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Leukozytäres System — Knochenmark

  • F. Ritzl
Part of the Handbuch der Medizinischen Radiologie / Encyclopedia of Medical Radiology book series (HDBRADIOL, volume 15 / 2)

Zusammenfassung

Der höher entwickelte Organismus verfügt über Abwehrmechanismen, die an die weißen Blutkörperchen und an ein weitgehend stationäres Zellsystem, das retikuloendotheliale System (RES), gebunden sind. Hierzu gehört die Phagozytose eingedrungener Fremdkörper, wie Bakterien und Viren, die neben dem retikuloendothelialen System, den Granulozyten und den Monozyten obliegt. Das stationäre Abwehrsystem der Makrophagen (RES) kann hier nicht weiter besprochen werden.

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Literatur

  1. Addis, T.: The number of formed elements in the urinary sediment of normal individuals. J. clin. Invest. 2, 409–415 (1926).PubMedCrossRefGoogle Scholar
  2. Alexanian, R., Donohue, D.M.: Neutrophilic granulocyte kinetics in normal man. J. appl. Physiol. 20, 803–808 (1965).PubMedGoogle Scholar
  3. Ambrus, C.M., Ambrus, J.L.: Regulation of the leukocyte level. Ann. N.Y. Acad. Sci. 77, 445–486 (1959).PubMedCrossRefGoogle Scholar
  4. Andreasen, E., Christensen, S.: The rate of mitotic activity in the lymphoid organs of the rat. Anat. Rec. 103, 401–412 (1949).PubMedCrossRefGoogle Scholar
  5. Andreasen, E., Ottesen, J.: Studies on the lymphocyte production: investigations on the nucleic acid turnover in the lymphoid organs. Acta physiol. scand. 10, 258–270 (1945).CrossRefGoogle Scholar
  6. Archer, R.K.: The Eosinophil Leucocytes. Chap. 16, p. 173. Oxford: Blackwell 1963.Google Scholar
  7. Athens, J.W., Haab, D.P., Raab, S.O., Boggs, D.R., Ashenbrucker, H., Cartwright, G.E., Wintrobe, M.M.: Leukokinetic studies XI. Blood granulocyte kinetics in polycythemia vera, infection and myelofibrosis. J. clin. Invest. 44,778–788 (1965 a + b).Google Scholar
  8. Athens, J.W., Haab, O.P., Raab, S.O., Mauer, A.M., Ashenbrucker, H., Cartwright, G.E., Wintrobe, M.M.: Leukokinetic studies. IV. The total blood, circulating and marginal granulocyte pools and the granulocyte turnover rate in normal subjects. J. clin. Invest. 40, 989–995 (1961b).PubMedCrossRefGoogle Scholar
  9. Boggs, D.R., Athens, J.W., Haab, O.P., Raab, S.O., Cartwright, G.E., Wintrobe, M.M.: Leuko kinetic studies. VIII. A search for an extramedullary tissue pool of neutrophilic granulocytes. Proc. Soc. exp. Biol. (N.Y.) 115, 792–796 (1964c).PubMedGoogle Scholar
  10. Athens, J.W., Raab, S.O., Haab, O.P., Boggs, D.R., Ashenbrucker, H., Cartwright, G.E., Wintrobe, M.M.: Leukokinetic studies. X. Blood granulocyte kinetics in chronic myelocytic leukemia. J. clin. Invest. 44, 765–777 (1965).PubMedCrossRefGoogle Scholar
  11. Athens, J.W., Raab, S.O., Haab, O.P., Mauer, A.M., Ashenbrucker, H., Cartwright, G.E., Wintrobe, M.M.: Leukokinetic studies. III. The distribution of granulocytes in the blood of normal subjects. J. clin. Invest. 40, 159–164 (1961a).PubMedCrossRefGoogle Scholar
  12. Athens, J.W., Raab, S.O., Haab, O.P., Mauer, A.M., Ashenbrucker, H., Cartwright, G.E., Wintrobe, M.M.: Leukokinetic studies. III. The distribution of granulocytes in the blood of normal subjects. J. clin. Invest. 40, 159–164 (1961).PubMedCrossRefGoogle Scholar
  13. Atkins, H.L., Richards, P., Schiffer, L.: Scanning of Liver, Spleen and Bone Marrow with Colloidal 99m Technetium. U.S.A.E.C. Report BNL-9210. Brookhaven National Laboratory (1964).Google Scholar
  14. Baggiolini, M., Hirsch, J.G., De Duve, C.: Resolution of granules from rabbit heterophil leukocytes into distinct populations by zonal sedimentation. J. Cell Biol. 40, 529–541 (1969).PubMedCrossRefGoogle Scholar
  15. Baggiolini, M., Hirsch, J.G., De Duve, C.: Further biochemical and morphological studies of granule fractions from rabbit heterophil leukocytes. J. Cell Biol. 45, 586–597 (1970).PubMedCrossRefGoogle Scholar
  16. Bainton, B.F., Farquhar, M.G.: Origin of granules in polymorphonuclear leukocytes: Two types derived from opposite faces of the Golgi complex in developing granulocytes. J. Cell Biol. 28, 277–301 (1966).PubMedCrossRefGoogle Scholar
  17. Bainton, B.F., Farquhar, M.G.: Differences in enzyme content of azurophil and specific granules of polymorphonuclear leukocytes I. Histochemical staining of bone marrow smears. J. Cell Biol. 39, 286–298 (1968a).PubMedCrossRefGoogle Scholar
  18. Bainton, B.F., Farquhar, M.G.: Differences in enzyme content of azurophil and specific granules of polymorphonuklear leukocytes. II. Cytochemistry and electron microscopy of bone marrow cells. J. Cell Biol. 39, 299–317 (1968b).PubMedCrossRefGoogle Scholar
  19. Bainton, D.F., Ullyot, J.L., Farquhar, M.G.: The development of neutrophilic polymorphonuclear leukocytes in human bone marrow. Origin and content of azurophil and specific granules. J. exp. Med. 134, 907–934 (1971).PubMedCrossRefGoogle Scholar
  20. Bianchi, P.A.: Thymidine kinases in human tumors. Biochem. J. 81, 21–22 (1961).Google Scholar
  21. Bianchi, P.A.: Thymidine phosphorylation and desoxyribonucleic acid synthesis in human leukemic cells. Biochem. Biophys. Acta 55, 547–549 (1962).PubMedCrossRefGoogle Scholar
  22. Bierring, F., Grunnet, I.: Quantitative bone marrow studies in the rat following a combination of subtotal splenectomy, total thymectomy and extensive removal of the lymph nodes. Acta anat. (Basel) 59, 182–187 (1964).Google Scholar
  23. Blomgren, H., Svedmyr, E.: Evidence for thymic dependence of PHA-reactive cells in spleen and lymph nodes and independence in bone marrow. J. Immunol. 106, 835–841 (1971).PubMedGoogle Scholar
  24. Boggs, D.R., Athens, J.W., Cartwright, G.E., Wintrobe, M.M.: The effect of adrenal glucocorticosteriods upon the cellular composition of inflammatory exudates. Amer. J. Path. 44,763–773 (1964 a).Google Scholar
  25. Boggs, D.R., Athens, J.W., Cartwright, G.E., Wintrobe, M.M.: The different effects of vinblastine sulfate and nitrogen mustard upon neutrophil kinetics in the dog. Proc. Soc. exp. Biol. (N.Y.) 121, 1085–1090 (1966).Google Scholar
  26. Boggs, D.R., Athens, J.W., Cartwright, G.E., Wintrobe, M.M.: The kinetics of neutrophils in exudates of patients with chronic myelocytic leukemia. Clin. Res. 13, 124 (1965).Google Scholar
