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Transport in Large Intestine

  • D. W. Powell
Part of the Membrane Transport in Biology book series (MEMBRANE, volume 4)

Abstract

Until recently, there has been relatively less understanding of fundamental mechanisms of electrolyte transport in the colonic epithelium than in the small intestine. The reason for this lag in research effort is not entirely clear. It may have been for the practical reason that “almost any study of colonic function involves work on colonic contents” (Wrong, 1971). Alternatively, it may have been for the more philosophical reasons cited — “The small intestine, after all, provides the main reason for the existence of the gut; all the rest is prologue or epilogue, for man can live without his stomach or his esophagus, and may thrive without his colon ...” (Spiro, 1975). In the present author’s opinion, the reason was probably scientific — the colonic epithelium was thought not to do as many interesting things as the small intestine. Thus, the colonic epithelium is incapable of active monosaccharide transport (Parsons and Paterson, 1960, 1965; Long et al. 1967; Heaton, 1972), or active amino acid transport1 (Baillien and Schoffeniels, 1961; Binder, 1970); and there is neither coupled sodium-glucose nor sodium-amino acid transport (Powell and Malawer, 1968; Billich and Levitan, 1969; Grady et al. 1970). However, unlike the small intestine, the colonic epithelium can transport sodium against a high concentration gradient and responds to alddsterone by increasing sodium transport. In addition, its internal milieu is such that nitrogen transport and organic anion transport may be among its important functions. These are the reasons why this epithelium is now beginning to receive attention. Many of these aspects are discussed in several excellent reviews of the general absorptive and secretory functions of the colon (Wrong, 1971; Hagihara and Griffen, 1972; Shields, 1972; Cummings, 1975).

Keywords

Colonic Epithelium Unstirred Layer Ammonia Transport Bicarbonate Secretion Electrolyte Transport 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ammon, H. V., PhillipsS. F.: Gastroenterology 65, 744 (1973).PubMedGoogle Scholar
  2. Aoyagi, T., Engstrom, G. W., Evans, W. B., Summerskill, W. H. J.: Gut 7, 631 (1966).PubMedGoogle Scholar
  3. Archampong, E. Q., Harris, J., Clark, C. G.: Gut 13, 880 (1972).PubMedGoogle Scholar
  4. Argenzio, R. A., Southworth, M.: Amer. J. Physiol. 228, 454 (1974).Google Scholar
  5. Argenzio, R.A., Lowe, J. E., Pickard, D. W., StevensC. E.: Amer. J. Physiol. 226, 1035 (1974a).PubMedGoogle Scholar
  6. Argenzio, R. A., Southworth, M, Stevens, C. E.: Amer. J. Physiol. 226, 1043 (1974b).PubMedGoogle Scholar
  7. Argenzio, R. A., Miller, N., von Engelhardt, W.: Amer. J. Physiol. 229, 997 (1975).PubMedGoogle Scholar
  8. Argenzio, R. A., Southworth, M., Lowe, J. E., Stevens, C. E.: Amer. J. Physiol. 233, E469 (1977).PubMedGoogle Scholar
  9. Asano, T.: Proc. Soc. exp. Biol. 131, 1201 (1969).PubMedGoogle Scholar
  10. Ash, R. W., Dobson, A.: J. Physiol. 169, 39 (1963).PubMedGoogle Scholar
  11. Aulsebrook, K. A.: Endocrinology 68, 1063 (1961).PubMedGoogle Scholar
  12. Baillien, M., Schoffeniels, E.: Biochim. biophys. Acta 53, 521 (1961a).PubMedGoogle Scholar
  13. Baillien, M., Schoffeniels, E.: Biochim. biophys. Acta 53, 537 (1961b).PubMedGoogle Scholar
  14. Bank, N., Schwartz, W. B.: J. appl. Physiol. 15, 125 (1960).PubMedGoogle Scholar
