The Role of Lysyl Residue in Collagen Structure with Calcification and Aging
Collagen comprises about 90% of bone matrix. There are conflicting theories of calcification mechanism. Ultrastructural studies of cartilage and bone matrix revealed the cellular process of initial calcification (BONUCCI, 1967). On the other hand, from the epitactic theory by NEUMAN and NEUMAN (1953) to the charge neutralization theory by URRY (1971), the major role of collagen remains that of inducing mineralization. Crosslinks of collagen occur following the enzymatic conversion of the lysyl or hydroxylysyl residue in peptide linkage to aldehyde. The degree of crosslinks may affect the number of residues of lysine or hydroxylysine obtained from collagen hydrolysate.
KeywordsHydrolysis Osteoporosis Citrate Aldehyde Proline
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