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Potent Inhibitory Activity of a New Antiestrogen, RU 16 117, on the Development and Growth of DMBA-Induced Rat Mammary Adenocarcinoma

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Breast Cancer

Abstract

Mammary carcinoma induced in the rat by dimethyl-benzanthracene (DMBA) administration (HUGGINS et al., 1961) is well-known to be dependent upon estrogens and prolactin (MEITES, 1972; QUADRI et al., 1974; CASSELL et al., 1971; LEUNG et al., 1975; DAO, 1962) for its development and growth.

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References

  1. ASSELIN, J., LABRIE, F., KELLY, P.A., PHILIBERT, D., RAYNAUD, J.P.: Specific progesterone receptors in dimethylbenzanthracene (DMBA)-induced mammary tumors. Steroids. 27, 395–404 (1976).

    Article  PubMed  CAS  Google Scholar 

  2. BIRGE, C.A., PEAKE, G.T., MARIZ, I.K., DAUGHADAY, W.H.: Radioimmu-noassayable growth hormone in the rat pituitary gland: effects of age, sex and hormonal state. Endocrinology, 81, 195–204 (1967).

    Article  PubMed  CAS  Google Scholar 

  3. CASSELL, E., MEITES, J., WELSCH, C.W.: Effects of ergocornine and ergocryptine on growth of 7,12 dimethylbenzanthracene-induced mammary tumors in rats. Cancer Res. 31, 1051–1053 (1971).

    PubMed  CAS  Google Scholar 

  4. DAO, T.L.: The role of ovarian hormones in initiating the induction of mammary cancer in rats by polynuclear hydrocarbons. Cancer Res. 22, 773–981 (1962).

    Google Scholar 

  5. DE SOMBRE, E.R., ARBOGAST, L.Y.: Effect of the antiestrogen CI 628 on the growth of rat mammary tumors. Cancer Res. 34, 1971–1976 (1974).

    Google Scholar 

  6. FERLAND, L., LABRIE, F., HOULD, R., BOUTON, M.M., Azadian-Boulanger, G., Raynaud, J.P.: Effects of RU 16117 (11 -methoxy ethinyl estradiol) on parameters of the estrous cycle in the rat. Fed. Proc. 34, 340 (1975).

    Google Scholar 

  7. HEUSON, J.C., WAELBROECK, C., LEGROS, N., GALLEZ, G., ROBYN, C., L’HERMITE, M.: Inhibition of DMBA-induced mammary carcinogenesis in the rat by 2-Br- -ergocryptine (CB-154) an inhibitor of prolactin secretion and by nafoxidine (U-11, 000A), an estrogen antagonist, Hormones and Antagonists. Gynec. Invest. 2, 130–137 (1971).

    Article  CAS  Google Scholar 

  8. HORWITZ, K.B., MCGUIRE, W.L., PEARSON, O.H., SEGALOFF, A.: Predicting response to endocrine therapy in human breast cancer: a hypothesis. Science 189, 726–727 (1975).

    Article  PubMed  CAS  Google Scholar 

  9. HUGGINS, C.: Two principles in endocrine therapy of cancers hormone deprival and hormone interference. Cancer Res. 25, 1163–1167 (1965).

    PubMed  CAS  Google Scholar 

  10. HUGGINS, C., GRAND, L.C., BRILLANTES, F.P.: Mammary cancer induced by a single feeding of polynuclear hydrocarbons and its suppression. Nature (Lond.) 189, 204–207 (1961).

    Article  CAS  Google Scholar 

  11. JENSEN, E.V., POLLEY, T.Z., SMITH, S., BLOCK, G.E., FERGUSON, D.J., DE SOMBRE, E.R.: In: Estrogen Receptors in Breast Cancer. McGuire, W.L., Carbone, P.P., Vollmer, E.P. (ed.). New York: Raven Press, pp. 37–56, 1975.

    Google Scholar 

  12. KELLY, P.A., BRADLEY, C., SHIU, R.P.C., MEITES, J., FRIESEN, H.G.: Prolactin binding to rat mammary tumor tissue. Proc. Soc. exp. Biol. (N.Y.) 146, 816–819 (1974).

    CAS  Google Scholar 

  13. KLEDZIK, G.S., BRADLEY, C.J., MEITES, J.: Reduction of carcinogen-induced mammary cancer incidence in rats by early treatment with hormones or drugs. Cancer Res. 34, 2953–2956 (1974).

    PubMed  CAS  Google Scholar 

  14. KRAMER, C.Y.: Extension of multiple range tests to group means with unequal numbers of replications. Biometrics 12, 307–310 (1956).

    Article  Google Scholar 

  15. LEUNG, B.S., SASAKI, G.H., LEUNG, J.S.: Estrogen-prolactin dependency in 7, 12-dimethyl-benz(a)anthracene-induced tumors. Cancer Res. 35, 612–627 (1975).

    Google Scholar 

  16. LOWRY, O.H., ROSEBROUGH, N.J., FARR, A.L., RANDALL, R.J.: Protein measurement with folin phenol reagent. J. biol. Chem. 193, 265–175 (1951).

