Das erythrozytäre System

  • R. Montz
Part of the Handbuch der Medizinischen Radiologie / Encyclopedia of Medical Radiology book series (HDBRADIOL, volume 15 / 2)


Zur Bestimmung der verschiedenen Blutvolumina bietet sich die Verdünnungsanalyse an, weil das Blut für jede intravenös applizierte Substanz der erste Verteilungsraum ist. Es eignen sich Substanzen, die den Blutraum nicht oder zumindest sehr langsam verlassen, und die im Blut spezifisch gemessen werden können. Diese Bedingungen erfüllen radioaktiv markierte Proteine (z.B. 125J-Humanserum-Albumin=125J-HSA) und Erythrozyten (z.B. 32P-, 51Cr- oder 99Tcm-Erythrozyten).


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  1. Aggeler, P.M., Pollycove, M., Hoag, S., Donald, W.G., Lawrence, J.H.: Polycythemia vera in childhood. Studies of iron kinetics with 59Fe and blood clotting factors. Blood 16, 345–350 (1961).Google Scholar
  2. Alavi, A., Bond, J.P., Kuhl, D.E., Creech, R.H.: Scan detection of bone marrow infarcts in sickle cell disorders. J. nucl. Med. 15, 1003–1007 (1974).PubMedGoogle Scholar
  3. Albert, S.N., Hirsch, E.F., Economopoulos, B., Albert, C.A.: Triple-tracer technique for measuring red-blood-cell, plasma and extracellularfluid vol- ume. J. nucl. Med. 9, 19–23 (1968).PubMedGoogle Scholar
  4. Alfrey, C.P., Lynch, E.C., Hettig, R.A.: Studies of iron kinetics using a linear scanner. I. Distribution of sites of uptake of plasma iron in hematological disorders. J. Lab. clin. Med. 73, 405–417 (1969).Google Scholar
  5. Anger, H.O., Van Dyke, D.: Human bone marrow distribution shown in vivo by iron-52 and the positron scintillation camera. Science 144, 1587–1589 (1964).PubMedCrossRefGoogle Scholar
  6. Arthur, K.: Radioactive phosphorus in the treatment of polycythaemia. A review of ten years’ experience. Clin. Radiol. 18, 287–291 (1967).PubMedCrossRefGoogle Scholar
  7. Ashby, W.: The span of life of the red blood cell. A résumé. Blood 3, 486 (1948).PubMedGoogle Scholar
  8. Askanazy, M.: In Henke, F., Lubarsch, O.: Handbuch der Speziellen Pathologischen Anatomie und Histologie. Bd. I, Teil 2. Berlin: Springer 1927.Google Scholar
  9. Barabas, A.P., Offen, D.N., Meinhard, E.A.: The arterial complications of polycythaemia vera. Brit. J. Surg. 60, 183–187 (1973).PubMedCrossRefGoogle Scholar
  10. Bardy, A., Fouyé, H., Gobin, R., Beydon, J., De Tovar, G., Panneciere, C., Hégésippe, M.: Technetium-99m labeling by means of stannous pyrophosphate: application to bleomycin and red blood cells. J. nucl. Med. 16, 435–437 (1975).PubMedGoogle Scholar
  11. Barrett, P.V.D., Cline, M.J., Berlin, N.I.: The association of the urobilin “Early Peak” and erythropoiesis in man. J. clin. Invest. 45, 1657 (1966).PubMedCrossRefGoogle Scholar
  12. Beamish, M.R., Ashley, Jones, P., Trevett, D., Howell Evans, I., Jacobs, A.: Iron metabolism in Hodgkin’s disease. Br. J. Cancer 26, 444–452 (1972).PubMedCrossRefGoogle Scholar
  13. Bearn, A.G., Parker, W.C.: Some observations On transferrin. In: Gross, F.: Iron metabolism, CIBASymposium, p. 60–72. Berlin-Göttingen-Heidelberg: Springer 1964.Google Scholar
  14. Benassi, E., Torretta, A.: Isotopen-Diagnostik und -Therapie von Polyglobulien und Leukämien. Munch. med. Wschr. 110, 765–775 (1968).Google Scholar
  15. Bender-Götze, C., Heinrich, H.C., Gabbe, E.E., Oppitz, K.H., Schäfer, K.H., Schröter, W., Whang, D.H.: Intestinal iron absorption under the influence of available storage iron and erythroblastic hyperplasia. Z. Kinderheilk. 118, 283–301 (1975).PubMedCrossRefGoogle Scholar
  16. Benestad, H.B.: Aplastic anaemia: considerations on the pathogenesis. Acta med. scand. 196, 255–262 (1974).PubMedCrossRefGoogle Scholar
  17. Berlin, N.I., Waldmann, T.A., Weissman, S.M.: Life span of red blood cell. Physiol. Rev. 39, 577 (1959).PubMedGoogle Scholar
  18. Bernadou, A., Clauvel, J.P., Antebi, L., Bilski-Pas Quier, G.: La maladie de Vaquez. Etude clinique et évolutive. A propos de 144 observations. Sem. Hôp. Paris 44/III, 2101–2112 (1968).Google Scholar
  19. Bessis, M.C., Breton-Gorius, J.: Iron metabolism in the bone marrow as seen by electron microscopy: A critical review. Blood 19, 635–663 (1962).PubMedGoogle Scholar
  20. Björn-Rasmussen, E., Hallberg, L., Isaksson, B., Arvidsson, B.: Food iron absorption in man. Applications of the two-pool extrinsic tag method to measure heure and nonheme iron absorption from the whole diet. J. clin. Invest. 53, 247–255 (1974).PubMedCrossRefGoogle Scholar
  21. Boender, C.A., Verloop, M.C.: Iron absorption, iron loss and iron retention in man: Studies after oral administration of a tracer dose of 59FeSO4 and I3 i BaSO4. Brit. J. Haemat. 17, 45–58 (1969).PubMedCrossRefGoogle Scholar
  22. Bonnet, J.D., Hagedorn, A.B., Owen, C., JR.: A quantitative method for measuring the gastrointes- tinal absorption of iron. Blood 15, 36–44 (1960).PubMedGoogle Scholar
  23. Bothwell, T.H.: Iron overload in the Bantu. In: Gross, F.: Iron metabolism. CIBA-Symposium, p. 362–375. Berlin-Göttingen-Heidelberg: Springer 1964.Google Scholar
  24. Bothwell, T.H., Hurtado, A.V., Donohue, D.M., Finch, C.A.: Erythrokinetics. IV. The plasma iron turnover as a measure of erythropoiesis. Blood 12, 409 (1957).PubMedGoogle Scholar
  25. Bothwell, T.H., Pirzio-Biroli, G., Finch, C.A.: Iron absorption, I. Factors influencing absorption. J. Lab. clin. Med. 51, 24–36 (1958).Google Scholar
  26. Bouroncle, B.A., Doan, C.A.: Myelofibrosis; clinical, hematologic and pathologic study of 110 patients. Amer. J. med. Sci. 243, 697–715 (1962).PubMedCrossRefGoogle Scholar
  27. Bozzini, C.E., Alippi, R.M., Montangero, V.: The importance of the blood flow to bone in the conversion of fatty to hemoglobin synthesizing marrow. Acta physiol. lat.-amer. 24, 14–18 (1974).PubMedGoogle Scholar
  28. Brise, H., Hallberg, L.: Iron absorption studies. II. A method for comparative studies on iron absorption in man using 2 radioiron isotopes. Acta med. scand. Suppl. 376, 171 (1962).Google Scholar
  29. Brouillard, R.P., Conrad, M.E., Bensinger, TH. A.: Effect of blood in the gut on measurements of endogenous carbon monoxide production. Blood 45, 67–69 (1975).PubMedGoogle Scholar
  30. Brunner, H.E.: Die Osteomyelofibrose. Acta haemat. 34, 257–276 (1965a).PubMedCrossRefGoogle Scholar
  31. Brunner, H.E.: Die Differentialdiagnose hämatologischer Erkrankungen mit Isotopenmethoden. Schweiz. med. Wschr. 95, 285–296 (1965b).Google Scholar
  32. Brunner, H.E.: Idiopathische Hämochromatose und Lebercirrhose mit Siderose. Differentialdiagnose durch Untersuchung der Ferro-und Erythrozytenkinetik mit radioaktivem Eisen (Fe-59) und Chrom (Cr-51). Klin. Wschr. 44, 1235–1243 (1966).PubMedCrossRefGoogle Scholar
  33. Burkhardt, R., Pabst, W., Kleber, A.: Knochenmark-Histologie und Klinik der Polycythaemia vera. Arch. klin. Med. 216, 64–104 (1969).Google Scholar
  34. Campbell, A., Emery, E.W., Godley, J.N., Prankerd, T.A.J.: Diagnosis and treatment of primary polycythaemia. Lancet 1970, 1074–1077.Google Scholar
  35. Chaudhuri, T.K., Ehrhardt, J.C., De Gowin, R.L., Christie, J.H.: 59Fe Whole-body scanning. J. nucl. Med. 15, 667–673 (1974).Google Scholar
