Abstract
The concept of antiandrogens is now nearly 40 years old. In the early days, it was the oestrogens which had in certain bioassays, like the chicken-comb test, antiandrogenic properties. A detailed discussion of this aspect has been provided by Yoss (17, pp. 474–476) in the first part of his textbook. Although there is no doubt that oestrogens can possess antiandrogenic activity in certain test models and at certain target organs, they are not listed among the antiandrogens any more.
From the Research Laboratories of Schering AG, Berlin-Bergkamen/Germany, Department of Endocrinpharmacology, 1000 Berlin 65, Müllerstraße 170–172, West-Germany.
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References
Belham, J.E., Neal, G.E.: Testosterone action in the rat ventral prostate. The effects of diethylstilboestrol and cyproterone acetate on the metabolism of [3H] testosterone and the retention of labelled metabolites by rat ventral prostate in vivo and in vitro. Biochem. J. 125, 81–91 (1971).
Belham, J.E., Neal, G.E., Williams, D.C.: Testosterone metabolism in the rat ventral prostate. Biochem. J. 109, 33P-34P (1968).
Belham, J.E., Neal, G.E., Williams, D.C.: The reception of androgens in the rat ventral prostate. Biochem. J. 114, 32P (1969).
Belham, J.E., Neal, G.E., Williams, D.C.: Testosterone metabolism in the rat ventral prostate. Biochim. biophys. Acta (Amst.) 187, 159–162 (1969).
Breuer, H., Hoffmann, W.: Wirkungsmechanismus eines Antiandrogens auf die Andro- gen-Biosynthese. Naturwissenschaften 54, 616–617 (1967).
Dorfman, R.I. (Ed.): “Methods in Hormone Research”, vol. IIa “Bioassay”, 2nd Edition. New York and London: Academic Press 1969.
Dorfman, R.I.: Biological activity of antiandrogens. Brit. J. Derm. 82, Suppl. 6, 3–8 (1970).
Fang, S., Anderson, K.M., Liao, S.: Receptor proteins for androgens. On the role of specific proteins in selective retention of 17β-hydroxy-5α-androstan-3-one by rat ventral prostate in vivo and in vitro. J. biol. Chem. 244, 6584–6595 (1969).
Fang, S., Liao, S.: Antagonistic action of antiandrogens on the formation of a specific dihydrotestosterone-receptor protein complex in rat ventral prostate. Molec. Pharmacol. 5, 428–431 (1969).
Fang, S., Liao, S.: Androgen receptors. Steroid- and tissue-specific retention of a 17β-hydroxy-5α-androstan-3-one-protein complex by the cell nuclei of ventral prostate. J. biol. Chem. 246, 16–24 (1971).
Geller, J., Damme, O. van, Garabieta, G., Loh, A., Rettura, J., Seifter, E.: Effects of cyproterone acetate on 3H-testosterone uptake and enzyme synthesis by the ventral prostate of the rat. Endocrinology 84, 1330–1335 (1969).
Geller, J., Loh, A., Winograd, J.: Effect of cyproterone acetate on 3H-testosterone uptake and enzyme synthesis by the ventral prostate of the rat. Excerpta med. (Amst.), Int. Congr. Ser. 157, Abstr. No. 312 (1968).
Hoffmann, W., Breuer, H.: Wirkung von l,2α-Methylen-6-chlor-Δ4,6-pregnadien-17α- ol-3,20-dion (Cyproteron) auf die Biogenese von C19-Steroiden in Rattentestes. Acta endocr. (Kbh.) 57, 623–638 (1968).
Neumann, F., Elger, W., Steinbeck, H., Berswordt-Wallrare, R. von: Antiandrogene. In: E. Klein (Ed.). “Das Testosteron - Die Struma”, S. 78–101. Berlin-Heidelberg-New York: Springer 1968.
Stern, J.M., Eisenfeld, A. J.: Androgen accumulation and binding to macromolecules in seminal vesicles: inhibition by cyproterone. Science 166, 233–235 (1969).
Stern, J.M., Eisenfeld, A.J.: Distribution and metabolism of 3H-testosterone in castrated male rats, effects of cyproterone, progesterone and unlabeled testosterone. Endocrinology 88, 1117–1125 (1971).
Voss, H.E.: Biologie der Androgene. In: H.E. Voss, G. Oertel (Eds.), “Androgene I”, Handbuch der experimentellen Pharmakologie XXXV/1, chapt. 6, pp. 327–528. Berlin- Heidelberg-New York: Springer 1973.
Walsh, P.C., Korenman, S.G.: Action of antiandrogens: preservation of 5α-reductase activity and inhibition of chromatin-dihydrotestosterone complex formation. Clin. Res. 18, 126 (1970).
Walsh, P.C., Korenman, S.G.: Mechanism of androgenic action: effect of specific intracellular inhibitors. J. Urol. (Baltimore) 105, 850–857 (1971).
References
Andersson, K.M., Liao, S.: Selective retention of dihydrotestosterone by prostatic nuclei. Nature (Lond.) 219, 277 (1963).
Baulieu, E.-E., Jung, I.: A prostatic cytosol receptor. Biochem. biophys. Kes. Commun. 38, 599 (1970).
Baulieu, E.-E., Jung, I., Blondeau, J.P., Kobel, P.: Androgen receptors in rat ventral prostate. Schering Workshop on Steroid Hormone ‘Receptors’, Berlin, December 7–9, In: Raspe, G. (Ed.). “Advances in the Biosciences 7”. Vieweg: Pergamon Press 1971.
Baulieu, E.-E., Lasnitzki, I., Röbel, P.: Metabolism of testosterone and action of metabolites on prostate glands grown in organ culture. Nature (Lond.) 219, 1155 (1968).
Beach, F.A., Westbrook, W.H.: Morphological and behavioral effects of an ‘antiandrogen’ in male rats. J. Endocr. 42, 379 (1968).
Belham, J.E., Neal, G.E.: Testosterone action in the rat ventral prostate. Bioehem. J. 125, 81 (1971).
Belham, J.E., Neal, G.E., Williams, D.C.: Testosterone metabolism in the rat ventral prostate. Bioehem. J. 109, 33P (1968).
Belham, J.E., Neal, G. E., Williams, D.C.: The reception of androgens in the rat ventral prostate. Bioehem. J. 114, 32P (1969).
Belham, J.E., Neal, G.E., Williams, D.C.: Testosterone metabolism in the rat ventral prostate. Biochim. biophys. Acta (Amst.) 187, 159 (1969).
Boris, A.: Endocrine studies of a nonsteroid anti-androgen and progestin. Endocrinology 76, 1062 (1965).
Boris, A., Martino, L. de, Trmal, T.: Studies on the endocrine properties of a new progestational steroid, 4,6-dichloro-16-methylene-17-hydroxy-4,6-pregnadiene-3,20-dione- 17-acetate (MDAP). Steroids 18, 399 (1971).
Boris, A., Stevenson, R.H.: Further studies on a nonsteroidal anti-androgen. Endocrinology 78, 549 (1966).
Bridge, R.W., Scott, W.W.: A new antiandrogen, SH-714. Invest. Urol. 2, 99 (1964).
Brooks, J.R., Busch, R.D., Lopez-Ramos, B., Holt, W.R., Steelman, S.L., Patαnelli, D.J.: The effect of a new anti-androgen on canine prostatic acid phosphatase. Proc. Soc. exp. Biol. (N.Y.) 142, 1063 (1972).
Bruchovsky, N., Wilson, J.D.: The conversion of testosterone to 5-alphα-androstan- 17-betα-ol-3-one by rat prostate in vivo and in vitro. J. biol. Chem. 243, 2012 (1968).
Byrnes, W.W., Stafford, R.O., Olson, K.J.: Anti-gonadal hormone activity of 11α- hydroxy-progesterone. Proc. Soc. exp. Biol. (N.Y.) 82, 243 (1953).
Chandra, P., Orii, H., Wacker, A.: Effect of an anti-androgenic steroid on the testo- sterone-stimulated activity of aggregate polymerase in the prostate nuclei of rats. Hoppe- Seylers Z. physiol. Chem. 348, 1085 (1967).
Dahnke, H-G., Scheuer, A., Mosebach, K.-O.: Der Einfluß von Testosteron und Cyproteronacetat auf die Mitoserate, den Nukleinsäurestoffwechsel und die Histomorphologie der Vesikulardrüsen von Ratten. 17. Symp. Dtsch. Ges. Endokrin. (Abstract No. 35) Acta endocr. (Kbh.) Suppl. 152, 35 (1971).
Dörner, G., Götz, F., Mainz, K.: Influence of antiandrogens on sexual behavior and gonadal function in male rats. Endocr. exp. 6, 17 (1972).
Dorfman, R.I.: Anti-androgens in a castrated mouse test. Steroids 2, 185 (1963).
Dorfman, R.I.: Antiandrogenie, antiestrogenic, and antiovulatory compounds. In: Martini, L. and Pecile, S. (Eds.). “Hormonal Steroids”, vol. 1. Proc. 1st Int. Congr. Hormonal Steroids, Milan/Italy. New York-London: Academic Press 1964.
Fang, S., Anderson, K.M., Liao, S.: Receptor proteins for androgens. J. biol. Chem. 244, 6584 (1969).
Fang, S., Liao, S.: Androgen receptors. J. biol. Chem. 246, 16 (1971).
Geller, J., Damme, O. van, Garabieta, G., Loh, A., Rettura, J., Seefter, E.: Effect of cyproterone acetate on 3H-testosterone uptake and enzyme synthesis by the ventral prostate of the rat. Endocrinology 84, 1330 (1969).
Geller, J., Moy, K.: Correlation of biologic and biochemical effects of antiandrogens on rat ventral prostate. Clin. Res. 20, 177 (1972).
Greer, D.S.: The distribution of radioactivity in non-excretory organs of the male rat after injection of testosterone-4-C14. Endocrinology 64, 898 (1959).
Hamada, H., Neumann, F., Junkmann, K.: Intrauterine antimaskuline Beeinflussung von Rattenfeten durch ein stark gestagen wirksames Steroid. Acta endocr. (Kbh.) 44, 380 (1963).
Harding, B.W., Samuels, L.T.: The uptake and subcellular distribution of C14-labeled steroid in rat ventral prostate following in vivo administration of testosterone-4-C14. Endocrinology 70, 109 (1962).
Hasan, S.H., Neumann, F., Schenck, B.: Long-term effect of cyproterone on testosterone levels in male rats. 19. Symp. Dtsch. Gesellschaft f. Endokrinologie, Berlin, March 1973. Acta endocr. (Kbh.) 173, 119 (1973).
Jäger, E., Mosebach, K.-O., Blumenthal, H.-P., Scheuer, A.: The influence of cyproterone acetate on the uptake of testosterone and on the DNA- and RNA-amount in liver, prostate and seminal vesicles of immature male rats in vivo. Acta endocr. (Kbh.) Suppl. 138, 43 (1969).
Jung, I., Baulieu, E.-E.: Neo-nuclear androgen receptor in rat ventral prostate. Bio- chimie 53, 807 (1971).
Junkmann, K., Neumann, F.: Zum Wirkungsmechanismns von an Feten antimaskulin wirksamen Gestagenen. Acta endocr. (Kbh.) Suppl. 90, 139 (1964).
Kincl, F.A., Dorfman, R.I.: Anti-ovulatory activity of subcutaneously injected steroids in the adult oestrus rabbit. Acta endocr. (Kbh.) Suppl. 73, 3 (1963).
Kincl, F.A., Dorfman, R.I.: Anti-ovulatory activity of steroids administered by gavage in the adult oestrus rabbit. Acta endocr. (Kbh.) Suppl. 73, 17 (1963).
Kincl, F.A., Maqueo, M., Dorfman, R.I.: Influence of various steroids on testes and accessory organs in the rat. Acta endocr. (Kbh.) 49, 145 (1965).
Kraft, H.G., Kiesler, H.: Anti-estrogenic and anti-androgenic activities of Chlormadinone acetate and related compounds. II. Int. Congr. Hormonal Steroids, Milan/Italy 1966. Experta med. (Amst.) Int. Congr. Ser. 111, 346 (1966).
Kühnel, W.: Antiandrogeneffekte an den Geschlechtsorganen männlicher Ratten. Verh. anat. Ges. (Jena) 64, 149 (1969).
Lakshman, A.B., Isaac, P.: Effects of cyproterone acetate on the adeno-hypophysial cells of male rats. J. Reprod. Fertil. 32, 141 (1973).
Lerner, L. J.: Hormone antagonists: inhibitors of specific activities of estrogen and androgen. Recent Progr. Hormone Res. 20, 435 (1964).
Lerner, L.J., Bianchi, A., Borman, A.: A-norprogesterone, an androgen antagonist. Proc. Soc. exp. Biol. (N.Y.) 103, 172 (1960).
Mahesh, V.B., Zarate, A., Roper, B.K., Greenblatt, R.B.: Studies on the action of 17α-methyl-B-nortestosterone as an antiandrogen. Steroids 8, 297 (1966).
Mainwaring, W.I.P.: The binding of (1,2-3H)testosterone within the nucleus of the rat prostate. J. Endocr. 44, 323 (1969).
Maxnwaring, W.I.P.: A soluble androgen receptor in the cytoplasm of rat prostate. J. Endocr. 45, 531 (1969).
Mainwaring, W.I.P.: The binding of androgenic steroids in target cells. In: James, V.H.T. and Martini, L. (Eds.), “Hormonal Steroids”, p. 368. Amsterdam: Excerpta Medica 1971.
Mainwaring, W.I.P., Mangan, F.R.: The specific binding of steroid-receptor complexes to DNA: evidence from androgen receptors in rat prostate. Schering Workshop on Steroid Hormone ‘Receptors’, Berlin, December 7–9, 1970. In: Raspè, G. (Ed.), “Advances in the Biosciences 7”. Vie weg: Pergamon Press 1971.
Mangan, F.R., Mainwaring, W.I.P.: The biochemical basis for the antagonism by BOMT of the effects of dihydrotesterone on the rat ventral prostate gland. Gynecol. Invest. 2, 300 (1971/1972).
Mangan, F.R., Mainwaring, W.I.P.: An explanation of the antiandrogenic properties of 6α-bromo-17β-hydroxy-17α-methyl-4-oxα-5α-androstane-3-one. Steroids 20, 331 (1972).
Massa, R., Martini, L.: Interference with the 5α-reduetase system. Gynecol. Invest. 2, 253 (1971/1972).
Mertelsmann, R., Kreuzer, T., Matthaei, H.: Wirkung von Testosteron und Cypro- teron auf die RNA-Polymerase-Aktivität von homogenisierten Zellkernen aus humaner Placenta. Hoppe-Seylers Z. physiol. Chem. 349, 10 (1968).
Neri, R.O.: Some biological properties of antiandrogens. In: James, V.H.T. and Martini, L. (Eds.), “Hormonal Steroids”. Amsterdam: Excerpta Medica 1971 (p. 1022).
Neri, R.O., Casmer, CH., Zeman, W.V., Fielder, F., Tabachnick, I.I.A.: Effects of an anti-androgen, SH 714 (6-chlor-Δ6-l,2α-methylen-17α-hydroxyprogesterone acetate, cyproterone acetate) on canine prostatic hyperplasia. Endocrinology 82, 311 (1968).
Neri, R., Florance, K., Koziol, P., Cleave, S. van: A biological profile of a nonsteroidal antiandrogen, Sch 13521 (4/-nitro-3/-trifiuoromethylisobutyranilide). Endocrinology 91, 427 (1972).
Neri, R. O., Monahan, M.: Effects of a novel nonsteroidal antiandrogen on canine prostatic hyperplasia. Invest. Urol. 10, 123 (1972).
Neri, R.O., Monahan, M.D., Meyer, J.G., Afonso, B.A., Tabachnick, I.A.: Biological studies on an anti-androgen (SH 714). Europ. J. Pharmacol. 1, 438 (1967).
Neumann, F.: Methods for evaluating antisexual hormones. Proceedings of the Int. Symposium “Methods in Drug Evaluation”, Milan 1965. North-Holland Publ. Company, p. 548 (1966).
Neumann, F., Berswordt-Wallrabe, R. von, Elger, W., Steinbeck, H.: Experimentelle Grundlagen und klinische Anwendungsmöglichkeiten von Antiandrogenen. Verh. dtsch. Ges. Path. 76, 1176 (1970).
Neumann, F., Elger, W.: The effect of a new antiandrogenic steroid, 6-ehloro-17-hydroxy- lα,2α-methylenepregnα-4,6-diene-3,20-dione acetate (cyproterone acetate) on the sebaceous gland of mice. J. invest. Derm. 46, 561 (1966).
Neumann, F., Elger, W., Berswordt-Wallrabe, R. von, Kramer, M.: Restitution der akzessorischen Geschlechtsdrüsen nach Langzeitbehandlung mit einem Androgen-Antagonisten (Cyproteronacetat). Naunyn-Sehmiedebergs Arch. Pharmak. exp. Path. 255, 236 (1966).
Neumann, F., Richter, K.-D., Günzel, P.: Wirkungen von Antiandrogenen. Zbl. Vet.- Med., Reihe A, 12, 171 (1965).
Neumann, F., Steinbeck, H.: Antiandrogene. Internist (Berl.) 12, 198 (1971).
Neumann, F., Steinbeck, H., Elger, W., Berswordt-Wallrabe, R. von: Hoden: Morphologie und Funktion unter der Einwirkung von PMS und HCG bei gleichzeitiger Antiandrogenbehandlung. Acta endoer. (Kbh.) 57, 639 (1968).
