Combined Modality Therapy of Childhood Non-Hodgkin’s Lymphoma
The survival of children with non-Hodgkin’s lymphoma (NHL) has improved in the recent past through the systematic application of intensive therapy employing involved field radiation plus combinations of drugs. A comprehensive review of combined modality therapy of NHL in childhood has been published recently . Table 1, which outlines the 2-year survival by stage of disease at diagnosis from selected representative series [1, 2, 5, 7, 10, 13], shows that as many as 80%–90% of children with stage I disease are curable with such an approach. Also shown is a remarkably uniform overall success rate of roughly 30% and a depressingly high rate of treatment failures in patients with generalized disease (stages III-IV).
KeywordsCentral Nervous System Disease Combine Modality Therapy Intrathecal Methotrexate Poor Prognosis Patient Involve Field Radiation
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