In vivo Thyroid Function Tests and Thyroid Imaging

  • W. R. Greig
  • H. W. Gray
Part of the Handbuch der Medizinischen Radiologie / Encyclopedia of Medical Radiology book series (HDBRADIOL, volume 15 / 2)


The epoch-making discovery of radioactive iodine by Fermi in 1934 and its in vivo application to clinical studies of thyroid disease by Hertz et al. in 1938, heralded significant advances in our understanding of thyroidal iodine metabolism and the now widespread use of radioactive tracers in clinical investigation. Paralleling intensive clinical research into aberrations of thyroidal iodine handling caused by disease, laboratory research using sophisticated techniques of chromatography, ultracentrifugation, autoradiography, electron microscopy, and more recently radioimmunoassay, has supplemented the fund of basic knowledge of the thyroid and has illuminated the many complexities of its physiology and biochemistry. These varied but related profiles have confirmed clearly that thyroid hormone biosynthesis is a series of separate, sequential, yet integrated biochemical processes culminating in the production, storage, and secretion of thyroxine and triiodothyronine. Such studies have provided a rational basis for the in vivo and in vitro evaluation of thyroid function, a more meaningful approach to the treatment of thyroid disorders, and a solid infrastructure from which future advance will be possible.


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  1. Abdel-Wahab, M.F., Ibrahim, M.S., Megahed, Y.M.: Technetium-99m in the study of thyroid dis- orders. Med. Pharmacol. exp. 17, 305–310, (1967).Google Scholar
  2. Alderson, P.O., Sumner, H.W., Siegel, B.A.: The single palpable thyroid nodule. Evaluation by 99mTc-Pertechnetate imaging. Cancer 37, 258–265 (1976).PubMedCrossRefGoogle Scholar
  3. Alevizaki, C.C., Gheorghiadis, N., Gonticas, S.C., Ikkos, D.G., Katsas, A., Tsialas, S. Diagnostic value of 13 Cs scanning in thyroid malignancy. Society of Nuclear Medicine, 11th Annual Meeting, Athens, September 1973, p. 28.Google Scholar
  4. Alexander, W.D. Gudmundsson, TH.V., Bluhm, M.M., Harden, R.Mcg.: Studies of iodide metabolism in Iceland. Acta Endocr. (Kbh.) 46 679–683 (1964).Google Scholar
  5. Alexander, W.D., Harden, R.Mcg., Mclarty, Mclarty, Shimmins, J.: Thyroid suppressibility after stopping long term treatment of thyrotoxicosis with antithyroid drugs. Metabolism 18, 58–62 (1969).Google Scholar
  6. Alexander, W.D., Harden, R.McG., Shimmins, J.: Thyroidal suppression by triiodothyronine as a guide to duration of treatment of thyrotoxicosis with antithyroid drugs. Lancet 1966, 11 1041–1044.Google Scholar
  7. Alexander, W.D., Harden, R.Mcg., Shimmins, J., Mclarty, D., Mcgill, P.: Development of thyroidal suppression by triiodothyronine during 6 months treatment of thyrotoxicosis with antithyroid drugs. J. clin. Endocr. 27, 1682–1689 (1967).Google Scholar
  8. Alexander, W.D., Harden, R.Mcg., Shimmins, J.: Studies of the thyroid iodide “trap” in man. Recent Prog. Hormone Res. 25, 423–446 (1969).Google Scholar
  9. Alexander, W.D., Koutras, D.A., Crooks, J., Buchanan, W.W., Mcdonald, E.M., Richmond,M.H., Wayne, E.J.: Quantitative studies of iodine metabolism in thyroid disease. Quart. J. Med. 31, 281–305 (1962).Google Scholar
  10. Alexander, W.D., Mclarty, D.G., Horton, P., Pharmakiotis, A.D.: Sequential assessment during drug treatment of thyrotoxicosis. Clin. Endocr. 2 43–50 (1973).Google Scholar
  11. Andros, G., Harper, P.V., Lathrop, K.A., Mccar-Dle, R.J.: Pertechnetate-99m localization in man with applications to thyroid scanning and the study of thyroid physiology. J. clin. Endocr. 25, 1067–1076 (1965).PubMedCrossRefGoogle Scholar
  12. Arnold, J.E., Pinskey, S.: Comparison Of 99rTc and 123I for thyroid imaging. J. nucl. Med. 17, 261–267 (1976).PubMedGoogle Scholar
  13. Artagaveytia, D., Degrossi, O.J., Percorini, V.: Thyroid tumour scanning with 197-HgCl2: Prelimi- nary note. Nucl.-Med. (Stuttg.) 9, 350–353 (1970).Google Scholar
  14. Balint, J.H., Fraser, R., Hanno, M.G.W.: Radioiodine measurements of thyroid function during and after P.A.S. treatment of tuberculosis. Brit. med. J. 1954I, 1234–1237.Google Scholar
