Specificity of Immune Response Control by H-Linked Ir Genes

  • E. Rüde
  • E. Günther
Conference paper
Part of the Colloquium der Gesellschaft für Biologische Chemie book series (MOSBACH, volume 27)


The processes required for the induction of an immune response are quite complex, and it is obvious that genetic regulation may take place at different levels. Among the genetic factors determining the ability of an individual to respond to an antigen dominant immune response (Ir) genes that are closely linked to the genes of the major histocompatibility complex (MHC) (H-linked Ir genes) play an important role (Benacerraf and McDevitt, 1972; Benacerraf and Katz, 1975). The presence of such an H-linked Ir gene in an individual is one of the prerequisites for the recognition of a particular antigen as an immunogen. H-linked Ir genes have been first recognized in studies on the immunogenicity of synthetic polypeptide antigens of limited heterogeneity in mice (McDevitt and Tyan, 1968). The same type of control has in the meantime been demonstrated for a large variety of natural antigens as well. Furthermore, H-linked Ir genes have been identified in several other species, such as guinea pigs (Ellman et al., 1970), rats (Günther et al., 1972; Würzburg, 1971), rhesus monkeys (Dorf et al., 1974), and chickens (Günther et al., 1974; Karakoz et al., 1974).


Major Histocompatibility Complex Bovine Insulin High Responder Aromatic Amino Acid Residue Stimulation Ratio 
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© Springer-Verlag Berlin · Heidelberg 1976

Authors and Affiliations

  • E. Rüde
  • E. Günther

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