Abstract
Endocrine ablative and additive hormone therapies have been used widely in the treatment of advanced breast cancer since Sir George Beatson’s report in 1896 describing remissions in response to bilateral oophorectomy (BEATSON, 1896). Either removal of endocrine producing organs or administration of pharmacologic quantities of hormones results in objective remissions in 25–40% of patients with advanced breast disease (KENNEDY, 1974). Recently, the ability to predict with confidence the breast cancer patient most likely to respond to endocrine manipulation was demonstrated using estrogen receptor analyses (e.g., JENSEN et al., 1971; WITTLIFF, 1974; McGUIRE et al., 1975).
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Wittliff, J.L., Beatty, B.W., Savlov, E.D., Patterson, W.B., Cooper, R.A. (1976). Estrogen Receptors and Hormone Dependency in Human Breast Cancer. In: St-Arneault, G., Band, P., Israël, L. (eds) Breast Cancer. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 57. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81043-5_7
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DOI: https://doi.org/10.1007/978-3-642-81043-5_7
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