  15. Barbezat, G. O.: Scand. J. Gastroent. 8, 1 (Suppl. 22) (1973).Google Scholar
  16. Barnaby, C. F., Edmonds, C. J.: J. Physiol. 205, 647 (1969).PubMedGoogle Scholar
  17. Barry, R. J. C., Eggenton, J.: Biomembranes 4B, 917 (1974).PubMedGoogle Scholar
  18. Barry, R. J. C., Smyth, D. H.: J. Physiol. 152, 48 (1960).PubMedGoogle Scholar
  19. Barry, R. J. C., Jackson, M. J., Smyth, D. H.: J. Physiol. 182, 150 (1966).PubMedGoogle Scholar
  20. Bastl, C., Hayslett, J. P., Binder, H. J.: Kidney International 12, 916 (1977).Google Scholar
  21. Behar, J.: Amer. J. Physiol. 227, 334 (1974).PubMedGoogle Scholar
  22. Bentley, P. J.: Gen. comp. Endocrinol. 2, 323 (1962).Google Scholar
  23. Bentley, P. J., Smith, M. W.: J. Physiol. 249, 103 (1975).PubMedGoogle Scholar
  24. Berger, E. Y., Kanzaki, G., Steel, J. M.: J. Physiol. 151, 352 (1960).PubMedGoogle Scholar
  25. Bergman, E. N., Reid, R. S., Murray, M. G., BrockwayJ. M., Whitelaw, F. G.: Biochem. J. 97, 53 (1965).PubMedGoogle Scholar
  26. Bieberdorf, F. A., Gorden, P., Fordtran, J. S.: J. clin. Invest. 51, 1958 (1972).PubMedGoogle Scholar
  27. Billich, C. O., Levitan, R.: J. clin. Invest. 48, 1336 (1969).PubMedGoogle Scholar
  28. Binder, H. J.: Biochim. biophys. Acta 219, 503 (1970).PubMedGoogle Scholar
  29. Binder, H. J.: Gastroenterology 67, 441 (1974).PubMedGoogle Scholar
  30. Binder, H. J.: Gastroenterology 70, A6/864 (1976).Google Scholar
  31. Binder, H. J.: In: Coupled Transport Phenomena in Cells and Tissues. (I. F. Hoffman, Ed.). New York: Raven Press 1977, p. 309.Google Scholar
  32. Binder, H. J., Rawlins, C. L.: Amer. J. Physiol. 225, 1232 (1973a).PubMedGoogle Scholar
  33. Binder, H. J., Rawlins, C. L.: J. clin. Invest. 52, 1460 (1973b).PubMedGoogle Scholar
  34. Binder, H. J., Filburn, C., Volpe, B. T.: Gastroenterology 68, 503 (1975).PubMedGoogle Scholar
  35. Bindslev, N., Skadhauge, E.: J. Physiol. 216, 735 (1971a).PubMedGoogle Scholar
  36. Bindslev, N., Skadhauge, E.: J. Physiol. 216, 753 (1971b).PubMedGoogle Scholar
  37. Bloch, R., Haberich, F. J., Lorenz-Meyer, H.: Pflügers Arch. 335, 198 (1972).PubMedGoogle Scholar
  38. Bond, J. H., Jr, Levitt, M. O.: J. clin. Invest. 57, 1158 (1976).PubMedGoogle Scholar
  39. Bown, R. L., Sladen, G. E., Rosasseau, B., GibsonJ. A., Clark, M. L., Dawson, A. M.: Clin. Sci. 43, 891 (1972).PubMedGoogle Scholar
  40. Bown, R. L., Gibson, J. A., Fenton, J. C. B., SneddenW., Clark, M. L., Sladen, G. E.: din. Sci. molec. Med. 48, 279 (1975).Google Scholar
  41. Bright-Asare, P., Binder, H. J.: Gastroenterology 64, 81 (1973).PubMedGoogle Scholar
  42. Brodsky, W. A., Schilb, J. P.: Fed. Proc. 26, 1314 (1967).PubMedGoogle Scholar
  43. Bromberg, P. A., Robbin, E. D., Forkner, C. E., Jr: J. clin. Invest. 39, 332 (1960).PubMedGoogle Scholar
  44. Bury, K. D., McClure, R. L., Wright, H. K.: Arch. Surg. 108, 854 (1974).PubMedGoogle Scholar
  45. Butler, T. C: Science 151, 1564 (1966).PubMedGoogle Scholar
  46. Carlisky, N. J., Lew, V. L.: J. Physiol. 206, 529 (1970).PubMedGoogle Scholar
  47. Carter, M. J., Parsons, D. S.: J. Physiol. 215, 71 (1971).PubMedGoogle Scholar
  48. Cassidy, M. M., Tidball, C. S.: Amer. J. Physiol. 217, 674 (1969).PubMedGoogle Scholar
  49. Castell, D. O., Moore, E. W.: Gastroenterology 60, 33 (1971).PubMedGoogle Scholar
  50. Chalfin, D., Cooperstein, I. L., Hogben, C. A. M.: Proc. Soc. exp. Biol. 99, 746 (1958).PubMedGoogle Scholar
  51. Chalupa, W.: Fed. Proc. 31, 1152 (1972).PubMedGoogle Scholar