  36. Christensen, B.E.: Erythrocyte pooling and sequestration in enlarged spleens. Scand. J. Haemat. 10, 106–119 (1973).PubMedCrossRefGoogle Scholar
  37. Cook, J.D.: Methods to determine plasma iron and total iron-binding capacity. In: Hallberg, L., Harwerth, H.G., Vanotti, A.: Iron deficiency, p. 397–407. New York: Academic Press 1970.Google Scholar
  38. Cook, J.D., Layrisse, M., Finch, C.A.: The measurement of iron absorption. Blood 33, 421–429 (1969).PubMedGoogle Scholar
  39. Cook, J.D., Layrisse, M., Martinez-Torres, C., Walker, R., Monsen, E., Finch, C.A.: Food iron absorption measured by an extrinsic tag. J. clin. Invest. 51, 805–815 (1972).PubMedCrossRefGoogle Scholar
  40. Cook, J.D., Lipschitz, D.A., Miles, L.E.M., Finch, C.A.: Serum ferritin as a measure of iron stores in normal subjects. Amer. J. clin. Nutr. 27, 681–687 (1974).PubMedGoogle Scholar
  41. Cook, J.D., Marsaglia, G., Eschbach, J.W., Funk, D.D., Finch, C.A.: Ferrokinetics: A biologic model for plasma iron exchange in man. J. clin. Invest. 49, 197 (1970).PubMedCrossRefGoogle Scholar
  42. Cook, J.D., Monsen, E.R.: Food iron absorption in human subjects. III. Comparison of the effect of animal proteins on nonheme iron absorption. Am. J. Clin. Nutr. 29, 859–867 (1976).PubMedGoogle Scholar
  43. Custer, R.P.: Studies on the structure and function of bone marrow. I. Variability of the hemopoietic pattern and consideration of method for examination. J. Lab. clin. Med. 17, 951–960 (1932).Google Scholar
  44. Custer, R.P., Ahlfeldt, F.E.: Studies on the structure and function of bone marrow. II. Variations in cellularity in various bones with advancing years of life and their relative response to stimuli. J. Lab. clin. Med. 17, 960–962 (1932).Google Scholar
  45. Dagg, J.H., Horton, P.W., Orr, J.S., Shimmins, J.: A direct method of determining red cell lifespan using radioiron: an application of the occupancy principle. Brit. J. Haemat. 22, 9 (1972).PubMedCrossRefGoogle Scholar
  46. Dahlem Workshop on Myelofibrosis-Osteosclerosis Syndrome. Berlin, 1974. Advances in the biosciences Vol. 16. New York: Pergamon Press; Braunschweig: Vieweg 1975.Google Scholar
  47. Dameshek, W.: Some speculations on the myeloproliferative syndromes. Blood 6, 372–375 (1951).PubMedGoogle Scholar
  48. De Gowin, R.L., Chaudhuri, T.K., Christie, J.H., Callis, M.N., Mueller, A.L.: Marrow scanning in evaluation of hemopoiesis after radiotherapy. Arch. intern. Med. 134, 297–303 (1974).Google Scholar
  49. Dewanjee, M.K.: Binding of 99mTc ion to hemoglobin. J. nucl. Med. 15, 703–706 (1974).PubMedGoogle Scholar
  50. Documenta Geigy: Wissenschaftliche Tabellen. 7. Auflage, 1968, J.R. Geigy S.A., Basel.Google Scholar
  51. Dormer, P., Lau, B.: Erythropoese bei Eisenmangel. Blut 34, 453–464 (1977).PubMedCrossRefGoogle Scholar
  52. Doering, P., Lorenz, B.: Zur Diagnostik der Osteomyeloretikulose bei Polyzythämie mit Radioeisen. Folia haemat. N.F. 8, 346–359 (1963).Google Scholar
  53. Donaldson, G.W.K., Mcarthur, M., Macpherson, A.I.S., Richmond, J.: Blood volume changes in splenomegaly. Brit. J. Haemat. 18, 45–55 (1970).PubMedCrossRefGoogle Scholar
  54. Donohue, D.M., Gabrio, B.W., Finch, C.A.: Quantitative measurement of hematopoietic cells of the marrow. J. clin. Invest. 37, 1564–1570 (1958).PubMedCrossRefGoogle Scholar
  55. Dubach, R., Callender, S.T.E., Moore, C.V.: Studies in iron transportation and metabolism. VI. Absorption of radioactive iron in patients with fever and with anemias of varied etiology. Blood 3, 526–540 (1948).PubMedGoogle Scholar
  56. Eakins, J.D., Brown, D.A.: An improved method for the simultaneous determination of iron-55 and iron-59 in blood by liquid scintillation counting. Int. J. appl. Radiat. 17, 391–397 (1966).PubMedCrossRefGoogle Scholar
  57. Edwards, C.L., Andrews, G.A., Sitterson, B.W., Kniseley, R.M.: Clinical bone marrow scanning with radioisotopes. Blood 23, 741–756 (1964).PubMedGoogle Scholar
  58. Elmlinger, P.J., Huff, R.L., Tobias, C.A., Lawrence, J.H.: Iron turnover abnormalities in patients having anemia: serial blood and in vivo tissue studies with 59Fe. Acta haemat. 9, 73–96 (1953).PubMedCrossRefGoogle Scholar
  59. Fawwaz, R.A., Winchell, H.S., Pollycove, M., Sargent, T.: Hepatic iron deposition in humans. I. First-pass hepatic deposition of intestinally absorbed iron in patients with low plasma latent iron-binding capacity. Blood 30, 417–424 (1967).PubMedGoogle Scholar
  60. Fawwaz, R.A., Winchell, H.S., Pollycove, M., Sargent, T., Anger, H., Lawrence, J.H.: Intestinal iron absorption studies using iron-52 and Anger positron camera. J. nucl. Med. 7, 569–574 (1966).PubMedGoogle Scholar
  61. Ferrant, A., Lewis, S.M., Szur, L.: The elution of 99Tcm from red cells and its effect on red cell vol- ume measurement. J. clin. Path. 27, 983–985 (1974).PubMedCrossRefGoogle Scholar
  62. Fillet, G., Cook, J.D., Finch, C.A.: Storage iron kinetics VII. A biologic model for reticuloendothelial iron transport. J. clin. Invest. 53, 1527–1533 (1974).PubMedCrossRefGoogle Scholar
  63. Finch, C.A.: Body iron exchange in man. J. clin. Invest. 38, 392–396 (1959).PubMedCrossRefGoogle Scholar
  64. Finch, C.A., Deubelbeiss, K., Cook, J.D., Eschbach, J.W., Harker, L.A., Funck, D.D., Marsaglia, G., Hillman, R.S., Slichter, S., Adamson, J.W., Ganzoni, A., Giblett, E.R.: Ferrokinetics in man. Medicine (Baltimore) 49, 17 (1970).Google Scholar
  65. Fintelmann, V.: Zur Diagnostik des Eisenmangels. Med. heute 17, 296–298 (1968).Google Scholar
  66. Fischer, J.: Hyperspienismus. Was er ist, was er nicht ist. Internist 12, 176–186 (1971).PubMedGoogle Scholar
  67. Fischer, J., Gamm, H., Brod, K.H., Wolf, R., Dennhardt, H., Roux, A.: Knochenmarkszintigraphie mit 99mTc-markiertem Rhenium-Schwefelkolloid. In: Pabst, H.W.: Nuklearmedizin. Radionuklide in der Hämatologie. Gegenwärtiger Stand der Therapie mit Radionukliden, S. 25–28. Stuttgart-New York: F.K. Schattauer 1973.Google Scholar
  68. Fischer, J., Wolf, R.: Funktionsdiagnostik mit Radioisotopen in der Hämatologie. Internist 10, 351–359 (1969).PubMedGoogle Scholar
  69. Fisher, J.W., Thompson, J.F., Espada, J.: A radioimmunoassay for human urinary erythropoietin. Israel J. med. Sci. 7, 873–876 (1971).Google Scholar
  70. Fitting, W.: Histologische Untersuchung über die Bedeutung des roten Knochenmarks. Frankfurt. Z. Path. 62, 345–370 (1951).PubMedGoogle Scholar
  71. Forth, W., Rummel, W.: Iron absorption. Physiol. Rev. 53, 724–792 (1973).PubMedGoogle Scholar
  72. Frischaue, H., Honetz, N., Keibl, E.: Weiter Untersuchungen zur Frage der Erythrokinetik bei Blutkrankheiten. Wien. klin. Wschr. 78, 777–783 (1966).Google Scholar
  73. Funk, D.D.: Plasma iron turnover in normal subjects. J. nucl. Med. 11, 107–111 (1970).PubMedGoogle Scholar
  74. Gamm, H., Fischer, J., Wolf, R.: Ergebnisse der Knochenmarkszintigraphie mit 99mTc-Schwefelkolloid und II IIn-Chlorid. In: Pabst, H.W.: Nuklearmedizin. Ergebnisse in Technik, Klinik und Therapie, S. 367–369. Stuttgart-New York: F.K. Schattauer 1974.Google Scholar