  15. Barker, M.H.: The blood cyanates in the treatment of hypertension. J. Amer. Med. Ass. 106, 762–767 (1936).CrossRefGoogle Scholar
  16. Baschieri, L., Benedetti, G., Luca, F., Negri, M.: Evaluation and limitations of the perchlorate test in the study of thyroid function. J. clin. Endocr. 23, 876–891 (1963).CrossRefGoogle Scholar
  17. Baylis, R.I.S., Hall, R.: In: Medicine. London: Medical Education (International) Ltd. 1972, p. 131.Google Scholar
  18. Beasley, T.M., Palmer, H.E., Nelp, W.B.: Distribution and excretion of technetium in humans. Health Phys. 12, 1425–1435 (1966).PubMedCrossRefGoogle Scholar
  19. Becker, F.O., Economou, S.G., Southwick, H.W., Eisenstein, R.: Adult thyroid cancer after head and neck irradiation in infancy and childhood. Ann. Int. Med. 83, 347–351 (1975).PubMedGoogle Scholar
  20. Begg, T.B., Hall, R.: Iodide goitre and hypothyroidism. Quart. J. Med. 32, 351–362 (1963).PubMedGoogle Scholar
  21. Belcher, E.H., Gomez-Crespo, G., Trott, N.G., Vetter, H.: A standard collimator for thyroid radioiodine uptake measurements. Nucl.-Med. (Stuttg.) 4, 78–90 (1964).Google Scholar
  22. Berson, S.A., Yalow, R.S.: The effect of cortisone on the iodide accumulating function of the thyroid gland in euthyroid subjects. J. clin. Endocr. 12, 407–422 (1952).PubMedCrossRefGoogle Scholar
  23. Berson, S.A., Yalow, R.S.: The iodide trapping and binding functions of the thyroid. J. clin. Invest. 34, 186–204 (1955).PubMedCrossRefGoogle Scholar
  24. Black, M.B.: 99“Tc Pertechnetate flow study for evaluation of ”cold“ thyroid nodules. Radiology 102, 705–706 (1972).Google Scholar
  25. Boyle, J.A., Thomson, J.A., Greig, W.R., Jackson, I.M.D., Boyle, I.T.: The thyroid scan in patients with Hashimoto’s disease. Acta Endocr. (Kbh.), 51, 337–340 (1966).Google Scholar
  26. Brucer, M.: Thyroid radioiodine uptake measurements. A standard system for universal intercalibration. Report ORINS-19. USAEC Technical Information Service (1959).Google Scholar
  27. Bull, G.M., Fraser, R.: Myxoedema from resorcinol ointment applied to leg ulcers. Lancet 1950, 851–855.CrossRefGoogle Scholar
  28. Burke, C.W., Eastman, C.J.: Thyroid hormones. Brit. med. Bull. 30, 93–99 (1974).Google Scholar
  29. Burke, G., Halko, A., Silverstein, G.E., Hilligoss, M.: Comparative thyroid uptake studies with 131I and 99mTc. J. clin. Endocr. 34, 630–637 (1972).PubMedCrossRefGoogle Scholar
  30. Burke, J.J., Mckay, W.J., Broderick, F.L., Indyk, J.S., Murray, I.P.C.: The role of radio-caesium in the differential diagnosis of the solitary non functioning thyroid nodule. Proceedings of the First World Congress of Nuclear Medicine, Tokyo, p. 1341 (1974).Google Scholar
  31. Carr, H.A., Temple, T.E., Staab, E.V.: Early visualisation of 99mTc-pertechnetate in metastatic thyroid cancer in a patient with Graves’ disease. J. nucl. Med. 12, 40–42 (1971).PubMedGoogle Scholar
  32. Cassidy, C.E.: Use of a thyroid suppresion test as a guide to prognosis of hyperthyroidism treated with antithyroid drugs. J. clin. Endocr. 25, 155–156 (1965).PubMedCrossRefGoogle Scholar
  33. Cassidy, C.E.: Thyroid suppression test as an index of outcome of hyperthyroidism treated with anti-thyroid drugs. Metabolism 19, 745–750 (1970).PubMedCrossRefGoogle Scholar
  34. Cassidy, C.E., Vanderlaan, W.P.: Thyroid-suppres-sion test in the progress of hyperthyroidism treated by antithyroid drugs. New Engl. J. Med. 262, 1228–1229 (1960).Google Scholar
  35. Catt, K.J.: The thyroid gland. Lancet 1970, I 1383–1389.Google Scholar
  36. Charkes, N.D.: Scintigraphic evaluation of nodular goitre. Sem. Nuc. Med. 1, 316–333 (1971).CrossRefGoogle Scholar
  37. Chesky, V.E., Hellwig, C.A., Welch, J.W.: Cancer of the thyroid associated with Hashimoto’s disease: an analysis of forty-eight cases. Amer. Surg. 28, 678–685 (1962).Google Scholar
  38. Clark, O.H., Greenspan, F.S., Coggs, G.C., Gold-Man, L.: Evaluation of solitary cold thyroid nodules by echography and thermography. Amer. J. Surg. 130, 206–211 (1975).Google Scholar
  39. Crile, G. JR., Dempsey, W.S.: Indications for removal of nontoxic nodular goitres. J. Amer. Med. Ass. 139, 1247–1251 (1949).CrossRefGoogle Scholar