Rajalakshmi, M., Prasad, M.R.N.: Alterations in sialic acid in the epididymis of the puberal rat in response to changes in functional activity of the testis. J. Reprod. Fertil. 24, 409 (1971).
Randall, L.O., Selitto, J. J.: Anti-androgenie activity of a synthetic phenanthrene. Endocrinology 62, 693 (1958).
Rasmusson, G.H., Chen, A., Reynolds, G.F., Patanelli, D.J., Patchett, A.A., Arth, G.E.: Antiandrogens. 2/,3/α-tetrahydrofuran-2/-spiro-17-(l,2α-methylene-4-andro- sten-3-one). J. med. Chem. 15, 1165 (1972).
Resko, J. A., Goy, R.W., Phoenix, C.H.: Uptake and distribution of exogenous testosterone-1,2-3H in neural and genital tissues of the castrate guinea pig. Endocrinology 80, 490 (1967).
Rosenkrantz, H., Ilievski, V.: Estimated testosterone requirements of the castrated male dog. Amer. J. vet. Res. 25, 47 (1963).
Rosenkrantz, H., Mason, M.M.: The bioevaluation of estrogenic compounds by the canine prostatic secretion method. Cancer Chemother. Rep. 20, 33 (1962).
Santti, R.S., Johansson, R.: Action of cyproterone on the rat prostate in organ culture. Gynecol. Invest. 2, 276 (1971/1972).
Saunders, H.L., Holden, K., Kerwin, J.F.: The anti-androgenic activity of 17α- methyl-B-nortestosterone (SK & F 7690). Steroids 3, 687 (1964).
Saunders, H.L., Kerwin, J.F.: The anti-androgenic activity of B-norandrostanes. In: Martini, L., Fraschini, FR. and Motta, M. (Eds.) “Hormonal Steroids”. Amsterdam: Excerpta Medica 1967 (p. 599).
Saunders, H.L., Tomaszewski, J., Pauls, J., Zuccarello, W.: Antifertility effect of 17α-methyl-B-nortestosterone (SK & F 7690). Endocrinology 85, 960 (1969).
Sayler, A.: The effect of anti-androgens on aggressive behavior in the gerbil. Physiol. Behav. 5, 667 (1970).
Scheuer, A., Dahnke, H.-G., Jäger, E., Mosebach, K.-O.: Einfluß von Cyproteronacetat auf den DNA- und RNA-Gehalt, den Einbau von (14C)Uridin in die RNA sowie die Aufnahme von (14C)Testosteron in einigen Organen unreifer männlicher Ratten. Hoppe- Seylers Z. physiol. Chem. 350, 1570 (1969).
Scheuer, A., Dahnke, H.-G., Mosebach, K.-O.: Veränderungen der Nukleinsäure- konzentrationen in einigen Organen wachsender männlicher Ratten sowie ihre Beeinflussung durch Cyproteronacetat und Testosteron. 17. Symp. Dtsch. Ges. Endokrin. Acta endoer. (Kbh.) Suppl. 152, 34 (1971).
Schmidtke, D., Schmidtke, H.-O.: Ein neues Antiandrogen beim Hund. Kleintier-Prax. 13, 146 (1968).
Schreiber, V., Pribyl, T., Rohacova, J.: Effect of the anti-androgen cyproterone acetate on the action of oestrogen on the rat endocrine system. Physiol, bohemoslov. 20, 255 (1971).
Schreiber, V., Pribyl, T., Rohacova, J.: Vergleich der Wirkung der Antiandrogene Cyproteron und Cyproteronacetat auf das endokrine System der Ratten. Endokrinologie 58, 414 (1971).
Steelman, S.L., Brooks, J.R., Morgan, E.R., Patanelli, D.J.: Anti-androgenic activity of spironolactone. Steroids 14, 449 (1969).
Steinbeck, H., Mehring, M., Neumann, F.: Comparison of the effects of cyproterone, cyproterone acetate and estradiol on testicular fimction, accessory sexual glands and fertility in a long-term study on rats. J. Reprod. Fertil. 26, 65 (1971).
Steinbeck, H., Neumann, F.: Influence of the antiandrogen cyproterone and its acetate on testicular function, onset of puberty, and bone growth and maturation. Amsterdam: Excerpta Medica 1971 (p. 1007).
Steinbeck, H., Neumann, F.: Effect of cyproterone acetate on puberty J. Reprod. Fertil. 26, 59 (1971).
Stern, J.M., Eiseneeld, A. J.: Androgen accumulation and binding to macromolecules in seminal vesicles: inhibition by cyproterone. Science 166, 233 (1969).
Stern, J.M., Eisenteld, A.J.: Distribution and metabolism of 3H-testosterone in castrated male rats; effects of cyproterone, progesterone and unlabeled testosterone. Endocrinology 88, 1117 (1971).
Tveter, K.J.: Effect of 17α-methyl-B-nortestosterone (SK & F 7690) on the binding in vitro of 5α-dihydrotestosterone to macromoleeular components from the rat ventral prostate. Acta endocr. (Kbh.) 66, 352 (1971).
Tveter, K.J., Aakvaag, A.: Uptake and metabolism in vivo of testosterone- 1,2-3H by accessory sex organs of male rats: influence of some hormonal compounds. Endocrinology 85, 683 (1969).
Tveter, K.J., Unhjem, O.: Selective uptake of androgen by rat seminal vesicle. Endocrinology 84, 963 (1969).
Tveter, K.J., Unhjem, O., Attramadal, A., Aakvaag, A., Hansson, V.: Androgenic receptors in rat and human prostate. Schering Workshop on Steroid Hormone ‘Receptors’, Berlin, December 7–9, 1970. In: Raspé, G. (Ed.), “Advances in the Biosciences 7”. Vieweg: Pergamon Press 1971.
Verhoeven, G., Moor, P. de: Nucleus-associated 5α-reductase activity in the rat. Gynecol. Invest. 2, 290 (1971/1972).
Viguier-Martinez, M., Pelletier, J.: Etude comparée des effets de la cyprotérone et de l’acétate de cyprotérone sur la LH hypophysäre, la LH plasmatique et l’appareil génital du Rat mâle prépubière. C.R. Acad. Sci. (Paris) Serie D, 274, 2696 (1972).
Walsh, P.C., Korenman, S.G.: Action of antiandrogens: preservation of 5α-reductase activity and inhibition of chromatin-dihydrotestosterone complex formation. Clin. Res. 18, 126 (1970).
Walsh, P.C., Korenman, S.G.: Mechanism of androgenic action: effect of specific intracellular inhibitors. J. Urol. (Baltimore) 105, 850 (1971).
Whalen, R.E., Luttge, W.G., Green, R.: Effects of the anti-androgen cyproterone acetate on the uptake of l,2-3H-testosterone in neural and peripheral tissues of the castrate male rat. Endocrinology 84, 217 (1969).
Whalen, R.E., Edwards, D.A.: Effects of the anti-androgen, cyproterone acetate, on the mating behavior and seminal vesicle tissue in male rats. Endocrinology 84, 155 (1969).
Wiechert, R., Steinbeck, H., Elger, W., Neumann, F.: Wirkungen und Struktur neuer antiandrogener Steroide. Arzneimittel-Forsch. 17, 1103 (1967).
References
Blaquier, J.A.: Selective uptake and metabolism of androgens by rat epididymis. The presence of a cytoplasmic receptor. Biochem. biophys. Res. Commun. 45, 1076 (1971).
Blaquier, J. A., Cameo, M.S., Burgos, M.H.: The role of androgens in the maturation of epididymal spermatozoa in the guinea pig. Endocrinology 90, 839 (1972).
Cameo, S., Blaquier, J. A., Burgos, M.H.: The androgen dependency of the process of sperm maturation in the guinea pig. Acta physiol. lat.-amer. Vol. 21, 254 (1971).
Cavazos, L.F., Melampy, R.M.: Effects of differential testosterone propionate levels on rat accessory gland activity. Iowa State Coll. J. Sei. 31, 19 (1956).
Elger, W., Berswordt-Wallrabe, R. von: Failure to induce sterility in male rats with continuously released micro-quantities of cyproterone acetate and norgestrel. 19. Symp. Dtseh. Ges. Endokrin., Berlin 1973. Acta endocr. (Kbh.) Suppl. 173, 120 (1973), Abstr.
Gaddum, P.: Sperm maturation in the male reproductive tract. Development of motility. Anat. Ree. 161, 471 (1968).
Gustafsson, B.: Luminal contents of the bovine epididymis under conditions of reduced spermatogenesis, luminal blockage and certain sperm abnormalities. Acta vet. scand. Suppl. 17, 1 (1966).
Hansson, V., Tveter, K.J.: Uptake and binding in vivo of 3H-labelled androgen in the rat epididymis and ductus deferens. Acta endocr. (Kbh.) 66, 745 (1971).
Lubicz-Nawrocki, C.M., Glover, T.D.: The influence of 17a-methyl-B-nortestosterone (SK and F 7690) on the fertilizing ability of spermatozoa in hamsters. J. Reprod. Fertil. 34, 331 (1973).
Martan, J.: Epididymal histochemistry and physiology. Biol. Reprod. Suppl. 1, 134 (1969).
Orgebin-Crist, M.: Maturation of spermatozoa in the rabbit epididymis: fertilizing ability and embryonic mortality in does inseminated with epididymal spermatozoa. Ann. Biol. anim. 7, 373 (1967).
Prasad, M.R.N., Rajalakshmi, M., Reddy, P.R.K.: Action of cyproterone acetate on male reproductive functions. Gynecol. Invest. 2, 203 (1971/1972).
Prasad, M.R.N., Singh, S.P., Rajalakshmi, M.: Fertility control in male rats by continuous release of microquantities of cyproterone acetate from subcutaneous silastic capsules. Contraception 2, 165 (1970).
Rajalakshmi, M., Prasad, M.R.N.: Alterations in sialic acid in the epididymis of the puberal rat in response to changes in functional activitv of the testis. J. Reprod. Fertil. 24, 409 (1971).
Rajalakshmi, M., Singh, S.P., Prasad, M.R.N.: Effects of microquantities of cyproterone acetate released through silastic capsules on the histology of the epididymis of the rat. Contraception 3, 335 (1971).
Ritzens, E.M., Nayfeh, S.N., French, F.S., Dobbins, M.C.: Demonstration of an androgen-binding component in rat epididymis cytosol and comparison with binding components in prostate and other tissue. Endocrinology 89, 143 (1971).
Scheuer, A., Dahnke, H.-G., Mosebach, K.-O.: Veränderungen der Nukleinsäure- konzentrationen in einigen Organen wachsender männlicher Ratten sowie ihre Beeinflussung durch Cyproteronacetat und Testosteron. Symp. Dtsch. Ges. Endokrin. (Abstract No. 34). Acta endocr. (Kbh.) Suppl. 152, 34 (1971).
Voglmayr, J.K., Wattes, G.M.H., Setchell, B.P.: Studies on spermatozoa and fluid collected directly from the testis of the conscious ram. Nature (Lond.) 210, 861 (1966).
References
Bagdon, R.E., Randall, L.O.: Toxicity studies of a synthetic phenanthrene (RO 2–7239) having anti-androgenic activity. Fed. Proc. 18, 365 (1959).
Beach, F.A., Westbrook, W.H.: Morphological and behavioural effects of an ‘antiandrogen’ in male rats. J. Endoer. 42, 379–382 (1968).
Berswordt-Wallrabe, R. von, Neumann, F.: Influence of a testosterone antagonist (cyproterone) on pituitary and serum FSH-content in juvenile male rats. Neuroendocrino- logy 2, 107–112 (1967).
Berswordt-Wallrabe, R. von, Neumann, F.: Influence of a testosterone antagonist (cyproterone) on pituitary and serum ICSH content in juvenile male rats. Neuroendo- crinology 3, 332–336 (1968).
Berswordt-Wallrabe, R. von, Neumann, F.: Cyproterone and gonadotrophic hormones in rats. Third Int. Congress of Endocrinology, Mexico City 1968. Excerpta med. (Amst.) Int. Congr. Ser. 157 (Abstract No. 470) (1968).
Bloch, G.J., Davidson, J.M.: Antiandrogen implanted in brain stimulates male repro ductive system. Science 155, 593–595 (1967).
Bloch, G.J., Davidson, J.M.: Behavioral and somatic responses to the antiandrogen cyproterone (l,2α-methylene-6-chloro-Δ6-M7α-hydroxy-progesterone. Hormon. and Behav. 2, 11–25 (1971).
Boris, A.: Further studies on the endocrinol ogy of a dodecahydro-phenanthrene derivative. Acta endocr. (Kbh.) 41, 280 (1962).
Boris, A.: Endocrine studies of a nonsteroid anti-androgen and progestin. Endocrinology 76, 1062–1067 (1965).
Boris, A., Stevenson, R.H.: Further studies on a nonsteroidal anti-androgen. Endocrinology 78, 549–555 (1966).
Chowers, I., McCann, S.M.: Content of luteinizing hormone-releasing factor and luteinizing hormone during the estrous cycle and after changes in gonadal steroid titers. Endocrinology 76, 700–708 (1965).
Davidson, J.M., Bloch, G.J.: Neuroendocrine aspects of male reproduction. Biol. Reprod. 1, 67–92 (1969).
Davidson, J.M., Bloch, G.J., Smith, E.R., Weick, R.F.: Comparative responses to androgen of anatomic, behavioral and other parameters. Excerpta med. (Amst.) Int. Congr. Ser. 210 (Abstract No. 105) (1970).
Davidson, J.M., Sawyer, C.H.: Evidence for a hypothalamic focus of inhibition of gonadotropin by androgen in the male. Proc. Soc. exp. Biol. (N.Y.) 107, 4–7 (1961).
Dorfman, R.I.: Antiandrogens. Proceedings of the Illrd International Congress on Hormonal Steroids, Hamburg, September 1970. Amsterdam: Excerpta Medica 1971, pp. 995.
Dorfman, R., Stevens, D.: The androgenic and anti-androgenic action of a perhydro- phenanthrene derivative. Acta endocr. (Kbh.) Suppl. 51, 867 (1960).
Dorfman, R., Stevens, D.: Some biological properties of a perhydraphenanthrene derivative. Endocrinology 67, 394–406 (1960).
Edwards, D.A.: Effects of cyproterone acetate on aggressive behaviour and the seminal vesicles of male mice. J. Endocr. 46, 477–481 (1970).
Engle, E.T.: The effect of daily transplants of the anterior lobe from gonadectomized rats on immature test animals. Amer. J. Physiol. 88, 101–106 (1929).
Evans, H. M., Simpson, M. E.: A comparison of anterior hypophyseal implants from normal and gonadectomized animals with reference to their capacity to stimulate the immature ovary. Amer. J. Physiol. 89, 371 (1929).
Eviatar, A., Danon, A., Sulman, F.G.: The mechanism of the “push and pull” principle V. effect of the antiandrogen RO 2–7239 on the endocrine system. Arch. int. Pharmacodyn. 133, 75–88 (1961).
Fichera, G.: Sur l’hypertrophie de la glande pituitaire consécutive à la castration. Arch, ital. Biol. 43, 405–426 (1905).
Fixson, U.: Preliminary report of a new orally active progestogen. Geburtsh. u. Frauen- heilk. 23, 371 (1963).
Goslar, H.G., Mehring, M., Neumann, F.: Einfluß der Antiandrogene Cyproteron und Cyproteronacetat auf das Enzymmuster im Hoden juveniler und erwachsener Ratten. Histochemie 23, 51–58 (1970).
Gusek, W., Kowalzig, H.G.: Verhalten der Leydigschen Zwischenzellen und der Zirbeldrüse unter dem Einfluß von Antiandrogen. Therapiewoche 21, 3935–3941 (1971).
Hahn, J.D., Neumann, F.: Untersuchungen zur Wirkung von 19-Nor-17α-hydroxy- progesteron-capronat auf Prostata, Samenblasen und Hoden der Ratte. 9. Frühjahrstagung Dtsch. Gesellschaft für Pharmakologie, Mainz 1968. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 260, Heft 2/3, S. 131 (1968).
Hahn, J.D., Neumann, F., Berswordt-Wallrabe, R. von: Tierexperimentelle Unter suchungen mit 19-Nor-17α-hydroxyprogesteron-capronat (Gestonoroncapronat) im Hinblick auf eine mögliche therapeutische Anwendung beim Prostataadenom. Der Urologe 7. 208–214 (1968).
Hasan, S. H., Neumann, F., Schenck, B.: Long-term effect of cyproterone on testosterone levels in male rats. 19. Symp. Dtsch. Ges. Endokrin., Berlin (Abstract No. 119). Acta endocr. (Kbh.) Suppl. 173, 119 (1973).
Heap, P.F., Lederis, K., Neumann, F.: Effects of cyproterone on the ultrastructure of the rat adenohypophysis. In: Heller, H. and Lederis, K. (Eds.). Subcellular Organization and Function in Endocrine Tissues. Cambridge: University Press 1971, pp.147–159.
Heinert, G., Taubert, H.-D.: Karyo-metrische und histometrische Untersuchungen an Rattenhoden nach Behandlung mit Cyproteron und Cyproteronacetat. Acta endocr. (Kbh.) Suppl. 152, 38 (1971).
Johnson, D.C., Naqvi, R.H.: Effect of cyproterone acetate on LH in immature rats. Endocrinology 84, 421–425 (1969).
Junkmann, K., Neumann, F.: Zum Wirkungsmechanismus von an Feten antimaskulin wirksamen Gestagenen. Acta endocr. (Kbh.) Suppl. 90, 139–154 (1964).
Korfsmeier, K.-H: Ultrastrukturelle Veränderungen in den neuro-sekretorischen Zentren des Hypothalamus und in der Eminentia mediana nach Behandlung mit Cyproteronacetat (Antiandrogen). Z. Zellforsch. 110, 600–610 (1970).
