Abstract
The epoch-making discovery of radioactive iodine by Fermi in 1934 and its in vivo application to clinical studies of thyroid disease by Hertz et al. in 1938, heralded significant advances in our understanding of thyroidal iodine metabolism and the now widespread use of radioactive tracers in clinical investigation. Paralleling intensive clinical research into aberrations of thyroidal iodine handling caused by disease, laboratory research using sophisticated techniques of chromatography, ultracentrifugation, autoradiography, electron microscopy, and more recently radioimmunoassay, has supplemented the fund of basic knowledge of the thyroid and has illuminated the many complexities of its physiology and biochemistry. These varied but related profiles have confirmed clearly that thyroid hormone biosynthesis is a series of separate, sequential, yet integrated biochemical processes culminating in the production, storage, and secretion of thyroxine and triiodothyronine. Such studies have provided a rational basis for the in vivo and in vitro evaluation of thyroid function, a more meaningful approach to the treatment of thyroid disorders, and a solid infrastructure from which future advance will be possible.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abdel-Wahab, M.F., Ibrahim, M.S., Megahed, Y.M.: Technetium-99m in the study of thyroid dis- orders. Med. Pharmacol. exp. 17, 305–310, (1967).
Alderson, P.O., Sumner, H.W., Siegel, B.A.: The single palpable thyroid nodule. Evaluation by 99mTc-Pertechnetate imaging. Cancer 37, 258–265 (1976).
Alevizaki, C.C., Gheorghiadis, N., Gonticas, S.C., Ikkos, D.G., Katsas, A., Tsialas, S. Diagnostic value of 13 Cs scanning in thyroid malignancy. Society of Nuclear Medicine, 11th Annual Meeting, Athens, September 1973, p. 28.
Alexander, W.D. Gudmundsson, TH.V., Bluhm, M.M., Harden, R.Mcg.: Studies of iodide metabolism in Iceland. Acta Endocr. (Kbh.) 46 679–683 (1964).
Alexander, W.D., Harden, R.Mcg., Mclarty, Mclarty, Shimmins, J.: Thyroid suppressibility after stopping long term treatment of thyrotoxicosis with antithyroid drugs. Metabolism 18, 58–62 (1969).
Alexander, W.D., Harden, R.McG., Shimmins, J.: Thyroidal suppression by triiodothyronine as a guide to duration of treatment of thyrotoxicosis with antithyroid drugs. Lancet 1966, 11 1041–1044.
Alexander, W.D., Harden, R.Mcg., Shimmins, J., Mclarty, D., Mcgill, P.: Development of thyroidal suppression by triiodothyronine during 6 months treatment of thyrotoxicosis with antithyroid drugs. J. clin. Endocr. 27, 1682–1689 (1967).
Alexander, W.D., Harden, R.Mcg., Shimmins, J.: Studies of the thyroid iodide “trap” in man. Recent Prog. Hormone Res. 25, 423–446 (1969).
Alexander, W.D., Koutras, D.A., Crooks, J., Buchanan, W.W., Mcdonald, E.M., Richmond,M.H., Wayne, E.J.: Quantitative studies of iodine metabolism in thyroid disease. Quart. J. Med. 31, 281–305 (1962).
Alexander, W.D., Mclarty, D.G., Horton, P., Pharmakiotis, A.D.: Sequential assessment during drug treatment of thyrotoxicosis. Clin. Endocr. 2 43–50 (1973).
Andros, G., Harper, P.V., Lathrop, K.A., Mccar-Dle, R.J.: Pertechnetate-99m localization in man with applications to thyroid scanning and the study of thyroid physiology. J. clin. Endocr. 25, 1067–1076 (1965).
Arnold, J.E., Pinskey, S.: Comparison Of 99rTc and 123I for thyroid imaging. J. nucl. Med. 17, 261–267 (1976).
Artagaveytia, D., Degrossi, O.J., Percorini, V.: Thyroid tumour scanning with 197-HgCl2: Prelimi- nary note. Nucl.-Med. (Stuttg.) 9, 350–353 (1970).
Balint, J.H., Fraser, R., Hanno, M.G.W.: Radioiodine measurements of thyroid function during and after P.A.S. treatment of tuberculosis. Brit. med. J. 1954I, 1234–1237.
Barker, M.H.: The blood cyanates in the treatment of hypertension. J. Amer. Med. Ass. 106, 762–767 (1936).
Baschieri, L., Benedetti, G., Luca, F., Negri, M.: Evaluation and limitations of the perchlorate test in the study of thyroid function. J. clin. Endocr. 23, 876–891 (1963).
