Immunology: Breast Cancer
Although the immunology of human breast cancer has for some time been an area of active investigation, there is still little definitive information on such basic questions as the frequency of immune reactions to breast tumor antigens, the specificity of those reactions that are detected, nor ultimately their clinical significance. The reasons for this lack of reliable information are in large measure technical. The methodology which has been more or less successfully applied to problems in animal tumor immunology has not yielded the same quality, or quantity, of data for human cancer where the necessity of working with outbred and in many respects uncontrollable populations is unavoidable. As in most other ambiguous situations, tumor immunologists tend to react to this dilemma in one of two ways. The optimists feel that the data for human cancer are basically “in the same direction” as that for animals and, consequently, the conclusions are probably similar. The pessimists feel that no amount of sound animal data will ever substitute for weak data in humans and that we might as well admit that we have come no further than BERG (1959) who correlated “lymphocytic infiltration” with favorable prognosis nearly 20 years ago.
KeywordsBreast Cancer Breast Cancer Patient Human Breast Cancer Germinal Center Lymphocytic Infiltration
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- 5.BLACK, M.M.: Lymphoreticuloendothelial reactivity as a component of the tumor-host relationship. In: Immunity and Tolerance in Oncogenesis, p. 863. Severi, L. (ed.) Univ. of Perugia, Italy 1970.Google Scholar
- 11.BLACK, M.M., ZACHRAU, R.E., SHORE, B., LEIS, H.P.: Tumor-Specific and Viral-Associated Antigens of Human Breast Cancers: Biological Significance, Cancer Res. In press.Google Scholar
- 29.HEPPNER, G.H.: Is there evidence that immunity influences tumor-host balance in breast cancer? Recent Results Cancer Res. 42, 63 (1973).Google Scholar
- 39.PILCH, Y.H., MYERS, G.H., SPARKS, F.C., GOLUB, S.H.: Prospects for the immunotherapy of cancer. Current Problems in Surgery, January and February, 1975.Google Scholar
- 47.WHITEHEAD, R.H., BOLTON, P.M., NEWCOMBE, R.G.: Is there a factor in sera from cancer patients that inhibits lymphocyte response to phytohaemagglutinin? Europ. J. Cancer 10, 815 (1974).Google Scholar