  52. Chalupa, W.: Proc. Nutr. Soc. 32, 99 (1973).PubMedGoogle Scholar
  53. Chalmers, T. C: New Engl. J. Med. 263, 23 and 77 (1960).PubMedGoogle Scholar
  54. Charney, A. N., Kinsey, M. D., Myers, L., Giannella, R. A., Gots, R. E.: J. clin. Invest. 56, 653 (1975).PubMedGoogle Scholar
  55. Clarke, A. M., Miller, M., Shields, R.: Gastroenterology 52, 846 (1967).PubMedGoogle Scholar
  56. Clarkson, T. W., Rothstein, A., Cross, A.: Amer. J. Physiol. 200, 781 (1961).PubMedGoogle Scholar
  57. CofrÉ, G., CrabbÉ, J.: Nature 207, 1299 (1965).PubMedGoogle Scholar
  58. CofrÉ, G., CrabbÉ, J.: J. Physiol. 188, 177 (1967).PubMedGoogle Scholar
  59. Conley, D., Coyne, M., Chung, A., Bonorrio, G., Schoenfield, L.: Gastroenterology 71, 72 (1976).PubMedGoogle Scholar
  60. Cooperstein, I. L., Brockman, S. K.: J. clin. Invest. 38, 435 (1959).PubMedGoogle Scholar
  61. Cooperstein, I. L., Hogben, C. A. M.: J. gen. Physiol. 42, 461 (1959).PubMedGoogle Scholar
  62. Corrtveau, M., Rojo-Ortega, J. M.: Virchows Arch. B. Cell. Path. 18, 129 (1975).Google Scholar
  63. Coyne, M. J., Bonorrio, G. G., Chung, A., Conley, D. R., Croke, J., Schoenfield, L. J.: Gastroenterology 71, 68 (1976).PubMedGoogle Scholar
  64. Crane, C. W.: Gut 6, 439 (1965).PubMedGoogle Scholar
  65. Cummings, J.H.: Gut 16, 323 (1975).PubMedGoogle Scholar
  66. Curran, P. F., Schwartz, G. F.: J. gen. Physiol. 43, 555 (1960).PubMedGoogle Scholar
  67. DaCRUZ, G. M. G., Gardner, J. D., Peskin, G. W.: Amer. J. Surg. 115, 203 (1968).PubMedGoogle Scholar
  68. D’Agostino, A., Leadbetter, W. F., Schwartz, W. B.: J. clin. Invest. 32, 444 (1953).PubMedGoogle Scholar
  69. Dalmark, M.: Scand. J. Gastroent. 5, 421 (1970).PubMedGoogle Scholar
  70. Davies, N. T., Munday, K. A., Parsons, B. J.: J. Endocrinol. 48, 39 (1970).PubMedGoogle Scholar
  71. Davies, N. T., Munday, K. A., Parsons, B. J.: J. Endocrinol. 54, 483 (1972).PubMedGoogle Scholar
  72. Dawson, A. M., Holdsworth, C. D., Webb, J.: Proc. Soc. exp. Biol. 117, 97 (1966).Google Scholar
  73. Dawson, D. C, Brande. M. M.: Fed. Proc. 35, 618 (1976).Google Scholar
  74. Dawson, D. C, Curran, P. F.: J. Membrane Biol. 28, 295 (1976).Google Scholar
  75. Deuel, H. J., Jr, Hollman, L., Reifman, A.: J. Nutr. 21, 373 (1941).Google Scholar
  76. Devroede, G. J., Phillips, S. F.: Gastroenterology 56, 101 (1969).PubMedGoogle Scholar
  77. Devroede, G. J., Phillips, S. F.: Gut 11, 438 (1970).PubMedGoogle Scholar
  78. Devroede, G.J., Phillips, S.F., Code, C.F., Lind, J.F.: Canad. J. Physiol. Pharm. 49, 1023 (1971).PubMedGoogle Scholar
  79. Diamond, J. M.: Fed. Proc. 33, 2220 (1974).PubMedGoogle Scholar
  80. Diamond, J. M., Bossert, W. H.: J. gen. Physiol. 50, 2061 (1967).PubMedGoogle Scholar
  81. Dietschy, J. M., Carter, N. W.: Science 150, 1294 (1965).PubMedGoogle Scholar
  82. Dietz, J., Field, M.: Amer. J. Physiol. 225, 858 (1973).PubMedGoogle Scholar
  83. Dobbins, J. W., Binder, H. J.: Gastroenterology 70, 1096 (1976).PubMedGoogle Scholar
  84. Dobson, A., Phillipson, A. J.: In: Handbook of Physiology, Section 6: Alimentary Canal, Vol. 5: Bile; Digestion; Ruminal Physiology (C. F. Code, Ed.). Baltimore, Md: Williams and Wilkins 1968, p. 2761.Google Scholar
  85. Dolman, D., Edmonds, C. T.: J. Physiol. 250, 597 (1975).PubMedGoogle Scholar
  86. Donowit. M., Binder, H. J.: Gastroenterology 69, 941 (1975).Google Scholar
  87. Donowitz, M., Binder, H. J.: J. infect. Dis. 134, 135 (1976).PubMedGoogle Scholar
  88. Down, P. F., Agostini, L., Murison, J., Wrong, D. M.: din. Sci. 43, 101 (1972).Google Scholar