Baylis, R.I.S., Hall, R.: In: Medicine. London: Medical Education (International) Ltd. 1972, p. 131.
Beasley, T.M., Palmer, H.E., Nelp, W.B.: Distribution and excretion of technetium in humans. Health Phys. 12, 1425–1435 (1966).
Becker, F.O., Economou, S.G., Southwick, H.W., Eisenstein, R.: Adult thyroid cancer after head and neck irradiation in infancy and childhood. Ann. Int. Med. 83, 347–351 (1975).
Begg, T.B., Hall, R.: Iodide goitre and hypothyroidism. Quart. J. Med. 32, 351–362 (1963).
Belcher, E.H., Gomez-Crespo, G., Trott, N.G., Vetter, H.: A standard collimator for thyroid radioiodine uptake measurements. Nucl.-Med. (Stuttg.) 4, 78–90 (1964).
Berson, S.A., Yalow, R.S.: The effect of cortisone on the iodide accumulating function of the thyroid gland in euthyroid subjects. J. clin. Endocr. 12, 407–422 (1952).
Berson, S.A., Yalow, R.S.: The iodide trapping and binding functions of the thyroid. J. clin. Invest. 34, 186–204 (1955).
Black, M.B.: 99“Tc Pertechnetate flow study for evaluation of ”cold“ thyroid nodules. Radiology 102, 705–706 (1972).
Boyle, J.A., Thomson, J.A., Greig, W.R., Jackson, I.M.D., Boyle, I.T.: The thyroid scan in patients with Hashimoto’s disease. Acta Endocr. (Kbh.), 51, 337–340 (1966).
Brucer, M.: Thyroid radioiodine uptake measurements. A standard system for universal intercalibration. Report ORINS-19. USAEC Technical Information Service (1959).
Bull, G.M., Fraser, R.: Myxoedema from resorcinol ointment applied to leg ulcers. Lancet 1950, 851–855.
Burke, C.W., Eastman, C.J.: Thyroid hormones. Brit. med. Bull. 30, 93–99 (1974).
Burke, G., Halko, A., Silverstein, G.E., Hilligoss, M.: Comparative thyroid uptake studies with 131I and 99mTc. J. clin. Endocr. 34, 630–637 (1972).
Burke, J.J., Mckay, W.J., Broderick, F.L., Indyk, J.S., Murray, I.P.C.: The role of radio-caesium in the differential diagnosis of the solitary non functioning thyroid nodule. Proceedings of the First World Congress of Nuclear Medicine, Tokyo, p. 1341 (1974).
Carr, H.A., Temple, T.E., Staab, E.V.: Early visualisation of 99mTc-pertechnetate in metastatic thyroid cancer in a patient with Graves’ disease. J. nucl. Med. 12, 40–42 (1971).
Cassidy, C.E.: Use of a thyroid suppresion test as a guide to prognosis of hyperthyroidism treated with antithyroid drugs. J. clin. Endocr. 25, 155–156 (1965).
Cassidy, C.E.: Thyroid suppression test as an index of outcome of hyperthyroidism treated with anti-thyroid drugs. Metabolism 19, 745–750 (1970).
Cassidy, C.E., Vanderlaan, W.P.: Thyroid-suppres-sion test in the progress of hyperthyroidism treated by antithyroid drugs. New Engl. J. Med. 262, 1228–1229 (1960).
Catt, K.J.: The thyroid gland. Lancet 1970, I 1383–1389.
Charkes, N.D.: Scintigraphic evaluation of nodular goitre. Sem. Nuc. Med. 1, 316–333 (1971).
Chesky, V.E., Hellwig, C.A., Welch, J.W.: Cancer of the thyroid associated with Hashimoto’s disease: an analysis of forty-eight cases. Amer. Surg. 28, 678–685 (1962).
Clark, O.H., Greenspan, F.S., Coggs, G.C., Gold-Man, L.: Evaluation of solitary cold thyroid nodules by echography and thermography. Amer. J. Surg. 130, 206–211 (1975).
Crile, G. JR., Dempsey, W.S.: Indications for removal of nontoxic nodular goitres. J. Amer. Med. Ass. 139, 1247–1251 (1949).
Davis, P.J.: Factors affecting the determination of the serum protein bound iodine. Amer. J. Med. 40, 918–940 (1966).
Groot, L.J.: Thyroid carcinoma. Med. Clin. N. Amer. 59 (5), 1233–1246 (1975).
Groot, L.J., Davis, A.M.: The early stage of thyroid hormone formation: Studies on rat thyroids in vivo. Endocrinology, 69, 695–705 (1961).