  27. Boggs, D.R., Athens, J.W., Haab, O.P., Raab, S.O., Cartwright, G.E., Wintrobe, M.M.: Induced inflammatory exudates in normal man. A method designed to study the qualitative and quantitative cellular response to a pyogenic stimulus. Amer. J. Path. 44, 61–71 (1964b).PubMedGoogle Scholar
  28. Boggs, D.R., Athens, J.W., Haab, O.P., Raab, S.O., Cartwright, G.E., Wintrobe, M.M.: Leuko kinetic studies. VIII. A search for an extramedullary tissue pool of neutrophilic granulocytes. Proc. Soc. exp. Biol. (N.Y.) 115, 792–796 (1964c).Google Scholar
  29. Bond, V.P., Feinendegen, L.E., Heinze, E., CottierH.: Distribution of transfused tritiated cytidine-labeled leukocytes and red cells in the bone marrow of normal and irradiated rats. Ann. N.Y. Acad. Sci. 113, 1009–1019 (1964).Google Scholar
  30. Bond, V.P., Fliedner, T.M., Cronkite, E.P., Rubini, J.R., Robertson, J.S.: Cell turnover in blood and blood forming tissues studied with tritiated thymidine. The Kinetics of Cellular Proliferation. (Ed. F. Stohlmann, Jr.), p. 188–200. New York-London: Grune & Stratton 1959.Google Scholar
  31. Boseila, A.-W.A.: Hormonal influence on blood and tissue basophilic granulocytes. Ann. N.Y. Acad. Sci. 103, 394 (1963).PubMedCrossRefGoogle Scholar
  32. Boyum, A., Boecker, W., Carsten, A.L., Cronkite, E.P.: Proliferation of human bone marrow cells in diffusion chambers implanted into normal or irradiated mice. Blood 40, 163–173 (1972).PubMedGoogle Scholar
  33. Bradley, T.R., Metcalf, D.: The growth of mouse bone marrow cells in vitro. Aust. J. exp. Biol. med. Sci. 44, 287 (1966).PubMedCrossRefGoogle Scholar
  34. Brahim, F., Osmond, D.G.: Migration of bone marrow lymphocytes demonstrated by selective bone marrow labeling with thymidine-H3. Anat. Rec. 168, 139–160 (1970).PubMedCrossRefGoogle Scholar
  35. Brubaker, L.H., Spivak, J.L., Perry, S.: Nonequivalence of 3H and 32P labeled diisopropylfluorophosphate for the study of granulocyte kinetics. J. Lab. clin. Med. 72, 747–758 (1968).PubMedGoogle Scholar
  36. Bruce, W.R., Mccullocx, E.A.: The effect of erythropoietic stimulation on the hemopoietic colony-forming cell in mice. Blood 23, 216–232 (1964).PubMedGoogle Scholar
  37. Bruce, W.R., Meeker, B.E.: Comparison of the sensitivity of normal hematopoietic and transplanted lymphoma colony forming cells to tritiated thymidine. J. nat. Cancer Inst. 34, 849–856 (1965).PubMedGoogle Scholar
  38. Brumby, M., Metcalf, D.: Migration of cells to the thymus demonstrated by parabiosis. Proc. Soc. exp. Biol. (N.Y.) 124, 99–103 (1967).Google Scholar
  39. Caffrey, R.W., Everett, N.B., Rieke, W.O.: Radioautographic studies of reticular and blast cells in the hemopoietic tissues of the rat. Anat. Rec. 155, 41–58 (1966).PubMedCrossRefGoogle Scholar
  40. Cannon, D.C., Wissler, R.W.: “Spleen cell migration in the immune response of the rat”. Arch. Path. 84, 109–117 (1967).PubMedGoogle Scholar
  41. Cartwright, G.E., Athens, J.W., Wintrobe, M.M.: The kinetics of granulopoiesis in normal man. Blood 24, 780–803 (1964).PubMedGoogle Scholar
  42. Chan, S.H.: Studies on colony-stimulating factor: Role of the kidney in clearing serum CSF. Proc. Soc. exp. Biol. (N.Y.) 134, 733–737 (1970).Google Scholar
  43. Chan, S.H., Metcalf, D., Stanley, E.R.: Stimulation and inhibition by normal human serum of colony formation in vitro by bone marrow cells. Brit. J. Haemat. 20, 329–341 (1971).PubMedCrossRefGoogle Scholar
  44. Chan, C., Sainte-Marie, G.: Distribution and morphology of the subcapsular and reticular cells of the ten-week-old rat thymus. J. Anat. 102, 477–491 (1968).PubMedGoogle Scholar
  45. Chanana, A.D., Cronkite, E.P., Joel, D.D., Schiffer, L.M., Schnappauf, H.: The role of immunologically committed lymphocytes in rejecting skin allografts. Transplantation 7, 459–467 (1969).PubMedCrossRefGoogle Scholar
  46. Chervenick, P.A.: Spleen colonies produced by cells obtained from colonies grown in vitro. Proc. Soc. exp. Biol. (N.Y.) 138, 967–970 (1971).Google Scholar
  47. Chervenick, P.A.: Increase in circulating stem cells in patients with myelofibrosis. Blood 41, 67–72 (1973).PubMedGoogle Scholar
  48. Chervenick, P.A., Boggs, D.R.: Bone marrow colonies: Stimulation in vitro by supernatant from incubated human blood. Science 169, 691–692 (1970).PubMedCrossRefGoogle Scholar
  49. Chervenick, P.A., Lobuglio, A.F.: Human blood monocytes: Stimulators of granulocyte and mononuclear colony formation in vitro. Science 178, 164–166 (1972).PubMedCrossRefGoogle Scholar
  50. Chretien, P.B., Behar, R.J., Kohn, Z., Moldovanu, G., Miller, D.G., Lawrence, W., Jr.: The canine lymphoid system: a study of the effect of surgical excision. Anat. Rec. 159, 5–16 (1967).PubMedCrossRefGoogle Scholar
  51. Claman, H.N., Chaperon, E.A.: Immunologic complementation between thymus and marrow cells—amodel for the two-cell theory of immunocompetence. Transplant. Rev. 1, 92–133 (1969).PubMedGoogle Scholar
  52. Clancy, J., Jr., Rieke, W.O.: In Proceedings of the Third Annual Leucocyte Culture Conference (Ed. W.O. RIEKE), p. 465–474. New York: AppletonCentury-Crofts 1969.Google Scholar
  53. Cline, M.J.: Leukocyte function in inflammation: The ingestion, killing and digestion of micro-organisms. Ser. Haematol. 3 (1970).Google Scholar
  54. Cohn, Z.A., Hirsch, J.G.: The isolation and proportion of the specific cytoplasmic granules of rabbit polymorphonuclear leukocytes. J. exp. Med. 112, 983–1004 (1960).PubMedCrossRefGoogle Scholar
  55. Cooper, M.D., Peterson, R.D., South, M.A., Good,R.A.: The function of the thymus system and the bursa system in the chicken. J. exp. Med. 123, 75–85 (1966).PubMedCrossRefGoogle Scholar
  56. Craddock, C.G.: Bone marrow lymphocytes of the rat as studied by autoradiography. Acta Haemat. 33, 19–27 (1965).PubMedCrossRefGoogle Scholar
  57. Craddock, C.G., Perry, S., Lawrence, J.S.: The dynamics of leukopoiesis and leukocytosis as studied by leukopheresis and isotopic techniques. J. clin. Invest. 35, 285–296 (1956).PubMedCrossRefGoogle Scholar
  58. Craddock, C.G., Nakai, G.S.: Leukemic cell proliferation as determined by in vitro deoxyribonucleic acid synthesis. J. clin. Invest. 41, 360–369 (1962).PubMedCrossRefGoogle Scholar
  59. Craddock, C.G., Nakai, G.S., Fukuta, H., Vanslager, L.M.: Proliferative activity of the lymphatic tissues of rats. J. exp. Med. 120, 389–412 (1964).PubMedCrossRefGoogle Scholar
  60. Cronkite, E.P.: Enigmas underlying the study of hemopoietic cell proliferation. Fed. Proc. 23, 649–661 (1964).PubMedGoogle Scholar
