Abstract
Although the immunology of human breast cancer has for some time been an area of active investigation, there is still little definitive information on such basic questions as the frequency of immune reactions to breast tumor antigens, the specificity of those reactions that are detected, nor ultimately their clinical significance. The reasons for this lack of reliable information are in large measure technical. The methodology which has been more or less successfully applied to problems in animal tumor immunology has not yielded the same quality, or quantity, of data for human cancer where the necessity of working with outbred and in many respects uncontrollable populations is unavoidable. As in most other ambiguous situations, tumor immunologists tend to react to this dilemma in one of two ways. The optimists feel that the data for human cancer are basically “in the same direction” as that for animals and, consequently, the conclusions are probably similar. The pessimists feel that no amount of sound animal data will ever substitute for weak data in humans and that we might as well admit that we have come no further than BERG (1959) who correlated “lymphocytic infiltration” with favorable prognosis nearly 20 years ago.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
ANDERSEN, V., BJERRUM, O., BENDIXEN, G., SCHIøDT, T., DISSING, I.: Effect of autologous mammary tumour extracts on human leucocyte migration in vitro, Int. J. Cancer 5, 357 (1970).
AVIS, F., MOSONOV, I., HAUGHTON, G.: Antigenic cross-reactivity between benign and malignant neoplasms of the human breast. J. nat. Cancer Inst. 52, 1041 (1974).
BALDWIN, R.W., EMBLETON, M.J., JONES, J.S.P., LANGMAN, M.J.S.: Cell-mediated and humoral immune reactions to human tumours, Int. J. Cancer 12, 73 (1973).
BERG, J.W.: Inflammation and prognosis in breast cancer. A search for host resistance. Cancer (Philad.) 12, 714 (1959).
BLACK, M.M.: Lymphoreticuloendothelial reactivity as a component of the tumor-host relationship. In: Immunity and Tolerance in Oncogenesis, p. 863. Severi, L. (ed.) Univ. of Perugia, Italy 1970.
BLACK, M.M., LEIS, H.P.: Cellular responses to autologous breast cancer tissue, Cancer (Philad.) 28, 263 (1971a).
BLACK, M.M., LEIS, H.P.: Cellular responses to autologous breast cancer tissue. Correlation with stage and lymphoreticular reactive. Cancer (Philad.) 28, 263 (1971b).
BLACK, M.M., LEIS, H.P.: Cellular responses to autologous breast cancer tissue. Sequential observations. Cancer (Philad.) 32, 384 (1973).
BLACK, M.M., LEIS, H.P., SHORE, B., ZACHRAU, R.E.: Cellular hypersensitivity to breast cancer. Assessment by a leucocyte migration procedure. Cancer (Philad.) 33, 952 (1974a).
BLACK, M.M., MOORE, D.H., SHORE, B., ZACHRAU, R.E., LEIS, H.P.: Effect of murine milk samples and human breast tissues on human leukocyte migration indices, Cancer Res. 34, 1054 (1974b).
BLACK, M.M., ZACHRAU, R.E., SHORE, B., LEIS, H.P.: Tumor-Specific and Viral-Associated Antigens of Human Breast Cancers: Biological Significance, Cancer Res. In press.
BLACK, M.M., ZACHRAU, R.E., SHORE, B., MOORE, D.H., LEIS, H.P.: Prognostically favorable immunogens of human breast cancer tissue: Antigenic similarity to murine mammary tumor virus. Cancer (Philad.) 35, 121 (1975).
CATALONA, W.J., CHRETIEN, P.B.: Abnormalities of quantitative di-nitrochlorobenzene sensitization in cancer patients: correlation with tumor stage and histology, Cancer (Philad.) 31, 353 (1973).
CATALONA, W.J., SAMPLE, W.F., CHRETIEN, P.B.: Lymphocyte reactivity in cancer patients: correlation with tumor histology and clinical stage, Cancer (Philad.) 31, 65 (1973).
CHARNEY, J., MOORE, D.H.: Neutralization of murine mammary tumour virus by sera of women with breast cancer, Nature (Lond.) 229, 627 (1971).
