Tumor Inductions by Cytostatics in Man

  • W. Hunstein
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 52)


By analogy with studies on ionizing radiation (48, 69), the title of this paper leads one to expect a number of individual case histories and statistical studies concerned with the induction of tumors by cytostatic drugs. The carcinogenic and leukemogenic effect of cytostatic drugs seems to be so surely proven in human beings that a discussion of this question seems hardly worth the effort. We know that cytostatic drugs have biologic effects that in 25 points are the same as these of ionizing radiation, and this knowledge has led to their classification as “radiomimetic” agents (13).


Multiple Myeloma Acute Leukemia Cytostatic Drug Tumor Induction Chronic Lymphatic Leukemia 
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  1. 1.
    ANDERSEN, E., VIDEBAEK, A.: A stem cell leukaemia in myelomatosis. Scand. J. Haemat. 7, 201 (1970).PubMedCrossRefGoogle Scholar
  2. 2.
    ANGUS, H. B., GUNZ, F. W.: Chronic granulocytic leukaemia and cancer. Blood 22, 88 (1963).PubMedGoogle Scholar
  3. 3.
    ARBUS, G. S., HUNG, R. H.: Hepatocarcinoma and myocardial fibrosis in an 8 3/4 year old renal transplant recipient. Canad. med. Ass. J. 9, 431 (1972).Google Scholar
  4. 4.
    ARSENEAU, J. C., SPONZO, R. W., LEVIN, D., SCHNIPPER, L. E., BRONNER, H. YOUNG, R. C., CANELLOS, G. P., JOHNSON, R. E., DE VITA, V. T.: Nonlym- phomatous malignant tumors complicating Hodgkin1s disease. New Engl. J. Med. 287, 119 (1972).CrossRefGoogle Scholar
  5. 5.
    BASHOUR, B. N., MANCER, K., RANCE, C. P.: Malignant mixed mullerian tumor of the cervix following cyclophosphamide therapy for nephrotic syndrome. J. Pediat. 82, 292 (1973).PubMedCrossRefGoogle Scholar
  6. 6.
    BERG, J. W.: The incidence of multiple primary cancers. J. nat. Cancer Inst. 38, 741 (1967).PubMedGoogle Scholar
  7. 7.
    BONADONNA, G., DELENA, M., BANFI, A., LATTUADA, A.: Secondary neoplasms in malignant lymphomas after intensive therapy. New Engl. J. Med. 289, 1242 (1973).Google Scholar
  8. 8.
    CASTRO, G. A. M., CHURCH, A., PECHET, L., SNYDER, L. M.: Leukemia after chemotherapy of Hodgkin’s disease. New Engl. J. Med. 289, 103 (1973).Google Scholar
  9. 9.
    CHLUD, K.: Das Therapiekonzept der chronischen Polyarthritis. Therapiewoche 21, 3527 (1971).Google Scholar
  10. 10.
    Cooperating Clinics Committee of the ARA: A controlled trial of cyclophosphamide in rheumatoid arthritis. New Engl. J. Med. 283, 883 (1970).Google Scholar
  11. 11.
    DAVIS, H. L., PROUT, M. N., MACKENNA, P. J., COLE, D. R., KOBITZ, B. C.: Acute leukemia complicating metastatic breast cancer. Cancer 31, 543 (1973).PubMedCrossRefGoogle Scholar
  12. 12.
    DEODHAR, S. D., KUKLINCA, A. G., VIDT, D. G., ROBERTSON, A. L., HAZARD, J. B.: Development of reticulum-cel1 sarcoma at the site of antilymphocyte globulin injection in a patient with renal transplant. New Engl. J. Med. 280, 1104 (1969).PubMedCrossRefGoogle Scholar
  13. 13.
    DUSTIN, P.: Nature (Lond.) 159, 794 (1947).CrossRefGoogle Scholar
  14. 14.
    EAST, J.: Immunpathology and neoplasms in New Zealand Black (NZB) and SJL/S mice. Progr. exp. Tumor Res. 13, 84 (1970).Google Scholar
  15. 15.
    Editorial: Transpalntation, Immunosuppression and Oncogenesis. J. Amer. med. Ass. 224, 1183 (1973).Google Scholar
  16. 16.