Korfsmeier, K.G., Davidoff, M.: Autoradiographische Untersuchungen zur Mitose- aktivät im Hypophysenvorderlappen männlicher Ratten nach Behandlung mit Anti- androgenen und nach Kastration. Z. Zellforsch. 104, 275–281 (1970).
Lisk, R.D.: Testosterone-sensitive centers in the hypothalamus of the rat. Acta endocr. (Kbh.) 41, 195–204 (1962).
Markewitz, M., Veenema, J., Fingerhut, B., Nehme-Haily, D., Sommers, S.C.: Cyproterone acetate (SH 714) effect on histology and nucleic acid synthesis in the testes of patients with prostatic carcinoma. Invest. Urol. 6, 638–649 (1969).
McArthur, N.H.: Ultrastructural changes in ependymal cells, tanycytes, and pituieytes of the distal infundibulum in newborn and adult male rats following castration and treatment with cyproterone acetate. Diss. Abstr. Int. B 31, 5764-B65-B (1971).
McEwen, B.S., Pfaff, D.W., Zigmond, R.E.: Factors influencing sex hormone uptake by rat brain regions. III. Effects of competing steroids on testosterone uptake. Brain Res. 21, 29–38 (1970).
Mietkiewski, K., Lukaszyk, A.: The response of the rat testis to prolonged administration of an androgen antagonist (cyproterone). Acta endocr. (Kbh.) 60, 561–570 (1969).
Mietkiewski, K., Malendowicz, L., Lukaszyk, A.: Cytological and cytochemical comparative study on the effect of cyproterone (anti-androgen) and gonadectomy on the gonadotrophic cells of the hypophysis in male rats. Acta endocr. (Kbh.) 61, 293–301 (1969).
Morse, H.C., Leach, D.E., Rowley, M.J., Heller, G. G.: Effect of cyproterone acetate on sperm concentration, seminal fluid volume, testicular cytology and levels of plasma and urinary ICSH, FSH and testosterone in normal men. J. Reprod. Fertil. 32, 365–378 (1973).
Neri, R.O., Florance, K., Koziol, P., van Cleave, S.: A biological profile of a nonsteroidal antiandrogen Sch 13521 (4’ -nitro- 3’ -tr ifluoromethy 1 -isobutyrani 1 ide). Endocrinology 91, 427 (1972).
Neri, R. O., Monahan, M.: Effects of a novel nonsteroidal antiandrogen on canine prostatic hyperplasia. Invest. Urol. 10, 123–130 (1972).
Neri, R.O., Monahan, M.D., Meyer, J.G., Afonso, B.A., Tabachnick, I.A.: Biological studies on an anti-androgen (SH 714). Eur op. J. Pharmacol. 1, 438–444 (1967).
Neubiann, F.: Auftreten von Kastrationszellen im Hypophysenvorderlappen männlicher Ratten nach Behandlung mit einem Antiandrogen. Acta endocr. (Kbh.) 53, 53–60 (1966).
Neumann, F.: Antagonismus von Testosteron und l,2-Methylen-6-chlor-pregna-4,6-dien- 17-ol-3,20-dion (Cyproteron) an den die Gonadotropinsekretion regulierenden Zentren bei männlichen Ratten. Acta endocr. (Kbh.) 53, 382–390 (1966).
Neumann, F., Berswordt-Wallrabe, R. von, Elger, W., Steinbeck, H., Hahn, J.D., Kramer, M.: Aspects of androgen-dependent events as studied by anti-androgens. Recent Progr. Hormone Res. 26, 337 (1970).
Neubiann, F., Elger, W., Berswordt-Wallrabe, R. von: Intersexuality of male foetuses and inhibition of androgenic function in adult animals with a testosterone blocker. Germ. med. Mtl. 12, 182 (1967).
Neubiann, F., Elger, W., Berswordt-Wallrabe, R. von, Kramer, M.: Beeinflussung der Regelmechanismen des Hypophysenzwischenhirnsystems von Ratten durch einen Testosteron-Antagonisten, Cyproteron (l,2α-Methylen-6-chlor-4,6-pregnadien-17α-ol-3,20- dion). Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 225, 221–235 (1966).
Neubiann, F., Elger, W., Berswordt-Wallrabe, R. von: Aufhebung der Testosteron propionat-induzierten Unterdrückung des Vaginal-Zyklus und der Ovulation durch ein antiandrogen wirksames Steroid an Ratten. Acta endocr. (Kbh.) 52, 63–71 (1966).
Neubiann, F., Elger, W., Steinbeck, H., Berswordt-Wallrabe, R. von: Antiandrogene, p. 78. In: Das Testosteron. Die Struma, 13. Symp. der Dtsch. Gesellschaft für Endokrinol. Würzburg, 2.-4. März 1967 (1968).
Neumann, F., Krabier, M., Raspé, G.: Das endokrinologisehe Wirkungsspektrum von 19-Nor-17α-hydroxy-progesteroncapronat (Gestonoroncapronatk Arzneimittel-Forsch. 18, 1289–1297 (1968).
Neumann, F., Richter, K.-D., Günzel, P.: Action of anti-androgens. Zbl. Yet.-Med. (A), 12, 171 (1965).
Randall, L.O., Selitto, J.J.: Anti-androgenic aetivitv of a synthetic phenauthrene. Endocrinology 62, 693–695 (1958).
Romeis, B.: Handbuch der mikroskopischen Anatomie des Menschen: Blutgefäß- und Lymphgefäßapparat innersekretorische Drüsen. Dritter Teil, 1940.
Saba, P., Marescotti, V., Tronchetti, F.: Effect of testosterone and of anti-androgens on the behavior of hypothalamic neurons in male rats. Washington DC, 4th Int. Congr. Endocrinol., June 1972 (Abstract No. 3).
Sar, M., Stumpf, W.E.: Cellular and subcellular androgen localization in the anterior pituitary. Washington DC, 4th Int. Congr. Endocrinol., June 1972 (Abstract No. 621).
Sayler, A.: The effect of anti-androgens on aggressive behavior in the gerbil. Physiol. Behav. 5, 667–671 (1970).
Schiebler, T.H., Meinhardt, D.W.: The effects of antiandrogens on the hypothalamus. In: Bargmann, W. and Scharrer, B. (Eds.). Aspects of Neuroendocrinology. Berlin-Heidelberg-New York: Springer 1970 (pp. 118–121) 5th Int. Symp. Neurosecretion, Kiel, August 1969.
Schiebler, T.H., Meinhardt, D.W.: Über die experimentelle Beeinflussung der neuro- sekretorischen Systeme des Hypothalamus durch Antiandrogene. In: Orthner, H. (Ed.). Journal of Neuro-Visceral Relations: Zentralnervöse Sexualsteuerung, Suppl. X. Wien- New York: Springer 1971, pp. 384–387. Verh. Symp. Deut. Neurovegetat. Ges. Göttingen, 30. Sept.—2. Okt. 1969.
Schiebler, T.H., Meinhardt, D.W.: Über die Wirkung von Antiandrogenen auf die neurosekretorischen Systeme des Hypothalamus. Z. Zellforsch. 100, 581–593 (1969).
Schneider, H.P.G., Staembiler, H.-J., Sachs, L., Schwarze, M.: Einfluß des Antiandrogens Cyproteron auf die LH-Freigabe-Funktion. Arch. Gynaekol. 206, 64–71 (1968).
Schreiber, V., Pribyl, T., Roháčová, J.: Vergleich der Wirkung der Antiandrogene Cyproteron und Cyproteron-acetat auf das endokrine System der Ratten. Endokrinologie 58,414–424(1971).
Städtlee, F., Horn, H. J., Moormann, J. G.: Histologische Befunde an menschlichen Hodenbiopsien unter Antiandrogen-Behandiung. Acta endocr. (Kbh.) Suppl. 152, 36 (1971).
Steinbeck, H., Mehring, M., Neumann, F.: Comparison of the effects of cyproterone, cyproterone acetate and estradiol on testicular function, accessory sexual glands and fertility in a long-term study on rats. J. Reprod. Fertil. 26, 65–76 (1971).
Steinbeck, H., Neumann, F.: Influence of the antiandrogen cyproterone and its acetate on testicular function, onset of puberty, and bone growth and maturation. Proceedings of the Illrd International Congress on Hormonal steroids, Hamburg, September 1970. Amsterdam: Excerpta Medica 1971, pp. 1007.
Stern, J.M., Eisenfeld, A.J.: Distribution and metabolism of 3H-testosterone in castrated male rats; effects of cyproterone, progesterone and unlabeled testosterone. Endocrinology 88, 1117–1125 (1971).
Viguier-Martinez, M., Pelletier, J.: Etude comparée des effets de la cyprotérone et de l’acétate de cyprotérone sur la LH hypophysaire, la LH plasmatique et l’appareil génital du Rat mâle prépubière. C.R. Acad. Sei. (Paris) Serie D, 274, 2696–2699 (1972).
Voigt, K.D., Apostolakis, M., Klosterhalfen, H.: The influence of cyproterone treatment on the excretion of steroids in male patients. In: Tamm, J. (Ed.). “Testosterone”, Proceedings of the Workshop Conference, Tremsbüttel 1967. Stuttgart: Georg Thieme 1968, S. 152–155.
Vokaer, R., Kridelka, J.C.: Clinical studies of the activity of a new progesterone-like steroid in women. Ann. Endocr. 24, 49–57 (1963).
Walsh, P.C., Swerdloff, R.S., Odell, W.D.: Antiandrogen: Effect on serum LH and FSH in rats and humans. Clin. Res. 18, 375 (1970).
Walsh, P.C., Swerdloff, R.S., Odell, W.D.: Cyproterone: Effect on serum gonadotropins. (Abstract). Biol. Reprod. 5, 97 (1971).
Walsh, P.C., Swerdloff, R.S., Odell, W.D.: Cyproterone: Effect on serum gonadotropins in the male. Endocrinology 90, 1655–1659 (1972).
Whalen, R.E., Edwards, D.A.: Effects of the anti-androgen, cyproterone acetate, on the mating behavior and seminal vesicle tissue in male rats. Endocrinology 84, 155 (1969).
Whalen, R.E., Luttge, W.G.: Contraceptive properties of the anti-androgen, cyproterone acetate. Nature (Lond.) 223, 633 (1969).
Whalen, R.E., Luttge, W.G., Green, R.: Effects of the anti-androgen cyproterone acetate on the uptake of l,2-3H-testosterone in neural and peripheral tissues of the castrate male rat. Endocrinology 84, 217–222 (1969).
Wiechert, R., Neumann, F.: Gestagene Wirksamkeit von 1-Methyl- und l,2a-Methylen- Steroiden. Arzneimittel-Forscb. 15, 244–246 (1965).
Wiechert, R., Steinbeck, H., Elger, W., Neumann, F.: Wirkungen und Struktur neuer antiandrogener Steroide. Arzneimittel-Forsch. 17, 1103–1116 (1967).
Woods, M.C., Simpson, M.E.: Pituitary control of the testis of the hypophysectomized rat. Endocrinology 69, 91–125 (1961).
Zucker, I.: Effects of an anti-androgen on the mating behaviour of male guinea-pigs and rats. J. Endocr. 35, 209–210 (1966).
References
Beach, F.A., Westbrook, W.H.: Morphological and behavioral effects of an ‘antiandrogen’ in male rats. J. Endocr. 42, 379 (1968).
Berswordt-Wallrabe, R. von, Neumann, F.: Influence of a testosterone antagonist (cyproterone) on pituitary and serum FSH-content in juvenile male rats. Neuroendo- crinology 2, 107 (1967).
Berswordt-Wallrabe, R. von, Neumann, F.: Failure to induce effects in the testis of hypophysectomized rats with a FSH preparation concomitantly treated with the anti- androgen cyproterone acetate. Fifth World Congress of Fertility and Sterility, Stockholm 1966. Excerpta Med. Int. Congress Series 109 (Abstract No. 227), Excerpta Med. Int. Congress Series 133, 581 (1967).
Berswordt-Wallrabe, R. von, Steinbeck, H., Neumann, F.: Effect of FSH on the testicular structure of rats. Endokrinologie 53, 35. (1968).
Boris, A.: Endocrine studies of a nonsteroid anti-androgen and progestin. Endocrinology 76, 1062 (1965).
Breuer, H., Hoffmann, W.: Wirkungsmechanismus eines Antiandrogens auf die Andro- gen-Biosynthese. Naturwissenschaften 54, 616 (1967).
Breuer, H., Hoffmann, W.: Effect of cyproterone on the biogenesis of testosterone and related compounds. In: Tamm, J., “Testosterone”. Proc. Workshop Conf., Tremsbüttel, 20.-22. April 1967. Stuttgart: Thieme 1968 (p. 162).
Christensen, A.K., Gillim, S.W.: The correlation of fine structure and function in steroid-secreting cells with emphasis on those of the gonads. In: McKerns, K.W. (Ed.). “The Gonads”, p. 415 (part 2) (1969).
Christensen, A.K., Mason, N.R.: Comparative ability of seminiferous tubules and interstitial tissue of rat testes to synthesize androgens from progesterone-4-14C in vitro. Endocrinology 76, 646 (1965).
Clermont, Y.: Contractile elements in the limiting membrane of the seminiferous tubules of the rat. Exp. Cell Res. 15, 438 (1958).
Cupceancu, B., Neumann, F.: Sensibilitätsunterschiede der verschiedenen Strukturen des Genitaltraktes von weiblichen Rattenfoeten unter dem Einfluß von Medroxypro- gesteronacetat oder Norethisteronacetat. Endokrinologie 54, 66 (1969).
Dorfman, R.I.: Anti-androgens in a castrated mouse test. Steroids 2, 185 (1963).
Dorfman, R.I.: Antiandrogenic, antiestrogenic, and antiovulatory compounds. In: Martini, L. and Pecile, S. (Eds.). “Hormonal Steroids”. Proc. 1st Int. Congr. Horm. Steroids, Mailand/Italy. New York: Academic Press, Vol. 1, 1964.
Dorfman, R.I.: Antiandrogens. In: James, Y.H.T. and Martini, L. (Eds.). “Hormonal Steroids”, Amsterdam, Proc. 3rd Int. Congr. Horm. Steroids, 7.—12. Sept. 1970, Hamburg. Excerpta Mediea 1971 (p. 995).
Dorfman, R.I., Forchielli, E., Gut, M.: Androgen biosynthesis and related studies. Recent Progr. Hormone Res. 19, 251 (1963).
Dörner, G., Götz, F., Mainz, K.: Influence of antiandrogens on sexual behaviour and gonadal function in male rats. Endocr. exp. 6, 17 (1972).
Engel, K., Karsznia, R.: Der Einfluß von Cyproteronacetat auf die Testosteron-Biosynthese im Rattenhoden. Hoppe-Seylers Z. physiol. Chem. 352, 559 (1971).
Ewald, W.: Inhibition of adrenal and testicular enzymes involved in steroid hormone biosynthesis by cyproterone and some anabolic steroids. In: Kracht, J. “Endokrinologie der Entwicklung und Reifung” Berlin: Springer 1970 (p. 426).
Geller, J., Baron, A., Warburton, V., Loh, A.: The effects of progestational agents on male gonadal and pituitary function. Ann. intern. Med. 70, 1062 (1969) (Abstract).
Geller, J., Fruchtman, B., Newman, H., Roberts, T., Silva, R.: Effect of progestational agents on carcinoma of the prostate. Cancer Chemother. Rep. 51, 41 (1967).
Geller, J., Vazakas, G., Fruchtman, B., Newman, H., Nakao, K., Loh, A.: The effect of cyproterone acetate on advanced carcinoma of the prostate. Surg. Gynec. Obstet. 127, 748 (1968).
Giordano, G., Balestreri, R., Foppiani, E., Elicio, N.: Testicular steroidogenesis in rats treated with cyproterone and cyproterone acetate. Arch. E. Maragliano Pat. Clin. 26, 1 (1970).
Glenn, E.M., Richardson, S.L., Bowman, B.J.: Biologic activity of 6-alpha-methyl compounds corresponding to progesterone, 17-alpha-hydroxyprogesterone acetate and compound S. Metabolism 8, 265 (1959).
Goslar, H. G., Mehring, M., Neumann, F.: Einfluß der Antiandrogene Cyproteron und Cyproteronacetat auf das Enzymmuster im Hoden juveniler und erwachsener Ratten. Histochemie 23, 51 (1970).
Gusek, W., Kowalzig, H.G.: Verhalten der Leydigschen Zwischenzellen und der Zirbeldrüse unter dem Einfluß von Antiandrogen. Therapiewoche 21, 3935 (1971).
Hagen, A.A., Eik-Nes, K.B.: In vivo conversion of 17α-hydroxypregnenolone to 17α- hydroxyprogesterone by the canine testis. Fed. Proc. 22, 330 (1963) (Abstract).
Hasan, S.H., Neumann, F., Schenck, B.: Long-term effect of cyproterone on testosterone levels in male rats. 19. Symp. Dtsch. Ges. Endokrin., Berlin (Abstract No. 119). Acta endocr. (Kbh.) Suppl. 173, 119 (1973).
Heinert, G., Taubert, H.-D.: Karyo-metrische und histometrische Untersuchungen an Rattenhoden nach Behandlung mit Cyproteron und Cyproteronacetat. Acta endocr. (Kbh.) Suppl. 152, 38 (1971).
Heller, C.G., Leach, D.R.: Cyproterone acetate: a correlation of its effect on plasma and urinary FSH, ICSH and testosterone, seminal fluid volume, sperm concentration, testicular cytology, and libido and potentia in normal men. 53rd Annual Meeting of the Endocrine Society, San Francisco 1971, June 24–26.