  61. Cronkite, E.P.: Kinetics of leukemic cell proliferation, in Perspectives in Leukemia, p. 158. New York: Grune & Stratton 1968.Google Scholar
  62. Cronkite, E.P.: Myelopoesis Normal biochemistry and physiology. In: Physiological Pharmacology (Eds. W.S. Root, N.I. Berlin), Vol. 5. New York: Academic Press 1974.Google Scholar
  63. Cronkite, E.P., Bond, V.P., Fliedner, T.M., Kill-Mann, S.A.: The use of tritiated thymidine in the study of haemopoietic cell proliferation. Ciba Foundation Symp. on Haemopoiesis (Eds. G.E.W.WOLSTENHOLME, M. O’CONNOR), p. 70–92. London: Churchill 1960.Google Scholar
  64. Cronkite, E.P., Fliedner, T.M.: Granulocytopoiesis. New Engl. J. Med. 270, 1347–1352 (1963).Google Scholar
  65. Cronkite, E.P., Fliedner, T.M., Bond, V.P., Rubini, J.R.: Dynamics of hemopoietic proliferation in man and mice studied by H3 Thymidine incorporation into DNA. Ann. N.Y. Acad. Sci. 77, 803–820 (1959).PubMedCrossRefGoogle Scholar
  66. Cronkite, E.P., Fliedner, T.M., Rubini, J.R., Bond, V.P., Hughes, W.L.: Dynamics of proliferating cell systems of man studied with tritiated thymidine. J. clin. Invest. 37, 887 (1958).Google Scholar
  67. Cronkite, E.P., Fliedner, T.M., Stryckmans, P., Chanana, A.D., Cutter, J., Ramos, J.: Flow patterns and rates of human erythropoiesis and granulocytopoiesis. Ser. Haematol. 5, 51–64 (1965).Google Scholar
  68. Cronkite, E.P., Jansen, C.R., Mather, G.C., Nielsen, N.O., Usenik, E.A., Adamik, E.R., Sipe, C.R.: Studies on lymphocytes: I. Lymphopenia produced by prolonged extracorporal irradiation of circulatory blood. Blood 20, 203–213 (1962).PubMedGoogle Scholar
  69. Cronkite, E.P., Vincent, P.C.: Granulocytopoieses. Ser. Haematol. 2, 3–43 (1969).Google Scholar
  70. Cudkowicz, M., Bennet, G., Shearer, M.: Plurlpotent stem cell function of the mouse marrow lymphocyte. Science 144, 866–868 (1964).PubMedCrossRefGoogle Scholar
  71. Curry, J.L., Trentin, J.J., Wolf, N.: Hemopoietic spleen colony studies. II. Erythropoiesis. J. exp. Med. 125, 703–720 (1967).PubMedCrossRefGoogle Scholar
  72. Dale, D.C., Alling, D.W., Wolff, S.M.: Cyclic hematopoieses: the mechanism of cyclic neutropenia in grey collie dogs. J. clin. Invest. 51, 2197–2204 (1972a).PubMedCrossRefGoogle Scholar
  73. Dale, D.C., Brown, C.H., Carbone, P., Wolff, S.M.: Cyclic urinary leukopoietic activity in grey collie dogs. Science 173, 152–153 (1971).PubMedCrossRefGoogle Scholar
  74. Dale, D.C., Ward, S.B., Kimball, H.R., Wolff, S.M.: Studies on neutrophil production and turnover in grey collie dogs with cyclic neutropenia. J. clin. Invest. 51, 2190–2196 (1972b).PubMedCrossRefGoogle Scholar
  75. Davies, A.J.S.: The thymus and the cellular bais of immunity. Transplant. Rev. 1, 43–91 (1969).PubMedGoogle Scholar
  76. De Bruyn, P.P.H., Michelson, S., Thomas, T.B.: The migration of blood cells of the bone marrow through the sinussoidal wall. J. Morph. 133, 417–438 (1971).PubMedCrossRefGoogle Scholar
  77. Delmonte, L., Munford, D.M.: In vitro commitment by hemopoietins of murine marrow exocolony forming units; preliminary report. Proc. Soc. exp. Biol. (N.Y.) 140, 1389–1392 (1972).PubMedGoogle Scholar
  78. Doenhoff, M.J., Davies, A.J.S., Leuchars, E., Wallis, V.: The thymus and circulatory lymphocytes of mice. Proc. roy. Soc. B. 176, 69–85 (1970).Google Scholar
  79. Donaldson, V.H.: Blood coagulation and related plasma enzymes in flammation. Ser. Haemat. III, 39–95 (1970).Google Scholar
  80. Donohue, D.M., Reiff, R.H., Hanson, M.L., Betson, Y., Finch, C.A.: Quantitative measurement of the erythrocytic and granulocytic cells of the marrow blood. J. clin. Invest. 37, 1571–1576 (1958).PubMedCrossRefGoogle Scholar
  81. Donohugh, D.L.: Eosinophils and Eosinophile. Calif. Med. 104, 421 (1966).PubMedGoogle Scholar
  82. Dukor, P., Dietrich, F.M.: Impairment of phytohaemagglutinininduced blastic transformation in lymphnodes from thymectomized mice. Int. Arch. Allergy 32, 521–544 (1967).CrossRefGoogle Scholar
  83. Dukor, P., Miller, J.F.A.P., Sacquet, E.: The immunological responsiveness of germ-free mice thymectomized at birth. II. Lymphoid tissue and histopathology. Clin. exp. Immunol. 3, 191–212 (1968).Google Scholar
  84. English, D.K., Andersen, B.R.: 99m-Te-S colloid labeling of human phagocytes. J. nucl. Med. 16, 5–9 (1975).PubMedGoogle Scholar
  85. English, D.K., Andersen, B.R., Akalin, H.E.: 99mTechnetium-S colloid-leukocytes for inflammatory processes. J. nucl. Med. 16, 527–533 (1975).Google Scholar
  86. Ernström, U., Hedback, A.-L.: Mitotic studies in thyroxin-stimulated thymo-lymphatic tissue; an investigation in guinea-pigs with the colchicine technique. Acta path. microbiol. scand. 65, 215–220 (1965).PubMedGoogle Scholar
  87. Ernström, U., Sandberg, G.: Migration of splenic lymphocytes. Acta path. microbiol. scand. 72, 379–384 (1968).PubMedCrossRefGoogle Scholar
  88. Everett, N.B., Caffrey, R.W.: In The Lymphocyte in Immunology and Haemopoieses’ (Ed. J.M. YOFFEY), p. 108–119. London: Edward Arnold 1967.Google Scholar
  89. Everett, N.B., Caffrey, R.W., Rieke, W.O.: Recirculation of lymphocytes. Ann. N.Y. Acad. Sci. 113, 887–897 (1964).PubMedCrossRefGoogle Scholar
  90. Everett, N.B., Rieke, W.O., Reinhardt, W.O., Yoffey, J.M.: CIBA Foundation Symposium on Haemopoiesis (Eds. G.E.W. Wolstenholme, M. O’Connr), p. 46–66. Boston: Little Brown 1960.Google Scholar
  91. Everett, N.B., Tyler, R.W.: Lymphopoiesis in the thymus and other tissues: functional implications. Int. Rev. Cytol. 22, 205–237 (1967).PubMedCrossRefGoogle Scholar
  92. Everett, N.B., Tyler, R.W.: In Germinal Centers in Immune Responses (Eds. H. COTTIER, N. ODARTCHENKO, R. SCHINDLER, C.C. CONGDON),p. 145–151. New York: Springer 1967.Google Scholar
  93. Everett, N.B., Tyler, R.W.: Radioautographic studies of the stem cell in the thymus of the irradiated rat. Cell Tissue Kinet. 2, 347–362 (1969).Google Scholar
  94. Feinendegen, L.E., Bond, V.P., Hughes, W.L.: Physiological thymidine reutilisation in rat bone marrow. Proc. Soc. exp. Biol. (N.Y.) 122, 448–455 (1966).Google Scholar
  95. Fischer, J., Brod, K.H., Gamm, H., Wolf, R.: Erste Erfahrungen mit der Knochenmarkszintigraphie in der Klinik. Verh. dtsch. Ges. inn. Med. 77, 409 (1971).Google Scholar
  96. Fischer, J., Gamm, H., Brod, K.H., Wolf, R., Dennhardt, H., Roux, A.: Knochenmarkszintigraphie mit 99m Tc-markiertem Rhenium-Schwefelkolloid. In: Nuklearmedizin. Radionuklide in der Hämatologie. Gegenwärtiger Stand der Therapie mit Radionukliden (Ed. H.W. Pabst ), S. 25–28. Stuttgart: Schattauer 1973.Google Scholar
