Abstract
In the last 15 years, there has been great progress in the study of antitumor antibiotics. Professor Umezawa in his early study on bleomycin (BLM) proposed the following principle: Even a cytotoxic agent may exhibit therapeutic action against certain types of tumors if it is distributed in the tumor in a higher concentration than in other tissues, or if it is not inactivated or activated in those tumors. This principle has been exemplified by the study of BLM.
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© 1978 Springer-Verlag Berlin · Heidelberg
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Matsuda, A. et al. (1978). Fundamental and Clinical Studies on New Bleomycin Analogs. In: Carter, S.K., Umezawa, H., Douros, J., Sakurai, Y. (eds) Antitumor Antibiotics. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 63. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81219-4_18
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DOI: https://doi.org/10.1007/978-3-642-81219-4_18
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