  75. Ganzoni, A.M.: Kinetik und Regulation der Erythrozytenproduktion. Experimentelle Untersuchungen an der normalen und anämischen Ratte. Experimentelle Medizin, Pathologie und Klinik, Band 31. Berlin-Heidelberg-New York: Springer 1970.Google Scholar
  76. Gehrmann, G.: Hämolyse und hämolytische Anämien. Stuttgart: Thieme 1969.Google Scholar
  77. Gelinsky, P., Müller, D.: Die Anämie bei Osteomyelosklerose. Vergleich zwischen hämatologischen und erythrokinetischen Untersuchungen. Klin. Wschr. 50, 21–32 (1972).PubMedCrossRefGoogle Scholar
  78. Gemsa, D., Schmid, R.: Hämoglobinstoffwechsel und Bilirubinbildung. Klin. Wschr. 52, 609–616 (1974).PubMedCrossRefGoogle Scholar
  79. Gevirtz, N.R., Wasserman, L.R., Sharney, L., Tendler, D.: Studies of plasma 59Fe disappearance-a manifestation of ineffective erythropoiesis and of hemolysis. Blood 25, 976–989 (1965).PubMedGoogle Scholar
  80. Giblett, E.R., Coleman, D.H., Pirzio-Biroli, G., Donohue, D.M., Motulsky, A.G., Finch, C.A.: Erythrokinetics: quantitative measurements of red cell production and destruction in normal subjects and patients with anemia. Blood 11, 291 (1956).PubMedGoogle Scholar
  81. Giebel, O.: Zur Problematik der Blutvolumenbestim- mung mit Hilfe von Radioisotopen. Anaesthesist 15, 173–175 (1966).PubMedGoogle Scholar
  82. Gilbert, H.S.: Definition, clinical features and diagnosis of polycythemia vera. In: Videbaek, A.: Polycythemia and myelofibrosis. Clinics in haematology 4 No. 2, p. 263–290. London-Philadelphia-Toronto: Saunders 1975.Google Scholar
  83. Glaubitt, D.M.H., Schlüter, I.H., Haberland, K.U.R.: Bone marrow imaging using 1111 In-citrate: 111In-Kinetics in the pelvic region. J. nucl. Med. 16, 769–774 (1975).PubMedGoogle Scholar
  84. Goldberg, A., Hutchinson, H.E., Macdonald, E.: Radiochromium in the selection of patients with haemolytic anaemia for splenectomy. Lancet 1966/ I, 109.Google Scholar
  85. Goldberg, A., Seaton, D.A.: The diagnosis and management of myelofibrosis, myelosclerosis and chronic myeloid leukaemia. Clin. Radiol. 11, 266–270 (1960).PubMedCrossRefGoogle Scholar
  86. Golde, D.W.. Bersch, N., Cline, M.J.: Polycythemia vera: Hormonal modulation of erythropoietis in vitro. Blood 49, 399–405 (1977).PubMedGoogle Scholar
  87. Goldeck, H., Groth, H., Horst, W.: Strahlentherapie mit Radiophosphor bei Polycythaemia rubra vera. Klin. Wschr. 30, 28–30 (1952).PubMedCrossRefGoogle Scholar
  88. Goldwasser, E., Eliason, J.F., Sikkema, D.: An assay for erythropoietin in vitro at the milliunit level. Endocrinology 97, 315–323 (1975).PubMedCrossRefGoogle Scholar
  89. Gralnick, H.R., Harbor, J., Vogel, C.: Myelofibrosis in chronic granulocytic leukemia. Blood 37, 152–162 (1971).PubMedGoogle Scholar
  90. Gray, S.J., Sterling, K.: The tagging of red cells and plasma proteins with radioactive chromium. J. clin. Invest. 29, 1604–1613 (1950).PubMedCrossRefGoogle Scholar
  91. Green, R., Charlton, R., Seftel, H., Bothwell, T., Mayet, F., Adams, B., Finch, C., Layrisse, M.: Body iron excretion in man. Amer. J. Med. 45, 336–353 (1968).PubMedCrossRefGoogle Scholar
  92. Hahn, D., Baviera, B., Ganzoni, A.M.: Functional heterogeneity of the iron transport compartment. I. In vivo radioiron clearance from high and low saturated transferrin. Acta haemat. 53, 285–291 (1975).Google Scholar
  93. Hahn, L., Hevesy, G.: A method of blood volume determination. Acta physiol. scand. 1, 3–10 (1940).Google Scholar
  94. Hahn, P.F., Bale, W.F., Ross, J.F., Balfour, W.M., Whipple, G.H.: Radioactive iron absorption by gastro-intestinal tract. J. exp. Med. 78, 169–188 (1943).PubMedCrossRefGoogle Scholar
  95. Hallberg, L., Sölvell, L.: Succinic acid as absorption promotor in iron tablets. Acta med. scand. Suppl. 459, 23–35 (1966).Google Scholar
  96. Hallberg, L., Sölvell, L.: Absorption of hemoglobin iron in man. Acta med. scand. 181, 335–354 (1967).PubMedCrossRefGoogle Scholar
  97. Halnan, K.E., Russell, M.H.: Polycythaemia vera. Comparison of survival and causes of death in patients managed with and without radiotherapy. Lancet 1965, 760–763.Google Scholar
  98. Hardewig, A.: Die Erythrozytenvolumenbestimmung im Blute mit Hilfe von radioaktivem Phosphor (32P). — Eine Literaturübersicht. Atomkernenergie 5, 340–343 (1960).Google Scholar
  99. Harman, J.B., Ledlie, E.M.: Survival of polycythaemia vera patients treated with radioactive phosphorus. Brit. med. J. 2, 146–148 (1967).PubMedCrossRefGoogle Scholar
  100. Haurani, F.I., Tocantins, L.M.: Ineffective erythropoiesis. Amer. J. Med. 31, 519–531 (1961).PubMedCrossRefGoogle Scholar
  101. Hausmann, K., Kuse, R., Meinecke, K.H., Bartels, H.: Interrelations between diagnostic criteria of the iron status and 50 mg ferrous iron absorption in iron-replete and iron-deficient subjects. Acta Haemat. 49, 129–141 (1973).PubMedCrossRefGoogle Scholar
  102. Heilmeyer, L., Keiderling, W.: Blutkrankheiten. In: Künstliche radioaktive Isotope in Physiologie, Diagnostik und Therapie (Hrsg. H. H. Schwiegk, F. Turba), S. 833–885. Berlin-Göttingen-Heidelberg: Springer 1961.Google Scholar
  103. Heimpel, H.: Hämatologie. In: Emrich, D.: Nuklearmedizin, Funktionsdiagnostik. Stuttgart: Thieme 1971.Google Scholar
  104. Heimpel, H.: Ineffektive Erythropoese — eine Störung der Zellbildung. Dtsch. Ärztebl. 20, 1343–1346 (1973).Google Scholar
  105. Heimpel, H., Adam, W., Wetzel, H.P., Schmolke, M., Graeff, U., Hoffmann, G.: Ergebnisse und diagnostische Bedeutung ferrokinetischer Untersuchungen beim Eisenmangel und bei Infektanämien mit Sideropenie. Nucl. Med. 6, 425–432 (1967).Google Scholar
  106. Heimpel, H., Busch, D., Schubothe, H.: Erythrozytenelimination und Erythrozytenumsatz bei verschiedenen hereditären hämolytischen Anämien. Klin. Wschr. 46, 490–497 (1968).PubMedCrossRefGoogle Scholar
  107. Heimpel, H., Finke, J., Keiderling, W.: Die Bestimmung der Lebenszeit menschlicher Erythrozyten mit radioaktivem Diisopropylfluorophosphat (DF32P) und ihre Anwendung in der Klinik. Dtsch. med. Wschr. 89, 1463 (1964).CrossRefGoogle Scholar
  108. Heinrich, H.C.: Intestinal iron absorption in man—methods of measurement, dose relationship, diagnostic and therapeutic applications. In: Hall-Berg, L., Harwerth, H.G., Vanotti, A.: Iron deficiency, p. 213–296. New York: Academic Press 1970.Google Scholar
  109. Heinrich, H.C., Bender-Götze, CH., Gabbe, E.E., Bartels, H., Opitz, K.H.: Absorption of inorganic iron-(59Fe2+) in relation to iron stores in pancreatic exocrine insufficiency due to cystic fibrosis. Klin. Wschr. 55, 587–593 (1977).PubMedCrossRefGoogle Scholar
  110. Heinrich, H.C., Gabbe, E.E., Bartels, H., Opitz, K.H., Bender-Götze, CH., Pfau, A.A.: Bioavailability of food iron-(59Fe), Vitamin B12-(60Co) and protein bound selenomethionine-(75Se) in pancreatic exocrine insufficiency due to cystic fibrosis. Klin. Wschr. 55, 595–601 (1977).PubMedCrossRefGoogle Scholar
  111. Heinrich, H.C., Gabbe, E.E., Kugler, G., Pfau, A.A.: Nahrungs-Eisenresorption aus Schweine-Fleisch, -Leber und -Hämoglobin bei Menschen mit normalen und erschöpften Eisenreserven. Klin. Wschr. 49, 819–825 (1971a).PubMedCrossRefGoogle Scholar
