Abstract
Macromomycin (MCR) is an antitumor antibiotic protein isolated from the culture filtrate of Streptomyces macromomyceticus by Chimura et. al. [1]. It was found to have antibacterial activity against Gram-positive organisms and to have antitumor activity against L1210 leukemia. It was also found by Kunimoto et. al. [2] that its effects on DNA synthesis and cell division of HeLa cells are reversed by incubation with trypsin. This suggests an action of the drug at the surface of the cell membrane.
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References
Chimura, H., Ishizuka, M., Hamada, M., Hori, S., Kimura, K., Iwanga, J., Takeuchi, T., Umezawa, H.: A new antibiotic, macromomycin, exhibiting antitumor activity and antimicrobial activity. J. Antibiot. (Tokyo) 21, 44–49 (1968).
Kunimoto, T., Hori, M., Umezawa, H.: Macromomycin, an inhibitor of membrane function of tumor cells. Cancer Res. 32, 1251–1256 (1972).
Lippman, M. M., Laster, W. R., Abbott, B. J., Venditti, J., Baratta, M.: Antitumor activity of macromomycin B (NSC-170105) against murine leukemias, melanoma and lung carcinoma. Cancer Res. 35, 939–945 (1975).
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© 1978 Springer-Verlag Berlin · Heidelberg
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Bono, V.H., Abraham, D. (1978). Preclinical Status of Macromomycin at the National Cancer Institute. In: Carter, S.K., Umezawa, H., Douros, J., Sakurai, Y. (eds) Antitumor Antibiotics. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 63. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81219-4_11
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DOI: https://doi.org/10.1007/978-3-642-81219-4_11
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-81221-7
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