Advertisement

131-J-Therapie (a−c) Present Status of Radioiodine Treatment of Hyperthyroidism

  • David V. Becker
Part of the Handbuch der Medizinischen Radiologie / Encyclopedia of Medical Radiology book series (HDBRADIOL, volume 15 / 2)

Abstract

Hyperthyroidism is the most common of the endocrine disorders but its etiology remains obscure today despite many years of detailed investigation. Since treatment cannot be directed at the cause of the disorder, it is directed instead at the thyroid gland itself, with the aim of reducing the level of circulating thyroid hormone. Surgery and radioiodine, the only permanent methods of treatment, achieve this aim by removing or destroying a significant proportion of the functioning follicular cells of the thyroid.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Barandes, M., Hurley, J.R., Becker, D.V.: Implica tions of rapid intrathyroidal iodine turnover for I31I therapy: the small pool syndrome. J. nucl. Med. 14, 379 (1973).Google Scholar
  2. Becker, D.V., Mc Conahey, W., Dobyns, B., Tompkins, E., Sheline, G., Workman, J.: The results of radioiodine treatment of hyperthyroidism. A preliminary report of the thyrotoxicosis therapy follow-up study. Abstracts, Sixth International Thyroid Conference, Vienna, Wiener Medizinischen Akademie, 1970, p. 80.Google Scholar
  3. Becker, D.V., Hurley, J.R.: Complications of Radioiodine treatment of hyperthyroidism. Semin. Nucl. Med. 1, 442–460 (1971).PubMedCrossRefGoogle Scholar
  4. Becker, D.V., Hurley, J.R. The impact of technology on Clinical Practice in Graves’ Disease. Proc. Mayo Clin. 47, 835–846 (1972).PubMedGoogle Scholar
  5. Beling, U., Einhorn, J.: Incidence of hypothyroidism and recurrences following 1131 treatment of hyperthyroidism. Acta radiol. (Stockh.) 56, 275 (1961).CrossRefGoogle Scholar
  6. Braverman, L.E., Woeber, K.A., Ingbar, S.H.: Induction of myxedema by iodide in patients euthyroid after radioiodine or surgical treatment of diffuse toxic goiter. New. Engl. J. Med. 281, 816 (1969).PubMedCrossRefGoogle Scholar
  7. Brill, A.B., Tomanaga, M., Heyssel, R.M.: Leukemia in Man Following Exposure to Ionizing Radiation: A Summary of the Findings in Hiroshima and Nagasaki, and a Comparison With Other Human Experience. Ann. intern. Med. 56, 590–609 (1962).PubMedGoogle Scholar
  8. Bronsky, D., Kiamko, R.T., Waldstein, S.S.: Posttherapeutic myxedema. Relative occurrence after treatment of hyperthyroidism by radioactive iodine (1131) or subtotal thyroidectomy. Arch. intern. Med. 121, 113 (1968).Google Scholar
  9. Burke, G., Silverstein, G.E.: Hyperthyroidism after treatment with sodium iodide I131 Incidence and relationship to antithyroid antibodies, longacting thyroid stimulator (LATS), and infiltrative ophthalmopathy. J. Amer. med. Ass. 210, 1051 (1969).CrossRefGoogle Scholar
  10. Chapman, E.M., Evans, R.D.: The treatment of hyperthyroidism with radioactive iodine. J. Amer. med. Ass. 131, 86 (1946).CrossRefGoogle Scholar
  11. Chapman, E.M., Maloof, F.: The use of radioactive iodine in the diagnosis and treatment of hyperthyroidism: Ten years’ experience. Medicine 34, 261 (1955).PubMedCrossRefGoogle Scholar
  12. Court-Brown, W.M., Doll, R.: Leukemia and Aplastic Anaemia in Patients Irradiated for Ankylosing Spondylitis. Spec. Rep. Ser. med. Res. Coun. (Lond.) 295, 1–135 (1957).Google Scholar
