Etiology of Childhood Bone Cancer: Epidemiologic Observations

  • R. W. Miller
Part of the Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer book series (RECENTCANCER, volume 54)


One of the most interesting clues to the origins of bone sarcoma has come from veterinary medicine. Veterinarians have long known that giant breeds of dogs are at much higher risk of bone cancer than smaller breeds. The difference was first quantitated in 1966 (41), and the risk was found to be 185 times greater in giant breeds, such as the Saint Bernard and Great Dane, than in breeds of small or medium size; the frequency of bone sarcoma was found to be 13 times that recorded in smaller dogs (Fig. 1). The histologic type could not readily be studied. It is noteworthy that veterinarians do not use the term Ewing’s tumor, perhaps partly because it is a very rare neoplasm in dogs and may not occur at all in other domestic species (2).


Death Certificate Osteogenesis Imperfecta Fibrous Dysplasia Bone Cancer Bone Sarcoma 
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© Springer-Verlag Berlin · Heidelberg 1976

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  • R. W. Miller

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