Groot, L.J., Stanbury, J.B.: The syndrome of congenital goiter with butanol insoluble serum iodine. Amer. J. Med. 27, 586–595 (1959).
Dos Remedios, L.V., Weber, P.M., Jasko, I.A.: Thyroid scintigraphy in 1000 patients. Rational use of 99mTc and 131I compounds. J. nucl. Med. 12, 673–677 (1971).
Evered, D.C., Clark, F., Petersen, V.B.: Thyroid function in euthyroid subjects with autonomous thyroid nodules. Clin. Endocr. 3, 149–154 (1974).
Falliers, C.J.: Goiter and thyroid dysfunction following the use of iodides in asthmatic children. A.M.A. J. Dis. Child. 99, 58–66 (1960).
Fermi, E.: Radioactivity induced by neutron bombardment. Nature 133, 757 (1934).
Floyd, J.C. JR., Beierwaltes, W.H., Dodson, V.N., Carr, E.A. JR.: Defective iodination of tyrosine; cause of nodular goitre ? J. clin. Endocr. 20, 881–888 (1960).
Fore, W., Wynn, J.: The thyrotrophin stimulation test. Amer. J. Med. 40, 90–96 (1966).
Fraser, G.R., Morgans, M.E., Trotter, W.R.: The syndrome of sporadic goitre and congenital deafness. Quart. J. Med. 29, 279–295 (1960).
Freeman, L.M., Megnert, P.: Metastatic thyroid car-cinoma evaluated with rapid scintiphotography. J. nucl. Med. 13, 335–337 (1972).
Fujimoto, Y., Oka, A., Nagataki, S.: Occurrence of papillary carcinoma in hyperfunctioning thyroid nodule. Report of a case. Endocr. jap. 19, (4), 371–374 (1972).
Gomez-Crespo, G., Vetter, H.: The calibration and standardization of thyroid radioiodine uptake measurements. Int. J. appl. Radiat. 17, 531–549 (1966).
Goolden, A.W.G.: Thyroid function tests and localisation studies. In: Radioisotopes in Medical Diagnosis. Belcher, E.H., Vetter, H. (eds.). London: Butterworths 1971a, p. 617.
Goolden, A.W.G.: Thyroid function tests and localisation studies. In: Radioisotopes in Medical Diagnosis. Belcher, E.H., Vetter, H. (eds.) London: Butterworths 1971 b, p. 634.
Goolden, A.W.G., Glass, H.I., Williams, E.D.: Use of 99Tcm for the routine assessment of thyroid function. Brit. Med. J. 1971, c IV 396–399.
Goolden, A.W.G., Mallard, J.R.: A method of correction for extrathyroidal radioactivity. Brit. J. Radio’. 31, 41–44 (1958).
Goolden, A.W.G., Williams, E.D., Thalassinos, N.C.: Studies of thyroid function using 99Tcm in thyrotoxic patients during treatment with antithyroid drugs. Clin. Endocr. 2, 65–73 (1973).
Gray, H.W.: M.D. Thesis, University of Glasgow, pp. 65–73 (1974a).
Gray, H.W.: M.D. Thesis, University of Glasgow, pp. 86–97 (1974b).
Gray, H.W., Hooper, L.A., Greig, W.R.: Method for reducing extrathyroidal neck radioactivity: use of a special collimated scintillation detector. J. nucl. Med. 13, 693–694 (1972).
Gray, H.W., Hooper, L.A., Greig, W.R.: An evaluation of the twenty-minute perchlorate discharge test. J. clin. Endocr. 37, 351–355 (1973a).
Gray, H.W., Hooper, L.A., Greig, W.R.: A simplified method for measuring thyroidal uptake of Technetium-99m using directional counting. J. Endocr. 59 1–5 (1973c).
Gray, H.W., Hooper, L.A., Mason, D.K., Small, M.S.: Autoradiography of pertechnetate-99 in rat thyroid. J. Endocr. 60 369–370 (1974a).
Gray, H.W., Murphy, A.V., Logan, R.W., Greig, W.R., Mcgirr, E.M.: Investigation of Nithsdale goitre. Scot. med. J. 14, 48–50 (1969).
Gray, H.W., Pack, A., Bessent, R.G., Greig, W.R.: Arteriovenous difference: a systematic error of early phase thyroidal clearance measurement. J. nucl. Med. 14, 238–239 (1973b).
Gray, H.W., Thomson, J.A., Greig, W.R., Mclen-Nan, I.: Intravenous perchlorate test in the diagnosis of Hashimoto’s disease Lancet 1974, I 335–338.