Hoffmann, W., Breuer, H.: Wirkung von l,2α-Methylen-6-chlor-Δ4,6-pregnadien-17α- ol-3,20-dion (Cyproteron) auf die Biogenese von C19-Steroiden in Rattentestes. Acta endocr. (Kbh.) 57, 623 (1968).
Hoffmann, W., Breuer, H., Neumann, F.: Wirkung einer Behandlung mit einem Antiandrogen (Cyproteron) auf die Aktivitäten von Steroidenzymen bei der Ratte. Arzneimittel-Forsch. 18, 586 (1968).
Horst, P., Bader, J.: Untersuchungen zur Bedeutung der Jungebermast. Züchtungskunde 41, 248 (1969).
Hovatta, O.: Effect of androgens and antiandrogens on the development of the myoid cells of the rat seminiferous tubules (organ culture). Z. Zellforsch. 131, 299 (1972).
Junkmann, K., Neumann, F.: Zum Wirkungsmechanismus von an Feten antimaskulin wirksamen Gestagenen. Acta endocr. (Kbh.) Suppl. 90, 139 (1964).
Kincl, F.A., Dorfman, R.I.: Anti-ovulatory activity of subcutaneously injected steroids in the adult oestrus rabbit. Acta endocr. (Kbh.) Suppl. 73, 3 (1963).
Kincl, F.A., Dorfman, R.I.: Anti-ovulatory activity of steroids administered by gavage in the adult oestrus rabbit. Acta endocr. (Kbh.) Suppl. 73, 17 (1963).
Kincl, F.A., Maqueo, M., Dorfman, R.I.: Influence of various steroids on testes and accessory organs in the rat. Acta endocr. (Kbh.) 49, 145 (1965).
Kraft, H.G., Kiesler, H.: Anti-estrogenic and anti-androgenic activities of Chlormadinone acetate and related compounds. II. Int. Congr. Hormonal Steroids, Mailand 1966. Excerpta Med. (Amst.), Int. Congr. Ser. 111, 346 (1966).
Kühnel, W.: Antiandrogeneffekte an den Geschlechtsorganen männlicher Ratten. Verh. anat. Ges. (Jena) 64, 149 (1969).
Lakshman, A. B., Isaac, P.: Effects of cyproterone acetate on the adenohypophysial cells of male rats. J. Reprod. Fertil. 32, 141 (1973).
Lunaas, T., Velle, W.: The effect of gonadotropins and synthetic gestagens on testicular steroid secretion in swine. Acta endocr. (Kbh.) Suppl. 100, 41 (1965).
Markewitz, M., Veenema, R.J., Fingerhut, B., Nehme-Haily, D., Sommers, S.C.: Cyproterone acetate (SH 714) effect on histology and nucleic acid synthesis in the testis of patients with prostatic carcinoma. Invest. Urol. 6, 638 (1969).
Mietkiewski, K., Lukaszyk, A.: The response of the rat testis to prolonged admini- tration of an androgen antagonist (cyproterone). Acta endocr. (Kbh.) 60, 561 (1969).
Miyake, T., Kobayashi F, Horibe, K., Kakushi, H., Hara, K.: Biological activities of Chlormadinone acetate (II), effects on the rat pregnancy, fetal development and parturition. Folia endocr. Japonica 41, 1154 (1966).
Morse, H.C., Leach, D.R., Rowley, M. J., Heller, C.G.: Effect of cyproterone acetate on sperm concentration, seminal fluid volume, testicular cytology and levels of plasma and urinary ICSH, FSH and testosterone in normal men. J. Reprod. Fertil. 32, 365 (1973).
Neri, R.O.: Some biological properties of antiandrogens. In: James, V.H.T. and Martini, L. (Eds.). “Hormonal Steroids”, Amsterdam. Proc. 3rd Int. Congr. Horm. Steroids, 7.—12. Sept. 1970, Hamburg. Excerpta Medica 1971 (p. 1022).
Neri, R.O., Florance, K., Koziol, P., van Cleave, S.: A biological profile of a nonsteroidal antiandrogen Sch 13521 (4′-nitro-3′-trifluoromethyl-isobutyranilide). Endocrinology 91, 427 (1972).
Neumann, F., Berswordt-Wallrabe, R. von: Effects of the androgen antagonist cyproterone acetate on the testicular structure, spermatogenesis and accessory sexual glands of testosterone-treated adult hypophysectomized rats. J. Endocr. 35, 363 (1966).
Neumann, F., Berswordt-Wallrabe, R. von: Androgenic effects of progesterone metabolites induce the spermatogenic activity of progesterone in hypophysectomized rats. Und Int. Congress on Hormonal Steroids, Mailand 1966. Excerpta Med. Int. Congress Series 111 (Abstract No. 670).
Neumann, F., Berswordt-Wallrabe, R. von: Ansprechbarkeit der Gonaden hypo- physektomierter männlicher und weiblicher Ratten auf extrahypophysäre gonadotrope Hormone nach einjähriger Involutionsperiode. 12. Symp. Dtsch. Ges. für Endokrinologie, Wiesbaden 1966. Berlin: Springer 1967, S. 328.
Neumann, F., Berswordt-Wallrabe, R. von, Elger, W., Steinbeck, H: Hormonhemmer — Untersuchungen mit Testosteron-Antagonisten. 18. Mosbacher Koll. der Gesellschaft für Biologische Chemie, “Wirkungsmechanismen der Hormone”, Mosbach 1967. Berlin: Springer 1967, S. 218.
Neumann, F., Berswordt-Wallrabe, R. von, Elger, W., Steinbeck, H., Hahn, J.D.: Effects of antiandrogens. III rd Int. Congress of Endocrinology, Mexico City 1968. Excerpta Med. (Amst.) Int. Congr. Ser. 184, 823 (1969).
Neumann, F., Berswordt-Wallrabe, R. von, Elger, W., Steinbeck, H., Hahn, J.D., Kramer, M.: Aspects of androgen-dependent events as studied by antiandrogens. Recent Progr. Hormone Res. 26, 337 (1970).
Neumann, F., Elger, W., Berswordt-Wallrabe, R. von: Intersexuality of male foetuses and inhibition of androgenic function in adult animals with a testosterone blocker. Germ. med. Mth. 12, 182 (1967).
Neumann, F., Elger, W., Berswordt-Wallrabe, R. von, Kramer, M.: Beeinflussung der Regelmechanismen des Hypophysenzwischenhirnsystems von Ratten durch einen Testosteron-Antagonisten, Cyproteron (l,2α-Methylen-6-chlor-Δ4,6-pregnadien-17α-ol-3,20- dion). Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 255, 221 (1966).
Neumann, F., Elger, W., Berswordt-Wallrabe, R. von, Kramer, M.: Restitution der akzessorischen Geschlechtsdrüsen nach Langzeitbehandlung mit einem Androgen-Antagonisten (Cyproteronacetat). Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 255, 236 (1966).
Neumann, F., Elger, W., Steinbeck, H, Berswordt-Wallrabe, R. von: Antiandrogene. In: Klein, E. (Ed.). „Das Testosteron — Die Struma, p. 78. 13. Symp. der Dtsch. Ges. für Endokrinologie, Würzburg, 2.—4. März 1967. Berlin: Springer 1968.
Neumann, F., Steinbeck, H, Berswordt-Wallrabe, R. von: Untersuchungen zur spermatogenen Aktivität von Gestagenen. Endokrinologie 52, 54 (1967).
Neumann, F., Steinbeck, H., Elger, W., Berswordt-Wallrabe, R. von: Hoden: Morphologie und Funktion unter der Einwirkung von PMS und HCG bei gleichzeitiger Antiandrogenbehandlung. Acta endocr. (Kbh.) 57, 639 (1968).
Ott, F., Hoffet, H.: Beeinflussung von Libido, Potenz und Hodenfunktion durch Antiandrogene. Schweiz, med. Wschr. 98, 1812 (1968).
Plant, T.M., Michael, R.P.: Testicular function of adult male rhesus monkeys. British-Dutch Endocrine Meeting, Hull, 4–7. September, 1972.
Revesz, C., Chappel, C.I., Gaudry, R.: Masculinization of female fetuses in the rat by progestational compounds. Endocrinology 66, 140 (1960).
Rohloff, D., Jakubowski, H., Kirschfeld, H.: Über den Einfluß von Chlormadinon, Nortestosteronoenanthat und Cyproteronacetat auf histologische Hodenmerkmale beim Eber. Berl. Münch, tierärztl. Wschr. 84, 343 (1971).
Ross, M.: The fine structure and development of the peritubular contractile cell component in the seminiferous tubules of the mouse. Amer. J. Anat. 121, 523 (1967).
Ross, M., Long, I.: Contractile cells in human seminiferous tubules. Science 153, 1271 (1966).
Schöler, H.F.L., de Wächter, A.M.: Evaluation of androgenic properties of progestational compounds in the rat by the female foetal masculinization test. Acta endocr. (Kbh.) 38, 128 (1961).
Schoonees, R., Schalch, D.S., Murphy, G.P.: The hormonal effects of antiandrogen (SH 714) treatment in man. Invest. Urol. 8, 635 (1971).
Sciarra, F., Sorcini, G.,Di Silverio, F., Gagliardi, V.: Biosintesi in vitro degli andro- geni nel testicolo di soggetti con cancro del la prostata, trattati con estrogeni e ciproterone acetato. Folia endocr. (Roma) 23, 264 (1970).
Scott, W.W., Schirmer, H.K.A.: A new oral progestational steroid effective in treating prostatic cancer. Trans. Amer. Ass. gen.-urin. Surg. 58, 54 (1966).
Scott, W.W., Wade, J.C.: Medical treatment of benign nodular prostatic hyperplasia with cyproterone acetate. J. Urol. (Baltimore) 101, 81 (1969).
Städtler, F., Horn, H.J., Moormann, J.G.: Histologische Befunde an menschlichen Hodenbiopsien unter Antiandrogenbehandlung. Acta endocr. (Kbh.) Suppl. 152, 36 (1971) (Abstract).
Steinbeck, H., Berswordt-Wallrabe, R. von, Elger, W., Hahn, J.D., Neumann, F.: Actions of androgen antagonists. Fundación para investigaciones hormonales, Simposio Esteroides Sexuales, Bogotá 1968. Ruiz Albrecht, F., Ramírez Sánchez, J. and Willo- mitzer, H. (Eds.). Saladruek, Berlin 1969.
Steinbeck, H., Mehring, M., Neumann, F.: Comparison of the effects of cyproterone, cyproterone acetate and estradiol on testicular function, accessory sexual glands and fertility in a long-term study on rats. J. Reprod. Fértil. 26, 65 (1971).
Steinbeck, H., Neumann, F.: Influence of the antiandrogen cyproterone and its acetate on testicular function, onset of puberty, and bone growth and maturation. Proceedings of the IIIrd International Congress on Hormonal Steroids, Hamburg, September 1970. Amsterdam: Excerpta Medica 1971, pp. 1007.
Steinberger, E., Steinberger, A.: The spermatogenic function of the testis. In: McKerns, K.W. (Ed.). “The Gonads”, p. 715 (part 3) (1969).
Suchowski, G.K., Junkmann, K.: A study of the virilizing effect of progestogens on the female rat fetus. Endocrinology 68, 341 (1961).
Suchowski, G.K., Rurolla, E., Arcari, G.: Studies of the so-called virilizing effects of steroids in female rat fetuses. Endocrinology 80, 255 (1967).
Viguier-Martinez, M., Pelletier, J.: Etude comparée des effets de la cyprotérone et de l’acétate de cyprotérone sur la LH hypophysäre, la LH plasmatique et l’appareil génital du rat mâle prépubière. C.R. Acad. Sei. (Paris), Serie D 274, 2696 (1972).
Voigt, K.D., Apostolakis, M., Klosterhalfen, H.: The influence of cyproterone treatment of the excretion of steroids in male patients. In: Tamm, J. (Ed.). “Testosterone”. Proceedings of the Workshop Conference, Tremsbüttel 1967. Stuttgart: Georg Thieme 1968, p. 152.
Walsh, P.C., Swerdloff, R.S., Odell, W.D.: Cyproterone: effect on serum gonadotropins. Biol. Reprod. 5, 97 (1971) (Abstract).
Walsh, P.C., Swerdloff, R.S., Odell, W.D.: Cyproterone: Effect on serum gonadotropins in the male. Endocrinology 90, 1655 (1972).
Wiechert, R., Steinbeck, H., Elger, W., Neumann, F.: Wirkungen und Struktur neuer antiandrogener Steroide. Arzneimittel-Forsch. 17, 1103 (1967).
Zaffaroni, A., Bowers, A.: New steroids with hormone like activities: C-6 substituted hormone analogs. In: Martini, L. and Pecile, S. (Eds.). “Hormonal Steroids”. Proc. 1st Int. Congr. Horm. Steroids, Mailand/Italy, Academic Press, Vol. 1 (1964).
References
Berswordt-Wallrabe, R. von, Neumann, F.: Influence of a testosterone antagonist (cyproterone) on pituitary and serum FSH-content in juvenile male rats. Neuroendocrinology 2, 107–112 (1967).
Bloch, G.J., Davidson, J.M.: Antiandrogen implanted in brain stimulates male reproductive system. Science 155, 593–595 (1967).
Clegg, E.J.: The age at which male rats become fertile. J. Reprod. Fertil. 1, 119 (1960).
Clermont, A., Perey, B.: Quantitative study of the cell population of the seminiferous tubules in immature rats. Amer. J. Anat. 100, 241 (1957).
Davidson, J.M., Bloch, G.J.: Neuroendocrine aspects of male reproduction. Biol. Reprod. 1, 67 (1969).
Elger, W., Berswordt-Wallrabe, von R.: Failure to induce sterility in male rats with continuously released micro-quantities of cyproterone acetate and norgestrel. 19. Symp. Dtsch. Ges. Endokrin., Berlin 1973. Acta endocr. (Kbh.) Suppl. 173, 120 (1973) (Abstract).
Hammerstein, J., Cupceancu, B.: Behandlung des Hirsutismus mit Cyproteronacetat. Dtsch. med. Wschr. 94, 829 (1969).
Hertel, P., Kramer, M., Neumann, F.: Einfluß eines Antiandrogens (Cyproteronacetat) auf Knochenwachstum und Knochenreifung männlicher Ratten. Arzneimittel-Forsch. 19, 1777–1790 (1969).
Neri, R., Florance, K., Koziol, P., Cleave, S. van: A biological profile of a nonsteroidal antiandrogen, Sch 13521 (4´nitro-3´-trifluoromethylisobutyramilide). Endocrinology 91, 427–437 (1972).
Neri, R.O., Monahan, M.D., Meyer, J.G., Aeonso, B.A., Tabachnick, I.A.: Biological studies on an anti-androgen (SH 714). Europ. J. Pharmacol. 1, 438 (1967).
Neumann, F., Berswordt-Wallrabe, R. von, Elger, W., Steinbeck, H., Hahn, J.D.: Effects of anti-androgens. Third Int. Congress of Endocrinology, Mexico City 1968. Excerpta med. (Amst.) Int. Congr. Ser. 184, 823–836 (1969).
Neumann, F., Elger, W., Berswordt-Wallrabe, R. von, Kramer, M.: Beeinflussung der Regelmechanismen des Hypophysenzwischenhirnsystems von Ratten durch einen Testosteron-Antagonisten, Cyproteron (l,2α-Methylen-6-chlor-4,6-pregnadien-17α-ol-3,20-dion). Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 255, 221–235 (1966).
Neumann, F., Elger, W., Berswordt-Wallrabe, R. von, Kramer, M.: Restitution der akzessorischen Geschlechtsdrüsen nach Langzeitbehandlung mit einem Androgen-Antagonisten (Cyproteronacetat). Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 255, 236–244 (1966).
Prasad, M.R.N., Singh, S.P., Rajalakshmi, M.: Fertility control in male rats by continuous release of microquantities of cyproterone acetate from subcutaneous silastic capsules. Contraception 2, 165–178 (1970).
Rajalakshmi, M., Prasad, M.R.N.: Alterations in sialic acid in the epididymis of the puberal rat in response to changes in functional activity of the testis. J. Reprod. Fertil. 24, 409 (1971).
Rajalakshmi, M., Singh, S.P., Prasad, M.R.N.: Effects of microquantities of cyproterone acetate released through silastic capsules on the histology of the epididymis of the rat. Contraception 3, 335–346 (1971).
Roosen-Runge, E.C.: The process of spermatogenesis in mammals. Biol. Rev. 37, 343 (1962).
Saunders, H.L., Kerwin, J.F.: The anti-androgenic activity of B-norandrostanes. Excerpta med. (Amst.) Int. Congr. Ser. 123, 599 (1967).
Saunders, H.L., Tomaszewski, J., Pauls, J., Zuccarello, W.: Antifertility effect of 17a- methyl-B-nortes tosterone (SK and F 7690). Endocrinology 85, 960 (1969).
Steinbeck, H., Mehring, M., Neumann, F.: Comparison of the effects of cyproterone, cyproterone acetate and oestradiol on testicular function, accessory sexual glands and fertility in a long-term study on rats. J. Reprod. Fertil. 26, 65–76 (1971).
Steinbeck, H., Neumann, F.: Effect of cyproterone acetate on puberty. J. Reprod. Fertil. 26, 59–63 (1971).
Steinbeck, H., Neumann, F.: Influence of the anti-androgen cyproterone and its acetate on testicular function, onset of puberty, and bone growth and maturation. Third Int. Congr. on Hormonal Steroids, Hamburg 1970. Excerpta med. (Amst.) Int. Congr. Ser. 219, 1007–1015 (1971).