  97. Fliedner, T.M.: In Germinal Centers in Immune Responses (Eds. H. Cottier, N. Odartchenko, R. Schindler, C.C. Congdon), p. 348. New York: Springer 1967.Google Scholar
  98. Fliedner, T.M., Cronkite, E.P., Killmann, S.A., Bond, V.P.: Granulocytopoiesis. II. Emergence and pattern of labeling of neutrophilic granulocytes in humans. Blood 24, 683–700 (1964).PubMedGoogle Scholar
  99. Fliedner, T.M., Cronkite, E.P., Robertson, J.S.: Granulocytopoiesis. Senescence and random loss of neutrophilic granulocytes. Blood 24, 402–414 (1964).PubMedGoogle Scholar
  100. Fliedner, T.M., Kesse. M., Cronkite, E.P., Robertson, J.S.: Cell proliferation in germinal centers of the rat spleen. Ann. N.Y. Acad. Sci. 113, 578–594 (1964).PubMedCrossRefGoogle Scholar
  101. Fliedner, T.M., Thomas, E.D., Meyer, L.M., Cronkite, E.P.: The fate of transfused tritium thymidine labeled marrow cells in irradiated recipients. Ann. N.Y. Acad. Sci. 114, 510–528 (1964).Google Scholar
  102. Fliedner, T.M., Thomas, E.D., Meyer, L.M., Cronkite, E.P.: The fate of transfused tritium thymidine labeled marrow cells in irradiated recipients. Ann. N.Y. Acad. Sci. 114, 510–528 (1964).PubMedCrossRefGoogle Scholar
  103. Ford, W.L.: The mechanism of lymphopenia produced by chronic irradiation of the rat spleen. Brit. J. exp. Path. 49, 502–510 (1968).PubMedGoogle Scholar
  104. Ford, W.L., Gowans, J.L.: The role of lymphocytes in antibody formation II. The influence of lymphocyte migration on the initiation of antibody formation in the isolated, perfused spleen. Proc. roy. Soc. B. 168, 224–262 (1967).Google Scholar
  105. Ford, W.L., Gowans, J.L.: The traffic of lymphocytes. Sem. Haemat. 6, 67–83 (1969).Google Scholar
  106. Fossati, G.C., Fumarola, D., Cerra, E., Cavalieri, D.: Ricerche sui meccanismi della riposta leucocitaria indotta da una sostanza isolata dal Penicilhum gilmanii: il leucogenenol. Riv. Emoter. Immunoemat. 16, 91–100 (1969).PubMedGoogle Scholar
  107. Galbraith, P.R., Valberg, L.S., Brown, M.: Patterns of granulocyte kinetics in health, infection and in carcinoma. Blood 25, 683–692 (1965).PubMedGoogle Scholar
  108. Gamm, H., Kroger, J., Preiss, J., Roux, A., Habighorst, L., Fischer, J., Stelzig, H., Wolf, R.: Szintigraphie und röntgenologische Befunde bei Myelofibrose. 10. Jahrestagung Ges. Nuclearmedizin. Freiburg, Sept. 1972. Berlin: Med. Informationsdienste 1972.Google Scholar
  109. Gamm, H., Preiss, J., Fischer, J., Wolf, R.: Die Knochenmarkszintigraphie bei M. Hodgkin. Verh. dtsch. Ges. inn. Med., Wiesbaden 1973, 79, 498–500. München: J.F. Bergmann 1973.Google Scholar
  110. Gerber, G.B., Remy-Defraigne, J.Z.: Synthesis of DNA in the isolated perfused rat liver. I. Synthesis of H3 thymidine in normal liver and after partial hepatectomy. Naturforsch. 18b, 216 (1963).Google Scholar
  111. Golde, D.W., Cline, M.J.: Identification of the colony-stimulating cell in human peripheral blood. J. clin. Invest. 51, 2981–2983 (1972).PubMedCrossRefGoogle Scholar
  112. Goldschneider, I., Mcgregor, D.D.: Migration of lymphocytes and thymocytes in the rat II. Circulation of lymphocytes and thymocytes from blood to lymph. Lab. Invest. 18, 397–406 (1968).PubMedGoogle Scholar
  113. Golub, E.S., Spitznagel, J.K.: The role of lysosomes in hypersensitivity reactions; tissue damage by polymorphonuclear neutrophil lysosomes. J. Immunol. 95, 1060–1066 (1966).Google Scholar
  114. Gordon, A.S., Neri, R.O., Siegd, C.D., Darnfest, B.S., Handler, E.S., Loebue, J., Eisler, M.: Evidence for a leukocytosis inducing factor. Acta haemat. (Basel) 23, 323–341 (1960).Google Scholar
  115. Gowans, J.L., Knight, E.J.: The route of recirculation of lymphocytes in the rat. Proc. roy. Soc. B 159, 257–282 (1964).Google Scholar
  116. Gowans, J.L., Mcgregor, D.D.: The Immunological activities of lymphocytes. Progr. Allergy 9, 1–78 (1965).Google Scholar
  117. Greenberg, P.L., Nichols, W.C., Schrier, S.L.: Granulopoiesis in acute myeloid leukemia and pre- leukemia. New Engl. J. Med. 284, 1225–1232 (1971).Google Scholar
  118. Greulich, R.C., Cameron, I.L., Thrasher, J.D.: Stimulation of mitosis in adult mice by administration of thymidine. Proc. nat. Acad. Sci. (Wash.) 47, 743–748 (1961).CrossRefGoogle Scholar
  119. Haas, R.J., Bohne, F., Fliedner, T.M.: On the development of slowly-turning-over cell types in neonatal rat bone marrow (studies utilizing the complete tritiated thymidine labeling method complemented by C-14 thymidine administration). Blood 34, 791–805 (1969).Google Scholar
  120. Haas, R.J., Bohne, F., Fliedner, T.M.: Cytokinetic analysis of $ slowly proliferating bone marrow cells during recovery from radiation injury. Cell Tissue Kinet. 4, 31–45 (1971).PubMedGoogle Scholar
  121. Hall, J.G.: Quantitative aspects of the recirculation of lymphocytes; an analysis of data from experiments on sheep. Quart. J. exp. Physiol. 52, 76–85 (1967).Google Scholar
  122. Hall, J.G., Morris, B.: The origin of the cells in the efferent lymph from a single lymph node. J. exp. Med. 121, 901–910 (1965).PubMedCrossRefGoogle Scholar
  123. Harper, P.V., Lathrop, K.A., Jiminez, F., Hinn, G.M., Anwar, M.: Technetium 99m-Sulfur colloid. In Radioactive Pharmaceuticals. Oak Ridge: U.S. Atomic Energy Commission 1966.Google Scholar
  124. Harris, P.F., Haigh, G., Kugler, J.H.: Quantitative studies of mitoses and DNA-synthesizing cells in bone marrow and blood of guinea-pigs recovering from sublethal whole-body gamma irradiation. Brit. J. Haemat. 9, 385–405 (1963).PubMedCrossRefGoogle Scholar
  125. Haskill, J.S., Mcknight, R.D., Galbraith, P.R.: Cell-cell interaction in vitro: Studied by density separation of colony forming, stimulating, and inhibiting cells from human bone marrow. Blood 40, 394–399 (1972).PubMedGoogle Scholar
  126. Höfer, R., Egert, H.: Radiogoldverteilung im Knochenmark. Szintigraphie and Radiokardiographie. Basel: Schwabe 1963.Google Scholar
  127. Hudson, G., Osmond, D.G., Roylance, P.J.: Cell populations in the bone marrow of the normal guinea-pig. Acta Anat. 53, 234–239 (1963).PubMedCrossRefGoogle Scholar
  128. Hudson, G., Yoffey, J.M.: The passage of lymphocytes through the sinusoidal endothelium of guinea-pig bone marrow. Proc. roy. Soc. B 165, 486–496 (1966).Google Scholar