  112. Heinrich, H.C., Gabbe, E.E., Kugler, G., Whang, D.H., Hausmann, K., Bartels, H., Kuse, R., Meinecke, K.H., Kugler, S., Stelzner, F.: Diagnostischer S9Fe:+-Resorptions-Test und diffus verteiltes Reserveeisen der Knochenmarksmakrophagen bei Magenmucosaatrophie und nach Magen-2/3-Resektion bzw. totaler Gastrektomie. Klin. Wschr. 49, 825–835 (1971b).PubMedCrossRefGoogle Scholar
  113. Heinrich, H.C., Gabbe, E.E., Meineke, B., Whang, D.H.: Biologische Halbwertzeit und Umsatzrate des Eisens im Gesamtkörper des Menschen: ein Beitrag zur Frage des Gesamtkörper-Eisenbedarfs. Klin. Wschr. 44, 904–906 (1966).PubMedCrossRefGoogle Scholar
  114. Heinrich, H.C., Gabbe, E.E., Oppitz, K.H., Whang, D.H., Bender-Götze, C., Schäfer, K.H., Schroter, W., Pfau, A.A.: Absorption of inorganic and food iron in children with heterozygous and homozygous /3-thalassemia. Z. Kinderheilk. 115, 1–22 (1973).PubMedCrossRefGoogle Scholar
  115. Heinrich, H.C., Gabbe, E.E., Whang, D.H.: Physikalische und biologische Halbwertzeit von radiochemisch reinem S9Fe. Z. f. Naturforsch. 26b, 13–20 (1971c).Google Scholar
  116. Hennekeuser, H.H., Fischer, R.: Extramedulläre Blutbildung und leukämoide Reaktion bei bösartigen Tumoren. Dtsch. med. Wschr. 92, 479–482 (1967).CrossRefGoogle Scholar
  117. Hennemann, H.H., Stecher, G.: Die Therapie der Polycythaemia vera. Dtsch. med. Wschr. 92, 1874–1876 (1967).CrossRefGoogle Scholar
  118. Hennig, K., Franke, W.-G., Strietzel, M.: Eigene Erfahrungen mit der Radiophosphorbehandlung bei Polycythaemia vera. Z. ges. inn. Med. 20, 14–20 (1965).Google Scholar
  119. Henry, R.E., Warnecke, M.A., Donati, R.M.: Effect of alterations in erythropoiesis on distribution of 99mTc sulfur colloid in the rat. Life Sciences 15, 1343–1351 (1974).PubMedCrossRefGoogle Scholar
  120. Hillman, R.S.: Characteristics of marrow production and reticulocyte maturation in normal man in response to anemia. J. clin. Invest. 48, 443–453 (1969).PubMedCrossRefGoogle Scholar
  121. Hillman, R.S., Henderson, P.A.: Control of marrow production by the level of iron supply. J. clin. Invest. 48, 454–460 (1969).PubMedCrossRefGoogle Scholar
  122. Hine, G.J., Johnston, R.E.: Absorbed Dose from Ra- dionuclides. J. nucl. Med. 11, 468–469 (1970).PubMedGoogle Scholar
  123. Höglund, S.: Iron absorption in apparently healthy men and women. III. Studies in iron absorption. Acta med. scand. 186, 487–491 (1969a).PubMedCrossRefGoogle Scholar
  124. Höglund, S.: Studies in iron absorption. VI. Transitory effect of oral administration of iron on iron absorption. Blood 34, 505–510 (1969b).PubMedGoogle Scholar
  125. Höglund, S., Ehn, L., Liedfn, G.: Studies in iron absorption. VII. Iron deficiency in young men. Acta haemat. 44, 193–199 (1970).PubMedCrossRefGoogle Scholar
  126. Höglund, S., Reizenstein, P.: Studies in iron absorption. V. Effect of gastrointestinal factors on iron absorption. Blood 34, 496–504 (1969).Google Scholar
  127. Hör, G., Pabst, H.W.: Radiophosphortherapie der Polycythaemia vera. Ther. Umsch. 30, 789–796 (1973).PubMedGoogle Scholar
  128. Horne, Mcd. K., III, Rosse, W.F., Flickinger, E.G., Saltzman, H.A.: “ Early-peak” carbon monoxide production in certain erythropoietic disorders. Blood 45, 365–375 (1975).PubMedGoogle Scholar
  129. Horst, W.: Zur Therapie der Polyzythämie mit künstlichen Radioisotopen. Strahlentherapie 85, 196–198 (1951).PubMedGoogle Scholar
  130. Horst, W., Rösler, H., Villanueva-Meyer, H.: 201 Fälle von Polyzythämie: 32P-Behandlungsergebnisse, Untersuchungen zur Ferrokinetik (51Cr und S9Fe) und über erythropoetische Plasmafaktoren vor, unter und nach Therapie. In: Keiderling, W., Hoffmann, G.: Radio-Isotope in der Hämatologie, S. 361–375. Stuttgart: Schattauer 1963.Google Scholar
  131. Horst, W., Sauer, H.: Die Strahlentherapie der Polyzythämie mit Radiophosphor. Dtsch. med. Wschr. 76, 1237–1240 (1951).CrossRefGoogle Scholar
  132. Horton, P.W., Hutcheon, A.W., Dagg, J.H.: Measurement of red cell lifespan by application of the occupancy principle. In: Dynamic studies with radioisotopes in Medicine 1974, p. 445–454. Wien 1975.Google Scholar
  133. Hosain, F., Marsaglia, G., Finch, C.A.: Blood ferro-kinetics in normal man. J. clin. Invest. 46, 1 (1967).PubMedCrossRefGoogle Scholar
  134. Honing, J., Valkema, A.J., Wilson, J.H.P., Woldring, M.G.: Properties of glycerol-75Se-Triether: a lipid-soluble marker for the estimation of intestinal fat absorption. J. Lab. clin. Med. 86, 286–294 (1975).Google Scholar
  135. Huff, R.L., Hennessy, T.G., Austin, R.E., Garcia, J.F., Roberts, B.M., Lawrence, J.H.: Plasma and red cell iron turnover in normal subjects and in patients having various hematopoietic disorders. J. clin. Invest. 30, 1512 (1951).PubMedCrossRefGoogle Scholar
  136. Huhn, D., Fateh-Moghadam, A., Demmler, K., Kronseder, A., Ehrhart, H.: Hämatologische und immunologische Befunde bei Knochenmark-aplasie. Klin. Wschr. 53, 7–15 (1975).PubMedCrossRefGoogle Scholar
  137. Hurley, P.J.: Red cell and plasma volumes in normal adults. J. nucl. Med. 16, 46–52 (1975).PubMedGoogle Scholar
  138. ICSH-Report: Recommended methods for radioisotope red-cell survival studies. Brit. J. Haemat. 21, 241–250 (1971).CrossRefGoogle Scholar
  139. ICSH: Standard techniques for the measurement of red cell and plasma volume. Brit. J. Haemat. 25, 801 (1973).CrossRefGoogle Scholar
  140. Ikkala, E., Kivilaakso, E., Hästbacka, J.: Splenectomy in blood diseases. A report of 80 cases. Ann. clin. Res. 6, 290–299 (1974).PubMedGoogle Scholar
  141. Jacobs. A., Rhodes, J., Peters, D.K., Campbell, H., Eakins, J.D.: Gastric acidity and iron absorption. Brit. J. Haemat. 12, 728–736 (1966).PubMedCrossRefGoogle Scholar
  142. Jepson, J.H.: Polycythemia: Diagnosis, pathophysiology and therapy. Canad. med. Ass. J. 100, 271–277, 327–334 (1969).Google Scholar
  143. Kaltwasser, J.P., Werner, E., Becker, HJ.: Serumferritin als Kontrollparamter bei oraler Eisenthera- pie. Dtsch. med. Wschr. 102, 1150–1155 (1977).CrossRefGoogle Scholar
  144. Karle, H.: The pathogenesis of the anaemia of chronic disorders and the role of fever in erythrokinetics. Scand. J. Haemat. 13, 81–86 (1974).PubMedCrossRefGoogle Scholar
  145. Keene, W.R., Jandl, J.H.: Studies of the reticuloendothelial mass and sequestering function of rat bone marrow. Blood 26, 157–175 (1965).Google Scholar
  146. Keiderling, W.: Eisenstoffwechsel. In: Künstliche radioaktive Isotope in Physiologie, Diagnostik und Therapie (Hrsg. H. Schwiegk, F. Turba), S. 133–178. Berlin-Göttingen-Heidelberg: Springer 1961.Google Scholar
  147. Kimber, C.L., Weintraub, L.R.: Sekundäre Eisenresorptionsstörung bei Eisenmangel. Fortschr. Med. 87, 818–822 (1969).Google Scholar
  148. Kniseley, R.M.: Marrow studies with radiocolloids. Semin. Nucl. Med. 2, 71–85 (1972).PubMedCrossRefGoogle Scholar
  149. Kniseley, R.M., Andrews, G.A., Tanida, R., Ed-Wards, C.L., Kyker, G.C.: Delineation of active marrow by whole-body scanning with radioactive colloids. J. nucl. Med. 7, 575–582 (1966).PubMedGoogle Scholar