    ELSON, L. A., Radiation and radiomimetic chemicals. London: Butterworths 1963.Google Scholar
  17. 17.
    FASS, H.: über die zytostatische Behandlung des Plasmozytoms. Med. Wschr. 16, 389 (1962).Google Scholar
  18. 18.
    FRAUMENI, J. F., MILLER, R. W.: Drug-induced cancer. J. nat. Cancer Inst. 48, 1268 (1972).Google Scholar
  19. 19.
    GARDNER, S.D., FIELD, A., COLEMAN, D., HULME, B.: New human papovavirus (B. K.) isolated from urine after renal transplantation. Lancet 1971 1, 1253.PubMedCrossRefGoogle Scholar
  20. 20.
    GATTI, R. A., GOOD, R. A.: Occurrence of malignancy in immunodeficiency diseases. Cancer 28, 89 (1971).PubMedCrossRefGoogle Scholar
  21. 21.
    GOERTTLER, K.: Modell und Wirklichkeit der iatrogenen Cancerogenese. Verh. dtsch. Ges. Path. 56, 138 (1972).Google Scholar
  22. 22.
    GREUL, W., HULAND, J., SCHÄFER, H. J.: Zur Frage der Langzeittherapie des Plasmazytoms. Dtsch. med. Wschr. 98, 496 (1973).Google Scholar
  23. 23.
    GROSS, L.: Transmission of cancer in men. Cancer 28, 785 (1971).PubMedCrossRefGoogle Scholar
  24. 24.
    GRUNDMANN, E., HOBIK, H. P.: Lymphoretikul äre Sarkome bei immunologisch geschädigten Mäusen. Z. Krebsforsch. 79, 298 (1973).CrossRefGoogle Scholar
  25. 25.
    GUNZ, F. W., ANGUS, H. B.: Leukemia and cancer in the same patient. Cancer 18, 145 (1965).PubMedCrossRefGoogle Scholar
  26. 26.
    HARRIS, C. C.: Malignancy during Methotrexate and steroid therapy for Psoriasis. Arch. Derm. 103, 501 (1971).PubMedCrossRefGoogle Scholar
  27. 27.
    HARTWICH, G.: Nebenwirkungen cytostatischer und immunsuppressiver Therapie. Fortschr. Med. 91, 357 (1973).PubMedGoogle Scholar
  28. 28.
    HOLLAND, J. F.: Epidemic acute leukemia. New Engl. J. Med. 283, 1165 (1970).Google Scholar
  29. 29.
    HOOVER, R., FRAUMENI, J. F.: Risk of cancer in renal transplant recipients. Lancet 1973 3, 55.CrossRefGoogle Scholar
  30. 30.
    HUNSTEIN, W.: Ist Myleran (Busulphan) ein leukaemogenes Agens? Schweiz, med. Wschr. 95, 1437 (1965).Google Scholar
  31. 31.
    JEREMY, D.: Transplantation of malignant melanoma with cadaver Kidney. Transplantation 13, 619 (1972).PubMedCrossRefGoogle Scholar
  32. 32.
    KELLETER, R., KUHN, D., SCHNYDER, U. W,.SCHROETER, R.: Lymphoretikuläre Hyperplasie nach dreijähriger Methotrexatbehandlung einer Psoriasis. Dtsch. med. Wschr. 97, 614 (1972).CrossRefGoogle Scholar
  33. 33.
    KLEMM, D., MERKER, H., WESTERHAUSEN, M.: Akute Neuproliferation bei para- proteinämische Hämoblastosen unter langdauernder Cytostatikabehandlung. Dtsch. med. Wschr. 93., 2063 (1968).Google Scholar
  34. 34.
    KNUDSON, A. G.: Mutation and human cancer. Advanc. Cancer Res. 17, 317 (1973).CrossRefGoogle Scholar
  35. 35.
    KYLE, R. A., PIERRE, R. V., BAYRD, E. D.: Multiple myeloma and acute myelomonocytic leukemia. New Engl. J. Med. 283, 1121 (1970).Google Scholar
  36. 36.
    KYUNG-WHAN, M., GYÖRKEY,.: Interstitial pulmonary fibrosis, atypical epithelial changes and bronchiolar cell carcinoma following busulfan therapy. Cancer 22, 1027 (1968).CrossRefGoogle Scholar
  37. 37.
