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The Immune-Status in Patients with Bone and Soft-Tissue Sarcomas

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Malignant Bone Tumors

Abstract

As the sarcoma develops in most cases at a stage of life when there is sufficient immunity, namely during the first three decades, immunological testing of sarcoma-bearing patients is extremely interesting. A further reason for examining sarcoma patients is the rapid development of metastases in this illness. This suggests that observation of the development over a short period will suffice for an assessment of the prognosis (8, 16). If careful clinical examination 6 months after actual treatment does not reveal metastases, the chances of survival are considerably better than if metastases are discovered.

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References

  1. AL-SARRAF, M., WONG, P., SARDESAI, S., VAITKEVICIUS, V.K.: Clinical immunologic responsiveness in malignant disease. Cancer 26, 262–268 (1970)

    Article  PubMed  CAS  Google Scholar 

  2. BRUN, F.E.: Die kutan-allergische Spätreaktion auf 2, 4-Dinitro-chlorobenzol bei Krebspatienten unter zytostatischer Chemotherapie. Schweiz, med. Wschr. 101, 1235–1243 (1971)

    CAS  Google Scholar 

  3. COHEN, A.M., KETCHAM, A.S., MORTON, D.L.: Tumor-specific cellular cytotoxicity to human sarcomas: evidence for a cell-mediated host immune response to a common sarcoma cell-surface antigen. J. nat. Cancer Inst. 50, 585–589 (1973)

    PubMed  CAS  Google Scholar 

  4. COLEY, W.B.: The treatment of inoperable sarcoma by bacterial toxins. Proc. roy. Soc. Surg. Sed. 3, 1 (1909)

    Google Scholar 

  5. EILBER, F.R., MORTON, D.L.: Impaired immunologic reactivity and recurrence following cancer surgery. Cancer, 25, 362–367 (1970)

    Article  PubMed  CAS  Google Scholar 

  6. HELLSTRöM, I., HELLSTRöM, K.E., SJöGREN, H.O.: Demonstration of cell-mediated immunity to human neoplasms of various histological types. Int. J. Cancer 7, 1–16 (1971)

    Article  PubMed  Google Scholar 

  7. HOLLINSHEAD, A.C., STEWART, H.M., HERBERMANN, R.B.: Delayed-hyper-sensitivity reactions to soluble membrane antigens of human malignant lung cells. J. nat. Cancer Inst. 52, 327–337 (1974)

    PubMed  CAS  Google Scholar 

  8. KOTZ, R., SALZER-KUNTSCHIK, M., ZWEYMüLLER, K., SALZER, M.: Therapy and prognosis of the Ewing-sarcoma. Öst. Z. Onkol. 1, 15–22 (1974)

    Google Scholar 

  9. KOTZ, R., RELLA, W.: Überprüfung der zellulären Abwehrlage bei Patienten mit Knochentumoren. Verh. dtsch. Ges. Path. 58. 471–474 (1974)

    CAS  Google Scholar 

  10. MARCOVE, R.C., MIKé, VALERIE, HUVOS, A.G., SOUTHAM, C.M., LEVIN, A.G.: Vaccine trials for osteogenic sarcoma. A preliminary report. Ca. Cancer J, Clin. 23, 74–80 (1973)

    Article  CAS  Google Scholar 

  11. MAVLIGIT, G.M., AMBUS, U., GUTTERMAN, J.U., HERSH, E.M., MCBRIDE, C.M.: Antigen solubilized from human solid tumours: lymphocyte stimulation and cutaneous delayed hypersensitivity. Nature New Biol. 243, 188–190 (1973)

    PubMed  CAS  Google Scholar 

  12. MENDOZA, C.B., MOORE, G.E., WATNE, A.L., HIRAMOTO, R., JURAND, J.: Immunologic response following homologous transplantation of cultured human tumor cells in patients with malignancy. Surgery 64, 897–900 (1968)

    PubMed  Google Scholar 

  13. NADLER, S.H., MOORE, G.E.: Immunotherapy of malignant disease. Arch. Surg. 99, 376–381 (1969)

    Article  PubMed  CAS  Google Scholar 

  14. PERLMANN, P., O’TOOLE, D., UNSGAARD, B.: Cell-mediated immune mechanism of tumor cell destruction. Fed. Proc. 32, 153–155 (1973)

    PubMed  CAS  Google Scholar 

  15. PERPER, R.J., ZEE, T.W., MICHELSON, M.M.: Purification of lymphocytes and platelets by gradient centrifugation. J. lab. clin. Med. 72, 842–848 (1968)

    PubMed  CAS  Google Scholar 

  16. SALZER, M., SALZER-KUNTSCHIK, M., ZHUBER, K., PRICE, C.H.G., WIL-LERT, H.G., IMMENKAMP, M., GROH, P., MATEJOVSKY, Z., KEYL, W.: Therapie und Prognose des kindlichen Osteosarkoms. Z. Orthop. (in press)

    Google Scholar 

  17. VáNKY. F., STJERNSWäRD, J., NILSONNE, U.: Cellular immunity to human sarcoma. J. nat. Cancer Inst. 46. 1145–1151 (1971)

    PubMed  Google Scholar 

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Kotz, R., Rella, W., Salzer, M. (1976). The Immune-Status in Patients with Bone and Soft-Tissue Sarcomas. In: Grundmann, E. (eds) Malignant Bone Tumors. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 54. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80997-2_16

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  • DOI: https://doi.org/10.1007/978-3-642-80997-2_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80999-6

  • Online ISBN: 978-3-642-80997-2

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