The Immunologic and Immunochemical Basis for the Kiel Classification

  • H. Stein
Part of the Handbuch der Speziellen Pathologischen Anatomie und Histologie book series (SPEZIELLEN, volume 1 / 3 / B)


As can be seen from the history of the classification of lymphomas (see p. 83ff.), the morphologic analysis of lymphoproliferative diseases did not advance beyond a certain state of knowledge. The main reason is that characteristic morphologic features, such as certain organelles (granules, etc.), are not found in most lymphoid cells. Since the morphologic description and evaluation of normal and neoplastic lymphoid cells is highly subjective, very different concepts of classification were developed, and, as we now know, numerous misinterpretations appeared. For example, the large cells of lymphatic tissue were usually mistaken for reticulum cells or “thrown into one pot” with real reticulum cells. It is now known that these large cells represent definite functional forms of the lymphoid cell series that appear after antigenic stimulation. For decades, morphologists also misinterpreted the derivation of plasma cells. It was said that plasma cells are derived from reticulum cells, 1 since it was previously believed that there are transitional morphologic forms between them.


Acute Lymphatic Leukemia Chronic Lymphocytic Leukemia Complement Receptor Chronic Lymphocytic Leukemia Cell Hairy Cell 
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© Springer-Verlag, Berlin · Heidelberg 1978

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  • H. Stein

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