    LAURSEN, B.: Cancer in the bladder in patients treated with chlornaphazine. Brit. med. J. 3, 684 (1970).PubMedCrossRefGoogle Scholar
  38. 38.
    LEB, D. E., HOWELL, R. S.: Carcinoma of the testis in a renal transplant recipient. Amer. J. med. Sei. 262, 171 (1971).CrossRefGoogle Scholar
  39. 39.
    LECATSAS, G., PROZESKY, O. W., WYK, J. van: Papovavirus in urine after renal transplantation. Nature 241, 343 (1973).Google Scholar
  40. 40.
    Leading article: Transplacental carcinogenesis. Lancet 1973 2, 1425.Google Scholar
  41. 41.
    LIPSMEYER, E. A.: Development of malignant cerebral lymphoma in a patient with SLE treated with immunosuppression. Arthr. and Rheum. 15, 183 (1972).CrossRefGoogle Scholar
  42. 42.
    LOKICH, J. J., MOLONEY, W. C.: Hodgkin’s disease and chronic lymphatic leukemia. Oncology 26, 466 (1972).PubMedCrossRefGoogle Scholar
  43. 43.
    MANNY, N., ROSENMAN, E., BENBASSAT, J.: Hazard of immunosuppressive therapy. Brit. med. J. 2, 291 (1972).PubMedCrossRefGoogle Scholar
  44. 44.
    MCEWAN, A., PETTY, L. G.: Oncogenicity of immunosuppressive drugs. Lancet 1972 1, 326.PubMedCrossRefGoogle Scholar
  45. 45.
    MICHLMAYR, G., GÜNTHER, R., LEDERER, B., HUBER, H.: Malignes Lymphom nach zweijähriger immunosuppressiver Therapie einer Periarteriitis nodosa. Med. Kl in. 68, 180 (1973).Google Scholar
  46. 46.
    MICHOT, F.: Beitrag zum Problem des Plasmozytoms ohne Paraprotein. Dtsch. med. Wschr. 93, 2072 (1968).Google Scholar
  47. 47.
    MICHOT, F.: Erfahrungen in der Langzeitbehandlung von Kol 1agenkrankheiten mit Azathioprin (Imman R). Med. Klin. 63, 1262 (1968).PubMedGoogle Scholar
  48. 48.
    MOLE, R. H.: Late effects of radiation: carcinogenesis. Brit. med. Bull. 29, 78 (1973).Google Scholar
  49. 49.
    NELSON, B. M., ANDREWS, G. A.: Breast cancer and cytologic dysplasia in many organs after busulfan (Myleran). Amer. J. clin. Path. 42, 37 (1964).Google Scholar
  50. 50.
    PENN, I., STARZL, T. E.: Immunosuppression and cancer. Proc. 4th Int. Congr. Transplant. Soc. (in press).Google Scholar
  51. 51.
    PENN, I., STARZL, T. E.: Malignant tumors arising de novo in immunosup- pressed organ transplant recipients. Transplantation 14, 407 (1972).PubMedCrossRefGoogle Scholar
  52. 52.
    PETERSEN, H. S.: Erythroeukaemia in a Melphalan-treated patient with primary macroglobulinaemia. Scand. J. Haemat. 10, 5 (1973).PubMedCrossRefGoogle Scholar
  53. 53.
    RENNER, K.: Kasuistischer Beitrag zur Frage der Neuentstehung maligner Neoplasmen unter cytostatischer Therapie. Strahlentherapie 142, 308 (1971).PubMedGoogle Scholar
  54. 54.
    RENNER, W. A.: Erfahrungen mit Endoxan und Mitarson bei einem metasta- sierenden Mamma Carcinom. Med. Klin. 58, 254 (1963).PubMedGoogle Scholar
  55. 55.
    RIECHE, K.: Zur Frage der Cancerogenitat von Cytostatika. Arch. Geschwulstforsch. 34, 240 (1969).PubMedGoogle Scholar
  56. 56.
    RIEDLER, G. F., VORBURGER, E., MAIER, C.: Unreifzel1 ige Leukosen und Myelom. Schweiz, med. Wschr. 102, 1592 (1972).Google Scholar
  57. 57.