  13. Dobyns, B.M., Sheline, G.E., Workman, J.B., Tompkins, E.A., Mcconahey, W.M., Becker, D.V.: Malignant and Benign Neoplasms of the Thyroid in Patients treated for Hyperthyroidism. A report of the Cooperative Thyrotoxicosis Follow-Up Study. J. clin. Endocr. 38, 976–998 (1974).PubMedCrossRefGoogle Scholar
  14. Doniach, I.: Reconsideration of 125-I therapy in Graves’ Disease. Lancet 1975 I, 870.CrossRefGoogle Scholar
  15. Dunn, J.T., Chapman, E.M.: Rising incidence of hypothyroidism after radioactive-iodine therapy in thyrotoxicosis. New Engl. J. Med. 271, 1037 (1964).Google Scholar
  16. Einhorn, J., Hulten, M., Lindsten, J., Wicklund, H., Zetterquist, P.: Clinical and Cytogenetic Investigation in Children of Parents Treated With Radioiodine. Acta radiol. 11, 193–208 (1972).CrossRefGoogle Scholar
  17. Evered, D., Young, E.T., Tunbridge, W.M.G., Ormston, B.J., Green, E., Petersen, V.B., Dickinson, P.H.: Thyroid function after subtotal thyroidectomy for hyperthyroidism. Brit. Med. J. 1, 25–27 (1975).PubMedCrossRefGoogle Scholar
  18. Green, M., Fisher, M., Miller, H., Wilson, G.M.: Blood radiation dose after 131-I therapy of thyrotoxicosis. Calculations with reference to leukemia. Brit. Med. J. 2, 210 (1962).CrossRefGoogle Scholar
  19. Greig, W.R.: Radiation, thyroid cells and 131-I therapy—a hypothesis. J. clin. Endocr. 25, 1411 (1965).PubMedCrossRefGoogle Scholar
  20. Hadden, D.R., Lowe, D.C., Montgomery, D.A.D., Shaaks, R.G., Weaver, J.A.: Propranolol and radioactive iodine in the treatment of thyrotoxicosis. Br. J. Pharmacol. 39, 198 (1970).Google Scholar
  21. Hagen, G.A., Ouellette, R.P., Chapman, E.M.: Comparison of high and low dosage levels of 1311 in the treatment of thyrotoxicosis. New Engl. J. Med. 277, 559Google Scholar
  22. Hedley, A.J.: The use of a computer in patient follow-up in Scotland. Scot. med. J. 15, 395 (1970).Google Scholar
  23. Hempelmann, L.H.: Risk of thyroid neoplasms after irradiation in childhood. Science 160, 159 (1968).PubMedCrossRefGoogle Scholar
  24. Lamberg, B.-A., Hernberg, C.A., Wahlberg, P., Hakkila, R.: Treatment of toxic nodular goitre with radioactive iodine. Acta med. scand. 165, 245 (1959).PubMedCrossRefGoogle Scholar
  25. Mccullagh, E.P.: Radioactive iodine in the treatment of hyperthyroidism. Ann. intern. Med. 37, 739 (1952).PubMedGoogle Scholar
  26. Mcdougall, I.R., Greig, W.R., Gray, H.W., Gillespie, F.C.: Iodine- 125 Treatment for Thyrotoxicosis. Lancet 1970 II, 840–842.CrossRefGoogle Scholar
  27. Mcgirr, E.M., Thomson, J.A., Murray, I.P.C.: Radioiodine therapy in thyrotoxicosis. A review of 908 cases. Scot. med. J. 9, 505 (1964).Google Scholar
  28. Maloof, F., Dobyns, B.M., Vickery, A.L.: The effects of various doses of radioactive iodine on the function and structure of the thyroid of the rat. Endocrinology 50, 612 (1952).PubMedCrossRefGoogle Scholar
  29. Neal, F.E.: Results of radioactive iodine treatment in thyrotoxicosis. Nucl. Med. (Stuttg.) (Suppl.) 2, 303 (1964).Google Scholar
  30. Nofal, M.M., Beierwaltes, W.H., Patno, M.E.: Treatment of hyperthyroidism with sodium iodide I 131. J. Amer. med. Ass. 197, 605 (1966).CrossRefGoogle Scholar
