Gliomas pp 20-34 | Cite as

Refinement of the Avian Oncornavirus-Induced Primary Rat Brain Tumor Model for Therapeutic Screening

  • D. D. Bigner
  • D. J. Self
  • J. Frey
  • R. Ishizaki
  • A. J. Langlois
  • J. A. Swenberg
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 51)

Abstract

The relevance of animal models for human disease is a topic often hotly debated by experimentalists, especially when the animal model is to be used to evaluate unproven and potentially hazardous therapeutic innovations prior to initial clinical investigation. For decades general oncologists (1, 2) have argued for the use of primary, autochthonous tumors rather than transplanted tumors on the basis of 1) potential or proven differences between transplanted tumor and host histocompatibility antigens; 2) the possibility of tumor contamination by virus or mycoplasma during transplant; and 3) the selection of cells during serial transplantation possessing growth properties unlike those of primary tumors. Moreover, neuro-oncologists (3, 4, 5) have felt that most transplanted brain tumor models differed greatly from the histological type of the most serious human brain tumor problem, the glioblastoma multiforme — anaplastic astrocytoma tumor group, and that blood supply and blood-brain barrier alterations were markedly different in transplanted and primary brain tumors. Nevertheless, the majority of therapeutic trials in brain tumor animal models, both chemotherapeutic and immunotherapeutic, have been conducted with transplanted tumors (620). One of the commonly used murine transplanted tumors, an ependomyoblastoma, was induced over 30 years ago and is now expressing large amounts of infectious murine mammary tumor virus (21).

Keywords

DMSO Leukemia Sarcoma Neurol Fibril 

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1975

Authors and Affiliations

  • D. D. Bigner
  • D. J. Self
  • J. Frey
  • R. Ishizaki
  • A. J. Langlois
  • J. A. Swenberg

There are no affiliations available

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