  40. Davis, P.J.: Factors affecting the determination of the serum protein bound iodine. Amer. J. Med. 40, 918–940 (1966).PubMedCrossRefGoogle Scholar
  41. Groot, L.J.: Thyroid carcinoma. Med. Clin. N. Amer. 59 (5), 1233–1246 (1975).Google Scholar
  42. Groot, L.J., Davis, A.M.: The early stage of thyroid hormone formation: Studies on rat thyroids in vivo. Endocrinology, 69, 695–705 (1961).CrossRefGoogle Scholar
  43. Groot, L.J., Stanbury, J.B.: The syndrome of congenital goiter with butanol insoluble serum iodine. Amer. J. Med. 27, 586–595 (1959).CrossRefGoogle Scholar
  44. Dos Remedios, L.V., Weber, P.M., Jasko, I.A.: Thyroid scintigraphy in 1000 patients. Rational use of 99mTc and 131I compounds. J. nucl. Med. 12, 673–677 (1971).Google Scholar
  45. Evered, D.C., Clark, F., Petersen, V.B.: Thyroid function in euthyroid subjects with autonomous thyroid nodules. Clin. Endocr. 3, 149–154 (1974).PubMedCrossRefGoogle Scholar
  46. Falliers, C.J.: Goiter and thyroid dysfunction following the use of iodides in asthmatic children. A.M.A. J. Dis. Child. 99, 58–66 (1960).Google Scholar
  47. Fermi, E.: Radioactivity induced by neutron bombardment. Nature 133, 757 (1934).CrossRefGoogle Scholar
  48. Floyd, J.C. JR., Beierwaltes, W.H., Dodson, V.N., Carr, E.A. JR.: Defective iodination of tyrosine; cause of nodular goitre ? J. clin. Endocr. 20, 881–888 (1960).PubMedCrossRefGoogle Scholar
  49. Fore, W., Wynn, J.: The thyrotrophin stimulation test. Amer. J. Med. 40, 90–96 (1966).PubMedCrossRefGoogle Scholar
  50. Fraser, G.R., Morgans, M.E., Trotter, W.R.: The syndrome of sporadic goitre and congenital deafness. Quart. J. Med. 29, 279–295 (1960).PubMedGoogle Scholar
  51. Freeman, L.M., Megnert, P.: Metastatic thyroid car-cinoma evaluated with rapid scintiphotography. J. nucl. Med. 13, 335–337 (1972).PubMedGoogle Scholar
  52. Fujimoto, Y., Oka, A., Nagataki, S.: Occurrence of papillary carcinoma in hyperfunctioning thyroid nodule. Report of a case. Endocr. jap. 19, (4), 371–374 (1972).PubMedCrossRefGoogle Scholar
  53. Gomez-Crespo, G., Vetter, H.: The calibration and standardization of thyroid radioiodine uptake measurements. Int. J. appl. Radiat. 17, 531–549 (1966).PubMedCrossRefGoogle Scholar
  54. Goolden, A.W.G.: Thyroid function tests and localisation studies. In: Radioisotopes in Medical Diagnosis. Belcher, E.H., Vetter, H. (eds.). London: Butterworths 1971a, p. 617.Google Scholar
  55. Goolden, A.W.G.: Thyroid function tests and localisation studies. In: Radioisotopes in Medical Diagnosis. Belcher, E.H., Vetter, H. (eds.) London: Butterworths 1971 b, p. 634.Google Scholar
  56. Goolden, A.W.G., Glass, H.I., Williams, E.D.: Use of 99Tcm for the routine assessment of thyroid function. Brit. Med. J. 1971, c IV 396–399.CrossRefGoogle Scholar
  57. Goolden, A.W.G., Mallard, J.R.: A method of correction for extrathyroidal radioactivity. Brit. J. Radio’. 31, 41–44 (1958).CrossRefGoogle Scholar
  58. Goolden, A.W.G., Williams, E.D., Thalassinos, N.C.: Studies of thyroid function using 99Tcm in thyrotoxic patients during treatment with antithyroid drugs. Clin. Endocr. 2, 65–73 (1973).PubMedCrossRefGoogle Scholar
  59. Gray, H.W.: M.D. Thesis, University of Glasgow, pp. 65–73 (1974a).Google Scholar
  60. Gray, H.W.: M.D. Thesis, University of Glasgow, pp. 86–97 (1974b).Google Scholar
  61. Gray, H.W., Hooper, L.A., Greig, W.R.: Method for reducing extrathyroidal neck radioactivity: use of a special collimated scintillation detector. J. nucl. Med. 13, 693–694 (1972).PubMedGoogle Scholar
  62. Gray, H.W., Hooper, L.A., Greig, W.R.: An evaluation of the twenty-minute perchlorate discharge test. J. clin. Endocr. 37, 351–355 (1973a).PubMedCrossRefGoogle Scholar
  63. Gray, H.W., Hooper, L.A., Greig, W.R.: A simplified method for measuring thyroidal uptake of Technetium-99m using directional counting. J. Endocr. 59 1–5 (1973c).CrossRefGoogle Scholar
  64. Gray, H.W., Hooper, L.A., Mason, D.K., Small, M.S.: Autoradiography of pertechnetate-99 in rat thyroid. J. Endocr. 60 369–370 (1974a).CrossRefGoogle Scholar
  65. Gray, H.W., Murphy, A.V., Logan, R.W., Greig, W.R., Mcgirr, E.M.: Investigation of Nithsdale goitre. Scot. med. J. 14, 48–50 (1969).Google Scholar