Grayson, R.R.: Factors which influence the radioactive iodine thyroidal uptake test. Amer. J. Med. 28, 397–415 (1960).
Greer, M.A.: The effect on endogenous thyroid activity of feeding dessicated thyroid to normal human subjects. New Engl. J. Med. 244, 385–390 (1951).
Greer, M.A., Smith, G.E.: Method for increasing the accuracy of the radioiodine uptake as a test for thyroid function by use of dessicated thyroid. J. clin. Endocr. 14, 1374–1381 (1954).
Greig, W.R., Gray, H.W., Mcgirr, E.M., Kambal, S., Rahman, I.A.: Investigation of endemic goitre in Sudan. Brit. J. Surg. 57, 11–16 (1970).
Groesbeck, H.P.: Evaluation of routine scintiscanning of nontoxic thyroid nodules. 1. The pre-operative diagnosis of thyroid carcinoma. Cancer 12, 1 (1959).
Hales, I., Lane, J., Richards, M., Stanley, P.G.: Abnormal iodinated proteins in two cases of ana-plastic carcinoma of thyroid. Acta Endocr. (Kbh.) 48, 513–521 (1965).
Hales, I., Stiel, J., Reeve, T., Heap, T., Myhill, J.: Prediction of the long term results of antithyroid drug therapy for thyrotoxicosis. J. clin. Endocr. 29, 998–1001 (1969).
Hall, R.: Immunologic aspects of thyroid function. New Engl. J. Med. 266, 1204–1211 (1962).
Halmolsky, M.W., Freedberg, A.S.: The ThyroidGland. New Engl. J. Med. 262, 23–27 and 129–137 (1960).
Hamburger, J.I.: Application of the radioiodine uptake to the clinical evaluation of thyroid disease. Sem. Nuc. Med. 1, 287–300 (1971).
Harper, P.V., Andros, G., Lathrop, K.: Argonne Cancer Research Hospital Semiannual Report to the Atomic Energy Commission 18, 76–88 (1962).
Hayek, A., Stanbury, J.B.: The diagnostic use of radionuclides in the thyroid disorders of childhood. Sem. Nuc. Med. 1, 334–344 (1971).
Hays, M.T., Green, F.A.: In vitro studies of 99mTcpertechnetate binding by human serum and tissues. J. nucl. Med. 14, 149–158 (1973).
Heck, L., Lathrop, K., Gottschalk, A., Harper, P.V., Fultz, M.: Perchlorate washout of pertechnetate from the thyroid gland. J. nucl. Med. 9, 323 (1968).
Hertz, S., Roberts, A., Evans, R.D.: Radioactive iodine as an indicator in the study of thyroid physiology. Proc. Soc. exp. Biol. (N.Y.) 38, 510–513 (1938).
Higgins, H.P., Ball, D., Eastham, S.: 20-min 99mTc thyroid uptake. A simplified method using the gamma camera. J. nucl. Med. 14, 907–911 (1973).
Hilditch, T.E., Gillespie, F.C., Shimmins, J., Harden, R.McG., Alexander, W.D.: A study of extra-thyroidal neck radioactivity using a radioisotope scanner. J. nucl. Med. 8, 810–821 (1967).
Hobbs, J.R., Bayliss, R.I.S., Maclagan, N.F.: The routine use of I-132 in the diagnosis of thyroid disease. Lancet 1963, 1 8–13.
Hoffer, P.B., Gottschalk, A.: Fluorescent thyroid scanning: scanning without radioisotopes. Initial clinical results. Radiology, 99, 117–123 (1971).
Hurley, P.J., Maisey, M.N., Natarajan, T.K., Wagner, H.N. JR.: A computerized system for rapid evaluation of thyroid function. J. clin. Endocr. 34, 354–360 (1972).
Hutchison, J.H., Mcgirr, E.M.: Sporadic non-endemic goitrous cretinism. Hereditary transmission. Lancet 1956, 11 1035–1037.
Ingbar, S.H., Freinkel, N.: A.C.T.H., cortisone and the metabolism of iodine. Metabolism 5, 652–666 (1956).
International Atomic Energy Agency: Thyroid radionuclide uptake measurements. Report of a panel convened by the I.A.E.A. 1971. Brit. J. Radiol. 46, 58–63 (1973).
Jackson, I.M.D., Thomson, J.A.: The relationship of carcinoma to the single thyroid nodule. Brit. J. Surg. 54, 1007–1009 (1967).
Jefferies, W.Mck., Levy, R.P., Storaasli, J.P.: Use of the TSH test in the diagnosis of thyroid disorders. Radiology 73, 341–344 (1959).