COCHRAN, A.J., GRANT, R.M., SPILG, W.G., MACKIE, R.M., ROSS, C.E., HOYLE, D.E., RUSSELL, J.M.: Int. J. Cancer 14, 19 (1974).
COCHRAN, A.J., MACKIE, R.M., THOMAS, C.E., GRANT, R.M., CAMERON-MOWAT, D.E., SPILG, W.G.S.: Cellular immunity to breast carcinoma and malignant melanoma, Brit. J. Cancer 28 (Suppl. I), 77 (1973).
COCHRAN, A.J., SPILG, W.G.S., MACKIE, R.M., THOMAS, C.E.: Postoperative depression of tumour-directed cell-mediated immunity in patients with malignant disease, Brit. med. J. 4, 67 (1972).
DIPAOLA, M., ANGELINI, L., BERTOLOTTI, A., COLIZZA, S.: Host resistance in relation to survival in breast cancer, Brit. med. J. 4, 268 (1974).
DMOCHOWSKI, L.: The viral factor in the genesis of breast cancer: Present evidence, Triangle 12, 37 (1973).
EDYNAK, E.M., HIRSHAUT, Y., BERNHARD, M., TREMPE, G.: Fluorescent Antibody studies of human breast cancer, J. nat. Cancer Inst. 48, 1137 (1972).
ELLIS, R.J., WERNICK, G., ZABRISKIE, J.B., GOLDMAN, L.I.: Immunologic competence of regional lymph nodes in patients with breast cancer. Cancer (Philad.) 35, 655(1975).
FOSSATI, G., CAMEVARI, S., DELLA PORTA, G., BALZARINI, G.P., VERONESI, U.: Cellular immunity to human breast carcinoma. Int. J. Cancer 10, 391 (1972).
GROSSER, N., THOMSON, D.M.P.: Cell-mediated antitumor immunity in breast cancer patients evaluated by antigen-induced leukocyte adherence inhibition in test tubes. Cancer Res. 35, 2571 (1975).
HELLSTRöM, I., HELLSTRöM, K.E., Sjögren, H.O., Warner, G.A.: Demonstration of cell-mediated immunity to human neoplasms of various histological types, Int. J. Cancer 7, 1 (1971a).
HELLSTRöM, I., HELLSTRöM, K.E., SJöGREN, H.O., WARNER, G.A.: Serum factors in tumor-free patients cancelling the blocking of cell-mediated tumor immunity, Int. J. Cancer 8, 185 (1971b).
HELLSTRöM, I., SJöGREN, H.O., WARNER, G., HELLSTRöM, K.E.: Blocking of Cell-Mediated tumor immunity by sera from patients with growing neoplasms, Int. J. Cancer 7, 226 (1971c).
HELLSTRöM, I., HELLSTRöM, K.E., WARNER, G.A.: Increase of lymphocyte-mediated tumor-cell destruction by certain patient sera, Int. J. Cancer 12, 348 (1973).
HEPPNER, G.H.: Is there evidence that immunity influences tumor-host balance in breast cancer? Recent Results Cancer Res. 42, 63 (1973).
HEPPNER, G., HENRY, E., STOLBACH, L., CUMMINGS, F., MCDONOUGH, E., CALABRESI, P.: Problems in the clinical use of the microcytotoxi-city assay for measuring cell-mediated immunity to tumor cells, Cancer Res. 35, 1931 (1975).
HOLLINSHEAD, A.C., JAFFURS, W.T., ALPERT, L.K., HARRIS, J.E., HERBERMAN, R.B.: Isolation and identification of soluble skin-reacitve membrane antigens of malignant and normal human breast cells, Cancer Res. 34, 2961 (1974).
HOSHINO, M., DMOCHOWSKI, L.: Electron microscope study of antigens in cells of mouse mammary tumor cell lines by peroxidase-labeled antibodies in sera of mammary tumor-bearing mice and of patients with breast cancer, Cancer Res. 33, 2551 (1973).
