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In vivo Thyroid Function Tests and Thyroid Imaging

  • W. R. Greig
  • H. W. Gray
Part of the Handbuch der Medizinischen Radiologie / Encyclopedia of Medical Radiology book series (HDBRADIOL, volume 15 / 2)

Abstract

The epoch-making discovery of radioactive iodine by Fermi in 1934 and its in vivo application to clinical studies of thyroid disease by Hertz et al. in 1938, heralded significant advances in our understanding of thyroidal iodine metabolism and the now widespread use of radioactive tracers in clinical investigation. Paralleling intensive clinical research into aberrations of thyroidal iodine handling caused by disease, laboratory research using sophisticated techniques of chromatography, ultracentrifugation, autoradiography, electron microscopy, and more recently radioimmunoassay, has supplemented the fund of basic knowledge of the thyroid and has illuminated the many complexities of its physiology and biochemistry. These varied but related profiles have confirmed clearly that thyroid hormone biosynthesis is a series of separate, sequential, yet integrated biochemical processes culminating in the production, storage, and secretion of thyroxine and triiodothyronine. Such studies have provided a rational basis for the in vivo and in vitro evaluation of thyroid function, a more meaningful approach to the treatment of thyroid disorders, and a solid infrastructure from which future advance will be possible.

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© Springer-Verlag Berlin · Heidelberg 1978

Authors and Affiliations

  • W. R. Greig
  • H. W. Gray

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