  129. Hughes, W.L., Commerford, S.L., Gitlin, D., Kreuzer, R.C., Schultze, B., Sha, V., Prilly, P.: De-oxyribonucleic acid metabolism in vivo. I. Cell proliferation and death as measured by incorporation and elimination of iododeoxyuridine. Fed. Proc. 23, 640–645 (1964).Google Scholar
  130. Iorio, R.J., Chanana, A.D., Cronkite, E.P., Joel, D.D.: Distribution of bovine thymic lymphocytes in the spleen and lymph nodes. Cell Tissue Kinet. 3, 161–173 (1970).PubMedGoogle Scholar
  131. Isaacs, R., Danielian, A.C.: Maintenance of leukocyte level and changes during irradiation. A study of the white blood corpuscles appearing in the saliva and their relation to those in the blood. Amer. J. med. Sci. 174, 70–84 (1927).CrossRefGoogle Scholar
  132. Iversen, J.G.: Phytohemagglutinin response of recirculating and non-recirculating rat lymphocytes. Exp. Cell Res. 56, 219–223 (1969).PubMedCrossRefGoogle Scholar
  133. Iversen, J.G., Benestad, H.B.: The presence of non-recirculating long-lived lymphocytes in rat blood. Scand. J. Haemat. 7, 368–373 (1970).PubMedCrossRefGoogle Scholar
  134. Janoff, A.: Mediators of tissue damage in human polymorphonuclear neutrophils. Ser. Hematol. 3, 96–130 (1970).Google Scholar
  135. Janout, V., Weiss, L.: Deep splenic lymphatics in the marmot. Anat. Rec. 172, 197–219 (1972).PubMedCrossRefGoogle Scholar
  136. Joel, D.D., Hess, M.W., Cottier, H.: Thymic origin of lymphocytes in developing Peyer’s patches of newborn mice. Nature, New Biol. 231, 24–25 (1971).Google Scholar
  137. Karnofsky, M.C.: Metabolic basis of phagocytic activity. Physiol. Rev. 42, 143 (1972).Google Scholar
  138. Keller, H.U., Sorkin, E.: Studies on chemotaxis. The significance of normal sera for chemotaxis induced by various agents. Immunology 9, 441 (1965).PubMedGoogle Scholar
  139. Killmann, S.A., Cronkite, E.P., Fliedner, T.M., Bond, V.P.: Mitotic indice of human bone marrow cells. I. Number and cytologic distribution of mitotis. Blood 19, 743–750 (1962).PubMedGoogle Scholar
  140. Killmann, S.A., Cronkite, E.P., Fliedner, T.M., Bond, V.P., Brecher, G.: Mitotic indices of human bone marrow cells. II. The use of mitotic indices for estimation of time parameters of proliferation in serially connected multiplicative cellular compartments. Blood 21, 141–163 (1963).PubMedGoogle Scholar
  141. Kindred, J.E.: Quantitative studies on lymphoid tissues. Ann. N.Y. Acad. Sci. 59, 746–756 (1955).PubMedCrossRefGoogle Scholar
  142. Kivilaakso, E., Rytmaa, T.: Erythrocytic chalone, a tissue specific inhibitor of cell proliferation in the erythron. Cell Tissue Kinet. IV, 1–9 (1971).Google Scholar
  143. Kniseley, R.M.: Marrow Studies with Radiocolloids. Semin. nucl. Med. 2, 71–85 (1972).CrossRefGoogle Scholar
  144. Kniseley, R.M., Andrewa, G.A., Tanida, R., Ed-Wards, C.L., Kyker, G.C.: Delineation of active marrow by whole body scanning with radioactive colloids. J. nucl. Med. 7, 575 (1966).PubMedGoogle Scholar
  145. Koburg, E.: Germinal Centers in Immune. Responses (Eds. COTTIER, H., ODARTCHENKO, N., SCHINDLER, R., CONGDON, C.C.), p. 176–182. New York: Springer 1967.Google Scholar
  146. Komiya, E.: Die zentralnervöse Regulation des Blutbildes. Stuttgart: Thieme 1956.Google Scholar
  147. Kurth, D., Athens, J.W., Conkite, E.P., Cartwright, G.E., Wintrobe, M.M.: Leukokinetic studies. I. V. Uptake of tritiated diisoporopylfluorophosphate by leukocytes. Proc. Soc. exp. Biol. (N.Y.) 107, 1422–1426 (1961).Google Scholar
  148. Lajtha, L.G.: Stem cell kinetics and erythropoietin. Erythropoie is iEds. L.O. Jacobsen, M. Doyle), p. 1940. New York-London: Grune & Stratton 1962.Google Scholar
  149. Leblond, C.P., Sainte-Marie, G.: In CIBA Foundation Symposium on Haemopoiesis (Eds. Wolstenholme, G.E.W.), p. 152–172. Boston: Little, Brown 1960.Google Scholar
  150. Lilien, D.L., Bennett, L.R.: A comparison of the uptake and disposition of radioiron and I 1 1 In-chloride in human erythrocytes (Abstract). J. nucl. Med. 13, 786–787 (1972).Google Scholar
  151. Lilien, D.L., Berger, H.G., Anderson, D.P., Ben-Nett, L.R.: 111 In-chloride. A new agent for bone marrow imaging. J. nucl. Med. 14, 184–186 (1973).PubMedGoogle Scholar
  152. Lisco, H.: Standard man. Argonne nat. Lab. Rep. 4253, 1948, Lemont, Ill.Google Scholar
  153. Litt, M.: Eosinophils and antigen-antibody reactions. Ann. N. Y. Acad. Sci. 116, 964 (1964).PubMedCrossRefGoogle Scholar
  154. Little, J.R., Brecher, G., Bradley, T.R., Rose, S.: Determination of lymphocyte turnover by continuous infusion of H3 thymidine. Blood 19, 236–242 (1962).PubMedGoogle Scholar
  155. Loken, M.K., Staab, E.V., Shea, A.W.: 1311 colloidal albumin as an agent for scanning liver and spleen. Invest. Radiol. 1, 295–300 (1966).PubMedCrossRefGoogle Scholar
  156. Mack, T., Robinson, W.A., Holton, C.P.: Colony growth of peripheral blood cells from patients with acute lymphocytic leukemia. Cancer Res. 32, 2054–2057 (1972).PubMedGoogle Scholar
  157. Malawista, S.E.: Colchicine: A common mechanism for its anti-inflammatory and antimitotic effects. Arthr. and Theum. 11, 191–197 (1968).CrossRefGoogle Scholar
  158. Maloney, M.A., Patt, H.M., Lund, J.E.: Granulocyte dynamics and the question of ineffective granulopoiesis. Cell Tissue Kinet. 4, 201–209 (1971).PubMedGoogle Scholar
  159. Mangalik, A., Robinson, W.A.: The effect of serum from patients with acute granulocytic leukening on granulocyte colony formation in vitro. A search for inhibition. Proc. Soc. exp. Biol. (N.Y.) 141, 515–518 (1972).Google Scholar
  160. Mangalik, A., Robinson, W.A.: Cyclic neutropenia: The relationship between urine granulocyte colony stimulating activity and neutrophil count. Blood 41, 79–84 (1973).PubMedGoogle Scholar
  161. Marchesi, V.T., Gowans, J.L.: The migration of lymphocytes through the endothelium of venules in lymph nodes: an electron microscope study. Proc. roy. Soc. B 159, 283–290 (1964).CrossRefGoogle Scholar
  162. Margolis, J.: The mode of action of Hageman factor in the release of plasma kinin. J. Physiol. 151, 238–252 (1960).PubMedGoogle Scholar
  163. Matsuyama, M., Margaret, M.B., Wiadrowski, N., Metcalf, D.: Autoradiographic analysis of lymphopoiesis and lymphocyte migration in mice bearing multiple thymus grafts. J. exp. Med. 123, 559–576 (1966).PubMedCrossRefGoogle Scholar
  164. Mauer, A.M., Athens, J.W., Aschenbrucker, H., Cartwright, G.E., Wintrobe, M.M.: Leuko kinetic studies. Il. A method for labeling granulo- cytes in vitro with radioactive diisopropylfluoro- phosphate. J. clin. Invest. 39, 1481–1486 (1960).PubMedCrossRefGoogle Scholar
