Abstract
The genetic origin of antibody diversity has been a subject of much thought and controversy over the past 20 years. Extensive studies of immunoglobulins, particularly at the amino acid sequence level, have provided us with a general scheme of the genetic loci which encode antibody molecules (Fig. 1). But many problems remain controversial, in particular the number of V genes and the mechanisms whereby two separate genes (V and C) encode a single, continuous polypeptide chain.
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Milstein, C., Brownlee, G.G., Cheng, C.C., Hamlyn, P.H., Proudfoot, N.J., Rabbitts, T.H. (1976). Immunoglobulin mRNA and Immunoglobulin Genes. In: Melchers, F., Rajewsky, K. (eds) The Immune System. Colloquium der Gesellschaft für Biologische Chemie, vol 27. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81083-1_7
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