  89. Duthie, H. L., Atwell, J. D.: Gut 4, 373 (1963).PubMedGoogle Scholar
  90. Edmonds, C. J.: J. Physiol. 193, 571 (1967a).PubMedGoogle Scholar
  91. Edmonds, C. J.: J. Physiol. 193, 589 (1967b).PubMedGoogle Scholar
  92. Edmonds, C. J.: J. Physiol. 193, 603 (1967c).PubMedGoogle Scholar
  93. Edmonds, C. J.: J. Physiol. 203, 533 (1969).PubMedGoogle Scholar
  94. Edmonds, C. J.: Gut 16, 315 (1975).PubMedGoogle Scholar
  95. Edmonds, C. J., Marriott, J. C.: J. Endocrinol. 39, 517 (1967).PubMedGoogle Scholar
  96. Edmonds, C. J., Marriott, J.: J. Physiol. 194, 457 (1968a).PubMedGoogle Scholar
  97. Edmonds, C. J., Marriott, J.: J. Physiol. 194, 479 (1968b).PubMedGoogle Scholar
  98. Edmonds, C. J., Marriott, J.: J. Physiol. 210, 1021 (1970).PubMedGoogle Scholar
  99. Edmonds, C. J., Nielsen, O. E.: Acta physiol. scand. 72, 338 (1968).PubMedGoogle Scholar
  100. Edmonds, C. J., Pilcher, D.: In: Transport Across the Intestine (A Glaxo Symposium) (W. L. Burlandand P. D. Samuel, Eds). Baltimore, Md: Williams and Wilkins 1972, p. 43.Google Scholar
  101. Edmonds, C. J., Pilcher, D.: Gut 14, 784 (1973).PubMedGoogle Scholar
  102. Edmonds, C. J., Richards, P.: Lancet 1970 2, 624.PubMedGoogle Scholar
  103. Elmslie, R. G., Mulholland, A. T., Shields, R.: Gut 7, 697 (1966).PubMedGoogle Scholar
  104. Evans, W. B., Aoyagi, T., Summerskill, W. H. J.: Gut 7, 635 (1966).PubMedGoogle Scholar
  105. Ewe, K.: Europ. J. clin. Invest. 2, 283 (1972).Google Scholar
  106. Ewe, K., Hölker, B.: Klin. Wschr. 52, 827 (1974).PubMedGoogle Scholar
  107. Ewe, K., Summerskill, W. H. J.: J. Lab. clin. Med.65,839 (1965).PubMedGoogle Scholar
  108. Ferretra, H. G., Smith, M. W.: J. Physiol. 198, 329 (1968).Google Scholar
  109. Ferreira, H. G., Harrison, F. A, Keynes, R. D.: J. Physiol. 187, 631 (1966).PubMedGoogle Scholar
  110. Field, M.: Gastroenterology66,1063 (1974).PubMedGoogle Scholar
  111. Fisher, K. A., Binder, H. J., Hayslett, J. P.: Amer. J. Physiol. 231, 987 (1976).PubMedGoogle Scholar
  112. Fleshle. B., Gabuzda, G. J.: Gut 6, 349 (1965).Google Scholar
  113. Florey, H. W., WrightR. D., Jennings, M. A.: Physiol. Rev. 21, 36 (1941).Google Scholar
  114. Fordtran, J. S., Rector, F. C., Jr, Newton, M. F., Soter, N., Kinney, J.: J. clin. Invest. 44, 1935 (1965).PubMedGoogle Scholar
  115. Forth, W.: Ann. Univ. Sarav. Med. 13, 163 (1966).Google Scholar
  116. Frizzell, R. A.: J. Membrane Biol. 35, 175 (1977).Google Scholar
  117. Frizzell, R. A., Jennings, B. L.: Fed. Proc. 36, 300 (1977).Google Scholar
  118. Frizzell, R. A., Schultz, S. G.: J. Membrane Biol. (in press) (1978).Google Scholar
  119. Frizzell, R. A., Turnheim, K.: J. Membrane Biol. 401, 193 (1978).Google Scholar
  120. Frizzell, R. A., Koch, M. J., Schultz, S. G.: J. Membrane Biol. 27, 297 (1976).Google Scholar
  121. Giddings, R. F., Argenzio, R. A., Stevens, C. E.: Amer. J. vet. Res. 35, 1511 (1974).PubMedGoogle Scholar
  122. Giebisch, G.: Yale J. Biol. Med. 48, 315 (1975).PubMedGoogle Scholar
  123. Giller, J., Phillips, S. F.: Amer. J. dig. Dis. 17, 1003 (1972).PubMedGoogle Scholar
  124. Gilles-Baillien, M., Schoffeniels, E.: Comp. biochem. Physiol. 23, 95 (1967 a).PubMedGoogle Scholar
  125. Gilles-Baillien, M., Schoffeniels, E.: Arch. Int. Physiol. Biochim. 75, 754 (1967 b).PubMedGoogle Scholar
  126. Goldschmidt, S., Dayton, A.B.: Amer. J. Physiol. 48, 419 (1919a).Google Scholar
  127. Goldschmidt, S., Dayton, A. B.: Amer. J. Physiol. 48, 459 (1919b).Google Scholar