  165. Maughan, W.Z., Bishop, C.R., Pryor, T.A., Athens, J.W.: The question of the blood neutrophil concen- trations and pitfalls in the statistical analysis of sampled data. Blood 41, 85–91 (1973).PubMedGoogle Scholar
  166. Mccall, M.S., Sutherland, D.A., Eisentraut, A.M., Lanz, H.: The tagging of leukemic leukocytes with radioactive chromium and measurement of the in vivo cell survival. J. Lab. clin. Med. 45, 717–724 (1955).Google Scholar
  167. Mcculloch, E.A.: Control of hematopoiesis at the cellular level. In Regulation of Hematolpoiesis, 2, 132–158 (Ed. Gordon, A.S. ). New York: Appleton-Century-Crofts 1970.Google Scholar
  168. Mcculloch, E.A., Till, J.E.: Cellular interactions in the control of hemopoiesis. 15–25. In Hemopoietic Cellular Proliferation (Ed. F. Stohlman). New York: Grune and Stratton 1970.Google Scholar
  169. Mccuskey, R.S., Meineke, H.A., Townsend, S.F.: Studies of the hemopoietic microenvironment. I. Changes in the microvascular system and stroma during erythropoietic regeneration and suppression in the spleens of CF 1 mice. Blood 39, 697–712 (1972).Google Scholar
  170. Mcgregor, D.D., Gowans, J.L.: The antibody response of rats depleted of lymphocytes by chronic drainage from the thoracic duct. J. exp. Med. 117, 303–320 (1963).PubMedCrossRefGoogle Scholar
  171. Mcmillan, R., Scott, J.L.: Leukocyte labeling with Chromium 51. I. Technique and results in normal subjects. Blood 32, 738–754 (1968).PubMedGoogle Scholar
  172. Mcmillan, R., Scott, J.L., Marino, J.V.: The in vivo survival of leukocytes labeled in vitro with radioactive chromate. Blood 28, 1009 (1966).Google Scholar
  173. Metcalf, D.: The Thymus. Recent Results in Cancer Research 5, 20. Berlin-Heidelberg-New York: Springer 1966.Google Scholar
  174. Metcalf, D.: Effect of thymidine suiciding on colony formation in vitro by mouse hematopoietic cells. Proc. Soc. exp. Biol. (N.Y.) 139, 511–514 (1972).Google Scholar
  175. Metcalf, D., Bradley, T.R., Robinson, W.: Analysis of colonies developing in vitro from mouse bone marrow cells stimulated by kidney feeder layers of leukemic serum. J. cell Physiol. 69, 93–107 (1967).CrossRefGoogle Scholar
  176. Metcalf, D., Chan, S.H., Gunz, F.W., Vincent, P., Ravich, R.B.M.: Colony-stimulating factor and inhibitor levels in acute granulocytic leukemia. Blood 38, 143–152 (1971).PubMedGoogle Scholar
  177. Metcalf, D., Osmond, D.G.: A radioautographic investigation of the identity of phytohaemagglutinin responsive cells in the lymphoid tissues of the rat. Exp. Cell Res. 41, 669–672 (1966).PubMedCrossRefGoogle Scholar
  178. Metcalf, D., Wiadrowski, M.: Autoradiographic analysis of lymphocyte proliferation in the thymus and in thymic lymphoma tissue. Cancer Res. 26, 483–491 (1966).PubMedGoogle Scholar
  179. Metchnikoff, E.: Sur la lutte descellules de l’organism contre l’invasion des microbes. Ann. Inst. Pasteur 1, 321–336 (1887).Google Scholar
  180. Meuwissen, H.J., Van Alten, P.A., Good, R.A.: Proceedings of the Third Annual Leucocyte Culture Conference (Ed. W.O. RIEKE), p. 227–236. New York: Appleton-Century-Crofts 1969.Google Scholar
  181. Micklem, H.S., Clarke, C.M., Evans, E.P., Ford, C.E.: Fate of chromosome-marked monse bone marrow cells transfused into normal syngeneic recipients. Transplantation 6, 299–302 (1968).PubMedCrossRefGoogle Scholar
  182. Miller, J.F.A.P., Mitchell, G.F.: Thymus and antigen-reactive cells. Transplant. Rev. 1, 3–42 (1969).PubMedGoogle Scholar
  183. Miller, J.F.A.P., Osoba, D.: Current concepts of the immunological function of the thymus. Physiol. Rev. 47, 437–520 (1967).PubMedGoogle Scholar
  184. Miller, J.F.A.P, Sprent, J.: Thymus-derived cells in mouse thoracic duct lymph. Nature, New Biol. 230, 267–270 (1971).CrossRefGoogle Scholar
  185. Moffatt, D.J., Rosse, C., Yoffey, J.M.: Identity of the haemopoietic stem cell. Lancet 1967I1 547–548.Google Scholar
  186. Morley, A.: The oscillatory nature of hemopoiesis. In Hemo- poietic Cellular Proliferation (Ed. F. STOHLMAN, Jr.), p. 3–15. New York: Grune and Stratton 1970.Google Scholar
  187. Nossal, G.J.V.: Studies on the rate of seeding of lymphocytes from the intact guinea pig thymus. Ann. N.X. Acad. Sci. 120, 171–181 (1964).CrossRefGoogle Scholar
  188. Nowell, P.C., Wilson, D.: Studies on the life history of lymphocytes. Jexp. Med. 133, 1131–1148 (1971).Google Scholar
  189. Odartchenko, N., Bond, V.P., Feinendegen, L.E., Cottier, H.: Kinetics of erythrocytic precursor proliferation in the dog. Cell Proliferation (Ed. L.F. LAMERTON), p. 172–187. London: Blackwell 1963.Google Scholar
  190. Odartchenko, N., Lewerenz, M., Sordat, B., Roos, B., Cottier, H.: Germinal Centers in Immune Responses (Eds. H. Cottier, N. Odartchenko, R. Schindler, C.C. Congdon), p. 212–217. New York: Springer 1967.Google Scholar
  191. Olson, I.A., Yoffey, J.M.: In the Lymphocyte in Immunology and Haemopoiesis (Ed. J.M. YOFFEY), p. 358–361. London: Edward Arnold 1966.Google Scholar
  192. Oort, J., Turk, J.L.: A histological and autoradiographic study of lymph nodes during the development of contact sensitivity in the guinea-pig. Brit. J. exp. Path. 46, 147–154 (1965).PubMedGoogle Scholar
  193. Osgood, E.E.: Number and distribution of human hernie cells. Blood 9, 1141–1154 (1954).PubMedGoogle Scholar
  194. Osgood, E.E., LI, J.G., Tivey, H., Duerst, M.L., Seaman, A.J.: Growth of human leukemic leukocytes in vitro and in vivo as measured by uptake of P32 desoxyribose nucleic acid. Science 114, 95–99 (1951).PubMedCrossRefGoogle Scholar
  195. Osmond, D.G.: The origin of peritoneal macrophages from the bone marrow. Anat. Rec. 154, 397 (1966).Google Scholar
  196. Osmond, D.G.: The Lymphocyte in Immunology and Haemopoiesis (Ed. J.M. YOFFEY), p. 120–130. London: Edward Arnold 1967a.Google Scholar
  197. Osmond, D.G.: The separation of lymphocytes from bone marrow by centrifugation in a density gradient. Anat. Rec. 157 295 (1967 b).Google Scholar
  198. Osmond, D.G.: Separation of lymphocytes from bone marrow by centrifugation in density gradients and by filtration trough glass bead columns. Exp. He-mat. 14, 37–38 (1967c).Google Scholar
  199. Osmond, G.: The Origins, Life spans and circulation of Lymphocytes. Sixth Leucocyte Culture Conference (Ed. O.R. MCINTYRE), p. 3–36. New York: Appleton-Century-Crafts 1973.Google Scholar
  200. Osmond, D.G., Everett, N.B.: Nucleophageocytosis in bone marrow. Nature 196, 488–489 (1962).PubMedCrossRefGoogle Scholar
