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Thrombozytäres System

  • P. Mariß
Part of the Handbuch der Medizinischen Radiologie / Encyclopedia of Medical Radiology book series (HDBRADIOL, volume 15 / 2)

Zusammenfassung

Aus der pluripotenten Stammzelle des Knochenmarks entwickeln sich über drei verschiedene Differenzierungsreihen Granulozyten, Erythrozyten und Thrombozyten. Im Proliferations- und Reifungsprozeß der thrombozytären Reihe, der beim Gesunden ca. 10 Tage dauert, bilden sich aus den Stammzellen über Megakaryoblasten die Megakaryozyten (Baldini u. Ebbe, 1974; Wintrobe, 1974; Begemann, 1975). Nach Endoreduplikation des Kerns, wobei Megakaryozyten unterschiedlicher Kernploidie (4 N–32 N) (Paulus, 1971) entstehen, reift das Zytoplasma unter Bildung von Zellorganellen und Demarkierung in zytoplasmatische Untereinheiten (Yamada, 1957). Am Ende des Reifungsvorganges werden diese ZytoplasmaFragmente eines Megakaryozyten fast gleichzeitig als Thrombozyten direkt in den Kreislauf abgegeben (Kinosita u. Ohno, 1961; De Bruyn, 1964).

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© Springer-Verlag Berlin · Heidelberg 1978

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  • P. Mariß

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