Viguier-Martinez, M., Pelletier, J.: Etude comparée des effects de la cyprotérone et de l’acétate de cyproterone sur la LH hypophysäre, la LH plasmatique et Fappareil génital du Rat mâle prépubère. C.R. Acad. Sci. (Paris) 274, 2696 D (1972).
Whalen, R.E., Luttge, W.G.: Contraceptive properties of the anti-androgen cyproterone acetate. Nature (Lond.) 223, 633–634 (1969).
Zucker, I.: Effects of an anti-androgen on the mating behaviour of male guinea-pigs and rats. J. Endocr. 35, 209–210 (1966).
References
Beach, F., Westbrook, W.: Morphological and behavioral effects of an ‘antiandrogen’ in male rats. J. Endocr. 42, 379–382 (1968).
Beeman, E.A.: The effect of male hormones on aggressive behavior in mice. Physiol. Zool. 20, 373–405 (1947).
Bertolini, A., Gessa, G.L., Vergoni, W., Ferrari, W.: Induction of sexual excitement with intraventricular ACTH; permissive role of testosterone in the male rabbit. Life Sci. 7, 1203–1206 (1968).
Bertolini, A., Vergoni, W., Gessa, G.L., Ferrari, W.: Induction of sexual excitement by the action of adrenocortieotrophic hormone in brain. Nature (Lond.) 221, 667–669 (1969).
Bloch, G.J., Davidson, J.M.: Behavioral and somatic responses to the antiandrogen cyproterone (l,2α-methylene-6-chloro-Δ6-17α-hydroxy-progesterone). Horm, and Behav. 2, 11–25 (1971).
Davidson, J.M., Bloch, G.J.: Neuroendocrine aspects of male reproduction. Biol. Reprod. 1, 67–92 (1969).
Davis, D.E.: The physiological analysis of aggressive behavior. In: Social Behavior and Organization Among Vertebrates. Ed. by Etkin, W. Chicago, Illinois: University of Chicago Press 1964, pp. 53–74.
Dörner, G., Götz, F., Mainz, K.: Influence of antiandrogens on sexual behaviour and gonadal function in male rats. Endocr. exp. 6, 17–27 (1972).
Edwards, D.A.: Effects of cyproterone acetate on aggressive behaviour and the seminal vesicles of male mice. J. Endocr. 46, 477–481 (1970).
Ericsson, R.J., Dutt, H.H., Archdeacon, J.W.: Progesterone and 6-chloro-Δ6-17- acetoxyprogesterone as inhibitors of spermatogenesis in the rabbit. Nature (Lond.) 204, 261–263 (1964).
Guhl, A.M.: Gonadal hormones and social behavior in infrahuman vertebrates. In: Sex and Internal Secretions. Vol. 11. Ed. by Young, W.C. Baltimore, Maryland: Williams and Wilkins 1961, pp. 1240–1267.
Hüttenrauch, O.E.: Versuche an Jungbullen über den Einfluß von Depotgestageneii auf Sexualverhalten und Ejakulatbeschaffenheit. Mariensee/Trenthorst: Max-Planck-Institut für Tierzucht und Tiererhaltung. Hannover: Tierärztliche Hochschule, Dissertation 1966.
Jöchle, W.: Die Anwendung der Gestagene in Veterinärmedizin und Zootechnik. In: Junkmann, K. (Ed.). “Gestagene”. Handbuch der experimentellen Pharmakologie, Vol. XXII/2, Kapitel XII, pp. 805. Berlin-Heidelberg-New York: Springer 1969.
Jöchle, W.: Zootechnische Indikationen in der Haustierhaltung, der Tierzucht und der tierischen Produktion. In: Junkmann, K. (Ed.). “Gestagene”. Handbuch der experimentellen Pharmakologie, Vol. XXII/2, Kapitel XII, pp. 822. Berlin-Heidelberg-New York: Springer 1969.
Sayler, A.: The effect of anti-androgens on aggressive behavior in the gerbil. Physiol. Behav. 5, 667–671 (1970).
Schmidtke, D., Schmidtke, H. O.: Ein neues Antiandrogen beim Hund. Kleintier-Prax. 13, 146–149 (1968).
Scott, J.P., Fredericson, E.: The causes of fighting in mice and rats. Physiol. Zool. 24, 273–309 (1951).
Starka, L.: Failure of antiandrogen cyproterone acetate to modify sexual stimulation induced by p-ehlorophenylalanine and testosterone. Arch. Sex. Behav. 1, 345–346 (1971).
Steinbeck, H., Elgeb, W., Neumann, P.: Sexual activity of male rats under the influence of oestradiol and antiandrogens and recurrence of libido after cessation of treatment. VI. Acta Endocrinologica Congress, Helsinki 1967. Acta endocr. (Kbh.) Suppl. 119, 63 (Abstract No. 47).
Stern, J., Murphy, M.: Effects of cyproterone acetate on the spontaneous activity and seminal vesicle weight of male rats. J. Endocr. 50, 441–443 (1971).
Whalen, R.E., Edwards, D.A.: Effects of the anti-androgen cyproterone acetate on mating behavior and seminal vesicle tissue in male rats. Endocrinology 84, 155–156 (1969).
Whalen, R. E., Luttge, W. G.: Contraceptive properties of the antiandrogen cyproterone acetate. Nature (Lond.) 223, 633–634 (1969).
Zucker, I.: Effects of an anti-androgen in the mating behaviour of male guineα-pigs and rats. J. Endocr. 35, 209–210 (1966).
References
Britten, N.R., Davidson, E.: Gene regulation of higher cells. Science 165,349 (1969).
Britten, N.R., Davidson, E.: A new model amid old problems. In: Bernhard, R. (Ed.). “Scientific Research”, p. 26, 1969, cited by Chandra, P.: Molekularbiologische Untersuchungen zur Wirkungsweise von Androgen-Antagonisten. Habilitationsschrift - Universität Frankfurt/M., 1970.
Chappel, C.I., Revesz, C., Gaudry, R.: Biological studies on new orally active 6,17- halogenated progesterones. Acta endocr. (Kbh.) Suppl. 51, 915 (1960).
Cupceancu, B., Neumann, F.: Sensibilitätsunterschiede der verschiedenen Strukturen des Genitaltraktes von weiblichen Rattenfoeten unter dem Einfluß von Medroxypro- gesteronacetat oder Norethisteronacetat. Endokrinologie 54, 66–80 (1969).
Elger, W.: Die Rolle der fetalen Androgene in der Sexualdifferenzierung des Kaninchens und ihre Abgrenzung gegen andere hormonale und somatische Faktoren durch Anwendung eines starken Antiandrogens. Arch. Anat. micr. Morph, exp. 55, 657–743 (1966).
Elger, W.: unpubliziert - 1973.
Elger, W., Neumann, F.: The role of androgens in the differentiation of the mammary gland in male mouse fetuses. Proc. Soc. exp. Biol. (N.Y.) 128, 637–640 (1966).
Elger, W., Neumann, F., Berswordt-Wallrabe, R. von: The influence of androgen antagonists and progestogens on the sex differentiation of different mammalian species. In: Hamburgh, M. and Barrington, E.J.W. (Eds.). “Hormones in Development”, chapt. 51, pp. 651–667. Appleton-Century-Crofts, Educational Division, Meredith Corporation, New York 1971.
Elger, W., Neumann, F., Steinbeck, H., Hahn, J.D.: The significance of hormones in mammalian sex differentiation as evidenced by experiments with synthetic androgens and antiandrogens. In: Gebian, H. and Plötz, E.J. (Eds.). “Mammalian Reproduction”, 21. Colloquium der Gesellschaft für Biologische Chemie, Mosbach/Baden - April 1970, pp. 33–44. Berlin-Heidelberg-New York: Springer 1970.
Elger, W., Steinbeck, H., Cupceancu, B., Neumann, F.: Influence of methyltestosterone and cyproterone acetate on Wolffian duct differentiation in female rat foetuses. J. Endocr. 47, 417–422 (1970).
Forsberg, J.G., Jacobsohn, D.: The reproductive tract of males delivered by rats given cyproterone acetate from days 7–21 of pregnancy. J. Endocr. 44, 461–462 (1969).
Forsberg, J.G., Jacobsohn, D., Norgren, A.: Development of the urogenital tract in male offspring of rats injected during pregnancy with a substance with antiandrogenic properties (cyproterone). Z. Anat. Entwickl.-Gesch. 126, 320–331 (1968).
Forsberg, J.G., Jacobsohn, D., Norgren, A.: Modification of reproductive organs in male rats influenced prenatally or pre- and postnatally by an “antiandrogenic” steroid (cyproterone). Z. Anat. Entwickl.-Gesch. 127, 175–186 (1968).
Goldfoot, D.A., Resko, J. A., Goy, R.W.: Induction of target organ insensitivity to testosterone in the male guine α-pig with cyproterone. J. Endocr. 50, 423–429 (1971).
Goldman, A.S., Baker, M.K.: Androgenicity in the rat fetus of metabolites of testosterone and antagonism by cyproterone acetate. Endocrinology 89, 276–280 (1971).
Gräf, K.-J.: Über den Einfluß eines stark wirksamen Antiandrogens auf die Sexualdifferenzierung des Meerschweinchens. Dissertation - Freie Universität Berlin 1971 (Forschungslaboratorien der Schering AG).
Gräf, K.-J., Kleinecke, R.-L., Neumann, F.: The stimulation of male duct derivatives in female guinea pigs with an antiandrogen, cyproterone acetate. J. Reprod. Fertil. (in press) (1973).
Gräf, K.-J., Neumann, F.: Influence of cyproterone acetate on sexual differentiation of male guineα-pigs. Z. Anat. Entwickl.-Gesch. 137, 200–220 (1972).
Greene, R.R., Burrill, M.W., Ivy, A.C.: Experimental intersexuality: The effect of antenatal androgens on sexual development of female rats. Amer. J. Anat. 65,415(1939).
Grumbach, M.M., Ducharme, J.R., Moloshok, R.E.: On the fetal masculinizing action of certain oral progestins. J. clin. Endocr. 19, 1369–1380 (1959).
Hahn, J.D., Hasselbach, CH. von, Berger, B., Neumann, F.: Sexual differentiation of the hypothalamic ‘PIF’-center and other brain areas. Symposion on Central Mechanisms Controlling the Pituitary Testicular Function. Florence/Italy: October 1972.
Hamada, H., Neumann, F., Junkmann, K.: Intrauterine antimaskuline Beeinflussung von Rattenfeten durch ein stark gestagen wirksames Steroid. Acta endocr. (Kbh.) 44, 380–388 (1963).
Hammerstein, J., Cupceancu, B.: Behandlung des Hirsutismus mit Cyproteronacetat. Dtsch. med. Wschr. 94, 829–834 (1969).
Hayashi, S.: Difference in responsiveness to estrogen of the anterior hypophysis between normal and neonatally estrogenized rats. J. Fac. Sci. (Tokyo) 11, 227–234 (1967).
Hayashi, S.: Difference in luteinization in intrasplenic ovarian grafts between normal and persistent-estrous rats following ovariectomy. J. Fac. Sci. (Tokyo) 11, 235–242 (1967).
Hayashi, S.: Suppression by estrogen injections of luteinization in intrasplenic ovarian grafts in ovariectomized “normal” and neonatally estrogenized rats. Annot. zool. jap. 42, 13–20 (1969).
Jacob, F., Monod, J.: Genetic regulator y mechanisms in the synthesis of proteins. J. molec. Biol. 3, 318–356 (1961).
Johnstone, E.E., Franklin, R.R.: Assay of progestins for fetal virilizing properties using the mouse. Obstet, and Gynec. 23, 359–362 (1964).
Jones, H.W., Welkins, L.: The genital anomaly associated with prenatal exposure to progestagens. Fertil. and Steril. 11, 148 (1960).
Jost, A.: Recherches sur la différenciation sexuelle de l’embryon de Lapin. I. Introduction et embryologie génitale normale. Arch. Anat. micr. Morph, exp. 36, 151–200 (1947).
Jost, A.: Recherches sur la différenciation sexuelle de l’embryon de Lapin. II. Action des androgènes de synthèse sur l’histogenèse génitale. Arch. Anat. micr. Morph, exp. 36, 242–270 (1947).
Jost, A.: Recherches sur la différenciation sexuelle de l’embryon de Lapin. III. Rôle des gonades foetales dans la différenciation sexuelle somatique. Arch. Anat. micr. Morph, exp. 36, 271–315 (1947).
Jost, A.: Moialitie3 in the action of gonadal and gonadstimulating hormones in the foetus. Mem. Soc. Endocr. 4, 237–248 (1955).
Jost, A.: Gonadal hormones in the sex differentiation of the mammalian fetus. In: Haan, R.L. de and Ursprung, H. (Eds.). “Organogenesis”, New York: Holt, Rinehart and Winston Inc. 1965.
Jost, A.: Steroids and sex differentiation of the mammalian fetus. In: Proc. Ilnd Int. Congress on Hormonal Steroids, Milan 1966. Excerpta Medica International Congress Series 132, p. 74 (1967).
Jost, A.: Modalities in the action of androgens on the foetus. In: Cassano, C., Finkel-Stein, M., Klopper, A., and Conti, C. (Eds.). “Trans. Third Meeting Int. Study Group for Steroid Hormones, Rome, Research on Steroids”, vol. 3, pp. 207–220. Amsterdam: North-Holland Publishing Co. 1968.
Junkmann, K.: Experimental aspects in the study of synthetic progestogens. Symposium of Family Planning, May 1962. J. Egypt. Med. Association, 1963, pp. 38–60.
Junkmann, K.: Experimentelle Gesichtspunkte bei der Prüfung synthetischer Gestagene. Dtsch. med. Wschr. 88, 629–638 (1963).
Junkmann, K.: Die tierexperimentelle Prüfung antikonzeptioneller Steroide. Internist (Berl.) 5, 237–242 (1964).
Junkmann, K., Neumann, F.: Zum Wirkungsmechanismus von an Feten antimaskulin wirksamen Gestagenen. Acta endocr. (Kbh.) Suppl. 90, 139–154 (1964).
Karlson, P.: Biochemische Wirkungsweise der Hormone. Dtsch. med. Wschr. 86, 668–674 (1961).
Kraay, R.J., Brennan, D.M.: Evaluation of Chlormadinone acetate and other progestogens for foetal masculinization in rats. Acta endocr. (Kbh.) 43, 412–418 (1963).
Kumaresan, P., Turner, C.W.: Effect of neonatal administration of testosterone propionate upon mammary gland growth in female rats. Endocrinology 79, 443–444 (1966).
Kurcz, M., Kovacs, K., Tiboldi, T., Orosz, A.: Effect of androgenisation on adeno- hypophyseal prolactin content in rats. Acta endocr. (Kbh.) 54, 663–667 (1967).
Lerner, L.J., Brennan, D.M., Phtllipo, M. de, Yiacas, E.: Comparison of biological activities of progesterone, norethisterone and the acetophenone derivatives of 16a, 17α- dihydroxyprogesterone. (Abstract). Fed. Proc. 20, 200 (1961).
Lerner, L.J., Phillipo, M. de, Yiacas, E., Brennan, D.M., Borman, A.: Comparison of the acetophenone derivative of 16a,17α-dihydroxyprogesterone with other progestational steroids for masculinization of the rat fetus. Endocrinology 71, 448–451 (1962).
Madjerek, Z., Visser, J. de, Vies, J. van der, Overbeek, G.A.: Allylestrenol, a pregnancy maintaining oral gestagen. Acta endocr. (Kbh.) 35, 8–19 (1960).
Mey, R., Scheid, H.: Tierexperimentelle Untersuchungen zur Frage einer androgenen Wirkung von Aethinyl-nor-testosteron. Geburtsh. u. Frauenheilk. 19, 783–788 (1959).
Mischler, T., Gawlak, D.: Antagonism between masculinizing steroids and cyproterone acetate in the rat fetus. Europ. J. Pharmacol. 9, 391–393 (1970).
Moore, C. R.: Embryonic sex hormones and sexual differentiation. Springfield/Ill,; C.C. Thomas 1947.
Neumann, F.: Die Bedeutung der Androgene für die Sexualdifferenzierung. Berl. Münch, tierärztl. Wschr. 83, 389–393 (1970).
Neumann, F., Berswordt-Wallrabe, R. von, Elger, W., Steinbeck, H., Hahn, J.D., Kramer, M.: Aspects of androgen-dependent events as studied by anti-androgens. Recent Progr. Hormone Res. 26, 337–410 (1970).
Neumann, F., Elger, W.: Physiological and psychical intersexuality of male rats by early treatment with an anti-androgenic agent (1,2α- methylene - 6 - chloro - Δ6 - hy dr oxypro-gesterone-acetate). Acta endocr. (Kbh.) Suppl. 100, 174 (1965) (Abstract No. 142).
Neumann, F., Elger, W.: The effect of the anti-androgen l,2α-methylene-6-chloro- Δ4,6-pregnadiene-17α-ol-3,20-dione-17α-acetate (cyproterone acetate) on the development of the mammary glands of male foetal rats. J. Endocr. 36, 347–352 (1966).
Neumann, F., Elger, W.: Steroidal stimulation of mammary glands in prenatally feminized male rats. Europ. J. Pharmacol. 1, 120–123 (1967).
Neumann, F., Elger, W., Berswordt-Wallrabe, R. von: The structure of the mammary glands and lactogenesis in feminized male rats. J. Endocr. 36, 353–356 (1966).
