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Neoplasms of Immunoglobulin-Producing Cells in Mice

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Lymphoid Neoplasias I

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 64))

Abstract

Although murine lymphoid tumors have been extensively used in experimental tumor research for many decades, their use has principally been related to virologic aspects and to studies of tumor immunity. In recent years, however, considerable interest has developed in their possible application as models of discrete lymphoid subpopulations. The underlying concept, based in part on studies of human lymphoid neoplasia, is that each lymphoid tumor represents the monoclonal neoplastic proliferation of a cell that belongs to a specific T- or B-cell subpopulation and is arrested in its differentiation at a particular stage.

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References

  1. Abelson, H. R., Rabstein, L. S.: Lymphosarcoma: virus induced thymic independent disease in mice. Cancer Res. 30 ,2213–2219 (1970)

    PubMed  CAS  Google Scholar 

  2. Anderson, C. L., Grey, H. M.: Receptors for aggregated IgG on mouse lymphocytes: Their presence on thymocytes, thymus derived and bone marrow derived lymphocytes. J. Exp. Med. 139 ,1175–1188 (1974)

    Article  PubMed  CAS  Google Scholar 

  3. Basten, A., Miller, J. F. A. P., Warner, N. L., Abraham, R., Chia, E., Gamble, J.: A subpopulation of T cells bearing Fc receptors. J. Immunol. 1159–1165 (1975)

    Google Scholar 

  4. Basten, A., Warner, N. L., Mandel, T.: A receptor for antibody on B lymphocytes II. Immunochemical and electromicroscopy characteristics. J. Exp. Med. 135 ,627–642 (1972)

    Article  PubMed  CAS  Google Scholar 

  5. Boylston, A. W., Mowbray, J. F.: Surface immunoglobulin of a mouse T cell lymphoma. Immunology 27 ,855–861 (1974)

    PubMed  CAS  Google Scholar 

  6. Brand, A., Gilmour, D. G., Goldstein, G.: Lymphocyte differentiating hormone of bursa of Fabricius. Science 193 ,319–321 (1976)

    Article  PubMed  CAS  Google Scholar 

  7. Cooper, M. D., Kearney, J. F., Lydyard, P. M., Grossi, E. C., Lawton, R. A.: Studies of generation of B cell diversity in mouse, man and chicken. Cold Spring Harbor Symp. Quant. Biol. 41 ,139–146 (1976)

    Google Scholar 

  8. Flaherty, L., Stanton, R., Boyse, E. A.: Contamination of Ia antiserum A.TL anti A.TH with antibodies related to the Tla region. Immunogenetics 4 ,101–103 (1977)

    Article  Google Scholar 

  9. Goding, J. W., Warr, G. W., Warner, N. L.: Genetic polymorphism of IgD-like cell surface immunoglobulin in the mouse. Proc. Natl. Acad. Sci. USA 73 ,1305–1309 (1976)

    Article  PubMed  CAS  Google Scholar 

  10. Harris, A. W., Bankhurst, A. D., Mason, S., Warner, N. L.: Differentiated functions expressed by cultured mouse lymphoma cells II. θ antigen, surface immunoglobulin, and a receptor for antibody on cells of a thymona cell line. J. Immunol. 110 ,431–438 (1973)

    PubMed  CAS  Google Scholar 

  11. Haustein, D., Marchalonis, J. J., Harris, A. W.: Immunoglobulin of T lymphoma cells. Biosynthesis, surface representation and partial characterization. Biochemistry 14 ,1826–1834 (1975)

    Article  PubMed  CAS  Google Scholar 

  12. Herzenberg, L. A., Herzenberg, L. A., Black, J. J., Loken, M. R., Okumura, K., Van Der Loo, W., Osbourne, B. A., Hewgill, D., Goding, J. W., Gutman, G., Warner, N. L.: Surface markers and functional relationships of cells involved in murine B-lymphocyte differentiation. Cold Spring Harbor Symp. Quant. Biol. 41 ,33–46 (1976)

    Google Scholar 

  13. Katz, D., Benacerraf, B.: The regulatory influence of activated T cells on B cell responses to antigen. Adv. Immunol. 15 ,2–94 (1972)