  201. Osmond, D.G., Everett, N.B.: Radioautographic studies of bone marrow lymphocytes in vivo and in diffusion chamber cultures. Blood 23, 1 17 (1964).Google Scholar
  202. Osmond, D.G., Yoshida, Y.: In Proceedings of the Fourth Annual Leucocyte Culture Conference (Ed. O.R. MCINTYRE), p. 97–109. New york: AppletonCentury-Crofts 1971.Google Scholar
  203. Ottesen, J.: On the age of human white cells in peripheral blood. Acta physiol. stand. 32 75–93 (1954).Google Scholar
  204. Otsuka, A.L., Robinson, W.A.: The effect of Concanavalin A on bone marrow colony formation in vitro. Proc. Soc. exp. Biol. (N.Y.) 140, 1441–1446 (1972).Google Scholar
  205. Paran, M., Ichikawa, Y., Sachs, L.: Feedback inhibition of the development of macrophage and granulocyte colonies. II. Inhibition by granulocytes. Proc. nat. Acad. Sci. (Wash.) 62, 81–87 (1969).CrossRefGoogle Scholar
  206. Parrott, D.M.V.: The response of draining lymph nodes to immunological stimulation in intact and thymectomized animals. J. clin. Path. 20, 456–465 (1967).Google Scholar
  207. Parrott, D.M.V., De Sousa, M.A.B.: The persistence of donorderived cells in thymus grafts, lymph nodes and spleens of recipient mice. Immunology 13, 193–200 (1967).PubMedGoogle Scholar
  208. Parrott, D.M.V., De Sousa, M.A.B., East, J.: Thymus despendent areas in the lymphoid organs of neonatally thymectomized mice. J. exp. Med. 123, 191–204 (1966).PubMedCrossRefGoogle Scholar
  209. Patt, H.: Leucopoesis in health and desease. N.Y. Sci. 113 (1964).Google Scholar
  210. Patt, H.M., Maldney, M.A.: A model of granulocyte kinetics. Am. N.Y. Sci. 113, 513–522 (1964).Google Scholar
  211. Perillie, P.E., Finch, S.C.: Quantitative studies of the local exudative cellular reaction in acute leukemia. J. clin. Invest. 43, 425–430 (1964).PubMedCrossRefGoogle Scholar
  212. Phelps, P., Mccarty, D.J.: Crystal-induced inflammation in canine joints. II. Importance of polymorphonuclear leukocytes. J. exp. Med. 124, 115–126 (1966).PubMedCrossRefGoogle Scholar
  213. Phelps, P., Mccarty, D.J., Jr.: Suppressive effects of indomethacin on crystal-induced inflammation in canine jounts and on neutrophilic motility in vitro. J. Pharmacol. exp. Ther. 158, 546–553 (1967).Google Scholar
  214. Raff, M.C.: Theta isoantigen as a marker of thymus-derived lymphocytes in mice. Nature 224, 378–379 (1969).PubMedCrossRefGoogle Scholar
  215. Raff, M.C., Owen, J.J.T.: Thymus-derived lymphocytes: their distribution and role in the development of peripheral lymphoid tissues of the mouse. Europ. J. Immunol. 1, 27–30 (1971).CrossRefGoogle Scholar
  216. Raff, M.C., Wortis, H.H.: Thymus dependence of 0-bearing cells in the peripheral lymphoid tissues of mice. Immunology 18, 931–942 (1970).PubMedGoogle Scholar
  217. Ramsell, T.G., Yoffey, J.M.: The bone marrow of the adult male rat. Acta Anat. 47, 55–65 (1961).PubMedCrossRefGoogle Scholar
  218. Reif, A.E., Allen, J.M.: Mouse thymic isoantigens. Nature 209, 521–523 (1966).PubMedCrossRefGoogle Scholar
  219. Reinhardt, W.O.: Some factors influencing the thoracic-duct output of lymphocytes. Ann. N. Y. Acad. Sci. 113, 844–866 (1964).PubMedCrossRefGoogle Scholar
  220. Rickard, K.A., Morley, A., Howard, D., Stohlman, F., Jr.: The in vitro colony forming cell and the response to neutropenia. Blood 37, 6 (1971).PubMedGoogle Scholar
  221. Rickard, K.A., Shadduck, R.K., Morley, A., Stohlman, F., Jr.: In vitro and in vivo colony technique in the study of granulopoiesis. In Hemopoietic cellular Proliferation (Ed. F. STOHLMAN, Jr.). New York: Grune and Stratton 1970.Google Scholar
  222. Rice, F.A.H.: Isolation from Penicillin gilmanii of a substance that causes leukocytosis in rabbits. Proc. Soc. exp. Biol. (N.Y.) 123, 189–192 (1966).Google Scholar
  223. Rice, F.A.H.: Leucocyte response to the injektion of leucogenenol in rabbits and mice. J. infect. Dis. 118, 76–84 (1968).PubMedCrossRefGoogle Scholar
  224. Rice, F.A.H., Connolly, J., Aziz, K., Mccurdy, J.D.: Autoradiographic studies of the action of leucogenenol on leukocytes in the bone marrow, spleen, and peripheral blood of the rat. J. infect. Dis. 123, 117–124 (1971).PubMedCrossRefGoogle Scholar
  225. Rice, F.A.H., Darden, J.H.: The effect of the intravenous injection of leucogenenol on the blood cells of the bone marrow. J. infect. Dis. 118, 289–292 (1968).PubMedCrossRefGoogle Scholar
  226. Rice, F.A.H., Shaikh, B.: Isolation of leucogenenol from bovine and human liver. Biochem. J. 116, 709–711 (1970).PubMedGoogle Scholar
  227. Rieke, W.O.: Lymphocytes from thymectomized rats: immunologic, proliferative, and metabolic properties. Science 152, 535–538 (1966).PubMedCrossRefGoogle Scholar
  228. Rieke, W.O., Schwarz, M.R.: The types of rat thoracic duct lymphocytes which respond to phytohemagglutinin in vitro. Acta Haemat. 38, 121–128 (1967).PubMedCrossRefGoogle Scholar
  229. Rieke, W.O., Schwarz, M.R.: In “The Lymphocyte in Immunology and Haemopoiesis” (Ed. J.M. YOFFEY), p. 224–233. London: Edward Arnold 1967.Google Scholar
  230. Robinson, A.E., Rosse, W.F., Goodrich, J.K.: Intrathoracic extramedullary hematopoiesis: a scan diagnosis. J. nucl. Med. 9, 416419 (1968).Google Scholar
  231. Robinson, S.H., Brecher, G., Lourie, I.S., Haley, J.E.: Leukocyte labeling in rats during and after continuous infusion of tritiated thymidine: implications for lymphocyte longevity and DNA reutilization. Blood 26, 281–295 (1965).PubMedGoogle Scholar
  232. Robinson, W.A., Entringer, M.A., Otsuka, A.L.: In vitro studies in acute granulocytic leukaemia in humans. In “The Nature of Leukemia” (Ed. VINCENT, P.C. ), p. 151–161. New South Wales, Australia: V.C.N. Blight, Government Printer 1972.Google Scholar
  233. ROBINSON, W.A., MANGALIK, A.: Regulation of granulopoiesis: Positive feedback. Lancet 1972VII 742–744.Google Scholar
  234. Robinson, W.A., Pike, B.L.: Leukopoietic activity in human urine. The granulocytic leukemias. New Engl. J. Med. 282, 1291–1297 (1970).Google Scholar
  235. Rosse, C.: Two morphologically and kinetically distinct populations of lymphoid cells in the bone marrow. Nature 227, 73–75 (1970).PubMedCrossRefGoogle Scholar
  236. Rothstein, G., Hugl, E.H., Chervenick, P.A., Athens, J.W., Macfarlane, J.: Humoral stimulators of granulocyte production. Blood 41, 73–78 (1973).PubMedGoogle Scholar
  237. Rubini, J.R., Cronkite, E.P., Bond, V.P., Fliedner, T.M.: Metabolism and fate of tritiated thymidine in man. J. clin. Invest. 39, 909 (1960).PubMedCrossRefGoogle Scholar