Karelitz, J.R., Richards, J.B.: Necessity of oblique views in evaluating the functional status of a thyroid nodule. J. nucl. Med. 15, 782–785 (1974).
Katz, A.D., Zager, W.J.: The lingual thyroid. Its diagnosis and treatment. Arch. Surg. 102, 582–585 (1971).
Kendall, L.W., Condon, R.E.: Prediction of malignancy in solitary thyroid nodules. Lancet 1969I, 1071–1073.
Komrower, G.M.: A case of myxoedema developing during p-amino-salicylic acid therapy. Brit. med. J. 1951, II 1193–1194.
Koutras, D.A., Pandos, P.G., Sfontouris, J., Kouloulommati-Spentza, A., Psarras, A., Malamos, B.: Thyroid scanning with Gallium-67 and Cae- sium-131. J. nucl. Med. 17, (4), 268–271 (1976).
Koutras, D.A., Sfontourts, J.: Comparison of the early thyroidal iodide clearance with estimates obtained at later intervals. J. Endocr. 35, 135–143 (1966).
Kuba, J., Wiedermann, M., Komenda, S.: Zur Pro-blematik der 99mTc-Pertechnetate Speicherung in der Schilddrüse. Nuclearmedizin 6, 53–64 (1967).
Larsson, L.G.: Studies on radioiodine treatment of thyrotoxicosis with special reference to the behaviour of the radioiodine tracer tests. Acta radiol. (Stockh.) Suppl. 126 (1955).
Lazarus, J.H., Bennie, E.H.: Effect of Lithium on thyroid function in man. Acta Endocr. (Kbh.) 70, 266–272 (1972).
Leading Article: The solitary thyroid nodule. Brit. med. J. 1971, III 720–721.
Leblanc, A.D., Bell, R.L., Johnson, P.C.: Measurement of 127I concentration in thyroid tissue by x-ray fluorescence. J. nucl. Med. 14, 816–819 (1973).
Le Roux, B.T.: Heterotopic mediastinal thyroid. Thorax 16, 192–196 (1961).
Levy, B.S., Ashburn, W.: Thyroid uptake studies using 132I. J. nucl. Med. 10 286–289 (1969)
Lewitus, Z., Rechnic, J., Lubin, E.: Sequential scanning of the thyroid as an aid in the diagnosis of subacute thyroiditis. Israel J. Med. Sciences, 3, 847–854 (1967).
Linsk, J.A., Paton, B.C., Persky, M., Isaacs, M., Kupperman, H.S.: The effect of phenylbutazone and a related analogue (G 25671) upon thyroid function. J. clin. Endocr. 17, 416–423 (1957).
London, W.T., Vought, R.L., Brown, F.A.: Bread—a dietary source of large quantities of iodine. New Engl. J. Med. 273, 381 (1965).
Lowry, R.C., Lowe, D., Hadden, D.R., Montgomery, D.A.D., Weaver, J.A.: Thyroid suppressibility: Follow up for 2 years after antithyroid treatment. Brit. med. J. 1971, 11 19–22.
Maisey, M.N., Moses, D.C., Hurley, P.J., Wagner, H.N. JR.: Improved methods for thyroid scanning. A correlation with surgical findings. J. Amer. med. Ass. 223, 761–763 (1973).
Maloof, F., Wang, C.A., Vickery, A.L.: Nontoxic goitre-diffuse or nodular. Med. Clin. N. Amer. 59, 1221–1232 (1975).
Matthews, C.M.E.: Theoretical aspects of radioactive tracer studies. In: Radioisotopes in Medical Diagnosis. Belcher, E.H., Vetter, H. (eds.). London: Butterworths 1971, p. 236.
Mcgill, P.E., Harden, R.Mcg., Robertson, I.W.K., Shimmins, J.: A comparison between the uptake of technetium-99m and iodine-131 by the thyroid gland. J. Endocr. 49 531–536 (1971).
Mcgirr, E.M., Hutchison, J.H., Clemont, W.E.: Sporadic non-endemic goitrous cretinism. Identification and significance of monoiodotyrosine and diiodotyrosine in serum and urine. Lancet 1956, I1 906–908.
Mcgirr, E.M., Hutchison, J.H., Clemont, W.E.: Sporadic goitrous cretinism. Dehalogenase deficiency in the thyroid gland of a goitrous cretin and in heterozygous carriers. Lancet 1959, 11 823–826.
