Abstract
The function of the immune system is based on a large variety of receptor molecules whose combining sites can recognize virtually every antigenic substance in the universe. This capacity is reflected in a pronounced structural variability of the receptor molecules and particularly of their variable and hypervariable regions (1, 2). The classical receptor, the antibody molecule, possesses a combining site that is constructed from 6 hypervariable sequence regions, three of which belong to the heavy and three to the light chain (1, 2). They are fixed in their three-dimensional arrangement by the so-called “framework stretches” of the variable regions.
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Eichmann, K., Berek, C., Hämmerling, G., Black, S., Rajewsky, K. (1976). Genetic Control of T and B Cell Receptor Specificity in the Mouse. In: Melchers, F., Rajewsky, K. (eds) The Immune System. Colloquium der Gesellschaft für Biologische Chemie, vol 27. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81083-1_6
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DOI: https://doi.org/10.1007/978-3-642-81083-1_6
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