  238. Rytömaa, T.: Granulocytic chalone and antichalone. In vitro IV, 47 (1968).Google Scholar
  239. Sabin, F.R., Cunningham, R.S., Doan, C.A., Kind-Wall, J.A.: The normal rhythm of the white blood cells. Bull. Johns Hopk. Hosp. 37, 14–67 (1925).Google Scholar
  240. Sainte-Marie, G., Leblond, C.P.: Tentative pattern for renewal of lymphocytes in cortex of the rat thymus. Proc. Soc. exp. Biol. (N.Y.) 97, 263–269 (1958).PubMedGoogle Scholar
  241. Sainte-Marie, G., Leblond, C.P.: Elaboration of a model for the formation of lymphocytes in the thymic cortex of young adult rats. Blood 26, 765–783 (1965).PubMedGoogle Scholar
  242. Sainte-Marie, G., Peng, F.S.: Emigration of thymocytes from the thymus. A review and study of the problem. Rev. Can. Biol. 30, 51–78 (1971).PubMedGoogle Scholar
  243. Schneeberger, R.: Der Pyriferbelastungstest mit Pyrexal Wander am Knochenmark des Gesunden unter Einwirkung von Cytostatica. Inaugural-Dissertation der Universität Zürich. Zürich: Iweis 1964.Google Scholar
  244. Schooley, J.C., Berman, I.: Morphologic and autoradiographie observations of H3-thymidine-labeled thoracic duct lymphocytes cultured in vivo. Blood 16, 1133–1144 (1960).Google Scholar
  245. Schooley, J.C., Bryant, B.J., Kelley, L.S.: In “The Kinetics of Cellular Proliferation” (Ed. F. Stohlman, Jr.), p. 208. New York: Grune and Stratton 1959.Google Scholar
  246. Schwarz, M.R.: Proceedings of the Sixth Leucocyte Culture Conference. New York: Academic Press 1971.Google Scholar
  247. Shadduk, R.K.: Granulocytes stimulating and inhibiting activity from neutrophils. (Pmn’s): Possible dual feedback control of granulopoiesis. Blood 38, 820 (1971).Google Scholar
  248. Shelley, W.B., Parnes, H.M.: The absolute basophil count. J. Amer. med. Ass. 192, 368–370 (1965).CrossRefGoogle Scholar
  249. Siminovitch, L., Graham, A.F.: Significance of ribonucleic acid turnover studies. J. Histochem. Cytochem. 4, 508–515 (1956).PubMedCrossRefGoogle Scholar
  250. Smith, J.B., Mcintosh, G.H., Morris, B.: The traffic of cells trough tissues; a study of peripheral lymph in sheep. J. Anat. 107, 87–100 (1970).PubMedGoogle Scholar
  251. Sorkin, E., Stecher, V.J., Borel, J.F.: Chemotaxis of leukocytes in inflammation. Ser. Haematol. 3, 131–162 (1970).PubMedGoogle Scholar
  252. Stanley, E.R., Metcalf, D.: The molecular weight of colonystimulating factor (CSF). Proc. Soc. Exp. Biol. Med. 137, 1029–1031 (1971).PubMedGoogle Scholar
  253. Stohlman, F., Jr.: Some aspects of erythrokinetics. Semin. Hemat. 4, 304–314 (1967).PubMedGoogle Scholar
  254. Stryckmans, P.A., Cronkite, E.P., Fache, J., Fliedner, T.M., Ramos, J.: DNA synthesis time of erythropoietic and granulopoietic cells in human beings. Nature (London) 211, 717–720 (1966).CrossRefGoogle Scholar
  255. Taplin, G.V., Johnson, D.E., Dorf, E.K., Kaplan, H.S.: Suspensions of radioalbumin aggregates for photoscanning the liver, lung and other organs. J. nucl. Med. 5, 259–275 (1964).PubMedGoogle Scholar
  256. Turk, J.L.: Cytology of the induction of hypersensitivity. Brit. med. Bull. 23, 3–8 (1967).Google Scholar
  257. Tyler, R.W., Everett, N.B.: Radioautographic study of hemopoietic repopulation using irradiated para-biotic rats- —relation to stem cell problem. Blood 28, 873–890 (1966).Google Scholar
  258. Tyler, R.W., Ginsburg, H., Everett, N.B.: Proceedings of the Third Annual Leucocyte Culture Conference (Ed. W.O. RIEKE),p. 461–464. New York: Appleton-Century-Crofts 1969.Google Scholar
  259. Valeriote, F.A., Bruce, W.R., Meeker, B.E.: Comparison of the sensitivity of normal hematopoietic transplanted lymphoma colony forming cells of mice to vinblastine administered in vivo. J. nat. Cancer Inst. 36, 21–27 (1966).PubMedGoogle Scholar
  260. Anger, H.O.: Differences in distribution of erythropoietic an reticuloendothelial marrow in hematologic disease. Blood 30, 364–374 (1967).PubMedGoogle Scholar
  261. Vejlens, G.: The distribution of leukocytes in the vascular system. Acta path. microbiol. scand. Suppl. 33 (1938).Google Scholar
  262. Vogel, J. M., Yankee, R.A., Kimball, H.R., Wolff, S.M., Perry, S.: The effect of etiocholanolone on granulocyte kinetics. Blood 30, 474–484 (1967).PubMedGoogle Scholar
  263. Walker, R.I. Herion, J.C., Glasser, R.M., Palmer, J.G.: Eosinophil kinetics. Blood 34 845 (1969). WEISSMAN, I.L.: Thymus cell migration. J. exp. Med. 126, 291–304 (1967).Google Scholar
  264. Webster, M.E., Ratnoff, O.D.: Role of Hageman factor in the activation of vasodilator activity in human plasma. Nature 192, 180 (1961).PubMedCrossRefGoogle Scholar
  265. Wintrobe, M.M.: Clinical Hematology. Philadelphia: Lea and Febiger 1956.Google Scholar
  266. Wolf, N.S., Trentin, J.J.: Hemopoietic colony studies. V. Effect of hemopoietic organ stroma on differentiation of pluripotent stem cell. J. exp. Med. 127, 205–214 (1968).Google Scholar
  267. Yoffey, J.M.: Bone Marrow Reactions. London: Edward Arnold 1966.Google Scholar
  268. Yoffey, J.M., Courtice, F.C.: Lymphatics, Lymph and the Lymphomyeloid Complex. London: Academic Press 1970.Google Scholar
  269. Yoffey, J.M., Drinker, C.K.: The cell content of peripheral lymph and its bearing on the problem of the circulation of the lymphocyte. Anat. Rec. 73, 417–427 (1939).CrossRefGoogle Scholar
  270. Yoffey, J.M., Hudson, G., Osmond, D.G.: The lymphocyte in guinea-pig bone marrow. J. Anat. 99, 841–860 (1965).PubMedGoogle Scholar
  271. Yoffey, J.M., Reinhardt, W.O., Everett, N.B.: The uptake of tritium-labeled thymidine by lymphoid tissue. J. Anat. 95, 293–299 (1961).PubMedGoogle Scholar
  272. Yoffey, J.M., Thomas, D.B., Moffatt, D.J., Sutherland, I.H., Rosse, C.: In CIBA Foundation Study Group No. 10 (Eds. G.E.W. WOLSTENHOLME, M. O’CoNNoR), p. 45–54. Boston: Little, Brown 1961.Google Scholar
  273. Yoshida, Y., Osmond, D.G.: Identity and proliferation of small lymphocyte precursors in cultures of lymphocyte-rich fractions of guinea pig bone marrow. Blood 37, 73–86 (1971).PubMedGoogle Scholar
  274. Zucker-Franklin, D.: Electron microscopic studies of human granulocytes: Structural variations related to function. Semin. Hemat. 5, 109–133 (1968).PubMedGoogle Scholar

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© Springer-Verlag Berlin · Heidelberg 1978

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  • F. Ritzl

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