HUMPHREY, L.J., ESTES, N.C., MORSE, P.A., JEWELL, W.R., BOUDET, R.A., HUDSON, M.J.K.: Serum antibody in patients with mammary disease, Cancer (Philad.) 34, 1516 (1974).
HUNTER, R.L., FERGUSON, D.J., COPPLESON, L.W.: Survival with mammary cancer related to the interaction of germinal center hyperplasia and sinus histiocytosis in axillary and internal mammary lymph nodes, Cancer (Philad.) 36, 528 (1975).
LANE, M., GOKSEL, H., SALERNO, R.A., HAAGENSEN, C.D.: Clinico-pathologic analysis of the surgical curability of breast cancers: a minimum ten-year study of a personal series. Ann. Surg. 153, 483 (1961).
MITCHELL, R.J.: The delayed hypersensitivity response in primary breast carcinoma as an index of host resistance, Brit. J. Surg. 59, 505 (1972).
MULLER, M., KEMMER, C., ZOTTER, S., GROSSMAN, H., MICHEEL, G.: Cross reaction between human breast cancer, mastophathy, and murine mammary carcinoma — Localization of the antigen in type A particle virus. Arch. Geschwulstforsch, 41, 100 (1973).
NEMOTO, T., HAN, T., MINOWADA, J., ANGKUR, V., CHAM, A., DAO, T.L.: Cell-mediated immune status of breast cancer patients: evaluation by skin tests, lymphocyte stimulation, and counts of rosette-forming cells, J. nat. Cancer Inst. 53, 641 (1974).
PILCH, Y.H., MYERS, G.H., SPARKS, F.C., GOLUB, S.H.: Prospects for the immunotherapy of cancer. Current Problems in Surgery, January and February, 1975.
POTVIN, C., TARPLEY, J.L., CHRETIEN, P.B.: Thymus-derived lymphocytes in patients with solid malignancies, Clin. Immunol. Immuno-pathology 3, 476 (1975).
PRIORI, E.S., SEMAN, G., DMOCHOWSKI, L., GALLAGER, H.S., ANDERSON, D.E.: Immunofluorescence studies on sera of patients with breast carcinoma, Cancer (Philad.) 28, 1462 (1971).
ROBERTS, M.M., JONES-WILLIAMS, W.: The delayed hypersensitivity reaction in breast cancer, Brit. J. Surg. 61, 549 (1974).
SEGALL, A., WEILER, O., GENIN, J., LACOUR, J., LACOUR, F.: In vitro study of cellular immunity against autochthonous human cancer, Int. J. Cancer 9, 417 (1972).
STJERNSWARD, J., JONDAL, M., VANKY, F., WIGZELL, H., SEALY, R.: Lymphopenia and change in distribution of human B and T lymphocytes in peripheral blood induced by irradiation for mammary carcinoma, Lancet 2, 1352 (1972).
TSAKRAKLIDES, E., TSAKRAKLIDES, V., ASHIKARI, H., ROSEN, P.P., SIEGAL, F.P., ROBBINS, G.F., GOOD, R.A.: In vitro studies of axillary lymph node cells in patients with breast cancer, J. nat. Cancer Inst. 54, 549 (1975).
TSAKRAKLIDES, V., OLSON, P., KERSEY, J.H., GOOD, R.A.: Prognostic Significance of the regional lymph node histology in cancer of the breast, Cancer (Philad.) 34, 1259 (1974).
WHITEHEAD, R.H., BOLTON, P.M., NEWCOMBE, R.G.: Is there a factor in sera from cancer patients that inhibits lymphocyte response to phytohaemagglutinin? Europ. J. Cancer 10, 815 (1974).
WHITTAKER, M.G., REES, K., CLARK, C.G.: Reduced lymphocyte transformation in breast cancer. Lancet I, 892 (1971).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1976 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Heppner, G.H. (1976). Immunology: Breast Cancer. In: St-Arneault, G., Band, P., Israël, L. (eds) Breast Cancer. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 57. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81043-5_9
Download citation
DOI: https://doi.org/10.1007/978-3-642-81043-5_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-81045-9
Online ISBN: 978-3-642-81043-5
eBook Packages: Springer Book Archive