Neumann, F., Elger, W., Kramer, M.: Development of a vagina in male rats by inhibiting androgen receptors with an anti-androgen during the critical phase of organogenesis. Endocrinology 78, 628–632 (1966).
Neumann, F., Elger, W., Steinbeck, H.: Drug-induced intersexuality in mammals. J. Reprod. Fertil. Suppl. 7, 9–24 (1969).
Neumann, F., Elger, W., Steinbeck, H.: Antiandrogens and reproductive development. Phil. Trans. B259, 179–184 (1970).
Neumann, F., Elger, W., Steinbeck, H.: Die Bedeutung der Androgene für die „Prägung des Gehirns. J. Neuro-visc. Rel. Suppl. 10, 296–309 (1971).
Neumann, F., Graf, K.-J., Elger, W.: Hormone induced disturbances in sexual differentiation. Symposion on “Hormones and Embryonic Development”, Gemeinsame Tagung der Britischen und Deutschen Pharmakologischen Gesellschaft, Berlin 1973. Naunyn- Schmiedeberg’s Archives of Pharmacology in press.
Neumann, F., Hamada, H.: Intrauterine Feminisierung männlicher Rattenfeten durch das stark gestagen wirksame 6-chlor-Δ6-l,2-methylen-17α-hydroxy-progesteronacetat. 10. Symp. Dtsch. Gesellschaft für Endokrinologie, Wien 1963. Berlin-Heidelberg-New York: Springer 1964, S. 301–304.
Neumann, F., Junkmann, K.: A new method for determination of virilizing properties of steroids on the fetus. Endocrinology 73, 33–37 (1963).
Neumann, F., Kramer, M.: Antagonism of androgenic and antiandrogenic action on the rat fetus. Endocrinology 75, 428–433 (1964).
Neumann, F., Richter, K.-D., Günzel, P.: Wirkungen von Antiandrogenen. Zbl. Vet.- Med., Reihe A, 12, 171–188 (1965).
Neumann, F., Steinbeck, H.: Influence of sexual hormones on the differentiation of neural centers. Arch. Sex. Behav. 2, 147–162 (1972).
Neumann, F., Steinbeck, H., Elger, W.: Sexualdifferenzierung. 16. Symp. Dtsch. Gesellschaft für Endokrinologie, Ulm 1970. „Endokrinologie der Entwicklung und Reifung“, S. 58–82. Berlin-Heidelberg-New York: Springer 1970.
Price, D., Ortiz, E., Zaaijer, J.P.: Organ culture studies of hormone secretion in endocrine glands of fetal guinea pigs. III. The relation of testicular hormone to sex differentiation of the reproductive ducts. Anat. Ree. 157, 27–41 (1967).
Raynaud, A.: Modification expérimentale de la différenciation sexuelle des embryons de souris, par action des hormones androgénes et oestrogènes. Acta Scientifique et Industrielles, Nos. 925-et 926, 1942.
Raynaud, A.: Morphogenesis of the mammary gland. In: Kon, S.K. and Cowie, A.T. (Eds.). “Milk - the mammary gland and its secretion”. New York and London: Academic Press, vol. 1, pp. 3–46, 1961.
Raynaud, A., Frilley, M.: Destruction des glandes génitales de l’embryon de souris par une irradiation au moyen des rayons X, à l’âge de 13 jours. Ann. Endocr. (Paris) 8,400 (1947).
Raynaud, A., Frilley, M.: Effets, sur la development du tractus génital des embryons de souris, de la destruction des ébauches de leurs glandes génitales, par une irradiation au moyen des rayons X, à l’âge de treize jours. C.R. Soc. Biol. (Paris) 141, 1134–1137 (1947).
Raynaud, A., Raynaud, J.: La production expérimentale des malformations mammaires chez le foetus de souris, par l’action des hormones sexuelles. Ann. Inst. Pasteur 90, 39–91 (1956).
Revesz, C., Chappel, C.I., Gaudry, R.: Masculinization of female fetuses in the rat by progestational compounds. Endocrinology 66, 140–144 (1960).
Rieser, U., Schulz, U., Neumann, F.: Ursachen der geschlechtsunterschiedlichen Milch- drüsengewebsentwicklung bei Ratten. Experientia (Basel) 26, 1148–1149 (1970).
Schöler, H.F.L., Wächter, A.M. de: Evaluation of androgenic properties of progestational compounds in the rat by the female foetal masculinization test. Acta endocr. (Kbh.) 38, 128–136 (1961).
Steinbeck, H., Neumann, F., Elger, W.: Effect of an antiandrogen on the differentiation of the internal genital organ in dogs. J. Reprod. Fertil. 23, 223–227 (1970).
Suchowsky, G.K., Junkmann, K.: Zur Frage der Virilisierung des Foetus durch Behandlung der Mutter mit Gestagenen. Geburtsh. u. Frauenheilk. 20, 1019–1023 (1960).
Thomson, K., Napp, J.-H.: Nebenwirkungen bei hochdosierter Nortestosteronmedikation in der Gravidität. Geburtsh. u. Frauenheilk. 20, 508–513 (1960).
Tomkins, G.M., Thompson, E.B.: Hormonal control of protein synthesis at the trans- lational level. 18. Colloquium der Gesellschaft für Biologische Chemie, Mosbach/Baden 1967, p. 107. Berlin-Heidelberg-New York: Springer.
Wenzel, M., Pollow-Hanisch, B., Pollow, K.: Änderung der Sexualspezifität bei der Androstendionreduktion durch Oestradiol-17/?-Wasserstoff in der Rattenleber nach Feminisierung durch Cyproteronacetat. Hoppe-Seylers Z. physiol. Chem. 350, 791–792 (1969).
Wiechert, R., Neumann, F.: Gestagene Wirksamkeit von 1-Methyl- und l,2α-Methylen- Steroiden. Arzneimittel-Forsch. 15, 244–246 (1965).
Wiesner, B.P.: The postnatal development of the genital organs in the albino rat - with a discussion of a new theory of sexual differentiation. J. Obstet. Gynaec. Brit. Emp. 41, 867–922 (1934).
Wiesner, B.P.: The postnatal development of the genital organs in the albino rat with a discussion of a new theory of sexual differentiation. VI. Effects of sex hormones in the heteronomous sex. J. Obstet. Gynaec. Brit. Emp. 42, 8–78 (1935).
Wilkins, L.: Masculinization of female fetus due to use of orally given progestins. J. Amer. med. Ass. 172, 1028–1032 (1960).
Wilkins, L., Jones, H.W., Holman, G.H., Stempeel, R.S.: Masculinization of the female fetus associated with administration of oral and intramuscular progestins during gestation. Non-adrenal female pseudohermaphroditism. J. clin. Endocr. 18, 559–585 (1958).
Winkler, K.: La valeur des anti-androgenes en dermatologie. Ann. Derm. Syph. (Paris) 95, 147–153 (1968).
Zarate, A., Mahesh, V.B., Greenblatt, R.B.: Effect of an antiandrogen, 17α-methyl-B-nortestosterone, on acne and hirsutism. J. clin. Endocr. 26, 1394–1398 (1966).
References
Arai, Y., Gorski, R.A.: Critical exposure time for androgenization of the rat hypothalamus determined by antiandrogen injection. Proc. Soc. exp. Biol. (N.Y.) 127, 590(1968).
Barraclough, C.A.: Production of anovulatory, sterile rats by single injection of testosterone propionate. Endocrinology 68, 62 (1961).
Barraclough, C.A.: Modifications in the CNS regulation of reproduction after exposure of prepubertal rats to steroid hormones. Recent Progr. Hormone Res. 22, 503 (1966).
Barraclough, C. A.: Modifications in reproductive function after exposure to hormones during the prenatal and early postnatal period. In: Martini, L. and Ganong, W.F. (Eds.). “Neuroendocrinology” 2, 62. New York-London: Academic Press 1967.
Barraclough, C.A., Gorski, R.A.: Evidence that the hypothalamus is responsible for androgen-indueed sterility in the female rat. Endocrinology 68, 68 (1961).
Barraclough, C.A., Gorski, R.A.: Studies on mating behavior in the androgen-sterilized female rat in relation to the hypothalamic regulation of sexual behavior. J. Endocr. 25, 175 (1962).
Bottiglioni, F., Collins, W.P., Flamigni, C., Neumann, F., Sommerville, I.F.: Studies on androgen metabolism in experimentally feminized rats. Endocrinology 89, 553 (1971).
Brain, P. F., Evans, C.M., Poole, A.E.: Studies on the effects of cyproterone acetate administered both in early life and to adults on subsequent fighting behaviour and organ weight changes in male albino mice. Acta endocr. (Kbh.) 177, 286 (1973).
Cagnoni, M., Fantini, F., Morace, G., Ghetti, A.: Failure of testosterone propionate to induce the ‘early-androgen’ syndrome in rats previously injected with progesterone. J. Endocr. 33, 527 (1965).
Dantchakofe, V.: Role des hormones dans la manifestation des instincts sexuels. C. R. Acad. Sei. (Paris) 206, 945 (1938).
Börner, G.: Hormonal induction and prevention of female homosexuality. J. Endocr. 42, 163 (1968).
Dörner, G., Fatschel, J.: Wirkungen neonatal verabreichter Androgene und Antiandrogene auf Sexualverhalten und Fertilität von Rattenweibchen. Endokrinologie 56, 29 (1970).
Doremann, R.I.: Antiandrogens. In: James, V.H.T. and Martini, L. “Hormonal Steroids”, Amsterdam: Excerpta Medica 1971 (p. 995).
Elger, W., Berswordt-Wallrabe, R. von, Neumann, F.: Der Einfluß von Antiandrogenen auf androgenabhängige Vorgänge im Organismus. Naturwissenschaften 54, 549 (1967).
Goldeoot, D.A., Resko, J.A., Goy, R.W.: Induction of target organ insensitivity to testosterone in the male guinea-pig with cyproterone. J. Endocr. 50, 423 (1971).
Gorski, R.A.: Localization and sexual differentiation of the nervous structures which regulate ovulation. J. Reprod. Fertil. Suppl. 1, 67 (1966).
Gorski, R.A., Barraclough, C.A.: Effects of low dosages of androgen on the differentiation of hypothalamic regulatory control of ovulation in rat. Endocrinology 73, 210 (1963).
Hahn, J.D., Elger, W., Steinbeck, H., Neumann, F.: Experimentell erzeugtes transsexuelles Verhalten männlicher Ratten. Symposium Sexuologicum, Prag 1968, S. 60 (Abstract No. 10).
Harris, G.W.: Sex hormones, brain development and brain function. Endocrinology 75, 627 (1964).
Kincl, F.A., Maqueo, M.: Prevention by progesterone of steroid-induced sterility in neonatal male and female rats. Endocrinology 77, 859 (1965).
Korfsmeier, K.-H.: Ultrastrukturelle Veränderungen in den neurosekretorischen Zentren des Hypothalamus und in der Eminentia mediana nach Behandlung mit Cyproteronacetat (Antiandrogen). Z. Zellforsch. 110, 600 (1970).
Kramer, M., Neumann, F., Elger, W.: Zur Bedeutung fetaler Androgene für die Geschlechtsdifferenzierung. 6. Frühjahrstagung d. Dtsch. Pharmakologischen Gesellschaft, Mainz 1965. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 251, 124 (1965).
Lloyd, C.W., Weisz, J.: Interrelationships of steroid and neural mechanisms. Excerpta Med. (Amst.) Int. Congr. Ser. 132, 917 (1967).
Moor, P. de, Denee, C.: The “puberty” of the rat liver. Feminine pattern of Cortisol metabolism in male rats castrated at birth. Endocrinology 82, 480 (1968).
Nadler, R.D.: Masculinization of female rats by intracranial implantation of androgen in infancy. J. comp, physiol. Psychol. 66, 157 (1968).
Nadler, R. D.: Differentiation of the capacity for male sexual behavior in the rat. Horm. Behav. 1, 53 (1969).
Neumann, F.: Tierexperimentelle Untersuchungen zur Transsexualität. 10. Wissenschaftliche Tagung der Deutschen Gesellschaft für Sexualforschung, Berlin 1969. Beitr. Sexualforsch. 49, 54 (1970).
Neumann, F., Berswordt-Wallrabe, R. von, Elger, W., Steinbeck, H.: Hormonhemmer — Untersuchungen mit Testosteron-Antagonisten. 18. Mosbacher Koll. der Gesell, für physiologische Chemie “Wirkungsmechanismen der Hormone”, Mosbach 1967, p. 218. Berlin-Heidelberg-New York: Springer 1967.
Neumann, F., Berswordt-Wallrabe, R. von, Elger, W., Steinbeck, H.: Activities of antiandrogens. Experiments in prepuberal and puberal animals and in foetuses. Workshop Conference on Testosterone, Hamburg 1967. In: Tamm, J. (Ed.). “Testosterone”, p. 134. Stuttgart: Thieme 1968.
Neumann, F., Berswordt-Wallrabe, R. von, Elger, W., Steinbeck, H., Hahn, J.D.: Effects of antiandrogens. Third Int. Congress of Endocrinology, Mexico City 1968. Excerpta med. (Amst.) Int. Congr. Ser. 184, 823 (1969).
Neumann, F., Berswordt-Wallrabe, R. von, Elger, W., Steinbeck, H., Hahn, J.D., Kramer, M.: Aspects of androgen-dependent events as studied by antiandrogens. Recent Progr. Hormone Res. 26, 337 (1970).
Neumann, F., Elger, W.: Physiological and psychical intersexuality of male rats by early treatment with an anti-androgenic agent (l,2a-methylene-6-chloro-J6-hydroxyproge- sterone-acetate). Acta endocr. (Kbh.) Suppl. 100, 174 (1965).
Neumann, F., Elger, W.: Proof of the activity of androgenic agents on the differentiation of the external genitalia, the mammary gland and the hypothalamic-pituitary system in rats. Proceedings of the Und Symp. on Steroid Hormones “Androgens in Normal and Pathological Conditions”, Ghent. Excerpta Med. (Amst.) Int. Congr. Ser. 101, 168 (1965).
Neumann, F., Elger, W.: Permanent changes in gonadal function and sexual behavior as a result of early feminization of male rats by treatment with an antiandrogenic steroid. Endokrinologie 50, 209 (1966).
Neumann, F., Elger, W.: Der Einfluß von Antiandrogenen auf Differenzierungsvorgänge. I. Schering — Symposium on Endocrinology “Advances in the Biosciences”, Berlin 1967, p. 80. Oxford: Pergamon Press — Vieweg 1969.
Neumann, F., Elger, W., Steinbeck, H.: Drug-induced intersexuality in mammals. Ann. Conference of the Society for the Study of Fertility, Newcastle 1968. J. Reprod. Fertil. Suppl. 7, 9 (1969).
Neumann, F., Elger, W., Steinbeck, H.: Die Bedeutung der Androgene für die “Prägung des Gehirns”. Symp. d. Dtsch. Neuro vegetativen Gesellschaft über zentralnervöse Sexualsteuerung, Göttingen 1969. J. Neuro-vise. Rel. Suppl. 10, 296 (1971).
Neumann, F., Elger, W., Steinbeck, H., Berswordt-Wallrabe, R. von: Antiandrogene. 13. Symp. Dtsch. Ges. für Endokrinologe, Würzburg 1967. In: Klein, E. (Ed.). “Das Testosteron — Die Struma”, p. 78. Berlin-Heidelberg-New York: Springer 1968.
Neumann, F., Hahn, J.D., Kramer, M.: Hemmung von testosteronabhängigen Differenzierungsvorgängen der männlichen Ratte nach der Geburt. Acta endocr. (Kbh.) 54, 227 (1967).
Neumann, F., Kramer, M.: Female brain differentiation of male rats as a result of early treatment with an androgen antagonist. IInd Int. Congr. on Hormonal Steroids, Mailand 1966. Excerpta Med. Int. Congress Series 111 (Abstract No. 129). Excerpta Med. Int. Congress Series 132, 932 (1967).
Neumann, F., Steinbeck, H.: Hormonale Beeinflussung des Verhaltens. Klin. Wsehr. 49, 790 (1971).
Neumann, F., Steinbeck, H.: Influence of sexual hormones on the differentiation of neural centers. Arch. sex. Behav. 2, 147 (1972).
Neumann, F., Steinbeck, H., Elger, W.: Sexualdifferenzierung. 16. Symp. Dtsch. Ges. für Endokrinologie, Ulm 1970. “Endokrinologie der Entwicklung und Reifung”, p. 58. Berlin-Heidelberg-New York: Springer 1970
Neumann, F., Steinbeck, H., Hahn, J.D.: Hormones and brain differentiation. Workshop Conference on Integration of Endocrine and Non-Endocrine Mechanisms in the hypothalamus, Stresa 1969. In: Martini, L., Motta, M. and Fraschini, F. (Eds.). “The Hypothalamus”, p. 569. New York-London: Academic Press 1970.
Pfeiffer, C. A.: Sexual differences in the hypophysis and their determination by the gonads. Amer. J. Anat. 58, 195 (1936).
Schiebler, T.H., Meinhardt, D.W.: Über die Wirkung von Antiandrogenen auf die neurosekretorischen Systeme des Hypothalamus. Z. Zellforsch. 100, 581 (1969).
Schiebler, T.H., Meinhardt, D.W.: The effects of antiandrogens on the hypothalamus. In: Bargmann, W. and Scharrer, B. (Eds.). “Aspects of Neuroendoerinology”, 5th Int. Symp. Neurosecretion, Kiel, August 1969, p. 118. Berlin-Heidelberg-New York: Springer 1970.