  128. Grady, G. F., Duhamel, R. C, Moore, E. W.: Gastroenterology 59, 583 (1970).PubMedGoogle Scholar
  129. Green, K., Matty, A. J.: Life Sci. 5, 205 (1966).Google Scholar
  130. Gutknecht, J., Tosteson, D. C.: Science 182, 1258 (1973).PubMedGoogle Scholar
  131. Hagihara, P. F., Griffen, W. O., Jr: Surg. Clin. N. America 52, 797 (1972).PubMedGoogle Scholar
  132. Harris, J., Shields, R.: Gut 11, 27 (1970).PubMedGoogle Scholar
  133. Harrison, H. C., Harrison, H. E.: Amer. J. Physiol. 217, 121 (1969).PubMedGoogle Scholar
  134. Head, L. H., Heaton, J. W., Jr, Kivel, R. M.: Gastroenterology 56, 571 (1969).PubMedGoogle Scholar
  135. Heaton, J. W., Jr: Amer. J. dig. Dis. 17, 7 (1972).PubMedGoogle Scholar
  136. Hendrix, T. R., Bayless, T. M.: Ann. Rev. Physiol. 32, 139 (1970).Google Scholar
  137. Hogben, C. A. M.: In: Electrolytes in Biological Systems (A. M. Shanes, Ed.). Washington, D. C.: American Physiological Society 1955, p. 176.Google Scholar
  138. Hogben, C. A. M., Tocco, D. J., Brodie, B. B., Schanker, L. S.: J. Pharmacol. exp. Ther. 125,275 (1959).PubMedGoogle Scholar
  139. Hollander, D., Truscott, T. C.: J. Lab. clin. Med. 83, 648 (1974).PubMedGoogle Scholar
  140. Hollander, D., Muralidhara, K. S., Rim, E.: Amer. J. Physiol. 230, 251 (1976).PubMedGoogle Scholar
  141. Holmberg, C., Perheentupa, J., Launiala, K.: J. clin. Invest. 56, 302 (1975).PubMedGoogle Scholar
  142. Hornych, A., Meyer, P., Milliez, P.: Amer. J. Physiol. 224, 1223 (1973).PubMedGoogle Scholar
  143. Houpt, T. R., Houpt, K. A.: Amer. J. Physiol. 214, 1296 (1968).PubMedGoogle Scholar
  144. Hubel, K. A.: Gastroenterology 54, 647 (1968).PubMedGoogle Scholar
  145. Hubel, K. A.: J. clin. Invest. 52, 3172 (1973).PubMedGoogle Scholar
  146. Hubel, K. A.: J. clin. Invest. 53, 964 (1974).PubMedGoogle Scholar
  147. Ingraham, R. C., Visscher, M. B.: J. gen. Physiol. 18, 695 (1935).PubMedGoogle Scholar
  148. Jackson, M.: Biomembranes 4B, 673 (1974).PubMedGoogle Scholar
  149. Jackson, M. J., Morgan, B. N.: Amer. J. Physiol. 228, 482 (1975).PubMedGoogle Scholar
  150. Jackson, M. J., Smyth, D. H.: Nature 219, 388 (1968).PubMedGoogle Scholar
  151. Jackson, M. J., Shiau, Y. F., Bane, S., Fox, M.: J. gen. Physiol. 63, 187 (1974).PubMedGoogle Scholar
  152. Jacobs, M. H.: Cold Spr. Harbor Symp. quant. Biol. 8, 30 (1940).Google Scholar
  153. Johansen, P. G., Hadorn, B., Anderson, C. M.: Nature 217, 468 (1968).PubMedGoogle Scholar
  154. Kettering, R. F., Summerskill, W. H. J.: Medicine 46, 91 (1967).PubMedGoogle Scholar
  155. Kimberg, D. V.: Gastroenterology 67, 1023 (1974).Google Scholar
  156. Lamers, J. M.: Biochim. biophys. Acta 413, 265 (1975).Google Scholar
  157. LeadingArticle. Lancet 1975 2, 214.Google Scholar
  158. Levitan, R.: J. Lab. clin. Med. 69, 558 (1967).PubMedGoogle Scholar
  159. Levitan, R.: Israel J. Med. Sci. 4, 140 (1968).PubMedGoogle Scholar
  160. Levitan, R.: Amer. J. clin. Nutr. 22, 315 (1969).PubMedGoogle Scholar
  161. Levitan, R., Ingelfinger, F. J.: J. clin. Invest. 44, 801 (1965).PubMedGoogle Scholar
  162. Levitan, R., Mauer, I.: J. Lab. clin. Med. 72, 739 (1968).PubMedGoogle Scholar
  163. Levitan, R., Fordtran, J. S., Burrows, B. A., Ingelfinger, F. J.: J. clin. Invest. 41,1754 (1962).PubMedGoogle Scholar
  164. Lew, V. L.: J. Physiol. 206, 509 (1970).PubMedGoogle Scholar
  165. Lew, V. L., Carlisky, N. J.: Biochim. biophys. Acta 135, 793 (1967).PubMedGoogle Scholar
  166. Long, C. L., Geiger, J. W., Kinney, J. M.: Metabolism 16, 413 (1967).PubMedGoogle Scholar