Mcgirr, E.M., Hutchison, J.H., Clemont, W.E., Kennedy, J.S., Currie, A.R.: Goitre and cretinism due to the production of an abnormal iodinated thyroid compound. Scot. med. J. 5, 189–203 (1960).
Means, J.H., DE Groot, L.J., Stanbury, J.B.: In: The Thyroid and its Diseases. p. 5. McGraw-Hill 1963
Meighan, J.W., Dworkin, H.J.: Failure to detect 1311 positive thyroid metastases with 99mTc. J. nucl. Med. 11, 173–174 (1970).
Miller, J.M., Hamburger, J.I., Mellinger, R.C.: The thyroid scintogram II. The cold nodule. Radiology 85, 702–710 (1965).
Miller, J.M., Kasenter, A.G., Marks, D.S.: Disparate imaging of the autonomous functioning thyroid nodule with 99mTc-pertechnetate and radioiodine. Radiology 119, 737–739 (1976).
Morgans, M.E., Trotter, W.R.: Defective organic binding of iodine by the thyroid in Hashimoto’s thyroiditis. Lancet 1957, 1, 553–555.
Morgans, M.E., Trotter, W.R.: Association of congenital deafness with goitre. The nature of the defect. Lancet 1958, I, 607–609.
Murray, I.P.C.: Personal communication, 1974.
Murray, I.P.C., Mcgirr, E.M., Thomson, J.A., Hutchison, J.H.: The role of thyroid dysgenesis in non-goitrous cretinism and juvenile myxoedema. Med. J. Aust. 2, 6–10 (1966).
Murray, I.P.C., Stewart, R.D.H., Indyk, J.S.: Thyroidscanning with 131Cs. Brit. med. J. 1970, 1v 653–656.
Myant, N.B., Pochin, E.E., Goldie, E.A.G.: The plasma iodide clearance rate of the human thyroid. Clin. Sci. 8, 109–131 (1949).
Myers, W.G.: Radioisotopes of iodine. In: Radioactive Pharmaceuticals. Proceedings of an Oak Ridge Institute of Nuclear Studies Symposium, November 1–4, 1965.
Usaec, Division of Technical Information. p. 217 (1966).
Myers, W.G.: Radioiodine-123 for Medical Research and Diagnosis. In `Recent Advances in Nuclear Medicine’. LAWRENCE, J.H. (ed.).: Grune and Stratton 1974.
Nagataki, S., Shizume, K., Nakao, K.: Thyroid function in chronic excess iodide ingestion: comparison of thyroidal absolute iodine uptake and degradation of thyroxine in euthyroid Japanese subjects. J. clin. Endocr. 27, 638–647 (1967).
Oddie, T.H., Meschan, I., Wortham, J.: Thyroid function assay with radioiodine II. Routine calculation of thyroidal and renal rate factors. J. clin. Invest. 34, 106–114 (1955).
Owen, C.A., Mcconahey, W.M.: An unusual iodinated protein in the serum in Hashimoto’s thyroiditis. J. clin. Endocr. 16, 1570–1579 (1956).
Paley, K.R., Sobel, E.S., Yalow, R.S.: Effect of oral and intravenous cobaltous chloride on thyroid function. J. clin. Endocr. 18, 850–859 (1958).
Papadopoulos, S., Macfarlane, S., Harden, R.Mcg.: A comparison between the handling of iodine and technetium by the thyroid gland of the rat. J. Endocr. 38, 381–387 (1967).
Paris, J., Mcconahey, W.M., Owen, C.A. JR., Woolner, L.B., Bahn, R.C.: Iodide goitre. J. clin. Endocr. 20, 57–67 (1960).
Pendred, V.: Deaf-mutism and goitre. Lancet 1896II 532.
Perlmutter, M., Slater, S.L.: Which nodular goitre should be removed? A physiologic plan for the diagnosis and treatment of nodular goitre. New Engl. J. Med. 255, 65–71 (1956).
Pitt-Rivers, R., Trotter, W.R.: The site of accumulation of iodide in the thyroid of rats treated with thiouracil. Lancet 1953, 11 918–919.
Plummer, H.S.: The clinical and pathological relationships of simple and exophthalmic goitre. Amer. J. med. Sci. 146, 790–795 (1913).
Psarras, A., Papadopoulos, S.N., Livadas, D., Pharmakiotis, A.D., Koutras, D.A.: The single thyroid nodule. Brit. J. Surg, 59, 545–548 (1972).
Rall, J.E.: The role of radioactive iodine in the diagnosis of thyroid disease. Amer. J. Med. 20, 719–731 (1956).
Rapaport, B., Groot, L.J.: Current concepts in thyroid physiology. Sem. Nucl. Med. 1, 265–286 (1971).