Schiebler, T.H., Meinhardt, D.W.: Über die experimentelle Beeinflussung der neurosekretorischen Systeme des Hypothalamus durch Antiandrogene. In: Orthner, H. (Ed.). “Zentralnervöse Sexualsteuerung”. J. Neuro-visc. Rel. Suppl. 10, 384 (1971).
Steinbeck, H., Neumann, F.: Aspects of steroidal influence on Fetal Development. In: Klingberg, M.A., Abramovici, A., and Chemke, J. (Eds.). “Drugs and Fetal Development”. Advanc. Exp. Med. Biol. Yol. 27, 227 (1972).
Steinbeck, H., Neumann, F.: Regulation of sexual behavior. In: Ban, T.A. et al. (Eds.). “Psychopharmacology, Sexual Disorders and Drug Abuse”. Amsterdam-London: North- Holland 1973.
Stewart, J., Kaczender-Henrik, E.: Male copulatory behavior in the male rat after perinatal treatment with an antiandrogenic steroid. Horm. Behav. 2, 255 (1971).
Stewart, J., Pottier, J., Kaczender-Henrik, E.: Male copulatory behavior in the female rat after perinatal treatment with an antiandrogenic steroid. Horm. Behav. 2, 247 (1971).
Tuohimaa, P., Niemi, M.: Feminized uptake of sex steroids in the hypothalamus of male rats treated neonatally with an anti-androgen (cyproterone). Acta endocr. (Kbh.) Suppl. 138, 102 (1969).
Tuohimaa, P., Niemi, M.: In vitro uptake of tritiated sex steroids by the hypothalamus of adult male rats treated neonatally with an antiandrogen (cyproterone). Acta endocr. (Kbh.) 71, 45 (1972).
Wenzel, M., Pollow-Hanisch, B., Pollow, K.: Änderung der Sexualspezifltät bei der Androstendionreduktion durch Östradiol-17/?-Wasserstoff in Rattenleber nach Feminisierung durch Cyproteronacetat. Hoppe-Seylers Z. physiol. Chem. 350, 791 (1969).
Whalen, R.E., Edwards, D.A.: Hormonal determinants of the development of masculine and feminine behavior in male and female rats. Anat. Ree. 157, 173 (1967).
Wollman, A.L., Hamilton, J.B.: Prevention by cyproterone acetate of androgenic, but not of gonadotrophic, elicitation of persistent estrus in rats. Endocrinology 81, 350 (1967).
Worsley, A.: (personal communication) (1973).
References
Archibald, A., Shuster, S.: Bioassay of androgen using the rat sebaceous gland. J. Endocr. 37, xxii (1967).
Archibald, A., Shuster, S.: The bioassay of androgens and antiandrogens using sebum secretion in the rat. Proc. roy. Soc. Med. 62, 887–888 (1969).
Bullough, W.S.: Mitotic activity in the adult female mouse, mus musculus L., a study of its relation to the oestrus cycle in normal and abnormal conditions. Phil. Trans. B231, 453 (1946).
Burdick, K.H., Hill, R.: The topical effect of the antiandrogen chlormadinone acetate and some of its chemical modifications on the hamster costovertebral organ. Brit. J. Derm. 82, Suppl. 6, 19–25 (1970).
Ebling, F.J.: Sebaceous glands. I. The effects of sex hormones on the sebaceous glands of the female albino rat. J. Endocr. 5, 297–302 (1948).
Ebling, F.J.: Sebaceous glands: changes in sebaceous glands following implantation of oestradiol benzoate in female albino rat. J. Endocr. 7, 288 (1951).
Ebling, F. J.: Changes in the sebaceous glands and epidermis during the oestrous cycle of the albino rat. J. Endocr. 10, 147–154 (1954).
Ebling, F.J.: The action of testosterone and oestradiol on the sebaceous glands and epidermis of the rat. J. Embrvl. exp. Morph. 5, 74–82 (1957).
Ebling, F.J.: The action of testosterone on the sebaceous glands and epidermis in castrated and hypophysectomized male rats. J. Endocr. 15, 297–306 (1957).
Ebling, F.J.: Hormonal control of the sebaceous gland in experimental animals. In: Montagna, W., Ellis, R.A., and Silver, A.F. (Eds.). “Advances in Biology of Skin”, vol. 4, “Sebaceous Glands”, pp. 200–219. Oxford: Pergamon Press 1963.
Ebling, F.J.: The action of an antiandrogenic steroid, 17α-methyl-B-nortestosterone, on sebum secretion in rats treated with testosterone. J. Endocr. 38, 181–185 (1967).
Ebling, F.J.: Steroid hormones and sebaceous secretion. In: Briggs, M.H. (Ed.). “Advances in Steroids”, vol. 2, pp. 1–39. New York-London: Academic Press 1970.
Ebling, F.J.: Factors influencing the response of the sebaceous glands of the rat to androgen. Brit. J. Derm. 82, Suppl. 6, 10–14 (1970).
Ebling, F.J.: The effects of cyproterone acetate and oestradiol upon testosterone stimulated sebaceous activity in the rat. Acta endocr. (Kbh.) 72, 361–365 (1973).
Ebling, F. J., Skinner, J.: The measurement of sebum production in rats treated with testosterone and oestradiol. Brit. J. Derm. 79, 386–393 (1967).
Frost, P., Gomez, E.C.: Inhibitors of sex hormones: development of experimental models. In: Montagna, W., Scott, E.J. van, and Stoughton, R.B. (Eds.). “Advances in Biology of the Skin”, vol. 12, pp. 403–420. Oxford: Pergamon Press 1972.
Glenn, E.M., Gray, J.: Effect of various hormones on the growth and histology of the gerbil (Meriones unguieulatus) abdominal sebaceous gland pad. Endocrinology 76,115–123 (1965).
Graaf, H.J. de: The effect of sex hormones on sebaceous glands. Ned. T. Geneesk. 87, 1450 (1943).
Hamad A, H., Neumann, F., Junkmann, K.: Intrauterine antimaskuline Beeinflussung von Rattenfeten durch ein stark gestagen wirksames Steroid. Acta endocr. (Kbh.) 44, 380–388 (1963).
Hamilton, J.B., Montagna, W.: Sebaceous glands of hamster; morphological effects of androgens on integumentary structures. Amer. J. Anat. 86, 191 (1950).
Haskin, D., Lasher, N., Rothman, S.: Some effects of ACTH, cortisone, progesterone and testosterone on sebaceous glands in white rat. J. invest. Derm. 20, 207 (1953).
Hooker, C.W., Pfeiefer, C.A.: Effects of sex hormones upon body growth, skin, hair and sebaceous glands in rat. Endocrinology 32, 69 (1943).
Jones, E.L., Woodbury, L.: The effect of antiandrogens on the response of rat preputial glands to testosterone. J. invest. Derm. 43, 165–170 (1964).
Junkmann, K., Neumann, F.: Zum Wirkungsmechanismus von an Feten antimaskulin wirksamen Gestagenen. Acta endocr. (Kbh.) Suppl. 90, 139–154 (1964).
Läuppi, E., Studer, A.: Inhibition of experimental, testosterone-induced epidermis proliferation in the female rat by a synthetic phenanthrene derivative with anti androgenic effect. Experientia (Basel) 15, 264 (1959).
Läuppi, E., Studer, A.: Additional studies on skin proliferation-inhibiting properties of a phenanthrene derivative (Ro 2–7239). Dermatologica (Basel) 120, 275 (1960).
Lapière, C.: Modifications of the sebaceous glands by local application of sex hormones to the skin of mice. C.R. Soc. Biol. (Paris) 147, 1302 (1953).
Montagna, W., Kenyon, P.: Growth potentials and mitotic division in sebaceous glands of rabbits. Anat. Rec. 103, 365 (1949).
Neumann, F.: Use of cyproterone acetate in the animal and clinical trials. IVth International Seminar on Reproductive Physiology and Sexual Endocrinology “Hormones and Antagonists”, Brussels: May 1972. Gynee. Invest. 2, 150–179 (1971/1972).
Neumann, F., Elger, W.: The effect of a new antiandrogenic steroid, 6-chloro-17-hydroxy- lα,2α-methylenepregnα-4,6-diene-3,20-dione acetate (cyproterone acetate) on the sebaceous glands of mice. J. invest. Derm. 46, 561–572 (1966).
Neumann, F., Kramer, M.: Antagonism of androgenic and antiandrogenic action on the rat fetus. Endocrinology 75, 428–433 (1964).
Neumann, F., Richter, K.-D., Gunzel, P.: Wirkungen von Antiandrogenen. Zbl. Vet.- Med., Reihe A, 12, 171–188 (1965).
Pochi, P.E., Strauss, J.S., Mescon, H.: Sebum secretion and urinary fractional 17-keto- steroid and total 17-hydroxycorticoid excretion in male castrates. J. invest. Derm. 39, 475 (1962).
Saunders, H.L., Ebling, F. J.: The antiandrogenic and sebaceous gland inhibitory activity of 6α, 6β-ethylene-17α-methyl-B-nortestosterone. J. invest. Derm. 52, 163–168 (1969).
Shuster, S.: The bioassay of androgen, antiandrogen and other hormones on the sebaceous gland. Brit. J. Derm. 82, Suppl. 6, 15–18 (1970).
Strauss, J.S., Klingman, A.M., Pochi, P.E.: The effect of androgens and estrogens on human sebaceous glands. J. invest. Derm. 39, 139 (1962).
Strauss, J.S., Pochi, P.E.: The quantitative gravimetric determination of sebum production. J. invest. Derm. 36, 293 (1961).
Strauss, J.S., Pochi, P.E.: The human sebaceous gland: its regulation by steroidal hormones and its use as an end organ for assaying androgenicity in vivo. Recent Progr. Hormone Res. 19, 385–444 (1963).
References
Bergstrand, C.G.: The influence of testosterone propionate on skeletal development in the immature rabbit. Acta endocr. (Kbh.) 4, 91–101 (1950).
Bierich, J.R., Blunck, W., Schönberg, D.: Über Frühreife. II. Mitteilung. Frühreife bei cerebral-organischen Erkrankungen. Mschr. Kinderheilk. 115, 509–516 (1967).
Bossi, E., Zurbrügg, R. P., Joss, E. E.: Androcur—das orale Antiandrogen. Medizinische Mitteilungen (Schering AG) 2, 2–10 (1973).
Helge, H., Weber, B., Hammerstein, J., Neumann, F.: Idiopathic precocious puberty: indication for therapeutic use of cyproterone acetate, an antigonadotropic and anti-androgenic substance? The Seventh Annual Conference of the European Society for Paediatric Endocrinology, Malmö 1969. Acta paediat scand. 58, 672 (1969).
Hertel, P., Kramer, M., Neumann, F.: Einfluß eines Antiandrogens (Cyproteronacetat) auf Knochenwachstum und Knochenreifung männlicher Ratten. Arzneimittel-Forsch. 19, 17–771790 (1969).
Hirtel, P., Neumann, P.: Beeinflussung der Knoehenreifung männlicher Ratten durch Testosteronpropionat und Cyproteronacetat (Antiandrogen). 15. Symp. Dtsch. Ges. für Endokrinologie, Köln 1969. Berlin-Heidelberg-New York: Springer, S. 430–431.
Howard, E.: Steroids and bone maturation in infant mice: relative activities of dehydroepiandrosterone and testosterone. Endocrinology 70, 131–141 (1962).
Joss, E.E., Zuppinger, K.A., Sobel, E.H.: Effect of testosterone propionate and methyl testosterone on growth and skeletal maturation in rats. Endocrinology 72, 123–130 (1963).
Levie, L. H.: Einfluß von Oestron, Testosteronpropionat und Pregnyl auf das Schwanzwachstum der Ratte. Acta brev. neerl. Physiol. 8, 53 (1938).
Reiss, M., Fernandes, J.E., Golla, Y.M.L.: The peripheral inhibitory influence of large doses of testosterone on epiphyseal cartilagious growth. Endocrinology 38, 65–70 (1946).
Rubinstein, H.S., Kurland, A.A., Goodwin, M.: The somatic growth depressing effect of testosterone propionate. Endocrinology 25, 724–728 (1939).
Rubinstein, H.S., Solomon, M.L.: Growth-stimulating effect of testosterone propionate. Proc. Soc. exp. Biol. (N.Y.) 44, 442–443 (1940).
Rubinstein, H.S., Solomon, M.L.: Effect on body growth of small doses of testosterone propionate administered at different seasons. Proc. Soc. exp. Biol. (N.Y.) 45, 745–748 (1940).
Saralamma, P.G., Krishnamurthy, S., Thangavelu, M.: Effect of testosterone propionate on bone growth in vitro. Curr. Sci. (India) 33, 176 (1964).
Schenck, B., Neumann, F.: Einfluß von Sexualhormonen auf Knoehenreifung und Knochenwachstum weiblicher Ratten. Arzneimittel-Forsch. 23, 887–907 (1973).
Silberberg, M., Silberberg, R.: Steroid hormones and bone. In: Bourne, G.H (Ed.). “The Biochemistry and Physiology of Bone”. New York and London: Academic Press, pp. 623–670, 1956.
Simpson, M.E., Marx, W., Becks, H., Evans, H.M.: Effect of testosterone propionate on the body weight and skeletal system of hypophysectomized rats. Synergism with pituitary growth hormone. Endocrinology 35, 309–316 (1944).
References
Aschheim, S., Varangot, J.: L’action du propionate de testostérone sur les functions ovariennes chez la Rate adulte. C.R. Soc. Biol. (Paris) 130, 830–833 (1939).
Burdick, H.O., Emerson, B.: Regression and resorption of the corpora lutea of early pregnancy following injections of testosterone propionate. Endocrinology 25, 913–918 (1939).
Burdick, H.O., Emerson, B., Whitney, R.: Effects of testosterone propionate on pregnancy and on passage of ova through the oviducts of mice. Endocrinology 26, 1081–1086 (1940).
Buschbeck, H.: Neuere Erkenntnisse über die Ovarialfunktion und ihre bildliche Darstellung. Zbl. Gynäk. 76, 1631–1636 (1954).
Buschbeck, H.: Z. Geburtsh. Gynäk. 142, 11 (1954).
Courrier, R., Gros, G.: Influence du propionate de testosterone sur l’utérus. C.R. Soc. Biol. (Paris) 127, 921–923 (1938).
Dorfman, R.I.: (Ed.). “Methods in Hormone Research”, vol. II, “Bioassay”, 2nd Edition. New York and London: Academic Press 1969.
Filler, W., Drezner, N.: The results of surgical castration in women under forty. Amer. J. Obstet. Gynec. 47, 122 (1944).
Gaarenstroom, J.H., Jongh, S.E. de: Contribution to the Knowledge of the Influences of Gonadotropic and Sex Hormones on the Gonads of Rats. New York-Amsterdam: Elsevier Publishing Company 1946.
Hamilton, J.B., Wolee, J.M.: The effect of male hormone substances upon birth and prenatal development in the rat. Anat. Ree. 70, 433–440 (1938).
Harder, F.O.: Untersuchungen der foetotoxischen Wirkung von Sexualhormonen an Ratten. Dissertation - Freie Universität Berlin 1970 (Forschungslaboratorien der Schering AG).
Jost, A.: Action du propionate de testosterone sur la gestation chez la souris. C.R. Soc. Biol. (Paris) 139, 483–485 (1945).
Junkmann, K.: Gedanken über den Sexualcyclus. Ärztl. Wschr. 9, 289–293 (1954).
Kinsey, A.C., Pomeroy, W.B., Martin, C.E., Gebhard, P.H.: Sexual Behavior in the Human Female. Philadelphia: W.B. Saunders Co. 1953.
Korenchevsky, Y.: The bisexual properties and cooperative activity of sexual hormones and their effects on females. Brit. med. J. 1937, 896–898.
Korenchevsky, V., Hall, K.: Bisexual and co-operative properties of the sex hormones as shown by the histological investigation of the sex organs of female rats treated with these hormones. J. Path. Bact. 45, 681–708 (1937).
Neumann, F.: Methods for evaluating antisexual hormones. In: Mantegazza, P. and Piccini, F. (Eds.). “Methods in Drug Evaluation”. Proceedings of the International Symposium, Milan 1965. Amsterdam: North-Holland Publ. Co. 1966, pp. 548–573.
Neumann, F.: Chemische Konstitution und pharmakologische Wirkung. In: Junkmann, K. (Ed.). “Gestagene”, Handbuch der experimentellen Pharmakologie, v 22/1, chapt. YI, pp. 680–1025. Berlin-Heidelberg-New York: Springer 1968.
Neumann, F. runpubliziert - 1973.
Neumann, F., Elger, W.: Eine neue Methode zur Prüfung antiandrogen wirksamer Substanzen an weibliehen Ratten. Acta endocr. (Kbh.) 52, 54–62 (1966).
Neumann, F., Elger, W., Berswordt-Wallrabe, R. von: Aufhebung der Testosteron- propionat-induzierten Unterdrückung des Vaginal-Zyklus und der Ovulation durch ein antiandrogen wirksames Steroid an Ratten. Acta endocr. (Kbh.) 52, 63–71 (1966).
Phelps, D., Burch, J.C., Ellison, E.T.: Effect of long-term injections of testosterone upon the guineα-pig endometrium. Endocrinology 23, 458–462 (1938).
Scipiades, E.: Effect of testosterone injections upon the course of pregnancy in unoperated and in castrated rats. Proc. Soc. exp. Biol. (N.Y.) 37, 242–244 (1937).
Voss, H.E.: Die Androgene des Hodens in ihren Beziehungen zu den anderen endokrinen Drüsen. In: Voss, H.E. und Oertel, G. (Eds.). “Androgene I”, Handbuch der experimentellen Pharmakologie XXXV/1. chapt. 5, pp. 253–326. Berlin-Heidelberg-New York: Springer 1973.
