Clinical Experiences with Aclacinomycin-A
ACM may be classified among the drugs of the anthracycline group such as DNM and ADM.
The LD50s of ACM in mice, rats and hamsters by any route of administration are 2–3 times as high as those of DNM and of ADM (Table 1).
ACM differs slightly in anticancer spectrum from DNM and ADM.
4. ACM is taken up by the lungs at high concentrations, and also by the spleen.
Both acute and subacute cardiotoxicity of ACM measured in terms of ECG patterns.
KeywordsCholesterol Sugar Hydrolysis Toxicity Leukemia
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