  31. Pennington, J.S., Martin, F.I.R.: Hypothyroidism following treatment of thyrotoxicosis with radioiodine. Med. J. Aust. 2, 641 (1967).Google Scholar
  32. Philp, J.R., Duthie, M.B., Crooks, J.: A follow-up scheme for detecting hypothyroidism in thyrotoxic patients treated with radioiodine. Lancet 1968 II, 1336.CrossRefGoogle Scholar
  33. Refetoff, S., Harrison, J., Karanfilski, B., Kaplan, E.L., De Groot, L.J., Bekerman, C.: Continuing occurrence of thyroid carcinoma after irradiation to the neck in infancy and childhood. New Engl. J. Med. 292, 171–173 (1975).Google Scholar
  34. Saenger, E.L., Thoma, G.E., Tompkins, E.A.: Incidence of leukemia following treatment of hyperthyroidism. Preliminary report of the Cooperative Thyrotoxicosis Therapy Follow-Up Study. J. Amer. med. Ass. 205, 855 (1968).CrossRefGoogle Scholar
  35. Safa, A.M., Skillern, P.G.: Treatment of hyperthyroidism with a large initial dose of sodium iodide I 131. Arch. intern. Med. 135, 673–675 (1975).Google Scholar
  36. Segal, R.L., Silver, S., Yohalem, S.B., Feitelberg, S.: Myxedema following radioactive iodine therapy of hyperthyroidism. Amer. J. Med. 31, 354 (1961).PubMedCrossRefGoogle Scholar
  37. Skillman, T.G., Mazzaferri, E.L., Gwinup, G.: Random dosage of 131I in the treatment of hyperthyroidism: Results of a prospective study. Amer. J. med. Sci. 257, 382 (1969).PubMedCrossRefGoogle Scholar
  38. Smidt, K.P., Johnston, E.: Undetected Iatrogenic Hypothyroidism: A Late Complication of Radio-Iodine Therapy. N. Z. med. J. 81, 325–328 (1975)PubMedGoogle Scholar
  39. Smith, R.N., Wilson, G.M.: Clinical trial of different doses of 131I in treatment of thyrotoxicosis. Brit. med. J. 1, 129 (1967).PubMedCrossRefGoogle Scholar
  40. Sterling, K., Hoffenberg, R.: Beta blocking agents and antithyroid drugs as adjuncts to radioiodine therapy. Semin. Nucl. Med. 1, 422 (1971).PubMedCrossRefGoogle Scholar
  41. Toft, A.D., Seth, J., Hunter, W.M., Irvine, W.J.: Plasma-Thyrotrophin and Serum-Thyroxine in Patients Becoming Hypothyroid in the Early Months After Iodine-131. Lancet 1974 I, 704–705.CrossRefGoogle Scholar
  42. Tubiana, M., Freychet, P., Perez, R., Di Paola, R.: Plasma thyrotropin levels in patients treated with radioiodine for hyperthyroidism. Rev. Europ. Etud. clin. biol. XVI, 1006–1010 (1971).Google Scholar
  43. Weidinger, P., Johnson, P.M., Werner, S.C.: Five Years Experience with Iodine-125 Therapy of Graves’ Disease. Lancet 1974 II, 74–77.CrossRefGoogle Scholar
  44. Werner, S.C., Quimby, E.H., Schmidt, C.: Radioactive iodine, I-131, in the treatment of hyperthyroidism. Amer. J. Med. 7, 731 (1949).PubMedCrossRefGoogle Scholar
  45. Werner, S.C.: Results in the treatment of hyperthyroidism with radioiodine, I131 Med. Clin. N. Amer. 36, 623 (1952).Google Scholar
  46. Werner, S.C.: Oak Ridge radioiodine I131 for hyperthyroidism-tenth anniversary. J. Amer. med. Ass. 161, 628 (1956).CrossRefGoogle Scholar
  47. Werner, S.C., Johnson, P.M., Goodwin, P.N., Wiener, J.D., Lindeboom, G.A.: Long-Term Results With Iodine-125 Treatment for Toxic Diffuse Goitre. Lancet 1970 II, 681–685.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1978

Authors and Affiliations

  • David V. Becker

There are no affiliations available

Personalised recommendations