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Immunologische Bestimmung von Tumorantigenen

  • Conference paper
Anwendung immunologischer Methoden

Part of the book series: Zusammenarbeit von Klinik und Klinischer Chemie ((ZUSAMMENARBEIT))

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Zusammenfassung

Noch vor wenigen Jahren schien das Ziel der klinischen Tumorimmunologie greifbar nahe: die Immundiagnose,. Immunprophylaxe und Immuntherapie maligner Erkrankungen. Der Nachweis tumorspezifischer Antigene in experimentellen Systemen (74), das Auftreten gegen sie gerichteter spezifischer körpereigener Immunabwehrreaktionen und schließlich die im Experiment erwiesene leichte Manipulierbarkeit dieser biologischen Vorgänge ließen keinen Zeifel daran aufkommen, daß die Diagnose, Prophylaxe und Therapie auf immunologischer Grundlage auch bei malignen Erkrankungen des Menschen nur eine Frage der Zeit sei. Dies um so mehr, als in den letzten Jahren bei fast allen untersuchten menschlichen Tumoren das Vorkommen von Tumorantigenen und Tumorabwehrreaktionen wahrscheinlich gemacht war (Tab. 1) (8, 9, 16, 29, 33, 35, 36, 37, 39, 40, 42, 49, 60, 61, 68, 69, 75, 86, 96, 97). Inzwischen wissen wir, daß tumorspezifische Antigene nicht immer streng tumorspezifisch sind. Man prägte daher den Ausdruck „tumorassoziierte Antigene“. Die Unterschiede zwischen Tumorzellen und Normalzellen sind häufig nur quantitativer Natur.

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Authors
  1. W. M. Gallmeier
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  2. U. Bruntsch
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Editors and Affiliations

  1. Biochemische Forschung E. Merck, Darmstadt, Deutschland

    Hermann Lang

  2. Institut für Klinische Chemie und Laboratoriumsdiagnostik, Universität Düsseldorf, Deutschland

    Wirnt Rick

  3. Institut für Klinische Chemie, Universitätskliniken Gießen, Deutschland

    Ladislaus Róka

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Gallmeier, W.M., Bruntsch, U. (1975). Immunologische Bestimmung von Tumorantigenen. In: Lang, H., Rick, W., Róka, L. (eds) Anwendung immunologischer Methoden. Zusammenarbeit von Klinik und Klinischer Chemie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80984-2_3

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  • DOI: https://doi.org/10.1007/978-3-642-80984-2_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-07481-6

  • Online ISBN: 978-3-642-80984-2

  • eBook Packages: Springer Book Archive

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