  150. Koblet, H.: Begriffe und Modelle der RadionuklidKinetik. In: Emrich, D.: Nuklearmedizin, Funktionsdiagnostik, S. 54–72. Stuttgart: Thieme 1971.Google Scholar
  151. Korsten, J., Grossman, H., Winchester, P.H., Canale, V.C.: Extramedullary hematopoiesis in patients with thalassemia anemia. Radiology 95, 257–263 (1970).PubMedGoogle Scholar
  152. Kramer, H., Wynne, K.N.: Method for clinical assessment of marrow hyperplasia in long bones. Lancet 1958II, 1045–1055.Google Scholar
  153. Krantz, S.B.: Pure red-cell aplasia. New Engl. J. Med. 291, 345–350 (1974).Google Scholar
  154. Krauss, S., Wasserman, L.R.: Leukemia in patients with polycythemia vera treated with radioisotopes. In: Cloutier, R.J., Edwards, C.L., Snyder, W.S.: Medical radionuclides: Radiation dose and effects, p. 441–452. U.S. Atomic Energy Commission, 1970.Google Scholar
  155. Kuba, J., Cihal, K.: Die Bestimmung des Erythrozytenabbauortes bei hämolytischen Erkrankungen mit Hilfe von Radioisotopen. Folia haemat. 86, 197–208 (1966).Google Scholar
  156. Kuba, J., Wiedermann, M., Wiedermann, B.: Zur Interpretation von Eisenstoffwechseluntersuchungen mit Radioeisen 59Fe. Folia haemat. 82, 58–75 (1964).Google Scholar
  157. Kuni, H., Graul, E.H.: Use of regulation characteristics of erythropoiesis for analysing data on computer-assisted erythrokinetics. In: Dynamic studies with radioisotopes in medicine, p. 507–518. IAEA, Wien 1971.Google Scholar
  158. Kuni, H., Graul, E.H., Hundeshagen, H.: Theoretische und methodische Fortschritte in der nuklearmedizinischen Hämatologie. II. Eisenstoffwechsel und Ferrokinetik. Acta Isotop. 2, 319 (1963).Google Scholar
  159. Kutzim, H., Wellner, U.: Untersuchungen des Eisenstoffwechsels mit einem neuen Modell der Eisenkinetik. In: Ergebnisse der klinischen Nuklearmedizin. Diagnostik, Therapie, Forschung. (Hrsg. W. Horst, H.W. Pabst), S. 516. Stuttgart-New York: F.K. Schattauer 1971.Google Scholar
  160. Kutzim, H., Wellner, U.: Die Bedeutung der Leber im Eisenstoffwechsel. In: Nuklearmedizin. Radionuklide in der Hämatologie, gegenwärtiger Stand der Therapie mit Radionukliden (Hrsg. P.M. Van Vaerenbergh, H.W. Pabst, G. Hör), S. 97. Stuttgart-New York: F.K. Schattauer 1973.Google Scholar
  161. Lajtha, L.G.: Aetiological factors in marrow damage in leukaemia and myelofibrosis. In: Dahlem Workshop, Advances in the biosciences. Vol. 16, p. 145–164. New York: Pergamon Press; Braunschweig: Vieweg 1975.Google Scholar
  162. Landaw, S.A., Callahan, E.W., Jr., Schmid, R.: Catabolism of heme in vivo: Comparison of the simultaneous production of bilirubin and carbon monoxide. J. clin. Invest. 49, 914–925 (1970).PubMedCrossRefGoogle Scholar
  163. Landaw, S.A., Winchell, H.S.: Endogenous production of carbon-14 labeled carbon monoxide: An in vivo technique for the study of heme catabolism. J. nucl. Med. 7, 696–707 (1966).PubMedGoogle Scholar
  164. Larsson, L.-G., Engstedt, L., Franzen, S., Jonsson, L.: Bone marrow scintigrams. An in vivo study of the bone marrow reticulum in malignant bone marrow diseases. Acta Un. int. Caner. 16, 1437–1477 (1960).Google Scholar
  165. Lawrence, J.H.: Polycythemia. Physiology, Diagnosis and Treatment, based on 303 cases. New York-London: Grune and Stratton 1955.Google Scholar
  166. Lawrence, J.H., Winchell, H.S., Donald, W.G.: Leukemia in polycythemia vera. Relationship to splenic myeloid metaplasia and therapeutic radia- tion dose. Ann. intern. Med. 70, 763–771 (1969).PubMedGoogle Scholar
  167. Layrisse, M., Cook, J.D., Martinez, C., Roche, M., Kuhn, IN., Walker, R.B., Finch, C.A.: Food iron absorption: A comparison of vegetable and animal foods. Blood 33, 430–443 (1969).PubMedGoogle Scholar
  168. Leyland, M.J., Ganguli, P.C., Blower, D., Delamore, LW.: Immunoradiometric assay for ferritin in human serum. Scand. J. Haemat. 14, 385–392 (1975).PubMedCrossRefGoogle Scholar
  169. Lindahl, J.: Appearance of “CO in expired air and incorporation of 14C in hemoglobin after administration of glycine-2–14C in man. Scand. J. clin. Lab. Invest. 33, 353–359 (1974).PubMedGoogle Scholar
  170. Lockner, D.: Quantitation of erythropoiesis by a new method. I. Studies in healthy subjects. Scand. J. clin. Lab. Invest. 18, 493 (1966).CrossRefGoogle Scholar
  171. Lockner, D., Skârberg, K.O.: Quantitation of erythropoiesis by a new method. III. The blocking effect of inactive iron on radioiron reutilization. Acta med. scand. 195, 319 (1974).PubMedCrossRefGoogle Scholar
  172. Loeb, V. Jr.: Treatment of polycythemia vera. In: Videbaek, A.: Polycythemia and myelofibrosis. Clinics in haematology 4, No. 2, p. 441–456. London-Phildelphia-Toronto: Saunders 1975.Google Scholar
  173. London, I.M., West, R., Shemin, D., Rittenberg, D.: On the origin of bile pigment in normal man. J. biol. Chem. 184, 351 (1950).PubMedGoogle Scholar
  174. Low-Beer, B.V.A.: The external and internal use of 32P. VII. Internat. Kongr. f. Radiologie, Kopenhagen 1953. In: Graul, E.H., Hess, F.: MünchenBerlin-Wien: Urban and Schwarzenberg 1955.Google Scholar
  175. Lundin, P.M., Ridell, B., Weinfeld, A.: The significance of bone marrow morphology for the diagnosis of polycythaemia vera. Scand. J. Haemat. 9, 271–282 (1972).PubMedCrossRefGoogle Scholar
  176. Martinez-Torres, C., Leets, I., Renzi, M., Layrisse, M.: Iron absorption by humans from veal liver. J. Nutr. 104, 983–993 (1974).PubMedGoogle Scholar
  177. Martinez-Torres, C., Renzi, M., Layrisse, M.: Iron absorption by humans from hemosiderin and ferri- tin, further studies. J. Nutr. 106, 128–135 (1976).PubMedGoogle Scholar
  178. Mcintyre, P.A., Larson, S.M., Eikman, E.A., Col-Man, M., Scheffel, U., Hodkinson, B.A.: Comparison of the metabolism of iron-labelled transferrin (Fe-TF) and indium-labelled Transfer-rin (In-TF) by the erythropoietic marrow. J. nucl. Med. 15, 856–862 (1974).PubMedGoogle Scholar
  179. Mckee, L.C., Jr., Price, R., Johnston, R.E., Heyssel, R.M., Johnson, L.E., Brill, A.B.: Long-term studies of iron metabolism in normal males: comparison of red cell radioactivity with whole-body counter data. J. nucl. Med. 15, 156–160 (1974).PubMedGoogle Scholar
  180. Mcneil, B.J., Holman, B.L., Button, L.N., Rosenthal, D.S.: Use of indium chloride scintigraphy in patients with myelofibrosis. J. nucl. Med. 15, 647–651 (1974).PubMedGoogle Scholar
  181. Merrick, M. V., Gordon-Smith, E.C., Lavender, J.P., Szur, L.: A comparison of I“In with 52Fe and 99mTc-sulfur colloid for bone marrow scanning. J. nucl. Med. 16, 66–68 (1975).PubMedGoogle Scholar
  182. Meuret, G.: Present status of 32P-Therapy in management of polycythemia vera. Klin. Wschr. 53, 555–558 (1975).PubMedCrossRefGoogle Scholar
  183. Meuret, G., Gehring, D., Hoffmann, G.: Zur Erythrokinetik bei myeloproliferativen Syndromen. Radiobiol. Radiother. (Berl.) 14, 61–71 (1973).Google Scholar
  184. Meuret, G., Hoffmann, G.: Pathogenese und Manifestation von Störungen der Erythro-und Granulopoese bei myeloproliferativen Syndromen. Klin. Wschr. 50, 853–861 (1972).PubMedCrossRefGoogle Scholar