  66. Gray, H.W., Pack, A., Bessent, R.G., Greig, W.R.: Arteriovenous difference: a systematic error of early phase thyroidal clearance measurement. J. nucl. Med. 14, 238–239 (1973b).PubMedGoogle Scholar
  67. Gray, H.W., Thomson, J.A., Greig, W.R., Mclen-Nan, I.: Intravenous perchlorate test in the diagnosis of Hashimoto’s disease Lancet 1974, I 335–338.Google Scholar
  68. Grayson, R.R.: Factors which influence the radioactive iodine thyroidal uptake test. Amer. J. Med. 28, 397–415 (1960).PubMedCrossRefGoogle Scholar
  69. Greer, M.A.: The effect on endogenous thyroid activity of feeding dessicated thyroid to normal human subjects. New Engl. J. Med. 244, 385–390 (1951).Google Scholar
  70. Greer, M.A., Smith, G.E.: Method for increasing the accuracy of the radioiodine uptake as a test for thyroid function by use of dessicated thyroid. J. clin. Endocr. 14, 1374–1381 (1954).PubMedCrossRefGoogle Scholar
  71. Greig, W.R., Gray, H.W., Mcgirr, E.M., Kambal, S., Rahman, I.A.: Investigation of endemic goitre in Sudan. Brit. J. Surg. 57, 11–16 (1970).PubMedCrossRefGoogle Scholar
  72. Groesbeck, H.P.: Evaluation of routine scintiscanning of nontoxic thyroid nodules. 1. The pre-operative diagnosis of thyroid carcinoma. Cancer 12, 1 (1959).PubMedCrossRefGoogle Scholar
  73. Hales, I., Lane, J., Richards, M., Stanley, P.G.: Abnormal iodinated proteins in two cases of ana-plastic carcinoma of thyroid. Acta Endocr. (Kbh.) 48, 513–521 (1965).Google Scholar
  74. Hales, I., Stiel, J., Reeve, T., Heap, T., Myhill, J.: Prediction of the long term results of antithyroid drug therapy for thyrotoxicosis. J. clin. Endocr. 29, 998–1001 (1969).PubMedCrossRefGoogle Scholar
  75. Hall, R.: Immunologic aspects of thyroid function. New Engl. J. Med. 266, 1204–1211 (1962).Google Scholar
  76. Halmolsky, M.W., Freedberg, A.S.: The ThyroidGland. New Engl. J. Med. 262, 23–27 and 129–137 (1960).CrossRefGoogle Scholar
  77. Hamburger, J.I.: Application of the radioiodine uptake to the clinical evaluation of thyroid disease. Sem. Nuc. Med. 1, 287–300 (1971).CrossRefGoogle Scholar
  78. Harper, P.V., Andros, G., Lathrop, K.: Argonne Cancer Research Hospital Semiannual Report to the Atomic Energy Commission 18, 76–88 (1962).Google Scholar
  79. Hayek, A., Stanbury, J.B.: The diagnostic use of radionuclides in the thyroid disorders of childhood. Sem. Nuc. Med. 1, 334–344 (1971).CrossRefGoogle Scholar
  80. Hays, M.T., Green, F.A.: In vitro studies of 99mTcpertechnetate binding by human serum and tissues. J. nucl. Med. 14, 149–158 (1973).PubMedGoogle Scholar
  81. Heck, L., Lathrop, K., Gottschalk, A., Harper, P.V., Fultz, M.: Perchlorate washout of pertechnetate from the thyroid gland. J. nucl. Med. 9, 323 (1968).Google Scholar
  82. Hertz, S., Roberts, A., Evans, R.D.: Radioactive iodine as an indicator in the study of thyroid physiology. Proc. Soc. exp. Biol. (N.Y.) 38, 510–513 (1938).Google Scholar
  83. Higgins, H.P., Ball, D., Eastham, S.: 20-min 99mTc thyroid uptake. A simplified method using the gamma camera. J. nucl. Med. 14, 907–911 (1973).Google Scholar
  84. Hilditch, T.E., Gillespie, F.C., Shimmins, J., Harden, R.McG., Alexander, W.D.: A study of extra-thyroidal neck radioactivity using a radioisotope scanner. J. nucl. Med. 8, 810–821 (1967).PubMedGoogle Scholar
  85. Hobbs, J.R., Bayliss, R.I.S., Maclagan, N.F.: The routine use of I-132 in the diagnosis of thyroid disease. Lancet 1963, 1 8–13.PubMedCrossRefGoogle Scholar
  86. Hoffer, P.B., Gottschalk, A.: Fluorescent thyroid scanning: scanning without radioisotopes. Initial clinical results. Radiology, 99, 117–123 (1971).PubMedGoogle Scholar
  87. Hurley, P.J., Maisey, M.N., Natarajan, T.K., Wagner, H.N. JR.: A computerized system for rapid evaluation of thyroid function. J. clin. Endocr. 34, 354–360 (1972).PubMedCrossRefGoogle Scholar
  88. Hutchison, J.H., Mcgirr, E.M.: Sporadic non-endemic goitrous cretinism. Hereditary transmission. Lancet 1956, 11 1035–1037.Google Scholar
  89. Ingbar, S.H., Freinkel, N.: A.C.T.H., cortisone and the metabolism of iodine. Metabolism 5, 652–666 (1956).PubMedGoogle Scholar