  167. Lucas, M. L., Schneider, W., Haberish, F. J., BlairJ. A.: Proc. roy. Soc. Med. (Lond.) 192, 39 (1975).Google Scholar
  168. McBee, R. H.: Amer. J. clin. Nutr. 23, 1514 (1970).PubMedGoogle Scholar
  169. Manning, R.T.: Biochem. Clin. 3, 225 (1964).PubMedGoogle Scholar
  170. Mekhjian, H. S., Phillips, S. F.: Gastroenterology 59, 120 (1970).PubMedGoogle Scholar
  171. Mekhjian, H. S., Phillips, S. F., Hofmann, A. F.: J. clin. Invest. 50, 1569 (1971).Google Scholar
  172. Metcalfe-Gibson, A., Ing, T. S., Kuiper, J. J., RichardsP., Ward, E. E., Wrong, O. M.: din. Sci. 33, 89 (1967).Google Scholar
  173. Milne, M. D., Schribner, B. H., Crawford, M. A.: Amer. J. Med. 24, 709 (1958).PubMedGoogle Scholar
  174. Milton-Thompson, G. J., CummIngs, J. H., Newman, A., Billings, J. A., MisiewiczJ. J.: Gut 16, 42 (1975).PubMedGoogle Scholar
  175. Mossberg, S. M.: Amer. J. Physiol. 213, 1327 (1967).PubMedGoogle Scholar
  176. Mossberg, S. M., Ross, G.: J. clin. Invest. 46, 490 (1967).PubMedGoogle Scholar
  177. Mossberg, S. M., Ross, G., Weingarten, B.: Nature 212, 1588 (1966).PubMedGoogle Scholar
  178. Nakamura, S., Gordon, H. A.: Proc. Soc. exp. Biol. 142, 1336 (1973).PubMedGoogle Scholar
  179. Nell, G., Overhoff, H., KulenkampffH., Specht, W., Rummel, W.: Naunyn-Schmiedebergs Arch. Pharm. 277, 53 (1973).Google Scholar
  180. Nellans, H. N., Frizzell, R. A., Schultz, S. G.: Amer. J. Physiol. 225, 467 (1973).PubMedGoogle Scholar
  181. Nellans, H. N., Frizzell, R. A., Schultz, S. G.: Amer. J. Physiol. 226, 1131 (1974).PubMedGoogle Scholar
  182. Nellans, H. N., Frizzell, R. A., Schultz, S. G.: Amer. J. Physiol. 228, 1808 (1975).PubMedGoogle Scholar
  183. O’Grady, F.: Proc. roy. Soc. Med. 59, 1246 (1966).PubMedGoogle Scholar
  184. Orloff, J., Berliner, R. W.: J. clin. Invest. 135, 223 (1956).Google Scholar
  185. Osterhout, W. J. V.: J. gen. Physiol. 8, 131 (1925).PubMedGoogle Scholar
  186. Parsons, B. J., Munday, k. A.: In: Transport Across the Intestines (A Glaxo Symposium) (W. L. Burlandand P. D. Samuel, Eds). Baltimore, Md: Williams and Wilkins 1972, p. 59.Google Scholar
  187. Parsons, D. S.: Quart. J. exp. Physiol. 41, 410 (1956).Google Scholar
  188. Parsons, D. S., Paterson, C. R.: Biochim. biophys. Acta 41, 173 (1960).PubMedGoogle Scholar
  189. Parsons, D. S., PatersonC. R.: Quart. J. exp. Physiol. 50, 220 (1965).PubMedGoogle Scholar
  190. Parsons, D. S., Powis, G.: J. Physiol. 217, 641 (1971).PubMedGoogle Scholar
  191. Patlak, C. S., Goldstein, D. A., Hoffman, J. A.: J. theoret. Biol. 5, 426 (1963).Google Scholar
  192. Perheentupa, J., Harrison, H. C, Harrison, H. E.: Biochim. biop phys. Acta 255, 858 (1972).Google Scholar
  193. Phillips, S. F.: Gastroenterology 56, 966 (1969).PubMedGoogle Scholar
  194. Phillips, S.F.: Gastroenterology 63, 495 (1972).PubMedGoogle Scholar
  195. Phillips, S. F., Code, C. F.: Amer. J. Physiol. 211, 607 (1966).PubMedGoogle Scholar
  196. Phillips, S. F., Giller, J.: J. Lab. clin. Med. 81, 733 (1973).PubMedGoogle Scholar
  197. Phillips, S. F., Schmalz, P. F.: Proc. Soc. exp. Biol. 135, 116 (1970).PubMedGoogle Scholar
  198. PitIth, M. M., Schedl, H. P.: Gastroenterology 71, 1039 (1976).Google Scholar
  199. Powell, D. W., Malawer, S. J.: Amer. J. Physiol. 215, 49 (1968).PubMedGoogle Scholar
  200. Powell, D. W., Malawer, S. J., Plotkin, G. R.: Amer. J. Physiol. 215, 1226 (1968).PubMedGoogle Scholar
  201. Powell, D. W., Solberg, L. I., Plotkin, G. R., Catlin, D. H., Maenza, R. M., Formal, S. B.: Gastroenterology 60, 1076 (1971).PubMedGoogle Scholar