    PubMed  CAS  Google Scholar 

  17. MCGUIRE, W.L., CARBONE, P.P., SEARS, M.E., ESCHER, G.C.: Estrogen receptors in human breast cancer: an overview. In: McGuire, W.L., Carbone, P.P., Vollmer, E.P. (eds.). Estrogen Receptors in Human Breast Cancer. New York: Raven Press, pp. 1–7, 1975.

    Google Scholar 

  18. MCGUIRE, W.L., JULIAN, J.D.: Comparison of macromolecular binding of estradiol in hormone-dependent and hormone independent rat mammary carcinoma. Cancer Res. 31, 1440–1445 (1971).

    PubMed  CAS  Google Scholar 

  19. MEITES, J.: Relation of prolactin and estrogen to mammary tumor genesis in the rat. J. nat. Cancer Inst. 48, 1217–1224 (1972).

    PubMed  CAS  Google Scholar 

  20. MEITES, J., CASSELL, E., CLARK, J.: Estrogen inhibition of mammary tumor growth in rats: counteraction by prolactin. Proc. Soc. exp. Biol. (N.Y.) 137, 1225–1227 (1971).

    CAS  Google Scholar 

  21. MOBBS, B.G.: The uptake of tritiated estradiol by dimethylbenzan-thracene-induced mammary tumors of the rat. J. Endocr. 36, 409–414 (1966).

    Article  PubMed  CAS  Google Scholar 

  22. NAGASAWA, H., YANAI, R.: Effects of prolactin or growth hormone on growth of carcinogen-induced mammary tumors of adreno-ovariecto-mized rats. Int. J. Cancer 6, 488–495 (1970).

    Article  PubMed  CAS  Google Scholar 

  23. ODELL, W.D., RAYFORD, P.L., ROSS, G.T.: Simplified partially automated method for radioimmunoassay of human thyroid-stimulating growth and luteinizing hormone. J. Lab. clin. Med. 70, 973–980 (1967).

    PubMed  CAS  Google Scholar 

  24. PEARSON, O.H., LLERENA, O., LLERENA, L., MOLINA, A., BUTTER, T.: Prolactin dependent rat mammary cancer: A model for man? Trans. Ass. Amer. Phys. 82, 225–238 (1969).

    CAS  Google Scholar 

  25. QUADRI, S.K., KLEDZIK, G.S., MEITES, J.: Enhanced regression of DMBA-induced mammary cancers in rats by a combination of ergocor-nine with ovariectomy or high doses of estrogen. Cancer Res. 34, 499–501 (1974).

    PubMed  CAS  Google Scholar 

  26. RAYNAUD, J.P., BONNE, C., BOUTON, M.M., MOGUILEWSKY, M., PHILIBERT, D., AZADIAN-BOULANGER, G.: Screening for anti-hormones by receptor studies. J. Steroid Biochem., 6, 615–622 (1975).

    Article  PubMed  CAS  Google Scholar 

  27. RODBARD, D., LEWALD, J.E.: Computer analysis of radioligand assay and radioimmunoassay data. In: 2nd Karolinska Symposium on Research Methods in Reproductive Endocrinology. Diczflausy, E. (ed.). Acta endocr. (Kbh.) Suppl. 147, 79–103, 1970.

    Google Scholar 

  28. TALWALKER, P.S., MEITES, J., MIZUMO, H.: Mammary tumor induction by estrogen or anterior pituitary hormones in ovariectomized rats given 7, 12-dimehtyl-1,2benzanthracene. Proc. Soc. exp. Biol. (N.Y.) 116, 531–534 (1964).

    CAS  Google Scholar 

  29. TERENIUS, L.: Selective retention of estrogens isomers in estrogen-dependent breast tumors of rats demonstrated by in vitro methods. Cancer Res. 28, 328–337 (1968).

    PubMed  CAS  Google Scholar 

  30. TERENIUS, L.: Antiestrogens and breast cancer. Europ. Cancer. 7, 57–64 (1971).

    CAS  Google Scholar 

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Authors
  1. F. Labrie
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  2. P. A. Kelly
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  3. J. Asselin
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  4. J.-P. Raynaud
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Editor information

Editors and Affiliations

  1. Institut d’hématologie-oncologie de Montréal, 5400 ouest, boulevard Gouin, Montréal, Québec, H4J 1C5, Canada

    Guy St-Arneault

  2. The University of Alberta, Clinical Sciences Building, Edmonton, Alberta, T6G 2G3, Canada

    Pierre Band

  3. Centre Hospitalier Universitaire, Lariboisière, Paris, France

    Lucien Israël M. D. (Professor de Médecine) (Professor de Médecine)

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© 1976 Springer-Verlag Berlin · Heidelberg

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Labrie, F., Kelly, P.A., Asselin, J., Raynaud, JP. (1976). Potent Inhibitory Activity of a New Antiestrogen, RU 16 117, on the Development and Growth of DMBA-Induced Rat Mammary Adenocarcinoma. In: St-Arneault, G., Band, P., Israël, L. (eds) Breast Cancer. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 57. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81043-5_10

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  • DOI: https://doi.org/10.1007/978-3-642-81043-5_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81045-9

  • Online ISBN: 978-3-642-81043-5

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