  90. International Atomic Energy Agency: Thyroid radionuclide uptake measurements. Report of a panel convened by the I.A.E.A. 1971. Brit. J. Radiol. 46, 58–63 (1973).CrossRefGoogle Scholar
  91. Jackson, I.M.D., Thomson, J.A.: The relationship of carcinoma to the single thyroid nodule. Brit. J. Surg. 54, 1007–1009 (1967).PubMedCrossRefGoogle Scholar
  92. Jefferies, W.Mck., Levy, R.P., Storaasli, J.P.: Use of the TSH test in the diagnosis of thyroid disorders. Radiology 73, 341–344 (1959).PubMedGoogle Scholar
  93. Karelitz, J.R., Richards, J.B.: Necessity of oblique views in evaluating the functional status of a thyroid nodule. J. nucl. Med. 15, 782–785 (1974).PubMedGoogle Scholar
  94. Katz, A.D., Zager, W.J.: The lingual thyroid. Its diagnosis and treatment. Arch. Surg. 102, 582–585 (1971).PubMedCrossRefGoogle Scholar
  95. Kendall, L.W., Condon, R.E.: Prediction of malignancy in solitary thyroid nodules. Lancet 1969I, 1071–1073.Google Scholar
  96. Komrower, G.M.: A case of myxoedema developing during p-amino-salicylic acid therapy. Brit. med. J. 1951, II 1193–1194.Google Scholar
  97. Koutras, D.A., Pandos, P.G., Sfontouris, J., Kouloulommati-Spentza, A., Psarras, A., Malamos, B.: Thyroid scanning with Gallium-67 and Cae- sium-131. J. nucl. Med. 17, (4), 268–271 (1976).PubMedGoogle Scholar
  98. Koutras, D.A., Sfontourts, J.: Comparison of the early thyroidal iodide clearance with estimates obtained at later intervals. J. Endocr. 35, 135–143 (1966).PubMedCrossRefGoogle Scholar
  99. Kuba, J., Wiedermann, M., Komenda, S.: Zur Pro-blematik der 99mTc-Pertechnetate Speicherung in der Schilddrüse. Nuclearmedizin 6, 53–64 (1967).PubMedGoogle Scholar
  100. Larsson, L.G.: Studies on radioiodine treatment of thyrotoxicosis with special reference to the behaviour of the radioiodine tracer tests. Acta radiol. (Stockh.) Suppl. 126 (1955).Google Scholar
  101. Lazarus, J.H., Bennie, E.H.: Effect of Lithium on thyroid function in man. Acta Endocr. (Kbh.) 70, 266–272 (1972).Google Scholar
  102. Leading Article: The solitary thyroid nodule. Brit. med. J. 1971, III 720–721.Google Scholar
  103. Leblanc, A.D., Bell, R.L., Johnson, P.C.: Measurement of 127I concentration in thyroid tissue by x-ray fluorescence. J. nucl. Med. 14, 816–819 (1973).PubMedGoogle Scholar
  104. Le Roux, B.T.: Heterotopic mediastinal thyroid. Thorax 16, 192–196 (1961).CrossRefGoogle Scholar
  105. Levy, B.S., Ashburn, W.: Thyroid uptake studies using 132I. J. nucl. Med. 10 286–289 (1969)Google Scholar
  106. Lewitus, Z., Rechnic, J., Lubin, E.: Sequential scanning of the thyroid as an aid in the diagnosis of subacute thyroiditis. Israel J. Med. Sciences, 3, 847–854 (1967).Google Scholar
  107. Linsk, J.A., Paton, B.C., Persky, M., Isaacs, M., Kupperman, H.S.: The effect of phenylbutazone and a related analogue (G 25671) upon thyroid function. J. clin. Endocr. 17, 416–423 (1957).PubMedCrossRefGoogle Scholar
  108. London, W.T., Vought, R.L., Brown, F.A.: Bread—a dietary source of large quantities of iodine. New Engl. J. Med. 273, 381 (1965).Google Scholar
  109. Lowry, R.C., Lowe, D., Hadden, D.R., Montgomery, D.A.D., Weaver, J.A.: Thyroid suppressibility: Follow up for 2 years after antithyroid treatment. Brit. med. J. 1971, 11 19–22.Google Scholar
  110. Maisey, M.N., Moses, D.C., Hurley, P.J., Wagner, H.N. JR.: Improved methods for thyroid scanning. A correlation with surgical findings. J. Amer. med. Ass. 223, 761–763 (1973).CrossRefGoogle Scholar
  111. Maloof, F., Wang, C.A., Vickery, A.L.: Nontoxic goitre-diffuse or nodular. Med. Clin. N. Amer. 59, 1221–1232 (1975).PubMedGoogle Scholar
  112. Matthews, C.M.E.: Theoretical aspects of radioactive tracer studies. In: Radioisotopes in Medical Diagnosis. Belcher, E.H., Vetter, H. (eds.). London: Butterworths 1971, p. 236.Google Scholar
  113. Mcgill, P.E., Harden, R.Mcg., Robertson, I.W.K., Shimmins, J.: A comparison between the uptake of technetium-99m and iodine-131 by the thyroid gland. J. Endocr. 49 531–536 (1971).Google Scholar
  114. Mcgirr, E.M., Hutchison, J.H., Clemont, W.E.: Sporadic non-endemic goitrous cretinism. Identification and significance of monoiodotyrosine and diiodotyrosine in serum and urine. Lancet 1956, I1 906–908.Google Scholar