  185. Meuret, G., Hoffmann, G., Gmelin, R.: Erfahrungen mit der Radiophosphor-Therapie bei Polycythaemia vera. Strahlentherapie 149, 49–54 (1975).PubMedGoogle Scholar
  186. Milner, G.R., Geary, C.G., Wadsworth, L.D., Doss, A.: Erythrokinetic studies as a guide to the value of splenectomy in primary myeloid metaplasia. Brit. J. Haemat. 25, 467–484 (1973).PubMedCrossRefGoogle Scholar
  187. Modan, B.: Inter-Relationship between poycythemia vera, leukemia and myeloid metaplasia. In: Videbaek, A.: Polycythemia and myelofibrosis. Clinics in haematology 4 No. 2, p. 427–440. London-Philadelphia-Toronto: Saunders 1975.Google Scholar
  188. Modan, B., Lilienfeld, A.M.: Polycythemia vera and leukemia—the role of radiation treatment: A study of 1222 patients. Medicine (Baltimore) 44, 305–344 (1965).CrossRefGoogle Scholar
  189. Montz, R.: Ein Maß für die Geschwindigkeit der Erythropoese aus der Ferrokinetik. Nucl.-Med. (Stuttg.) 9, 50–61 (1970a).Google Scholar
  190. Montz, R.: Über die Rolle der Leber in der 59Fe- Kinetik. Nucl.-Med. (Stuttg.) 9, 62–69 (1970b).Google Scholar
  191. Montz, R.: Der Wert der Radioeisendiagnostik bei hämolytischen Erkrankungen. In: Van Vaerenbergh, P.M., Pabst, H.W., Hör, G.: Nuklearmedizin. Radionuklide in der Hämatologie. Gegenwärtiger Stand der Therapie mit Radionukliden, S. 13–18. Stuttgart-New York: F.K. Schattauer 1973.Google Scholar
  192. Montz, R.: Nuklearmedizinische Diagnostik des erythrozytären Systems. Radiologe 14, 72 (1974).PubMedGoogle Scholar
  193. Montz, R., Schneider, C.: Sphärozytose: Die Knochenmarkfunktion im Stadium der Dekompensation und der Kompensation durch Splenektomie, untersucht mit Radio-Eisen. Nucl.-Med. (Stuttg.) 5, 339–354 (1966).Google Scholar
  194. Montz, R., Schneider, C.: Neue Möglichkeiten zur Differentialdiagnose zwischen Polyzythämia vera und Myelofibrose mittels Radioeisen. Rad. biol. ther. 9, 25–32 (1968).Google Scholar
  195. Montz, R., Schneider, C.: Eine Methode zur Bestimmung der Größe des erythropoetischen Knochenmarks beim Menschen aus der Radioeisenkinetik. Blut 21, 283 (1970).PubMedCrossRefGoogle Scholar
  196. Montz, R., Schneider, C.: Die diagnostische Bedeutung von Blutbildungsherden im Knie. In: Horst, W., Pabst, H.W.: Ergebnisse der klinischen Nuklearmedizin, S. 1111–1114. Stuttgart-New York: F.K. Schattauer 1971.Google Scholar
  197. Montz, R., Schneider, C.: Der Informationsgehalt der Eisenverweildauer im Knochenmark. In: Van Vaerenbergh, P.M., Pabst, H.W., Hör, G.: Nuklearmedizin, Radionuklide in der Hämatologie, Gegenwärtiger Stand der Therapie mit Radionukliden, S. 13. Stuttgart-New York: Schattauer 1972a.Google Scholar
  198. Montz, R., Schneider, C.: Eine neue Methode zur einfachen Bestimmung der Hämoglobin-Synthese aus der 59Fe-Kinetik. Nucl.-Med. (Stuttg.) 11, 59 (1972 b)Google Scholar
  199. Montz, R., Schneider, C., Treske, U.: Frühdiagnostik proliferativer Knochenmarkerkrankungen mit Radioeisen. Dtsch. med. Wschr. 97, 994–1000 (1972)CrossRefGoogle Scholar
  200. Moore, C.V.: Iron nutrition. In: Gross, F.: Iron metabolism, CIBA-Symposium, p. 241–255. BerlinGöttingen-Heidelberg: Springer 1964.Google Scholar
  201. Moore, C.V., Brown, E.B.: Der Eisenstoffwechsel. Documenta Geigy, Acta clin. 7 (1967).Google Scholar
  202. Müller, E.F.: Knochenmark und Leukozyten. Virchows Arch., path. Anat. 246, 49 (1923).Google Scholar
  203. Najean, Y., Cacchione, R., Dresch, C., Rain, J.D.: Methods of evaluating the sequestration site of red cells labelled with 51Cr: A review of 96 cases. Brit. J. Haemat. 29, 495–510 (1975).PubMedCrossRefGoogle Scholar
  204. Najean, Y., Castro-Malaspina, H., Colonna, P., Dresch, C.: The influence of circadian variations in plasma iron on the measure of plasm iron turnover. Eur. J. Nucl. Med. 2, 189–191 (1977).PubMedCrossRefGoogle Scholar
  205. Najean, Y., Donio, J., Dresch, C.: Modèle de l’érythropoièse obtenu a partis de l’utilisation de 3H-Thymidine par la moelle „in vitro“ et sa vérification par l’étude de la cinétique du radio-fer „in vivo”. I. Résultats obtenus chez des sujets normaux. Rev. franç. Étud. clin. biol. 14, 575–586 (1969).PubMedGoogle Scholar
  206. Najean, Y., Dresch, C., Ardaillou, N., Bernard, J.: Iron metabolism—study of different kinetic models in normal conditions. Amer. J. Physiol. 213 (2), 533 (1967).PubMedGoogle Scholar
  207. Najean, Y., Dresch, C., Boulard, M.: Regulation of the iron transport compartment. In: Iron deficiency, Colloquia Geigy (Eds. L. Hallberg, H.G. Harwerth, A. Vanotti), p. 21. London-New York: Academic Press 1970b.Google Scholar
  208. Najean, Y., Dresch, C., Faille, A.: Investigation of erythropoiesis and iron kinetics in man. In: Iron deficiency, Collognia Geigy (Eds. L. Hallberg, H.G., Harwerth, A. Vanotti), p. 306. London-New York: Academic Press 1970b.Google Scholar
  209. Najean, Y., Dresch, C., Faille, A., Boulard, M.: Metabolisme du fer — Donnees generales sur la cinetique du radiofer chez l’homme. In: Dynamic studies with radioisotopes in medicine, p. 467–487. IAEA, Wien 1971.Google Scholar
  210. Nelp, W.B., Larson, S.M., Bower, R.E., Grouse, L.D.: Temporary dissociation of RES and erythron activity in the marrow following irradiation. J. nucl. Med. 8, 295 (1967a).Google Scholar
  211. Nelp, W.B., Larson, S.M., Lewis, R.J.: Distribution of the erythron and the RES in the bone marrow organ. J. nucl. Med. 8, 430–436 (1967b).PubMedGoogle Scholar
  212. Neumann, E.: Das Gesetz der Verbreitung des gelben und roten Markes in den Extremitätenknochen. Zbl. med. Wiss. 20, 321 (1882).Google Scholar
  213. Nightingale, D., Prankerd, T.A.J., Richards, J.D.M., Thompson, D.: Splenectomy in anaemia. Quart. J. Med. 41, 261–267 (1972).PubMedGoogle Scholar
  214. Nordoy, A., Neset, G.: Splenectomy in hematologic diseases. Acta med. scand. 183, 117–126 (1968).PubMedCrossRefGoogle Scholar
  215. Nyssen, M., Andre-Fouet, X., Mazuyer, E., Megard, M., Dorche, J.: Etude de fer serique et de la capacité de fixation du fer par le serum chez le sujet age „sain“. Lyon méd. 232, 705–708 (1974).Google Scholar
  216. Oettgen, H.F., Pribilla, W.: Die Erythrokinetik bei Osteomyelofibrose. Klin. Wschr. 42, 483–490 (1964).PubMedCrossRefGoogle Scholar
  217. Osgood, E.E.: Contrasting incidence of acute monocytic and granulocytic leukemias in 32P-treated patients with polycythemia vera and chronic lymphocytic leukemia. J. Lab. clin. Med. 64, 560–573 (1964a).PubMedGoogle Scholar
  218. Osgood, E.E.: Treatment of chronic leukemias. J. nucl. Med. 5, 139–153 (1964b).PubMedGoogle Scholar
  219. Osgood, E.E.: Polycythemia vera: Age relationships and survival. Blood 26, 243–256 (1965a).PubMedGoogle Scholar
  220. Osgood, E.E.: The relative dosage required of total body X-ray vs intravenous 32P for equal effectiveness against leukemic cells of the lymphocytic series or granulocytic series in chronic leukemia. J. nucl. Med. 6, 421–432 (1965b).Google Scholar
  221. Palme, G.: Polyzythämie and Polyglobulie. Dtsch. med. J. 19, 472–474 (1968).Google Scholar
  222. Paterson, B.: The treatment of malignant disease by radiotherapy. 2nd Ed., London: Edward Arnold 1967.Google Scholar
