Chemical Structure and Biological Activities of Murine Histocompatibility Antigens

  • R. Henning
  • J. W. Schrader
  • R. J. Milner
  • K. Reske
  • J. A. Ziffer
  • B. A. Cunningham
  • G. M. Edelman
Conference paper
Part of the Colloquium der Gesellschaft für Biologische Chemie book series (MOSBACH, volume 27)


Histocompatibility antigens are glycoproteins found on the surface membranes of vertebrate cells. The significance of these antigens in the rejection of allografts between individuals has been well established (1), and the genetics of these polymorphic systems have been studied in detail in the mouse (H-2) and in man (HL-A). The segment of the 17th chromosome of the mouse containing the major histocompatibility complex is shown in Figure 1. Despite all the information available regarding these molecules, the physiological function of H-2 and HL-A antigen is not known. A number of studies has shown that histocompatibility antigens are involved in cell-mediated lysis of xenoor allogeneic cells (2, 3). Recently it has been observed that murine histocompatibility antigens participate in the lysis of syngeneic chemically modified cells (4), virally infected cells (5) and neo-plastic cells (6, 7, 8). These data support the notion that histocompatibility antigens play an important role in the elimination of antigenically abnormal cells, and thus, they may form a highly complicated system of membrane proteins that serve as signals to distinguish “self” from “non-self”.


Heavy Chain Spleen Cell Viral Antigen Histocompatibility Antigen Cytotoxic Lymphocyte 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1976

Authors and Affiliations

  • R. Henning
  • J. W. Schrader
  • R. J. Milner
  • K. Reske
  • J. A. Ziffer
  • B. A. Cunningham
  • G. M. Edelman

There are no affiliations available

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