  115. Mcgirr, E.M., Hutchison, J.H., Clemont, W.E.: Sporadic goitrous cretinism. Dehalogenase deficiency in the thyroid gland of a goitrous cretin and in heterozygous carriers. Lancet 1959, 11 823–826.Google Scholar
  116. Mcgirr, E.M., Hutchison, J.H., Clemont, W.E., Kennedy, J.S., Currie, A.R.: Goitre and cretinism due to the production of an abnormal iodinated thyroid compound. Scot. med. J. 5, 189–203 (1960).Google Scholar
  117. Means, J.H., DE Groot, L.J., Stanbury, J.B.: In: The Thyroid and its Diseases. p. 5. McGraw-Hill 1963Google Scholar
  118. Meighan, J.W., Dworkin, H.J.: Failure to detect 1311 positive thyroid metastases with 99mTc. J. nucl. Med. 11, 173–174 (1970).PubMedGoogle Scholar
  119. Miller, J.M., Hamburger, J.I., Mellinger, R.C.: The thyroid scintogram II. The cold nodule. Radiology 85, 702–710 (1965).PubMedGoogle Scholar
  120. Miller, J.M., Kasenter, A.G., Marks, D.S.: Disparate imaging of the autonomous functioning thyroid nodule with 99mTc-pertechnetate and radioiodine. Radiology 119, 737–739 (1976).PubMedGoogle Scholar
  121. Morgans, M.E., Trotter, W.R.: Defective organic binding of iodine by the thyroid in Hashimoto’s thyroiditis. Lancet 1957, 1, 553–555.Google Scholar
  122. Morgans, M.E., Trotter, W.R.: Association of congenital deafness with goitre. The nature of the defect. Lancet 1958, I, 607–609.Google Scholar
  123. Murray, I.P.C.: Personal communication, 1974.Google Scholar
  124. Murray, I.P.C., Mcgirr, E.M., Thomson, J.A., Hutchison, J.H.: The role of thyroid dysgenesis in non-goitrous cretinism and juvenile myxoedema. Med. J. Aust. 2, 6–10 (1966).PubMedGoogle Scholar
  125. Murray, I.P.C., Stewart, R.D.H., Indyk, J.S.: Thyroidscanning with 131Cs. Brit. med. J. 1970, 1v 653–656.Google Scholar
  126. Myant, N.B., Pochin, E.E., Goldie, E.A.G.: The plasma iodide clearance rate of the human thyroid. Clin. Sci. 8, 109–131 (1949).PubMedGoogle Scholar
  127. Myers, W.G.: Radioisotopes of iodine. In: Radioactive Pharmaceuticals. Proceedings of an Oak Ridge Institute of Nuclear Studies Symposium, November 1–4, 1965.Google Scholar
  128. Usaec, Division of Technical Information. p. 217 (1966).Google Scholar
  129. Myers, W.G.: Radioiodine-123 for Medical Research and Diagnosis. In `Recent Advances in Nuclear Medicine’. LAWRENCE, J.H. (ed.).: Grune and Stratton 1974.Google Scholar
  130. Nagataki, S., Shizume, K., Nakao, K.: Thyroid function in chronic excess iodide ingestion: comparison of thyroidal absolute iodine uptake and degradation of thyroxine in euthyroid Japanese subjects. J. clin. Endocr. 27, 638–647 (1967).PubMedCrossRefGoogle Scholar
  131. Oddie, T.H., Meschan, I., Wortham, J.: Thyroid function assay with radioiodine II. Routine calculation of thyroidal and renal rate factors. J. clin. Invest. 34, 106–114 (1955).PubMedCrossRefGoogle Scholar
  132. Owen, C.A., Mcconahey, W.M.: An unusual iodinated protein in the serum in Hashimoto’s thyroiditis. J. clin. Endocr. 16, 1570–1579 (1956).PubMedCrossRefGoogle Scholar
  133. Paley, K.R., Sobel, E.S., Yalow, R.S.: Effect of oral and intravenous cobaltous chloride on thyroid function. J. clin. Endocr. 18, 850–859 (1958).PubMedCrossRefGoogle Scholar
  134. Papadopoulos, S., Macfarlane, S., Harden, R.Mcg.: A comparison between the handling of iodine and technetium by the thyroid gland of the rat. J. Endocr. 38, 381–387 (1967).PubMedCrossRefGoogle Scholar
  135. Paris, J., Mcconahey, W.M., Owen, C.A. JR., Woolner, L.B., Bahn, R.C.: Iodide goitre. J. clin. Endocr. 20, 57–67 (1960).PubMedCrossRefGoogle Scholar
  136. Pendred, V.: Deaf-mutism and goitre. Lancet 1896II 532.Google Scholar
  137. Perlmutter, M., Slater, S.L.: Which nodular goitre should be removed? A physiologic plan for the diagnosis and treatment of nodular goitre. New Engl. J. Med. 255, 65–71 (1956).Google Scholar
  138. Pitt-Rivers, R., Trotter, W.R.: The site of accumulation of iodide in the thyroid of rats treated with thiouracil. Lancet 1953, 11 918–919.Google Scholar
  139. Plummer, H.S.: The clinical and pathological relationships of simple and exophthalmic goitre. Amer. J. med. Sci. 146, 790–795 (1913).CrossRefGoogle Scholar