  202. Price, J. B., Schwartz, G. F., Molavi, A., Britton, R. C., Vorhees, A. B. Jr: Surg. Forum 18,331 (1967).Google Scholar
  203. Price, J. B., Sawda, M., Voorhees, A. B., Jr: Amer. J. Surg, 119, 595 (1970).PubMedGoogle Scholar
  204. Racusen, L., Binder, H. J.: Gastroenterology 73, 790 (1977).PubMedGoogle Scholar
  205. Rask-Madsen, J.: Scand. J. Gastroent. 8, 327 (1973).PubMedGoogle Scholar
  206. Rask-Madsen, J.: Scand. J. Gastroent. 9, 223 (1974).PubMedGoogle Scholar
  207. Rask-Madsen, J., Jensen, B.: Scand. J. Gastroent. 8, 169 (1973).PubMedGoogle Scholar
  208. Richards, P., Metcalfe-Gibson, A., Word, E. E., Wrong, O., Houghton, B. J.: Lancet 19672, 845.PubMedGoogle Scholar
  209. Rogoeczi, E., Irons, L., Koj, A., McFarland, A. S.: Biochem. J. 95, 521 (1965).Google Scholar
  210. Rosenfeld, J. B., Aboulafia, E. D., Schwartz, W. B.: Amer. J. Physiol. 204, 568 (1963).PubMedGoogle Scholar
  211. Rousseau, B., Sladen, G. E.: Biochim. biophys. Acta 233, 591 (1971).PubMedGoogle Scholar
  212. Rubens, R. D., Lambert, H. P.: Gut 13, 915 (1972).PubMedGoogle Scholar
  213. Rubinstein, R., Howard, A. V., Wrong, O. M.: Clin. Sci. 37, 549 (1969).PubMedGoogle Scholar
  214. Salas-Coll, C., Kermode, J. C., Edmonds, C. J.: Clin. Sci. molec. Med. 51, 287 (1976).Google Scholar
  215. Sallee, V. L., Dietschy, J. M.: J. Lipid Res. 14, 475 (1973).PubMedGoogle Scholar
  216. Salter, D. N.: Proc. Nutr. Soc. 32, 65 (1973).PubMedGoogle Scholar
  217. Schanker, L. S., Tocco, D. J., Brodie, B. B., Hogben, C. A. M.: J. Pharmacol. exp. Ther. 123, 81 (1958).PubMedGoogle Scholar
  218. Schenker, S., Breen, K. J., Hoyumpa, A. M., Jr: Gastroenterology66,121 (1974).PubMedGoogle Scholar
  219. Schmitt, M. G., Soergel, K. H., Wood, C. M.: Gastroenterology 70, 211 (1976).PubMedGoogle Scholar
  220. Schultz, S. G.: J. gen. Physiol. 59, 794 (1972).PubMedGoogle Scholar
  221. Schultz, S. G., Curran, P. F.: In: Handbook of Physiology, Section 6: Alimentary Canal, Vol. 2: Intestinal Absorption (C. F. Code, Ed.). Baltimore, Md: Williams and Wilkins 1968, p. 1245.Google Scholar
  222. Schultz, S. G., Curran, P. F.: Current Topics in Membranes and Transport 5, 225 (1974).Google Scholar
  223. Schultz, S. G., Frizzell, R. A., Nellans, H. N.: J. Membrane Biol. 33, 351 (1977).Google Scholar
  224. Schwiter, E. J., Hepner, G. W., Rose, R. C: Gut 16, 477 (1975).PubMedGoogle Scholar
  225. Shields, R.: Brit. J. Surg. 53, 893 (1966).PubMedGoogle Scholar
  226. Shields, R.: In: Recent Advances in Gastroenterology (J. Badenochand B.N. Brooke, Eds). Baltimore, Md: Williams and Wilkins 1972, p. 215.Google Scholar
  227. Shields, R., Miles, J. B.: Postgrad. med. J. 41, 435 (1965).PubMedGoogle Scholar
  228. Shields, R., Mulholland, A. T., Elmslie, R. G.: Gut 7, 686 (1966).PubMedGoogle Scholar
  229. Shore, P. A., Brgdie, J. B., Hogben, C. A. M.: J. Pharmacol. exp. Ther. 119, 361 (1957).PubMedGoogle Scholar
  230. Silva, P., Charney, A. N., Epstein, F. H.: Amer. J. Physiol. 229, 1576 (1975).PubMedGoogle Scholar
  231. Simonetta, M., Faelli, A., Cremaschi, D., Gordon, H. A.: Proc. Soc. exp. Biol. 150, 541 (1975).PubMedGoogle Scholar
  232. Skadhauge, E.: Comp. Biochem. Physiol. 23, 483 (1967).PubMedGoogle Scholar
  233. Skadhauge, E.: Comp. Biochem. Physiol. 24, 7 (1968).PubMedGoogle Scholar
  234. Smith, B., Butler, M.: Brit. J. exp. Path. 55, 615 (1974).PubMedGoogle Scholar
  235. Smith, M. W., James, P. S.: Biochim. biophys. Acta 419, 391 (1976).PubMedGoogle Scholar
