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Combined Modality Therapy of Childhood Non-Hodgkin’s Lymphoma

  • S. B. Murphy
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 65)

Abstract

The survival of children with non-Hodgkin’s lymphoma (NHL) has improved in the recent past through the systematic application of intensive therapy employing involved field radiation plus combinations of drugs. A comprehensive review of combined modality therapy of NHL in childhood has been published recently [9]. Table 1, which outlines the 2-year survival by stage of disease at diagnosis from selected representative series [1, 2, 5, 7, 10, 13], shows that as many as 80%–90% of children with stage I disease are curable with such an approach. Also shown is a remarkably uniform overall success rate of roughly 30% and a depressingly high rate of treatment failures in patients with generalized disease (stages III-IV).

Keywords

Central Nervous System Disease Combine Modality Therapy Intrathecal Methotrexate Poor Prognosis Patient Involve Field Radiation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    AUR, R. J. A., personal communicationGoogle Scholar
  2. 2.
    Aur, R. J. A., Hustu, H. O., Simone, J. V., Pratt, C. B., Pinkel, D.: Therapy of localized and regional lymphosarcoma of childhood. Cancer 27, 1328–1351 (1971)PubMedCrossRefGoogle Scholar
  3. 3.
    Carbone, P., Kaplan, H. S., Musshof, K., Smither, D. W., Tubiana, M.: Report of the committee on Hodgkin’s disease staging classification. Cancer Res. 31, 1860–1861 (1971)PubMedGoogle Scholar
  4. 4.
    Frias, A., Sullivan, M. P.: Convoluted cell lymphoma and “T” cell leukemia: Survival, patterns of relapse, and rescue with LSA2-L2 therapy. (Abst. C-155) Proc. AACR and ASCO 18, 305 (1977)Google Scholar
  5. 5.
    Glatstein, E., Kim, H., Donaldson, S., Dorfman, R. F., Gribble, T. J., Wilbur, J. R., Rosenberg, S. A., Kaplan, H. S.: Non-Hodgkin’s lymphomas. VI. Results of treatment in childhood. Cancer 34, 204–211(1974)PubMedCrossRefGoogle Scholar
  6. 6.
    Hutter, J. J., Favara, B. E., Nelson, M., Holton, C. P.: Non-Hodgkin’s lymphoma in children. Correlation of CNS disease with initial presentation. Cancer 36, 2132–2137 (1975)PubMedCrossRefGoogle Scholar
  7. 7.
    Lemerle, M., Gerard-Marchant, R., Sarrazin, D.: Lymphosarcoma and reticulum cell sarcoma in children. Retrospective study of 172 cases. Cancer 32, 1499–1507 (1973)PubMedCrossRefGoogle Scholar
  8. 8.
    Murphy, S. B.: Prognostic Features and Obstacles to Cure of Childhood Non-Hodgkin’s Lymphoma, Seminars in Oncology, 4, 265–271 (1977)PubMedGoogle Scholar
  9. 9.
    Murphy, S. B.: The management of childhood non-Hodgkin’s lymphoma, Cancer Treat. Rep. 61, 1161–1173(1977)PubMedGoogle Scholar
  10. 10.
    Murphy, S. B., Frizzera, G., Evans, A. E.: A study of childhood non-Hodgkin’s lymphoma. Cancer 36, 2121–2131 (1975)PubMedCrossRefGoogle Scholar
  11. 11.
    Nelson, D. R., Cassady, J. R., Traggis, D., Baez, A., Vawter, G. F., Jaffe, N., Filler, R. M.: The role of radiation therapy in localized resectable intestinal non-Hodgkin’s lymphoma in children. Cancer 39, 89–97(1977)PubMedCrossRefGoogle Scholar
  12. 12.
    Peto, R., Pike, M. C., Armitage, P., Breslow, N. E., Cox, D. R., Howard, S. V., Mantel, N., Mcpherson, K., Peto, J., Smith, P. G.: Design and analysis of randomized clinical trials requiring prolonged observation of each patient. Br. J. Cancer 35, 1–39 (1977)PubMedCrossRefGoogle Scholar
  13. 13.
    Pinkel, D., Johnson, W., Aur, R. J. A.: Non-Hodgkin’s lymphoma in children. Br. J. Cancer 31, Suppl., 298–323 (1975)Google Scholar
  14. 14.
    Sullivan, M. P.: Treatment of lymphoma. Cancer 35,991–995 (1975)PubMedCrossRefGoogle Scholar
  15. 15.
    Sullivan, M. P., personal communicationGoogle Scholar
  16. 16.
    Wollner, N., Burchenal, J. H., Lieberman, P. H., Exelby, P., D’angio, G., Murphy, M. L.: Non- Hodgkin’s lymphoma in children. Med. Pediatr. Oncol. 1, 235–263 (1975)PubMedCrossRefGoogle Scholar
  17. 17.
    Wollner, N., Burchenal, J. H., Lieberman, P. H., Exelby, P., D’angio, G., Murphy, M. L.: Non- Hodgkin’s lymphoma in children. A comparative study of two modalities of therapy. Cancer 37, 123- 134(1976)PubMedCrossRefGoogle Scholar
  18. 18.
    Ziegler, J. L., Bluming, A. Z.: Intrathecal chemotherapy in Burkitt’s lymphoma. Br. Med. J. 3, 508- 512(1971)PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin · Heidelberg 1978

Authors and Affiliations

  • S. B. Murphy

There are no affiliations available

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