  140. Psarras, A., Papadopoulos, S.N., Livadas, D., Pharmakiotis, A.D., Koutras, D.A.: The single thyroid nodule. Brit. J. Surg, 59, 545–548 (1972).PubMedCrossRefGoogle Scholar
  141. Rall, J.E.: The role of radioactive iodine in the diagnosis of thyroid disease. Amer. J. Med. 20, 719–731 (1956).PubMedCrossRefGoogle Scholar
  142. Rapaport, B., Groot, L.J.: Current concepts in thyroid physiology. Sem. Nucl. Med. 1, 265–286 (1971).CrossRefGoogle Scholar
  143. Rogers, W.M.: In: The Thyroid (3rd ed.), Werner, S.C., Ingbar, S.H. (eds.). New York: Harper and Row 1971, p. 304.Google Scholar
  144. Rollo, F.D.: 125I for measuring the radioiodine uptake of the thyroid. J. nucl. Med. 12, 8–13 (1971).PubMedGoogle Scholar
  145. Sartin, M.A., Bogardus, C.R., Smith, C.: A pitfall in thyroid scanning. Radiology 116, 225 (1975).PubMedGoogle Scholar
  146. Schoot, Van Der, J.B.: Gallium-67, its tumour affinity and tumour specificity. Radiol. clin. (Basel), 41, 371–377 (1972).Google Scholar
  147. Shambaugh, G.E., Quinn, J.L., Oyasu, R.: Disparate thyroid imaging. Combined studies with sodium pertechnetate Tc99m and radioactive iodine. J. Amer. med. Ass. 228, 866–869 (1974).CrossRefGoogle Scholar
  148. Shands, W.C.: Carcinoma of the thyroid in association with struma lymphomatosa (Hashimoto’s disease). Ann. Surg. 151, 675–682 (1960).PubMedCrossRefGoogle Scholar
  149. Shimmins, J., Alexander, W.D., Mclarty, D.G., Robertson, J.W.K., Sloan, D.J.P.: 99n’Tc-Pertechnetate for measuring thyroid suppressibility. J. nucl. Med. 12, 51–54 (1971).PubMedGoogle Scholar
  150. Shimmins, J., Jasani, B., Hilditch, T., Harden, R.Mcg., Alexander, W.D.: Affect of extrathyroidal activity on the estimation of radioiodine clearance. J. clin. Endocr. 28, 111–113 (1968a).PubMedCrossRefGoogle Scholar
  151. Shimmins, J., Harden, R.Mcg., Alexander, W.D. Loss of pertechnetate from the human thyroid. J. nucl. Med. 10, 637–640 (1969a).PubMedGoogle Scholar
  152. Shimmins, J., Hilditch, T., Harden, R.Mcg., Alexander, W.D.: Thyroidal uptake and turnover of the pertechnetate ion in normal and hyperthyroid subjects. J. clin. Endocr. 28, 575–581 (1968b).Google Scholar
  153. Shimmins, J.,Hilditch, T.E., Harden, R.Mcg. Alexander, W.D.: Neck extrathyroidal activity of 99mTc-pertechnetate. J. nucl. Med. 10, 483–486 (1969 b).Google Scholar
  154. Shimoaka, K., Sokal, J.E.: Differentiation of benign and malignant thyroid nodules by scintiscan. Arch. intern. Med. 114, 36–39 (1964).Google Scholar
  155. Shipley, R.A., Chudzik, E.B.: Thyroidal uptake and plasma clearance of 1311 and î27I in cirrhosis of the liver. J clin. Endocr. 17, 1229–1236 (1957).PubMedCrossRefGoogle Scholar
  156. Simpson, W.J.: The failure of radiophosphorus to identify malignant solitary thyroid nodules. J. nucl. Med. 6, 917–920 (1965).PubMedGoogle Scholar
  157. Sisson, J.C.: Principles of, and pitfalls in, thyroid function tests. J. nucl. Med. 6, 853–901 (1965).PubMedGoogle Scholar
  158. Sloan, L.W., Feind, C.R.: In: The Thyroid (3rd ed.). Werner, S.C., Ingbar, S.H. (eds.). New York: Harper and Row 1971, p. 317.Google Scholar
  159. Socolow, E.L., Ingbar, S.H.: Metabolism of “Pertechnetate by the thyroid gland of the rat. Endocrinology 80, 337–344 (1967).PubMedCrossRefGoogle Scholar
  160. Sodee, D.B.: The evaluation of metastatic thyroid carcinoma with Tc-99m pertechnetate. Radiology 88, 145–147 (1967).PubMedGoogle Scholar
  161. Sorensen, L.B., Archambault, M.: Visualization of the liver by scanning with Mo99 (molybdate) as tracer. J. Lab. clin. Med. 62, 330–340 (1963).PubMedGoogle Scholar
  162. Stanbury, J.B., Brownell, G.L., Riggs, D.S., Perinetti, H., Itoir, J., Del Castillo, E.B.: Endemic Goitre. The adaption of Man to Iodine Deficiency. Cambridge, Mass.: Harvard University Press 1954, p. 44.Google Scholar
  163. Steinberg, M., Cavalieri, R.R., Choy, S.H.: Uptake of Technetium 99m-Pertechnetate in a primary thyroid carcinoma. Need for caution in evaluating nodules. J. clin. Endocr. 31, 81–84 (1970).PubMedCrossRefGoogle Scholar
  164. Stewart, R.D.H., Murray, I.P.C.: An evaluation of the perchlorate discharge test. J. clin. Endocr. 26, 1050–1058 (1966).PubMedCrossRefGoogle Scholar
