Chambault, A. M., Leray-Pecker, F., Feldman, G., Hanoune, J.: J. gen. Physiol. 64, 104 (1974).Google Scholar
  17. Christinaz, P., Schatzmann, H. J.: J. Physiol. 224, 391 (1972).PubMedGoogle Scholar
  18. Claret, M., Coraboeuf, E., Ehrhart, J. C: C.: R. Soc. Biol. 160, 476 (1966).Google Scholar
  19. Claret, M., Coraboeuf, E.: J. Physiol. 210, 137 (1970).Google Scholar
  20. Claret, M., Mazet, J.-L.: J. Physiol. 223, 279 (1972).PubMedGoogle Scholar
  21. Claret, B., Claret, M., Mazet, J.-L.: J. Physiol. 230, 87 (1973).PubMedGoogle Scholar
  22. Claret, B., Claret, M., Mazet, J.-L., GuillonG.: C. R. Acad. Sci. Paris 281, 1855 (1975).Google Scholar
  23. Claret-Berthon, B., Claret, M., Mazet, J. L.: J. Physiol. 272, 529 (1977).PubMedGoogle Scholar
  24. Dambach, G., Friedmann, N.: Biochim. biophys. Acta 367, 366 (1974).PubMedGoogle Scholar
  25. Dawkins, M. J. R.; Judah, J. D., Rees, K. R.: J. Pathol. Bact. 77, 257 (1959).Google Scholar
  26. D’Silva, J. L., Neil, M. W.: J. Physiol. 124, 515 (1954).PubMedGoogle Scholar
  27. Dubinsky, W. P., Cokrell, R. S.: FEBS Letters 59, 39 (1975).PubMedGoogle Scholar
  28. Elshove, A., Van Rossum, G. D. V.: J. Physiol. 168, 531 (1963).PubMedGoogle Scholar
  29. Emmelot, P., Bos, C. J.: Biochim. biophys. Acta 150, 354 (1968).PubMedGoogle Scholar
  30. Flink, E. B., Hastings, A. B., Lowry, J. K.: Amer. J. Physiol. 163, 598 (1950).PubMedGoogle Scholar
  31. Folke, M.: Proc. Int. Un. physiol. Sci. 9, 181 (1971).Google Scholar
  32. Folke, M.: Acta physiol. scand. 84, 43A (1972).Google Scholar
  33. Folke, M.: In: Regulation of Hepatic Metabolism (Alfred Benzon Symposium VI) (F. Lundquist and N. Tystrup, Eds.). Copenhagen: Munksgaard 1974, p. 596.Google Scholar
  34. Folke, M., Paloheimo, M.: Acta physiol. scand. 95, 44A (1975).Google Scholar
  35. Folke, M., Sestoft, L.: J. Physiol. 269, 407 (1977).PubMedGoogle Scholar
  36. Friedmann, N., Dambach, G.: Biochim. biophys. Acta 307, 399 (1973).Google Scholar
  37. Friedmann, N.: In: Regulation of Hepatic Metabolism (Alfred Benzon Symposium VI) (F. Lundquist and N. Tystrup, Eds.). Copenhagen: Munksgaard 1974, p. 32.Google Scholar
  38. Frimmer, M., KrehW.: Naunyn-Schmiedebergs Arch. Pharmak. 270, 313 (1971a).Google Scholar
  39. Frimmer, M., Kreh, W.: Naunyn-Schmiedebergs Arch. Pharmak. 268, 119 (1971b).Google Scholar
  40. Frimmer, M., Kroker, R.: Naunyn-Schmiedebergs Arch. Pharmak. 276, 99 (1973).Google Scholar
  41. Garneit, H. M., Kemp, R. B.: Biochim. biophys. Acta 382, 526 (1975).Google Scholar
  42. Garrahan, P. J., Glynn, I. M.: J. Physiol. 192, 159 (1967).PubMedGoogle Scholar
  43. Garrahan, P. J., Garay, R. P.: J. Physiol. 231, 297 (1973).PubMedGoogle Scholar
  44. Goldman, D. E.: J. gen. Physiol. 27, 37 (1943).PubMedGoogle Scholar
  45. Graf, J., Petersen, O. H.: Proc. roy. Soc. 187, 363 (1974).Google Scholar
  46. Green, R. D., Dale, M. M., Haylett, D. G.: Experientia 28, 1073 (1972).PubMedGoogle Scholar
  47. Haylett, D. G., Jenkinson, D. H.: J. Physiol. 225, 721 (1972a).PubMedGoogle Scholar
  48. Haylett, D. G., Jenkinson, D. H.: J. Physiol. 225, 751 (1972b).PubMedGoogle Scholar