Rogers, W.M.: In: The Thyroid (3rd ed.), Werner, S.C., Ingbar, S.H. (eds.). New York: Harper and Row 1971, p. 304.
Rollo, F.D.: 125I for measuring the radioiodine uptake of the thyroid. J. nucl. Med. 12, 8–13 (1971).
Sartin, M.A., Bogardus, C.R., Smith, C.: A pitfall in thyroid scanning. Radiology 116, 225 (1975).
Schoot, Van Der, J.B.: Gallium-67, its tumour affinity and tumour specificity. Radiol. clin. (Basel), 41, 371–377 (1972).
Shambaugh, G.E., Quinn, J.L., Oyasu, R.: Disparate thyroid imaging. Combined studies with sodium pertechnetate Tc99m and radioactive iodine. J. Amer. med. Ass. 228, 866–869 (1974).
Shands, W.C.: Carcinoma of the thyroid in association with struma lymphomatosa (Hashimoto’s disease). Ann. Surg. 151, 675–682 (1960).
Shimmins, J., Alexander, W.D., Mclarty, D.G., Robertson, J.W.K., Sloan, D.J.P.: 99n’Tc-Pertechnetate for measuring thyroid suppressibility. J. nucl. Med. 12, 51–54 (1971).
Shimmins, J., Jasani, B., Hilditch, T., Harden, R.Mcg., Alexander, W.D.: Affect of extrathyroidal activity on the estimation of radioiodine clearance. J. clin. Endocr. 28, 111–113 (1968a).
Shimmins, J., Harden, R.Mcg., Alexander, W.D. Loss of pertechnetate from the human thyroid. J. nucl. Med. 10, 637–640 (1969a).
Shimmins, J., Hilditch, T., Harden, R.Mcg., Alexander, W.D.: Thyroidal uptake and turnover of the pertechnetate ion in normal and hyperthyroid subjects. J. clin. Endocr. 28, 575–581 (1968b).
Shimmins, J.,Hilditch, T.E., Harden, R.Mcg. Alexander, W.D.: Neck extrathyroidal activity of 99mTc-pertechnetate. J. nucl. Med. 10, 483–486 (1969 b).
Shimoaka, K., Sokal, J.E.: Differentiation of benign and malignant thyroid nodules by scintiscan. Arch. intern. Med. 114, 36–39 (1964).
Shipley, R.A., Chudzik, E.B.: Thyroidal uptake and plasma clearance of 1311 and î27I in cirrhosis of the liver. J clin. Endocr. 17, 1229–1236 (1957).
Simpson, W.J.: The failure of radiophosphorus to identify malignant solitary thyroid nodules. J. nucl. Med. 6, 917–920 (1965).
Sisson, J.C.: Principles of, and pitfalls in, thyroid function tests. J. nucl. Med. 6, 853–901 (1965).
Sloan, L.W., Feind, C.R.: In: The Thyroid (3rd ed.). Werner, S.C., Ingbar, S.H. (eds.). New York: Harper and Row 1971, p. 317.
Socolow, E.L., Ingbar, S.H.: Metabolism of “Pertechnetate by the thyroid gland of the rat. Endocrinology 80, 337–344 (1967).
Sodee, D.B.: The evaluation of metastatic thyroid carcinoma with Tc-99m pertechnetate. Radiology 88, 145–147 (1967).
Sorensen, L.B., Archambault, M.: Visualization of the liver by scanning with Mo99 (molybdate) as tracer. J. Lab. clin. Med. 62, 330–340 (1963).
Stanbury, J.B., Brownell, G.L., Riggs, D.S., Perinetti, H., Itoir, J., Del Castillo, E.B.: Endemic Goitre. The adaption of Man to Iodine Deficiency. Cambridge, Mass.: Harvard University Press 1954, p. 44.
Steinberg, M., Cavalieri, R.R., Choy, S.H.: Uptake of Technetium 99m-Pertechnetate in a primary thyroid carcinoma. Need for caution in evaluating nodules. J. clin. Endocr. 31, 81–84 (1970).
Stewart, R.D.H., Murray, I.P.C.: An evaluation of the perchlorate discharge test. J. clin. Endocr. 26, 1050–1058 (1966).
Strauss, H.W., Hurley, P.J., Wagner, H.N. JR.: Ad-vantages of 99mTc Pertechnetate for thyroid scanning in patients with decreased radioiodine uptake. Radiology 97, 307–310 (1970).