    Google Scholar 

  14. Marchalonis, J. J., Warr, G. W., Bucana, C. D., Hoyer, L. C, Szenberg, A., Warner, J. L.: Demonstration and partial characterization of murine B and T cell surface immunoglobulin using avian antibodies. ICN-UCLA symposium, Regulation of the immune system, E. Sercarz, L. A. Herzenberg, and F. Fox, eds. Academic Press, 1977

    Google Scholar 

  15. McKenzie, I. F. C., Gardiner, J., Cherry, M., Snell, G. D.: Lymphocyte antigens: Ly-4, Ly-6 and Ly-7. Transplant. Proc. 9, 667–670 (1970)

    Google Scholar 

  16. Melchers, F., Boehmer, H. Von, Phillips, R. A.: B lymphocyte subpopulations in the mouse. Organ distribution and ontogeny of immunoglobulin synthesizing and of mitogen sensitive cells. Transplant. Rev. 25 ,26–58 (1975)

    PubMed  CAS  Google Scholar 

  17. Mitchell, G. F.: T cell modification of B cell responses to antigen in mice. Contemp. Top. Immunobiol. 3 ,97–116 (1974)

    PubMed  CAS  Google Scholar 

  18. Moretta, L., Ferrarini, M., Mingari, M. C., Moretta, A., Webb, S.: Subpopulations of human T cells identified by receptors for immunoglobulins and mitogen responsiveness. J. Immunol. 777, 2171–2174 (1976)

    Google Scholar 

  19. Mosely, J. M., Marchalonis, J. J., Harris, A. W., Pye, J.: Molecular properties of T lymphoma immunoglobulins. J. Immunogenet. in press (1977)

    Google Scholar 

  20. Murphy, D. B., Okumura, K., Herzenberg, L. A., Herzenberg, L. A., McDevitt, H. O.: Selective expression of separate I region loci in functionally different lymphocyte subpopulations. Cold Spring Harbor Symp. Quant. Biol. 41 ,497–504 (1976)

    Google Scholar 

  21. Parkhouse, R. M. E., Abney, E. R., Bourgois, A., Willcox, H. N. A.: Functional and structural characterization of immunoglobulin on murine B lymphocytes. Cold Spring Harbor Symp. Quant. Biol. 47,193–200(1976)

    Google Scholar 

  22. Pernis, B., Forni, L., Lussati, A. L.: Synthesis of multiple immunoglobulin classes by single lymphocytes. Cold Spring Harbor Symp. Quant. Biol. 41 ,175–184 (1976)

    Google Scholar 

  23. Potter, M.: Immunoglobulin producing tumors and myeloma proteins of mice. Physiol. Rev. 52,631–719(1972)

    PubMed  CAS  Google Scholar 

  24. Potter, M., Warner, N. L., Melchers, F.: Functional properties of tumors of T and B lymphocytes. Natl. Cancer Inst. Workshop (1977)

    Google Scholar 

  25. Preudhomme, J. L., Seligmann, M.: Anti-human immunoglobulin G activity of membrane-bound monoclonal immunoglobulin M in lymphoproliferative disorders. Proc. Natl. Acad. Sci. USA 69 ,2132–2135(1972)

    Article  CAS  Google Scholar 

  26. Rollinghoff, M., Rouse, B. T., Warner, N. L.: Tumor immunity to murine plasma cell tumors I. Tumor associated transplantation antigens of NZB and BALB/c plasma cell tumors. J. Natl. Cancer Inst. 50,159–172 (1973)

    PubMed  CAS  Google Scholar 

  27. Ryser, J. E., Vassali, P.: Mouse bone marrow lymphocytes and their differentiation. J. Immunol. 113 ,159–172 (1973)

    Google Scholar 

  28. Shortman, K., Fidler, J. M., Schlegel, R. A., Nossal, G. J. V., Howard, M., Lipp, J., Boehmer, H. Von. Subpopulations of B lymphocytes: physical separation of functionally distinct stages of B cell differentiation. Contemp. Top. Immunobiol. 5, 1–45 (1976)

    PubMed  CAS  Google Scholar 

  29. Sklar, M. D., White, B. J., Rowe, W. P.: Initiation of oncogenic transformation of mouse lymphocytes in vitro by Abelson leukemia virus. Proc. Natl. Acad. Sci. USA 71,4077–4081 (1974)

