Breast Cancer pp 183-188 | Cite as

The Role of Hormones in the Modern Treatment of Advanced Breast Cancer

  • H. J. Tagnon
Part of the Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer book series (RECENTCANCER, volume 57)


In this chapter an attempt will be made to define the significance and role of hormonal treatment of breast cancer. This type of treatment can no longer be used alone and it should be considered in the general perspective of a resolute attempt to utilize all existing biological and pharmacologic information available for the improvement of patient care. This is not a complete review of the subject but rather a chapter in the nomenclature and critical evaluation of methods of treatment now available to a “task force” with ambitious therapeutic aims. Recent progress in the treatment of Hodgkin’s disease, leukemia, osteogenic sarcoma, and of other tumor types has provided the encouragement for a renewed and concerted attack on breast cancer, a disease which affects 1 out of every 20 women and has a mortality rate of probably over 75% which has practically remained unchanged in the last 50 years.


Breast Cancer Estrogen Receptor Advanced Breast Cancer Cytotoxic Chemotherapy Mammary Cancer 
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  1. 1.
    BULBROOK, R.D., GREENWOOD, F.C., HAYWARD, J.L.: Selection of breast cancer patients for adrenalectomy or hypophysectomy by determination of urinary 17-hydroxycorticosteroids and aetiocholanolone. Lancet I, 1154–1157 (1960).CrossRefGoogle Scholar
  2. 2.
    Cooperative Breast Cancer Group: Testosterone propionate therapy in breast cancer. J. Amer. med. Ass. 188, 1069–1072 (1964).CrossRefGoogle Scholar
  3. 3.
    Cooperative Breast Cancer Group: Progress report: results of studies by the Cooperative Breast Cancer Group 1959–60. Cancer Chemother. Rep. 11, 109–141 (1961).Google Scholar
  4. 4.
    Council on Drugs: Androgens and estrogens in the treatment of disseminated mammary carcinoma. J. Amer. med. Ass. 172, 1271–1283 (1960).CrossRefGoogle Scholar
  5. 5.
    FRACCHIA, A.A., FARROW, J.H., MILLER, T.R., TOLLEFSEN, R.H., GREENBERG, H.J., KNAPPER, W.H.: Hypophysectomy as compared with adrenalectomy in the treatment of advanced carcinoma of the breast. Surg. Gynec. Obstet. 133, 241–246 (1971).PubMedGoogle Scholar
  6. 6.
    Groupe Europeen du Cancer du Sein: Le traitement hormonal du cancer du sein en phase avancée. Comparaison entre le propionate de testosterone et la combinaison propionate de testosterone-delta-I-testololactone. Rev. franç. Et. clin. biol. 9, 88–90 (1964).Google Scholar
  7. 7.
    HORWITZ, K.B., MCGUIRE, W.L., PEARSON, O.H., SEGALOFF, A.: Predicting response to endocrine therapy in human breast cancer: a hypothesis. Science 189, 726–727 (1975).PubMedCrossRefGoogle Scholar
  8. 8.
    LECLERCQ, G., HEUSON, J.C., DEBOEL, M.C., MATTHEIEM, W.H.: Estrogen receptors in breast cancer: a changing concept. Brit. med. J. 1, 185–189 (1975).PubMedCrossRefGoogle Scholar
  9. 9.
    MCGUIRE, W.L., CARBONE, P.P., VOLLMER, E.P.: Estrogen Receptors in Human Breast Cancer. New York: Raven Press, 1975.Google Scholar
  10. 10.
    STAQUET, M., TAGNON, M., KENIS, Y., BONADONNA, G., CARTER, S.K., SOKAL, G., TROUET, A., GHIONE, M., PRAGA, C., LENAZ, L., KARIM, O.S.: EORTC International Symposium. Adriamycin Review. Medikon, Ghent: European Press, 1974.Google Scholar
  11. 11.
    STOLL, B.A.: Mammary Cancer and Neuroendocrine Therapy. London: Butterworths, 1974.Google Scholar
  12. 12.
    TAGNON, H.J.: Clinical results with hormones in disseminated mammary cancer. In: Chemotherapy of Cancer. PLATTNER, P.A. (ed.). New York: Elsevier, 1964.Google Scholar

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© Springer-Verlag Berlin · Heidelberg 1976

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  • H. J. Tagnon

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