    ROUZAUD, M., LEROUX, M. E., LAMISSE, F.: Erythromyelose aigue aleicemique et lesions diffuses de periarterite noueuse. Sem. Hop. Paris 45, 2831 (1969).PubMedGoogle Scholar
  58. 58.
    RUPPPRECHT, L., BLESSING, M. M.: Fibrosarkon der Harnblase nach siebenjähriger Chemotherapie einer Lymphogranulomatose im Kindesalter. Dtsch. med. Wschr. 93, 1663 (1973).Google Scholar
  59. 59.
    SCHAEFER, U. W., KANZLER, G.: Leukämie bei Morbus Hodgkin. Med. Klin. 67, 1024 (1972).PubMedGoogle Scholar
  60. 60.
    SCHEIDEGGER, S.: Lungenfibrose, rezidivierende Vasculitis und multizentrisches Lungencarcinom nach cytostatischer Therapie mit Alkeran. Verh. dtsch. Ges. Path. 56, 364 (1972).Google Scholar
  61. 61.
    SCHILLING, R. F., MEYER, O. O.: Treatment of chronic granulocytic leukemia with 1,4-Dimethansulfonyloxybutase (Myleran). New Eng. J. Med. 254, 986 (1956).PubMedCrossRefGoogle Scholar
  62. 62.
    SCHMITT-KÖPPLER, A.: Die Umkehrwirkung eines Zytostatikums als mögliche Ursache eines Analkarzinoms. Therapiewoche 22, 1592 u. 1595 (1972).Google Scholar
  63. 63.
    SCHOLZ, G., REHN, K., HUNSTEIN, W.: Hodgkinsarkom bei immunsuppressiv behandeltem Erythematodes visceralis. Verh. dtsch. Ges. inn. Med. 79, 1376 (1973).PubMedGoogle Scholar
  64. 64.
    SHARON, E., PAOLINO, J. S., KAPLAN, D.: Lymphoma and Azathioprine. Arthr. Rheum. (N. Y.) 15, 558 (1972).CrossRefGoogle Scholar
  65. 65.
    SMIT, C. G. S., MEYLER, L.: Acute myeloid leukaemia after treatment with cytostatic agents. Lancet 1970 2, 671.PubMedCrossRefGoogle Scholar
  66. 66.
    STICH, W., LANGHAMMER, H.: Multiple Karzinome und Leukämie. Münch, med. Wschr. 109, 1597 (1969).Google Scholar
  67. 67.
    THIEDE, T., CHIEVITZ, E., CHRISTENSEN, B. C.: Chiornaphazine as a bladder carcinogen. Acta med. scand. 175, 721 (1964).PubMedCrossRefGoogle Scholar
  68. 68.
    TOMATIS, R., MOHR, L. U., DAVIS, W.: Transplacental Carcinogenesis. International Agency for Research on Cancer. Scientific publication No. 4 (1973).Google Scholar
  69. 69.
    UNSCEAR: Ionizing radiation: levels and effects, Vol. II: Effects (a report of the United Nations Scientific Committee on the effects of atomic radiation to the General Assembly, with appendices). New York: United Nations 1972.Google Scholar
  70. 70.
    UROWITZ, M. B., GORDON, D. A., SMYTHE, H. A., PRUZANSKI, W., OGRYZLO, M. A.: Azathioprine in rheumtoid arthritis. Arthr. and Rheum. 16, 411 (1973).CrossRefGoogle Scholar
  71. 71.
    WHITELAW, D. M.: Multiple primary carcinomas associated with Hodgkin’s disease. Canad. med. Ass. J. 99, 291 (1968).Google Scholar
  72. 72.
    WILDHACK, R.: Monozytenleukämie mit yG-Paraproteinämie nach Röntgenbestrahlung und zytostatischer Behandlung eines Myosarkoms. Dtsch. med. Wschr. 95, 40 (1970).Google Scholar
  73. 73.
    ZWAAN, F. E., SPECK, B.: Acute myelomonocytic leukemia in a patient with Hodgkin’s disease. Acta haemat. 49, 291 (1973).PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin · Heidelberg 1975

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  • W. Hunstein

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