  223. Perkins, J., Israels, M.C.G., Wilkinson, J.F.: Polycythemia vera: clinical studies on a series of 127 patients managed without radiation therapy. Quart. J. Med. 33, 499 (1964).PubMedGoogle Scholar
  224. Peschle, C., Jori, G.P., Condorelli, M.: Independence of iron absorption from the rate of erythropoiesis. Blood 44, 353–358 (1974).PubMedGoogle Scholar
  225. Pirzio-Biroli, G., Bothwell, T.H., Finch, C.A.: Iron absorption. II. The absorption of radioiron administered with a standard meal in man. J. Lab. clin. Med. 51, 37–48 (1958).PubMedGoogle Scholar
  226. Pöttgen, W.: Die moderne Theorie des Hypersplenismus auf der Grundlage zellkinetischer Befunde. Dtsch. med. Wschr. 97, 1100–1102 (1972).Google Scholar
  227. Pollycove, M.: Iron Kinetics. In: Gross, F.: Iron metabolism CIBA-Symposium, p. 148–182. BerlinGöttingen-Heidelberg: Springer 1964.Google Scholar
  228. Pollycove, M., Fawwaz, R.A., Winchell, H.S.: Transient hepatic deposition of iron in primary hemochromatosis with iron deficiency following venesection. J. nucl. Med. 12, 28–30 (1971).PubMedGoogle Scholar
  229. Pollycove, M., Mortimer, R.: The quantitative determination of iron kinetics and hemoglobin synthesis in human subjects. J. clin. Invest. 40, 753 (1961).PubMedCrossRefGoogle Scholar
  230. Pollycove, M., Tono, M.: Studies of the erythron. Semin. Nucl. Med. 5, 11 (1975).PubMedCrossRefGoogle Scholar
  231. Pollycove, M., Winchell, H.S., Lawrence, J.H.: Classification and evolution of patterns of erythropoiesis in polycythemia vera as studied by iron kinetics. Blood 28, 807–829 (1966).PubMedGoogle Scholar
  232. Powsner, E.R., Raeside, D.E.: Diagnostic Nuclear Medicine. New York-London: Grune and Stratton 1971.Google Scholar
  233. Pribilla, W., Oettgen, H.F.: Isotopenuntersuchungen bei Osteomyelofibrose. Blut 18, 178 (1968).PubMedCrossRefGoogle Scholar
  234. Price, D.C., Cohn, S.H., Wasserman, L.R., Reizenstein, P.G., Cronkite, E.P.: The determination of iron absorption and loss by whole-body counting. Blood 20, 517–531 (1962).PubMedGoogle Scholar
  235. Price, D.C., Forsyth, E.M., Cohn, S.H., Cronkite, E.P.: The study of menstrual and other blood loss and consequent iron deficiency, by 59Fe whole-body counting. Canad. med. Ass. J. 90, 51–54 (1964).Google Scholar
  236. Price, R.R., Mckee, L.C., Jr., Krantz, S.B., Brill, A.B.: Estimation of slow dynamic function parameters in iron kinetics studies using quantitative measurements and compartmental modelling analysis. In: Dynamic studies with radioisotopes in medicine 1974, p. 429–444. IAEA, Wien 1975.Google Scholar
  237. Raffin, S.B., Woo, C.H., Roost, K.T., Price, D.C., Schmid, R.: Intestinal absorption of hemoglobin iron—Heme cleavage by mucosal heme oxygenase. J. clin. Invest. 54, 1344–1352 (1974).PubMedCrossRefGoogle Scholar
  238. Reinecke, V., Naegele, W., Strötges, M.W., Poll, W.: In Vitro determination of unbound and total iron-binding capacity in serum by radioiron using a new ion exchange strip. Nucl.-Med. 15, 119–125 (1976).Google Scholar
  239. Retzlaff, J.A., Tauxe, W.N., Kiely, J.M., Stroebel, C.F.: Erythrocyte volume, plasma volume, and lean body mass in adult men and women. Blood 33, 649–667 (1969).PubMedGoogle Scholar
  240. Ricketts, C., Jacobs, A., Cavill, I.: Ferrokinetics and erythropoiesis in man: The measurement of effective erythropoiesis, ineffective erythropoiesis and red cell lifespan using 59Fe. Brit. J. Haemat. 31, 65–75 (1975).PubMedCrossRefGoogle Scholar
  241. Roberts, B.E., Miles, D.W., Woods, C.G.: Polycythaemia vera and myelosclerosis: a bone marrow study. Brit. J. Haemat. 16, 75–85 (1969).PubMedCrossRefGoogle Scholar
  242. Rochna Viola, E.M., De Garreta, A.C.: Estudio de la absorciôn intestinal de hierro por determination de la retention corporal de hierro. Rev. Biol. Med. Nucl. 6, 101–106 (1974).Google Scholar
  243. Ronai, P., Winchell, H.S., Anger, H.O., Lawrence, J.H.: Whole-body scanning of 59Fe for evaluating body distribution of erythropoietic marrow, splenic sequestration of red cells and hepatic deposition of iron. J. nucl. Med. 10, 469–474 (1969).PubMedGoogle Scholar
  244. Ruckensteiner, E.: Zur Strahlentherapie der Polycythaemia rubra vera (Vaquez, Osler). Wien. klin. Wschr. 79, 772–775 (1967).Google Scholar
  245. Rybo, G.: Menstrual loss of iron. In: Iron deficiency (Eds. L. Hallberg, H.G. Harwerth, A. Vanotti), p. 163–171. Academic Press: London 1970.Google Scholar
  246. Saito, H., Sargent, T., Parker, H.G., Lawrence, J.H.: Normal iron absorption in man. Proc. Congr. int. Soc. Haemat. 3, 511–522 (1962).Google Scholar
  247. Saito, H., Sargent, T. Parker, H.G., Lawrence, J.H.: Whole body iron loss in normal men measured with a gamma spectrometer. J. nucl. Med. 5, 571–580 (1964).PubMedGoogle Scholar
  248. Samson, D., Halliday, D., Nicholson, D.C., Chanarin, I.: Quantitation of ineffective erythropoiesis from the incorporation of (15N)deltaaminolaevulinic acid and (’ 5N)glycine into early labelled bilirubin. I. Normal subjects, II. Anaemic patients. Brit. J. Haemat. 34, 33–44 u. 45–53 (1976).Google Scholar
  249. Schiffer, L.M., Price, D.C., Cuttner, J., Cohn, S.H., Cronkite, E.P.: A note concerning the “100 per cent value” in iron absorption studies by whole body counting. Blood 23, 757–760 (1964).PubMedGoogle Scholar
  250. Schneider, C., Montz, R.: Die quantitative Verteilung des erythropoetischen Knochenmarks beim Menschen gemessen mit Radioeisen. Klin. Wschr. 44. 969–973 (1966).PubMedCrossRefGoogle Scholar
  251. Schreiner, D.P.: Reticuloendothelial scans in disorders involving the bone marrow. J. nucl. Med. 15, 1158–1162 (1974).PubMedGoogle Scholar
  252. Schulz, K., Nowotny, P., Bast, G., Preussner, S., Konrad, H., Kiencke, H.: Vergleichende Untersuchungen zur Erythrozytenkinetik und zur Knochenmarksmorphologie bei Patienten mit Osteomyelosklerose und Osteomyelofibrose. Acta Haemat. 43, 280–290 (1970).PubMedCrossRefGoogle Scholar
  253. Schumacher, H.R., Erslev, A.J.: Bone marrow kinetics. In: Szirmai, E.: Nuclear Hematology, p. 89–132. New York-London: Academic Press 1965.Google Scholar
  254. Schwartz, K.-D., Krüger, M.: Improvement in labeling erythrocytes with 99mTc-Pertechnetate. J. nucl. Med. 12, 323–324 (1971).PubMedGoogle Scholar
  255. Sharney, L., Schwartz, L., Wasserman, L.R., Port, S., Leavitt, D.: Pool systems in iron metabolism: with special reference to polycythemia vera. Proc. Soc. exp. Biol. (N.Y.) 87, 489–492 (1954).Google Scholar
  256. Shillingford, J.P.: The red bone marrow in heart failure. J. clin. Path. 3, 24–28 (1950).PubMedCrossRefGoogle Scholar
  257. Silverstein, M.N.: Postpolycythemia myeloid meta- plasia. Arch. intern. Med. 134, 113–115 (1974).Google Scholar
  258. Silverstein, M.N., Remine, W.H.: Sex, splenectomy, and myeloid metaplasia. J. Amer. med. Ass. 227, 424–425 (1974).CrossRefGoogle Scholar
  259. Sinniah, R., Neill, D.W.: Serum iron, total iron-binding capacity, and percentage saturation in normal subjects. J. clin. Path. 21, 603–610 (1968).PubMedCrossRefGoogle Scholar
  260. Smith, T.D., Richards, P.: A simple kit for the preparation of 99mTc-labelled red blood cells. J. Nucl. Med. 17, 126–132 (1976).PubMedGoogle Scholar
