RNA-dependent DNA Polymerase in a “Virus-Free” System

  • G. Bauer
  • P. H. Hofschneider
Conference paper
Part of the Colloquium der Gesellschaft für Biologische Chemie in Mosbach Baden book series (MOSBACH, volume 28)


RNA-dependent DNA polymerase (reverse transcriptase) is known to be a regular constituent of RNA tumor viruses and of relatives of this viral group. The role of the enzyme during replication of these viruses has been clarified (1; see also H. Varmus, this Volume). The viral reverse transcriptase synthesizes a double-stranded DNA copy of the viral RNA genome. This DNA (the “provirus”) is subsequently integrated into the host genome and transcribed like a cellular gene.


Glycerol Leukemia Recombination Sedimentation Sarcoma 


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  1. 1.
    Verma, I.M.: Biochim. Biophys. Acta 473, 1–38 (1977)PubMedGoogle Scholar
  2. 2.
    Temin, H.M.: J. Natl. Cancer Inst. 46, III–VII (1971)Google Scholar
  3. 3.
    Margalith, M., Gerard, G.F., Green, M.: Biochim. Biophys. Acta 425, 305–315 (1976)PubMedGoogle Scholar
  4. 4.
    Smith, C.C., Maverakis, N.H., Ackermann, W.W.: Proc. Soc. Exp. Biol. Med. 152, 645–650 (1976)PubMedGoogle Scholar
  5. 5.
    Brun, G., Rougeon, F., Lamber, M., Chapeville, F.: Eur. J. Biochem. 41, 241–251 (1974)PubMedCrossRefGoogle Scholar
  6. 6.
    Bolden, A., Fry, M., Muller, R., Citarella, R., Weissbach, A.: ABB 153, 26–33 (1972)PubMedGoogle Scholar
  7. 7.
    Weissbach, A.: Cell 5, 101–108 (1975)PubMedCrossRefGoogle Scholar
  8. 8.
    Nowinski, R.C., Watson, K.F., Yaniv, A., Spiegelman, S.: J. Virol. 10, 959–964 (1972)PubMedGoogle Scholar
  9. 9.
    Mizutani, S., Temin, H.M.: J. Virol. 12, 440–448 (1973)PubMedGoogle Scholar
  10. 10.
    Tooze, J. (ed.): The Molecular Biology of Tumour Viruses. New York: Cold Spring Harbor Laboratory 1973Google Scholar
  11. 11.
    Temin, H.M.: Adv. Cancer Res. 19, 47–104 (1974)PubMedCrossRefGoogle Scholar
  12. 12.
    Cooper, G.M., Temin, H.M.: J. Virol. 17, 422–430 (1976)PubMedGoogle Scholar
  13. 13.
    Weiss, R.A., Friis, R.R., Katz, E., Vogt, P.K.: Virology 46, 920–928 (1971)PubMedCrossRefGoogle Scholar
  14. 14.
    Vogt, P.K., Friis, R.R.: Virology 43, 223–234 (1971)PubMedCrossRefGoogle Scholar
  15. 15.
    Stehelin, D., Varmus, H.E., Bishop, J.M., Vogt, P.K.: Nature (London) 260, 170–173 (1976)CrossRefGoogle Scholar
  16. 16.
    Varmus, H.E., Stehelin, D., Spector, D., Tal, J., Fujita, D., Padgett, T., Roulland-Dussoix, D., Kung, H.-J., Bishop, J.M.: In: Animal Virology, Baltimore, D. et al. (eds.). 1976, pp. 339–358Google Scholar
  17. 17.
    Padgett, T.G., Stubblefield, E., Varmus, H.E.: Cell 10, 649–657 (1977)PubMedCrossRefGoogle Scholar
  18. 18.
    Weissbach, A., Bolden, A., Muller, R., Hanafusa, H., Hanafusa, T.: J. Virol. 10, 321–327 (1972)PubMedGoogle Scholar
  19. 19.
    Mason, W.S., Friis, R.R., Lineal, M., Vogt, P.K.: Virology 61, 559–574 (1974)PubMedCrossRefGoogle Scholar
  20. 20.
    Bauer, G., Hofschneider, P.H.: Proc. Natl. Acad. Sci. USA 73, 3025–3029 (1976)PubMedCrossRefGoogle Scholar
  21. 21.
    Bauer, G., Jilek, G., Hofschneider, P.H.: In: Modern Trends in Human Leukemia II. Neth, R., et al. (eds.). München: J.F. Lehmanns Verlag, 1976, pp. 515–530Google Scholar
  22. 22.
    Bauer, G.: Thesis. Universität München 1976Google Scholar
  23. 23.
    Bauer, G., Jilek, G., Hofschneider, P.H.: J. Virol. in press (1977)Google Scholar

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© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • G. Bauer
  • P. H. Hofschneider

There are no affiliations available

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