Effects of Supply and Withdrawal of Fluoride on the Concentration of Fluoride and Glycosaminoglycans in Cortical Bone from Rabbits
Fluoride effects on bone have been extensively studied but little attention has been paid to possible alterations of the organic constituents. The reversibility of manifest skeletal fluorosis has also been scarcely investigated. As acid glycosaminoglycans (GAG:s) have been associated with bone mineralization, and skeletal fluorosis is characterized by excessive bone formation and resorption, this investigation was carried out with the aims of studying the relationship between morphological alterations and concentrations of fluoride and organic constituents (GAG:s and hydroxyproline) during fluoride ingestion and after its withdrawal. Furthermore age-related changes were studied and an attempt was made to isolate keratan sulphate.
KeywordsHyaluronic Acid Cortical Bone Fluoride Concentration Keratan Sulphate Organic Constituent
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