  49. Heckmann, K. D., Parsons, D. S.: Biochim. biophys. Acta 36, 203 (1959).PubMedGoogle Scholar
  50. Heller, P., Van der Kloot, W.: J. Physiol. 243, 577 (1974).PubMedGoogle Scholar
  51. Hems, R., Lund, P., Krebs, H. A.: Biochem. J. 150, 47 (1975).PubMedGoogle Scholar
  52. Hodgkin, A. L., Katz, B.: J. Physiol. 108, 37 (1949).PubMedGoogle Scholar
  53. Hooper, G., Dick, D. A. T.: J. Gen. Physiol. 67, 469 (1976).PubMedGoogle Scholar
  54. Howard, R. B., Lee, J. C., Pesch, L. A.: J. Cell. Biol. 57, 642 (1973).PubMedGoogle Scholar
  55. Humphrey, E. W.: Cancer Res. 21, 1566 (1961).PubMedGoogle Scholar
  56. Humphrey, E. W.: Surgery (St. Louis) 60, 411 (1966).Google Scholar
  57. Humphrey, E. W., Maeno, T.: Biochim. biophys. Acta 183, 236 (1969).Google Scholar
  58. Judah, J. D., McLean, A. E. M.: Biochem. Pharmac. 11, 593 (1962).Google Scholar
  59. Judah, J. D., Ahmed, K.: Biochim. biophys. Acta 71, 34 (1963).Google Scholar
  60. Judah, J. D., Ahmed, K.: J. cell. comp. Physiol. 64, 355 (1964).Google Scholar
  61. Kleineke, J., Stratman, F. W.: FEBS Letters 43, 75 (1974).PubMedGoogle Scholar
  62. Kleinzeller, A., Knotkova, A.: J. Physiol. 175, 172 (1964).PubMedGoogle Scholar
  63. Keynes, R. D., Steinhardt, R. A.: J. Physiol. 198, 581 (1968).PubMedGoogle Scholar
  64. Kolb, H. A., Adam, G.: J. Memb. Biol. 26, 121 (1976).Google Scholar
  65. Lambotte, L., Kesyens, P. J., Haxhe, J. J.: Arch. int. Physiol. Biochim. 74, 541 (1966).Google Scholar
  66. Lambotte, L.: Europ. Surg. Res. 2, 241 (1970).Google Scholar
  67. Lambotte, L.: J. Physiol. 232, 181 (1973a).PubMedGoogle Scholar
  68. Lambotte, L.: Surgery (St. Louis) 73, 8 (1973 b).Google Scholar
  69. Lambotte, L., Pontegnie-Istace, S.: Arch. int. Physiol. Biochim. 83, 623 (1975).PubMedGoogle Scholar
  70. Langendorf, H. G., Siebert, G., Kesselring, K., HannoverR.: Nature 209, 1130 (1966).PubMedGoogle Scholar
  71. Leaf, A.: Biochem. J. 62, 241 (1956).PubMedGoogle Scholar
  72. Lehninger, A.E.: Biochem. J. 119, 129 (1970).PubMedGoogle Scholar
  73. LI, C., McIlwain, H.: J. Physiol. 139, 178 (1957).PubMedGoogle Scholar
  74. Limberger, J.: Z. Krebsforsch. 65, 590 (1963).PubMedGoogle Scholar
  75. Lindenmayer, G. E., Schwartz, A., Thompson, H. K.: J. Physiol. 236, 1 (1974).PubMedGoogle Scholar
  76. Loewenstein, W. R., Nakas, M., Socolar, S. J.: J. gen. Physiol. 50, 1865 (1967).PubMedGoogle Scholar
  77. Loewenstein, W. R., Kanno, Y.: J. Cell Biol. 33, 225 (1967).PubMedGoogle Scholar
  78. Macknight, A. D. C, Pilgrim, J. P., Robinson, B. A.: J. Physiol. 238, 279 (1974).PubMedGoogle Scholar
  79. McLaughlin, C. W.: Biochim. biophys. Acta 323, 285 (1973).PubMedGoogle Scholar
  80. McLean, A.E. M.: Biochem. J. 87, 161 (1963).PubMedGoogle Scholar
  81. Mazet, J.-L., Claret, M., Claret, B.: J. Membrane Biol. 18, 335 (1974).Google Scholar
  82. Moore, L., Chen, T., Knapp, H. R., Landon, E. J.: J. biol. Chem. 250, 4562 (1975).PubMedGoogle Scholar
  83. Mullins, L. J., Noda, K.: J. gen. Physiol. 47, 117 (1963).PubMedGoogle Scholar
  84. Oleiveira-Castro, G. M., Loewenstein, W. R.: J. Membrane Biol. 5, 51 (1971).Google Scholar