  236. Smyth, D. H., Taylor, E. B.: J. Physiol. 141, 73 (1958).PubMedGoogle Scholar
  237. Soergel, K. H., Whalen, G. E., Harris, H. A., Geenen, J. E.: J. clin. Invest. 47, 1071 (1968).PubMedGoogle Scholar
  238. Spiro, H. M.: New Engl. J. Med. 293, 83 (1975).PubMedGoogle Scholar
  239. Stevens, C. E.: In: Transport Mechanisms In Epithelia (H. H. Ussing and N. A. Thorn, Eds). Copenhagen: Munksgaard, New York: Academic 1973, p. 404.Google Scholar
  240. Stevens, C. E., Dobson, A., Mammano, J. H.: Amer. J. Physiol. 216, 983 (1969).PubMedGoogle Scholar
  241. Stoebel, D. P., Goldner, A. M.: The Physiologist 18, 410 (1975).Google Scholar
  242. Summerskill, W. H. J., Aoyagi, T., Evans, W. B.: Gut 7, 497 (1966).PubMedGoogle Scholar
  243. Summerskill, W. H. J., Wolpert, E.: Amer. J. clin. Nutr. 23, 633 (1970).PubMedGoogle Scholar
  244. Swales, J. D., Papadmtriou, M., Wrong, O. M: Gut 14, 697 (1973).PubMedGoogle Scholar
  245. Swales, J. D., Tange, J. D., Wrong, O. M.: Clin. Sci. 39, 769 (1970).PubMedGoogle Scholar
  246. Swallow, J. H., Code, C. F.: Amer. J. Physiol. 212, 717 (1967).PubMedGoogle Scholar
  247. Taub, M., Bonorris, G., Chung, A., Coyne, M. J., Schoenfield, L. S.: Gastroenterology 72, 101 (1977).PubMedGoogle Scholar
  248. Teorell, T.: Skand. Arch. Physiol. 66, 225 (1933).Google Scholar
  249. Turnberg, L. A.: Gut 11, 1049 (1970).PubMedGoogle Scholar
  250. Turnberg, L. A.: Gut 12, 544 (1971).PubMedGoogle Scholar
  251. Turnberg, L. A., Bieberdorf, F. A., Morawski, S. G., Fordtran, J. G.: J. clin. Invest. 49, 557 (1970).PubMedGoogle Scholar
  252. Ussing, H. H., Andersen, B.: In: Proceedings of the 3rd International Congress of Biochemistry, Brussels, 1955. New York: Academic 1956, p. 434.Google Scholar
  253. Vince, A., Dawson, A. M., Park, N., O’Grady, F.: Gut 14, 171 (1973).PubMedGoogle Scholar
  254. Visscher, M. B., Varco, R. H., Carr, C. W., Dean, R. B., Erichson, D.: Amer. J. Physiol. 141,488 (1944).Google Scholar
  255. Weast, R. C. (Ed.): CRC Handbook of Chemistry and Physics. Cleveland, Ohio: The Chemical Rubber Company 1971.Google Scholar
  256. Wilson, D. R., Ing, T. S., Metcalfe-Gibson, A., WrongO. M.: Clin. Sci. 34, 211 (1968).PubMedGoogle Scholar
  257. Wilson, T. H., Kazyak, L.: Biochim. biophys. Acta 24, 124 (1957).PubMedGoogle Scholar
  258. Wilson, T. H.: Biochem. J. 56, 521 (1954).PubMedGoogle Scholar
  259. Wingate, D. L., Krag, E., Mekhjian, H. S., Phillips, S. F.: Clin. Sci. molec. Med. 45, 593 (1973).Google Scholar
  260. Wolpert, E., Phillips, S. F., Summerskill, W. H. J.: New Engl. J. Med. 283, 159 (1970).PubMedGoogle Scholar
  261. Wolpert, E., Phillips, S. F., Summerskill, W. H. J.: Lancet 1971 2, 1387.PubMedGoogle Scholar
  262. Wooton, J. F., Argenzio, R. A.: Amer. J. Physiol. 229, 1062 (1975).Google Scholar
  263. Wrong, O. M.: In: The Scientific Basis of Medicine, Annual Reviews (I. Gillilandand J. Francis, Eds). London: Athlone 1971, p. 192.Google Scholar
  264. Wrong, O., Metcalfe-Gibson, A., Morrison, R. B. I., Ng, S. T., Howard, A. V.: Clin. Sci. 28,357 (1965).PubMedGoogle Scholar
  265. Yang, M. G., Manoharan, K., Mickelsen, O.: J. Nutr. 100, 545 (1970).PubMedGoogle Scholar
  266. Yau, W. M., Makhlouf, G. M.: Gastroenterology 67, 662 (1974).PubMedGoogle Scholar
  267. Yau, W. M., Makhlouf, G. M.: Amer. J. Physiol. 228, 191 (1975).PubMedGoogle Scholar
  268. Yorio, T., Bentley, P. J.: Amer. J. Physiol. 232, F5 (1977).PubMedGoogle Scholar

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