Strickland, A.L., Macfie, J.A., Wyk, J.J., French, F.S.: Ectopic thyroid glands simulating thyroglossal duct cysts. Hypothyroidism following surgical excision. J. Amer. med. Ass. 208, 307–310 (1969).
Thomas, I.D., Oddie, T.H., Myhill, J.: A diagnostic radioiodine uptake test in patients receiving anti-thyroid drugs. J. clin. Endocr. 20, 1601–1607 (1960).
Thys, L.G., Roos, P., Wiener, J.D.: Use of ultrasound and digital scintiphoto analysis in the evaluation of solitary thyroid nodules. J. nucl. Med. 13, 504–509 (1972).
Tong, W.: Thyroid hormone synthesis and release. In: The Thyroid, (3rd ed.). WERNER, S.C., INGBAR, S.H., (eds.). New York: Harper and Row 1971, pp. 24–40.
Treves, S., Crigler, J.F. JR.: Diagnostic use of 1311 in children. Safety and utility compared to other tests. Paediatrics, 51, 929–930 (1973).
Usher, M.S., Arzoumanian, A.Y.: Thyroid nodule scans made with pertechnetate and iodine may give inconsistent results. J. nucl. Med. 12, 136–137 (1971).
Valenta, L.: Metastatic thyroid carcinoma in man concentrating iodine without organification. J. clin. Endocr. 26, 1317–1324 (1966).
Thoff, W., Pover, G.G., Eiser, N.M.: Technetium-99m in the diagnosis of thyrotoxicosis. Brit. med. J. 1972 IV 203–206.
Veall, N., Vetter, H.: In `Radioisotope Techniques in Clinical Research and Diagnosis’. London-Washington D.C.: Butterworth, p. 289.
Vought, R.L., London, W.T., Lutwak, L., Dublin, T.D.: Reliability of estimates of serum inorganic iodine and daily faecal and urinary iodine excretion from single casual specimens. J. clin. Endocr. 23, 1218–1228 (1963).
Wayne, E.J., Koutras, D.A., Alexander, W.D.: In: Clinical Aspects of Iodine Metabolism. pp. 3–38. Blackwell Scientific Publications 1964a.
Wayne, E.J., Koutras, D.A., Alexander, W.D.: In: Clinical Aspects of Iodine Metabolism. pp. 149–171. Blackwell Scientific Publications 1964 b.
Weiner, J.D., Roos, P.: Failure of 197HgC12 Scintography to distinguish between benign and malignant `cold’ thyroid nodules. Nucl.-Med. (Stuttg.) 9, 1–4 (1970).
Weinstein, M.B., Ashkar, F.S., Caron, C.D.: 75Se Selenomethionine as a scanning agent for the differential diagnosis of the cold thyroid nodule. Sem. Nuc. Med. 1, 390–396 (1971).
Wellman, H.N., Anger, R.T. JR.: Radioiodine dosimetry and the use of radioiodines other than 131I in thyroid diagnosis. Sem. Nuc. Med. 1, 356–378 (1971).
Werner, S.C., Hamilton, H., Nemeth, M.: Graves’disease: hyperthyroidism or hyperpituitarism. J. clin. Endocr. 12, 1561–1571 (1952).
Wiener, S.N., Ghose, M.K.: Thyroid metastases diagnosed by 99mTc scanning. A case report. J. Canad. Ass. Radiol. 21, 190–191 (1970).
Williams, E.D., Glass, H.I., Goolden, A.W.G., Satyavanich, S.: Comparison of two methods for measuring the thyroid uptake of 99mTc. J. nucl. Med. 13, 159–162 (1972).
Wilson, L.B.: The pathology of the thyroid gland in exophthalmic goitre. Amer. J. med. Sci. 146, 781–790 (1913).
Wolff, J., Maurey, J.R.: Thyroidal iodide transport I.V. The role of ion size. Biochim. biophys. Acta (Amst.) 69, 48–58 (1963).
Wolff, J.: Transport of iodide and other anions in the thyroid gland. Physiol. Rev. 44, 45–90 (1964).
Wollman, S.H., Reed, F.E.: Kinetics of accumulation of radioiodine by thyroid gland: short time intervals. Amer. J. Physiol. 202, 182–188 (1962).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1978 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Greig, W.R., Gray, H.W. (1978). In vivo Thyroid Function Tests and Thyroid Imaging. In: Hundeshagen, H. (eds) Nuklearmedizin / Nuclear Medicine. Handbuch der Medizinischen Radiologie / Encyclopedia of Medical Radiology, vol 15 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81170-8_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-81170-8_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-81171-5
Online ISBN: 978-3-642-81170-8
eBook Packages: Springer Book Archive