RNA-dependent DNA Polymerase in a “Virus-Free” System

  • G. Bauer
  • P. H. Hofschneider
Conference paper
Part of the Colloquium der Gesellschaft für Biologische Chemie in Mosbach Baden book series (MOSBACH, volume 28)


RNA-dependent DNA polymerase (reverse transcriptase) is known to be a regular constituent of RNA tumor viruses and of relatives of this viral group. The role of the enzyme during replication of these viruses has been clarified (1; see also H. Varmus, this Volume). The viral reverse transcriptase synthesizes a double-stranded DNA copy of the viral RNA genome. This DNA (the “provirus”) is subsequently integrated into the host genome and transcribed like a cellular gene.


Polymerase Gene Avian Leukosis Virus Particle Enzyme Globin mRNA Avian Sarcoma Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Verma, I.M.: Biochim. Biophys. Acta 473, 1–38 (1977)PubMedGoogle Scholar
  2. 2.
    Temin, H.M.: J. Natl. Cancer Inst. 46, III–VII (1971)Google Scholar
  3. 3.
    Margalith, M., Gerard, G.F., Green, M.: Biochim. Biophys. Acta 425, 305–315 (1976)PubMedGoogle Scholar
  4. 4.
    Smith, C.C., Maverakis, N.H., Ackermann, W.W.: Proc. Soc. Exp. Biol. Med. 152, 645–650 (1976)PubMedGoogle Scholar
  5. 5.
    Brun, G., Rougeon, F., Lamber, M., Chapeville, F.: Eur. J. Biochem. 41, 241–251 (1974)PubMedCrossRefGoogle Scholar
  6. 6.
    Bolden, A., Fry, M., Muller, R., Citarella, R., Weissbach, A.: ABB 153, 26–33 (1972)PubMedGoogle Scholar
  7. 7.
    Weissbach, A.: Cell 5, 101–108 (1975)PubMedCrossRefGoogle Scholar
  8. 8.
    Nowinski, R.C., Watson, K.F., Yaniv, A., Spiegelman, S.: J. Virol. 10, 959–964 (1972)PubMedGoogle Scholar
  9. 9.
    Mizutani, S., Temin, H.M.: J. Virol. 12, 440–448 (1973)PubMedGoogle Scholar
  10. 10.
    Tooze, J. (ed.): The Molecular Biology of Tumour Viruses. New York: Cold Spring Harbor Laboratory 1973Google Scholar
  11. 11.
    Temin, H.M.: Adv. Cancer Res. 19, 47–104 (1974)PubMedCrossRefGoogle Scholar
  12. 12.
    Cooper, G.M., Temin, H.M.: J. Virol. 17, 422–430 (1976)PubMedGoogle Scholar
  13. 13.
    Weiss, R.A., Friis, R.R., Katz, E., Vogt, P.K.: Virology 46, 920–928 (1971)PubMedCrossRefGoogle Scholar
  14. 14.
    Vogt, P.K., Friis, R.R.: Virology 43, 223–234 (1971)PubMedCrossRefGoogle Scholar
  15. 15.
    Stehelin, D., Varmus, H.E., Bishop, J.M., Vogt, P.K.: Nature (London) 260, 170–173 (1976)CrossRefGoogle Scholar
  16. 16.
    Varmus, H.E., Stehelin, D., Spector, D., Tal, J., Fujita, D., Padgett, T., Roulland-Dussoix, D., Kung, H.-J., Bishop, J.M.: In: Animal Virology, Baltimore, D. et al. (eds.). 1976, pp. 339–358Google Scholar
  17. 17.
    Padgett, T.G., Stubblefield, E., Varmus, H.E.: Cell 10, 649–657 (1977)PubMedCrossRefGoogle Scholar
  18. 18.
    Weissbach, A., Bolden, A., Muller, R., Hanafusa, H., Hanafusa, T.: J. Virol. 10, 321–327 (1972)PubMedGoogle Scholar
  19. 19.
    Mason, W.S., Friis, R.R., Lineal, M., Vogt, P.K.: Virology 61, 559–574 (1974)PubMedCrossRefGoogle Scholar
  20. 20.
    Bauer, G., Hofschneider, P.H.: Proc. Natl. Acad. Sci. USA 73, 3025–3029 (1976)PubMedCrossRefGoogle Scholar
  21. 21.
    Bauer, G., Jilek, G., Hofschneider, P.H.: In: Modern Trends in Human Leukemia II. Neth, R., et al. (eds.). München: J.F. Lehmanns Verlag, 1976, pp. 515–530Google Scholar
  22. 22.
    Bauer, G.: Thesis. Universität München 1976Google Scholar
  23. 23.
    Bauer, G., Jilek, G., Hofschneider, P.H.: J. Virol. in press (1977)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • G. Bauer
  • P. H. Hofschneider

There are no affiliations available

Personalised recommendations