  261. Spiers, F.W., Beddoe, A.H., King, S.D., Hayter, C.J., Smith, A.H., Burkinshaw, L., Roberts, B.E.: The absorbed dose to bone marrow in the treatment of polycythaemia by 32P. Brit. J. Radiol. 49, 133–140 (1976).PubMedCrossRefGoogle Scholar
  262. Stich, W.: Physiologie und Pathologie der Hämsynthese. Folia haemat. NF. 9, 197–216 (1964).Google Scholar
  263. Strandberg, O.: Anemia in rheumatoid arthritis. Acta med. stand. Suppl. 454 (1966).Google Scholar
  264. Streicher, H.-J.: Indikation zur Splenektomie. Dtsch. Ärtzebl. 35, 2391–2396 (1975).Google Scholar
  265. Stroebel, C.F., Fowler, W.S.: Secondary polycythemia. Med. Clin. N. Amer. 1956, 1061–1076.Google Scholar
  266. Strumia, M.M., Strumia, P.V., Bassert, D.: Splenectomy in leukemia: Hematologic and clinical effects on 34 patients and review of 299 published cases. Cancer Res. 26/I, 519–528 (1966).Google Scholar
  267. Szur, L., Bettit, J.E., Lewis, S.M., Bruce-Tagoe, A.A., Short, M.D.: The effect of radiation on splenic function in myelosclerosis: studies with 52Fe and 99Tcm. Brit. J. Radiol. 46, 295–301 (1973).PubMedCrossRefGoogle Scholar
  268. Szur, L., Lewis, S.M.: The haematological complications of polycythemia vera and treatment with radioactive phosphorus. Brit. J. Radiol. 39, 122–130 (1966).PubMedCrossRefGoogle Scholar
  269. Szur, L., Smith, M.D.: Red-cell production and destruction in myelosclerosis. Brit. J. Haemat. 7, 147–168 (1961).PubMedCrossRefGoogle Scholar
  270. Thomson, R.A.E., Corriveau, O.J., Rubin, P.: 59Fe labeling in bone. J. nucl. Med. 15. 161–163 (1974).PubMedGoogle Scholar
  271. Treves, S., Spencer, R.: Liver and spleen scintigraphy in children. Semin. nucl. Med. 3, 55–68 (1973).Google Scholar
  272. Tubiana, M., Flamant, R., Attie, E., Hayat, M.: A study of hematological complications occurring in patients with polycythemia vera treated with 32P. (Based on a series of 296 patients.) Blood 32, 536–548 (1968).PubMedGoogle Scholar
  273. Tubiana, M., Parmentier, C., Attie, E., Hayat, M.: L’évolution terminale des polyglobulies. Nouv. Rev. franç. Hémat. 9, 860–873 (1969).PubMedGoogle Scholar
  274. Turnbull, H.M.: The anatomy of erythropoiesis. In: Vaughan, J.M.: The anemias. London: Oxford Med. Publ. 1936.Google Scholar
  275. Van Dyke, D.: Similarity in the distribution of skeletal blood flow and erythropoietic marrow. Clin. Orthop. Rel. Res. 52, 37–51 (1967).CrossRefGoogle Scholar
  276. Van Dyke, D., Anger, H.O.: Patterns of marrow hypertrophy and atrophy in man. J. nucl. Med. 6, 109–120 (1965).Google Scholar
  277. Van Dyke, D., Anger, H.O., Parker, H., Mcrae, J., Dobson, E.L., Yano, Y., Naets, J.P., Linfoot, J.: Markedly increased bone blood flow in myelofibrosis. J. nucl. Med. 12, 506–512 (1971).PubMedGoogle Scholar
  278. Van Dyke, D., Anger, H.O., Pollycove, M.: The effect of erythropoietic stimulation on marrow distribution in man, rabbit and rat as shown by Fe59 and Fe52. Blood 24, 356–371 (1964).Google Scholar
  279. Van Dyke, D.C., Anger, H.O., Yang, Y.: Progress in determining bone marrow distribution in vivo. In: Lawrence, H.J.: Progress in atomic medicine. Vol. 2, p. 65–83. New York: Grune and Stratton 1968.Google Scholar
  280. Van Dyke, D., Shkurkin, C., Price, D., Yano, Y., Anger, H.O.: Differences in distribution of erythropoietic and reticuloendothelial marrow in hematologic disease. Blood 30, 364–374 (1967).PubMedGoogle Scholar
  281. Varela, J.E., Rochna Viola, E.M., Carmena, A.O., Etcheverry, M.A., Kremenchuzky, S.: Polycythemia vera. Results of repeated radioisotope studies in 53 patients during a five-year period. Nucl.Med. (Stuttg.) 3, 1–19 (1962).Google Scholar
  282. Viala, J.J., Dechavanne, M., Gentilhomme, O., Favregilly, J., Revol, L.: L’érythropoièse inefficace; à propos de 49 cas diagnostiqués par méthode radio-isotopique. Nouv. Rev. franç. Hémat. 13, 363–365 (1973).PubMedGoogle Scholar
  283. Visfeldt, J., Franzen, S., Nielsen, A., Tribukait, B.: Primary polycythaemia. 3. Studies on the significance of the history of the disease and of the treatment for the development of clones in bone marrow cells. Acta path. microbiol. scand. A 81, 195–203 (1973).Google Scholar
  284. Walz, A., Pribilla, W., Haring, R., Koeppe, P.: Gleichzeitige Messung der Vitamin-B12- und Eisen-Resorption mit einem Ganzkörperaktivitätszähler nach Gastrektomie, Magenresektion und bei atrophischer Gastritis. Dtsch. med. Wschr. 95, 25–30 (1970).CrossRefGoogle Scholar
  285. Ward, H.P., Block, M.H.: The natural history of Agnogenic Myeloid Metaplasia (AMM) and a critical evaluation of its relationship with the Myeloproliferative Syndrom. Medicine (Baltimore) 50, 357–420 (1971).Google Scholar
  286. Ward, H.P., Vautrin, R., Kurnick, J.: Presence of a myeloproliferative factor in patients with polycythemia vera and agnogenic myeloid metaplasia. I Expansion of the erythropoietin-responsive stem cell compartment. Proc. Soc. exp. Biol. (N.Y.) 147, 305–308 (1974).Google Scholar
  287. Warner, G.T.: The use of total-body counters for the study of iron metabolism and iron loss. Postgrad. med. J. 49, 477–485 (1973).PubMedCrossRefGoogle Scholar
  288. Wasserman, L.R., Gilbert, H.S.: The treatment of polycythemia vera. Med. Clin. N. Amer. 50, 1501–1518 (1966).PubMedGoogle Scholar
  289. Watkins, P.J., Hamilton Fairley, G., Bodley Scott, R.: Treatment of polycythaemia vera. Brit. med. J. 2, 664–666 (1967).PubMedCrossRefGoogle Scholar
  290. Weinreich, J.: Die Indikation zur Milzexstirpation bei hämatologischen Erkrankungen. Dtsch. med. Wschr. 95, 348–349 (1970).CrossRefGoogle Scholar
  291. Wellner, U.: Die Bestimmung des Erythrozyteneisenumsatzes mit Hilfe 51Cr-markierter Erythrozyten. In: Horst, W.: Frontiers of Nuclear Medicine, S. 177–183. Berlin-Heidelberg-New York: Springer 1971.CrossRefGoogle Scholar
  292. Wellner, U., Kutzim, H.: Compartmentanalyse eines neuen Eisenstoffwechselmodells. In: Horst, W., Pabst, H.W.: Ergebnisse der klinischen Nuklearmedizin, S. 530–537. Stuttgart-New York: F.K. Schattauer 1971.Google Scholar
  293. Werner, E., Kaltwasser, J.P., Becker, HJ.: Quantitative Bestimmung von Blutverlusten mit dem Ganzkörperzähler. Klin. Wschr. 50, 543–547 (1972).PubMedCrossRefGoogle Scholar
  294. Westin, J., Wahlström, J., Swolin, B.: Chromosome studies in untreated polycythaemia vera. Scand. J. Haematol. 17, 183–196 (1976).PubMedCrossRefGoogle Scholar
  295. White, P., Coburn, R.F., Williams, W.J., Goldwein, M.I., Rother, M.L., Shafer, B.C.: Carbon monoxide production associated with ineffective erythropoiesis. J. clin. Invest. 46, 1986–1998 (1967).PubMedCrossRefGoogle Scholar
  296. Wright, R.R., Tono, M., Pollycove, M.: Blood volume. Semin. nucl. Med. 5, 63–78 (1975).Google Scholar
  297. Zum Winkel, K.: Nuklearmedizin. Berlin-HeidelbergNew York: Springer 1975.CrossRefGoogle Scholar

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© Springer-Verlag Berlin · Heidelberg 1978

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  • R. Montz

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