    Article  PubMed  CAS  Google Scholar 

  30. Takahashi, R., Old, L. J., Boyse, E. A.: Surface alloantigens of plasma cells. J. Exp. Med. 131,1325–1341(1970)

    Article  PubMed  CAS  Google Scholar 

  31. Toda, R., Taniguchi, M., David, C. S.: Suppressive and enhancing T-cell factors as I-region gene products: properties and the subregion assignment. Cold Spring Harbor Symp. Quant. Biol. 41 ,119–128 (1976)

    Google Scholar 

  32. Warner, N. L.: Autoimmunity and the pathogenesis of plasma cell tumor induction in NZB inbred and hybrid mice. J. Immunogenet. 2 ,1–20 (1975)

    Google Scholar 

  33. Warner, N. L., Goding, J. W.: I region transplantation antigens on T lymphomas of congenic resistant strain origin. In: Membrane Receptors of Lymphocytes. Seligmann, M., Preudhomme, J. L., Kourilsky, F. M. (eds.) North Holland Pub. 1975, pp. 287–292.

    Google Scholar 

  34. Warner, N. L., Goding, J. W., Gutman, G. A., Warr, G. W., Herzenberg, L. A., Osborne, B. A., Van Der Loo, W., Black, S. J., Loken, M. R.: Allotypes of mouse IgM immunoglobulin. Nature 265, 447–449 (1977)

    Article  PubMed  CAS  Google Scholar 

  35. Warner, N. L., Harris, A. W., Gutman, G.: Membrane immunoglobulin and Fc receptors of murine T and B cell lymphomas. In: Membrane Receptors of Lymphomas, Seligmann, M., Preudhomme, J. L., Kourilsky, F. M. (eds.) North Holland Pub. 1975, pp. 203–216

    Google Scholar 

  36. Warner, N. L., Potter, M., Metcalf, D. (eds.): Multiple myeloma and related immunoglobulin producing neoplasms. U.I.C.C. Technical report series, 1974, Vol. 13

    Google Scholar 

  37. Weimann, B. J. Induction of immunoglobulin synthesis in Abelson murine leukemia virus transformed mouse lymphoma cells in culture. Cold Spring Harbor Symp. Quant. Biol. 41 ,163–164 (1974)

    Google Scholar 

  38. Vitetta, E. S., Cambier, J., Forman, J., Kettman, J. R., Yuan, D., Uhr, J. W.: Immunoglobulin receptors on murine B lymphocytes. Cold Spring Harbor Symp. Quant. Biol. 41 ,185–192 (1976)

    Google Scholar 

  39. Yoshida, T. O., Anderson, B.: Evidence for a receptor recognizing antigen complexed immunoglobulin on the surface of activated mouse thymus lymphocytes. Scand. J. Immunol. 1 ,401–408 (1972)

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. N. L. Warner
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Editors and Affiliations

  1. Institut de Cancérologie et d’Immunogénétique, Hôpital Paul-Brousse, 14-16, Avenue Paul-Vaillant-Couturier, F-94800, Villejuif, France

    Georges Mathé

  2. Laboratory of Immunochemistry and Immunopathology INSERM (U 108), and Laboratory of Cytology Research Institute on Blood Diseases, Hôpital Saint-Louis 2, Place du Docteur-A. Fournier, F-75010, Paris, France

    Maxime Seligmann

  3. Department of Radiations, Institut Gustave-Roussy, 16bis, Avenue Paul-Vaillant-Couturier, F-94800, Villejuif, France

    Maurice Tubiana

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© 1978 Springer-Verlag Berlin · Heidelberg

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Warner, N.L. (1978). Neoplasms of Immunoglobulin-Producing Cells in Mice. In: Mathé, G., Seligmann, M., Tubiana, M. (eds) Lymphoid Neoplasias I. Recent Results in Cancer Research, vol 64. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81246-0_37

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  • DOI: https://doi.org/10.1007/978-3-642-81246-0_37

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81248-4

  • Online ISBN: 978-3-642-81246-0

  • eBook Packages: Springer Book Archive

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