  165. Strauss, H.W., Hurley, P.J., Wagner, H.N. JR.: Ad-vantages of 99mTc Pertechnetate for thyroid scanning in patients with decreased radioiodine uptake. Radiology 97, 307–310 (1970).PubMedGoogle Scholar
  166. Strickland, A.L., Macfie, J.A., Wyk, J.J., French, F.S.: Ectopic thyroid glands simulating thyroglossal duct cysts. Hypothyroidism following surgical excision. J. Amer. med. Ass. 208, 307–310 (1969).CrossRefGoogle Scholar
  167. Thomas, I.D., Oddie, T.H., Myhill, J.: A diagnostic radioiodine uptake test in patients receiving anti-thyroid drugs. J. clin. Endocr. 20, 1601–1607 (1960).PubMedCrossRefGoogle Scholar
  168. Thys, L.G., Roos, P., Wiener, J.D.: Use of ultrasound and digital scintiphoto analysis in the evaluation of solitary thyroid nodules. J. nucl. Med. 13, 504–509 (1972).Google Scholar
  169. Tong, W.: Thyroid hormone synthesis and release. In: The Thyroid, (3rd ed.). WERNER, S.C., INGBAR, S.H., (eds.). New York: Harper and Row 1971, pp. 24–40.Google Scholar
  170. Treves, S., Crigler, J.F. JR.: Diagnostic use of 1311 in children. Safety and utility compared to other tests. Paediatrics, 51, 929–930 (1973).Google Scholar
  171. Usher, M.S., Arzoumanian, A.Y.: Thyroid nodule scans made with pertechnetate and iodine may give inconsistent results. J. nucl. Med. 12, 136–137 (1971).PubMedGoogle Scholar
  172. Valenta, L.: Metastatic thyroid carcinoma in man concentrating iodine without organification. J. clin. Endocr. 26, 1317–1324 (1966).PubMedCrossRefGoogle Scholar
  173. Thoff, W., Pover, G.G., Eiser, N.M.: Technetium-99m in the diagnosis of thyrotoxicosis. Brit. med. J. 1972 IV 203–206.Google Scholar
  174. Veall, N., Vetter, H.: In `Radioisotope Techniques in Clinical Research and Diagnosis’. London-Washington D.C.: Butterworth, p. 289.Google Scholar
  175. Vought, R.L., London, W.T., Lutwak, L., Dublin, T.D.: Reliability of estimates of serum inorganic iodine and daily faecal and urinary iodine excretion from single casual specimens. J. clin. Endocr. 23, 1218–1228 (1963).PubMedCrossRefGoogle Scholar
  176. Wayne, E.J., Koutras, D.A., Alexander, W.D.: In: Clinical Aspects of Iodine Metabolism. pp. 3–38. Blackwell Scientific Publications 1964a.Google Scholar
  177. Wayne, E.J., Koutras, D.A., Alexander, W.D.: In: Clinical Aspects of Iodine Metabolism. pp. 149–171. Blackwell Scientific Publications 1964 b.Google Scholar
  178. Weiner, J.D., Roos, P.: Failure of 197HgC12 Scintography to distinguish between benign and malignant `cold’ thyroid nodules. Nucl.-Med. (Stuttg.) 9, 1–4 (1970).Google Scholar
  179. Weinstein, M.B., Ashkar, F.S., Caron, C.D.: 75Se Selenomethionine as a scanning agent for the differential diagnosis of the cold thyroid nodule. Sem. Nuc. Med. 1, 390–396 (1971).Google Scholar
  180. Wellman, H.N., Anger, R.T. JR.: Radioiodine dosimetry and the use of radioiodines other than 131I in thyroid diagnosis. Sem. Nuc. Med. 1, 356–378 (1971).CrossRefGoogle Scholar
  181. Werner, S.C., Hamilton, H., Nemeth, M.: Graves’disease: hyperthyroidism or hyperpituitarism. J. clin. Endocr. 12, 1561–1571 (1952).PubMedCrossRefGoogle Scholar
  182. Wiener, S.N., Ghose, M.K.: Thyroid metastases diagnosed by 99mTc scanning. A case report. J. Canad. Ass. Radiol. 21, 190–191 (1970).PubMedGoogle Scholar
  183. Williams, E.D., Glass, H.I., Goolden, A.W.G., Satyavanich, S.: Comparison of two methods for measuring the thyroid uptake of 99mTc. J. nucl. Med. 13, 159–162 (1972).PubMedGoogle Scholar
  184. Wilson, L.B.: The pathology of the thyroid gland in exophthalmic goitre. Amer. J. med. Sci. 146, 781–790 (1913).CrossRefGoogle Scholar
  185. Wolff, J., Maurey, J.R.: Thyroidal iodide transport I.V. The role of ion size. Biochim. biophys. Acta (Amst.) 69, 48–58 (1963).CrossRefGoogle Scholar
  186. Wolff, J.: Transport of iodide and other anions in the thyroid gland. Physiol. Rev. 44, 45–90 (1964).PubMedGoogle Scholar
  187. Wollman, S.H., Reed, F.E.: Kinetics of accumulation of radioiodine by thyroid gland: short time intervals. Amer. J. Physiol. 202, 182–188 (1962).PubMedGoogle Scholar

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© Springer-Verlag Berlin · Heidelberg 1978

Authors and Affiliations

  • W. R. Greig
  • H. W. Gray

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