  85. Parsons, D. S., Van Rossum, G. D. V.: J. Physiol. 164, 116 (1962).PubMedGoogle Scholar
  86. Penn, R.D.: J. Cell Biol. 29, 171 (1966).PubMedGoogle Scholar
  87. Petersen, O. H.: J. Physiol. 239, 647 (1974).PubMedGoogle Scholar
  88. Petersen, O. H.: Physiol. Rev. 56, 535 (1976).PubMedGoogle Scholar
  89. Rasmussen, H., Jensen, P., Lake, W., Friedmann, N., Goodman, D. B. P.: Advan. CycMc nucleotide Res. 5, 375 (1975).Google Scholar
  90. Rossi, C. S., Carafoli, E., Drahota, Z., Lehninger, A. L.: In: Regulation of Metabolic Process in Mitochondria (S. McTager, S. Papa, E. Quagliariello, and E. C. Slater, Eds.). Amsterdam: Elsevier 1966, p. 317.Google Scholar
  91. Russo, M. A., Van Rossum, G. D. V., Galeotti, T.: J. Memb. Biol. 31, 267 (1977).Google Scholar
  92. Sanui, H., Pace, N.: J. gen. Physiol. 42, 1325 (1959).PubMedGoogle Scholar
  93. Scarpa, A, Azzi, A.: Biochim. biophys. Acta 150, 473 (1968).PubMedGoogle Scholar
  94. Schanne, O., Coraboeuf, E.: Nature 210, 1390 (1966).PubMedGoogle Scholar
  95. Seglen, P. O.: Biochim. biophys. Acta 264, 398 (1972).PubMedGoogle Scholar
  96. Seidman, I., Cascarano, J.: Amer. J. Physiol. 211, 1165 (1966).PubMedGoogle Scholar
  97. Somlyo, A. P., Somlyo, A. V., Friedmann, N.: Ann. N.Y. Acad. Sci. 185, 108 (1971).PubMedGoogle Scholar
  98. Song, L. S., Rubin, W., Rifkind, A. B., KappasA: J. Cell Biol. 41, 124 (1969).PubMedGoogle Scholar
  99. Steinhardt, R. A.: J. Physiol. 200, 459 (1969).PubMedGoogle Scholar
  100. Thiers, R. E., Vallee, B. L.: J. biol. Chem. 226, 911 (1957).PubMedGoogle Scholar
  101. Toida, N., Tamai, T., Takagisi, T.: Kyushu J. med. Sci. 9, 163 (1958).Google Scholar
  102. Toda, G., Oka, H., Oda, T., Ikeda, Y.: Biochim. biophys. Acta 413, 52 (1975).PubMedGoogle Scholar
  103. Ussing, H. H.: Physiol. Rev. 29, 127 (1949).PubMedGoogle Scholar
  104. Van Rossum, G. D. V.: Biochim. biophys. Acta 122, 312 (1966a).Google Scholar
  105. Van Rossum, G. D. V.: Biochim. biophys. Acta 122, 323 (1966b).Google Scholar
  106. Van Rossum, G. D. V.: Nature 225, 638 (1970a).PubMedGoogle Scholar
  107. Van Rossum, G. D. V.: Biochim. biophys. Acta 205, 7 (1970b).PubMedGoogle Scholar
  108. Van Rossum, G. D. V.: J. gen. Physiol. 55, 18 (1970c).PubMedGoogle Scholar
  109. Van Rossum, G. D. V.: Biochem. J. 129, 427 (1972).PubMedGoogle Scholar
  110. Van Rossum, G. D. V., Smith, K. P., Beeton, P.: Nature, Lond. 260, 335 (1976).Google Scholar
  111. Wallach, S., Reizenstein, D. L., Bellavia, J. V.: J. gen. Physiol. 49, 743 (1966).PubMedGoogle Scholar
  112. Williams, J. A., Withrow, C. D., Woodbury, D. M.: J. Physiol. 212, 101 (1971a).PubMedGoogle Scholar
  113. Williams, J. A., Withrow, C. D., Woodbury, D. M.: J. Physiol. 212, 117 (1971b).PubMedGoogle Scholar
  114. Williams, J. A., Woodbury, D. M.: J. Physiol. 212, 85 (1971).PubMedGoogle Scholar
  115. Woods, H. F., Krebs, H. A.: Biochem. J. 125, 129 (1971).PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1979

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  • M. Claret

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