Voss, H.E.: Einflüsse der Androgene auf Organe außerhalb der Genitalsphäre und des Endokriniums. In: Voss, H.E. and Oertel, G. (Eds.). “Androgene I”, Handbuch der experimentellen Pharmakologie XXXV/1, chapt. 7, pp. 529–590. Berlin-Heidelberg- New York: Springer 1973.
Waxenberg, S.E., Drellich, M.G., Sutherland, A.M.: The role of hormones in human behavior. I. Changes in female sexuality after adrenalectomy. J. clin. Endocr. 19, 193–202 (1959).
Wiechert, R., Neumann, F.: Gestagene Wirksamkeit von 1-Methyl- und l,2α-Methylen- Steroiden. Arzneimittel-Forsch. 15, 244–246 (1965).
References
Boris, A.: Endocrine studies of a nonsteroid anti-androgen and progestin. Endocrinology 76, 1062 (1965).
Boris, A., De Martino, L., Trmal, T.: Studies on the endocrine properties of a new progestational steroid 4,6-dichloro-16-methylen-17-hydroxy-4,6-pregnadiene-3,20-dione–17-aeetate (MDAP). Steroids 18, 399 (1971).
Ellendorff, F., Rover, H.F., Smidt, D.: The effect of cyproterone acetate on the duration of pregnancy and parturition in mice. J. Reprod. Fertil. 32, 299 (1973).
Fixson, U.: Vorläufige Mitteilung über ein neues oral wirksames Gestagen (SH 714). Geburtsh. u. Frauenheilk. 23, 371 (1963).
Hertz, R., Tullner, W.W.: Progestational activity of certain steroid- 17-spirolactones. Proc. Soc. exp. Biol. (N.Y.) 99, 451 (1958).
Juillard, M.T., Peyre, A.: Action de l’acétate de cyprotérone sur l’épithélium vaginal de Souris. C.R. Soc. Biol. (Paris) 165, 944 (1971).
Neumann, F., Berswordt-Wallrabe, R. von, Elger, W., Steinbeck, H., Hahn, J.D., Kramer, M.: Aspects of androgen-dependent events as studied by antiandrogens. Laurentian Hormone Conference, Mont Tremblant 1969. Recent Progr. Hormone Res. 26, 337 (1970).
Neumann, F., Hempel, R.: Hemmung der Uteruswirkung von Oxytocin durch Gestagene. Acta endocr. (Kbh.) 48, 645 (1965).
Neumann, F., Richter, K.-D., Günzel, P.: Wirkungen von Antiandrogenen. Zbl. Vet.- Med., Reihe A, 12, 171 (1965).
Rocky, S., Neri, R.O.: Comparative biological properties of Sch 12600: (6-chloro-4,6-pregnadien-16-methylen-17-α-ol-3,20-dione-17-acetate) and Chlormadinone acetate. Fed. Proc. 27, 624 (1968).
Schreiber, V., Přibyl, T., Rohacova, J.: Effect of the anti-androgen cyproterone acetate on the action of oestrogen on the rat endocrine system. Physiol, bohemoslov. 20, 255 (1971).
Schreiber, V., Pôibyl, T., Rohaöova, J.: Vergleich der Wirkung der Antiandrogene Cyproteron und Cyproteronacetat auf das endokrine System der Ratten. Endokrinologie 58, 414 (1971).
Wiechert, R., Neumann, F.: Gestagene Wirksamkeit von 1-Methyl- und l,2a-Methylen- Steroiden. Arzneimittel-Forsch. 15, 244 (1965).
Zaffaroni, A., Bowers, A.: New steroids with hormone-like activities C-6 substituted hormone analogs. In: Martini, L. and Pecile, A. (Eds.) “Hormonal Steroids”, Vol. 1, p. 29 (1964). New York and London: Academic Press.
References
Bloch, G.J., Davidson, J.M.: Behavioral and somatic responses to the antiandrogen cyproterone. Hormon. Behav. 2, 11 (1971).
Dörner, G., Götz, F., Mainz, K.: Influence of antiandrogens on sexual behaviour and gonadal function in male rats. Endocr. exp. 6, 17 (1972).
Dorfman, R.I., Dorfman, A.S.: A test for anti-androgens. Acta endocr. (Kbh.) 33, 308 (1960).
Dorfman, R. I., Stevens, D.: The androgenic and anti-androgenic action of a perhydro- phenanthrene derivative. Acta endocr. (Kbh.) Suppl. 51, 867 (1960).
Lerner, L. J., Bianchi, A., Borman, A.:Δ1-Testololactone, a nonandrogenic augmentor and inhibitor of androgens. Cancer 13, 1201 (1960).
Lerner, L. J., Bianchi, A., Dzelzkalns, M., Borman, A.: Androgenic and anti-androgenic activities of A-nortestosterone and testosterone. Fed. Proc. 21, 210 (1962).
Lerner, L.J., Bianchi, A., Dzelkalns, M., Borman, A.: Anti-androgenic activities of A-nortestosterone and C-nor-D-homo-17a-epitestosterone acetate. Proc. Soc. exp. Biol. (N.Y.) 115, 924 (1964).
Mahesh, V.B., Zarate, A., Roper, B.K., Greenblatt, R.B.: Studies on the action of 17a-methyl-B-nortestosterone as an antiandrogen. Steroids 8, 297 (1966).
References
Doménico, A., Neumann, F.: Wirkung von antiandrogen wirksamen Steroiden auf die Funktion und Morphologie der Nebennieren von Ratten. 12. Symp. Dtsch. Gesellschaft für Endokrinologie, Wiesbaden 1966. Berlin-Heidelberg-New York: Springer 1967, pp. 312— 314.
Hamada, H., Neumann, F., Junkmann, K.: Intrauterine antimuskuline Beeinflussung von Rattenfeten durch ein stark gestagen wirksames Steroid. Acta endocr. (Kbh.) 44, 380–388 (1963).
Kramer, M., Damrosch, L., Klink, G.: Sonstige Wirkungen von Gestagenen. In: Junkmann, K. (Ed.). “Gestagene”, Handbuch der experimentellen Pharmakologie, vol. 22/1, chapt. 5, pp. 450–679. Berlin-Heidelberg-New York: Springer 1968.
Neri, R.O., Monahan, M.D., Meyer, J.G., Afonso, B.A., Tabachnik, I.A.: Biological studies on an anti-androgen (SH 714). Europ. J. Pharmacol. 1, 438–444 (1967).
Winkler, G.K., Harkness, R.A.: The effect of a strongly progestational steroid on adrenal function in the guinea-pig. J. Endocr. 30, iii—iv (1964).
Winkler, G.K., Harkness, R.A.: Einfluß eines synthetischen Progesteronderivates (l,2a-Methylen-6-chloro-Δ6-17α-hydroxyprogesteronacetat) auf die 17-Hydroxycortico- steroidausscheidung im Harn beim Meerschweinchen. Klin. Wschr. 42, 922–923 (1964).
References
Broderson, S.H.: Effects of antiandrogen or castration on the plasmalogen concentration in the kidney of the male rat and on the hematocrit. Acta histochem. (Jena) 38, 82–87 (1970).
Medlinsky, J. T., Napier, C.D., Gurney, C.W.: The use of an antiandrogen to further investigate the erythropoietic effects of androgens. J. Lab. clin. Med. 74, 85–92 (1969).
Mirand, E.A., Groenewald, J.H., Kenny, G.M., Murphy, G.P.: The inhibitory effects of antiandrogen (SH 714) on erythropoietic activity. Experientia (Basel) 25,1104 (1969).
Shirakura, T., Azuma, M., Maekawa, T.: Effect of androgen antagonist on erythropoietic action of testosterone. Acta haemat. jap. 40, 299–304 (1968).
References
Goldman, A.S.: Further studies on steroid inhibitors of Δ5,3β-hydroxysteroid dehydrogenase andΔ5-Δ43-ketosteroid isomerase in pseudomonas testosteronii and in bovine adrenals. J. clin. Endoer. 18, 1539–1546 (1968).
Wacker, A., Chandra, P., Träger, L.: Steroid antagonists: their mechanism of action. In: Raspé, G. (Ed.). “Advances in the Biosciences”, vol. 2, pp. 256–272. Oxford: Pergamon Press 1969.
Wacker, A., Träger, L., Maturova, M., Beckmann, H.: Hemmung der steroidabhängigen Enzyminduktion durch Steroide und Alkaloide bei Mikroorganismen. Naturwissenschaften 54, 90 (1967).
References
Selye, H.: Hormones and Resistance. Berlin-Heidelberg-New York: Springer 1971.
References
Broderson, S.H.: Effects of antiandrogen or castration on the plasmalogen concentration in the kidney of the male rat and on the hematocrit. Acta histochem. (Jena) 38, 82–87 (1970).
References
Belanger, L.F., Choqfette, L.P.E., Cousineau, A.: Osteolysis in reindeer antlers; sexual seasonal variations. Calcif. Tiss. Res. 1, 37–43 (1967).
Bubenik, G.A., Brown, G.M., Bubenik, A.B., Grota, L. J.: Immunohistological localization of testosterone in the antlers. In preparation.
References
Wenzel, M., Pitzel, L., Bollert, B.: Sexualspezifität der 4-Hydroxylierung von 5α- Androstan-3,17-dion in Ratten und der Einfluß des Antiandrogens Cyproteronacetat. Hoppe-Seylers Z. physiol. Chem. 353, 861–868 (1972).
References
Schreiber, V., Roháčová, J.: An increase in thyroid radioiodine uptake following the administration of cyproterone acetate. Experientia (Basel) 27, 848–849 (1971).
References
Barbosa, J., Seal, U.S., Doe, R.P.: Effects of steroids on plasma proteins-progestational agents. J. clin. Endocr. 32, 547 (1971).
Brodie, B.B., Gillette, J.R., LaDu, B.N.: Enzymatic metabolism of drugs and other foreign compounds. Ann. Rev. Biochem. 27, 427 (1958).
Chandra, P., Orh, H., Wacker, A.: Studies on the regulation of a sex-associated protein in rat liver. Hoppe-Seylers Z. physiol. Chem. 349, 784 (1968).
Denef, C., Vandeputte, M., Moor, P. De: Paradoxical effects of the androgen antagonist cyproterone acetate on steroid metabolism in the rat. Endocrinology 83, 945 (1968).
Dutton, G.J.: The biosynthesis of glucuronides. In: Dutton, G.J. (Ed.). “Glucuronic acid, free and combined.” New York-London: Academic Press 1966.
Elton, R.L., Edgren, R.A., Calhoun, D.W.: Biological activities of some 6-methylated progesterones. Proc. Soc. exp. Biol. (N.Y.) 108, 175 (1960).
Hempel, R.: Der Einfluß eines Antiandrogens auf die Schlafdauer männlicher und weiblicher Mäuse und Ratten nach Hexobarbitalgabe. Naunyn-Schmiedebergs.Arch. Pharmak. exp. Path. 257, 27 (1967).
Hempel, R.: Zur hormonellen Beeinflussung des Hexobarbitalschlafes der Ratte. Arch. Pharmakol. exp. Path. 259, 413 (1968).
Hoffmann, W., Breuer, H., Neumann, F.: Wirkimg einer Behandlung mit einem Anti- androgen (Cyproteron) auf die Aktivitäten von Steroidenzymen bei der Ratte. Arzneimittel- Forsch. 18, 586 (1968).
Jäger, E., Mosebach, K.-O., Blumenthal, H.-P., Scheuer, A.: The influence of cyproterone acetate on the uptake of testosterone and on the DNA- and RNA-amount in liver, prostate and seminal vesicles of immature male rats in vivo. Acta endocr. (Kbh.) Suppl. 138, 43 (1969).
Knauer, E.: Einfluß des Antiandrogens Cyproteron auf den in vivo Stoffwechsel des Testosterons in Leber und Yesikulardrüsen der Ratte. Dissertation, Bonn (1970).
Kovacs, K., Blascheck, J.A., Gard, B.D., Somogyi, A.: Effect of cyproterone acetate on the liver ultrastructure in rats. Horm. Metab. Res. 3, 44 (1971).
Künzel, B., Müller-Oerlinghausen, B.: Wirkung von Testosteron und einem Anti Androgen (Cyproteronacetat) auf die Glucuronidbildung in der Rattenleber. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 262, 112 (1969).
Langecker, H.: Geschlechtsdifferenzen bei pharmakologischen Reaktionen und ihre Beziehung zu Abbauvorgängen. Berl. Med. 16, 258 (1965).
Lerner, L.J., Bianchi, A., Borman, A.: A-Norprogesterone, an androgen antagonist. Proc. Soc. exp. Biol. (N.Y.) 103, 172 (1960).
Quinn, G.P., Axelrod, J., Brodie, B.B.: Species and sex differences in metabolism and duration of action of hexobarbital (Evipal). Fed. Proc. 13, 395 (1954).
Quinn, G.P., Axelrod, J., Brodie, B.B.: Species,strain and sex differences in metabolism of hexobarbital, amidopyrine, antipyrine and anilin. Biochem. Pharmacol. 1, 152 (1958).
Remmer, H.: Geschlechtspezifische Unterschiede in der Entgiftimg von Evipan und Thiopental bei Ratten. Naunyn-Schmiedebergs Arch. Pharmak. 288, 173 (1958).
Revesz, U., Banik, K., Herr, F.: Hormonal and biological activities of 3β, 17α-diaeetoxy- 6-chloropregna-4,6-diene-20-one. Steroids 10, 291 (1967).
Rubin, A., Stohler, C.M., Novick, W.J.: Inhibition of testosterone stimulation of microsomal hexobarbital metabolism by 17α-methyl-B-nortestosterone. Biochem. Pharmacol. 14, 1898 (1965).
Sammelwitz, P.H., Schreck, C.B., Hopwood, M.L.: Binding of cyproterone acetate to plasma proteins. Proc. Soc. exp. Biol. (N.Y.) 143, 189 (1973).
Samuels, L.T., West, O.D.: The intermediary metabolism of the non-benzenoid steroid hormones. Vitam. and Horm. 10, 251 (1952).
Scheuer, A., Dahnke, H.-G., Jäger, E., Mosebach, K.-O.: Einfluß von Cyproteronacetat auf den DNA- und RNA-Gehalt, den Einbau von (14C)Uridin in die RNA sowie die Aufnahme von (14C)-Testosteron in einigen Organen unreifer männlicher Ratten. Hoppe-Seylers Z. physiol. Chem. 350, 1570 (1969).
Staib, R., Sonnenschein, R., Staib, W.: Der Testosteronstoffweehsel in der isoliert perfundierten Rattenleber. Europ. J. Biochem. 13, 142 (1970).
References
Hahn, J.D.: Effect of cyproterone acetate on sexual dimorphism of the exorbital lacrimal gland in rats. J. Endocr. 45, 421 (1969).
Hahn, J.D., Neumann, P.: Sexualunterschiede an geschlechtsunspezifischen Organen von Nagern und ihre hormonelle Beeinflussung. Symp. Dtsch. Ges. Endokrin. 15, 427 (1969). Berlin-Heidelberg-New York: Springer.
Hahn, J.D., Neumann, F.: Untersuchungen zum Geschlechtsdimorphismus von sechs Enzymen der Mauseniere mit Hilfe von Cyproteronacetat. Histochemie 17, 39 (1969).
References
Claus, R., Hoffmann, B.: Bestimmung von Testosteron und 5α-Androst-16-en-3-on, einem Ebergeruchsstoff, im Schweineblut. Landw. Zentrbl. 15, 1557 (1970).
Claus, R., Hoffmann, B.: Bestimmung von geruchswirksamen Steroiden beim Schwein. Zuchthygiene Suppl. 5, 78 (1972).
Horst, P., Bader, J.: Untersuchungen zur Bedeutung der Jungebermast. Züchtungskunde 41, 248–261 (1969).
Patterson, R.L.S.: Identification of 3α-hydroxy-5α-androst-16-ene as the musk odour component of boar submaxillary salivary gland and its relationship to the sex odour taint in pork meat. J. Sci. Food Agric. 19, 434–438 (1968).
Sink, J.D.: Theoretical aspects of sex odor in swine. J. theor. Biol. 17, 174–180 (1967).
References
Archibald, A., Shuster, S.: Bioassay of androgen using the rat sebaceous gland. J. Endocr. 37, xxii (1967).
Archibald, A., Shuster, S.: The measurement of sebum secretion in the rat. Brit. J. Derm. 82, 146–151 (1970).
Belham, J.E., Neal, G.E.: Testosterone action in the rat ventral prostate. The effects of diethylstilboestrol and cyproterone acetate on the metabolism of [3H] testosterone and the retention of labelled metabolites by rat ventral prostate in vivo and in vitro. Biochem. J. 125, 81–91 (1971).
Belham, J.E., Neal, G.E., Williams, D.C.: Testosterone metabolism in the rat ventral prostate. Biochem. J. 109, 33P-34P (1968).
Belham, J.E., Neal, G.E., Williams, D.C.: The reception of androgens in the rat ventral prostate. Biochem. J. 114, 32P (1969).
Belham, J.E., Neal, G.E., Williams, D.C.: Testosterone metabolism in the rat ventral prostate. Biochim. biophys. Acta (Amst.) 187, 159–162 (1969).
Breuer, H., Hoffmann, W.: Wirkungsmechanismus eines Antiandrogens auf die Androgen-Biosynthese. Naturwissenschaften 54, 616–617 (1967).
Bridge, B.W., Scott, W.W.: A new antiandrogen, SH-714. Invest. Urol. 2, 99–103 (1964).
Christensen, A.K., Mason, N.B.: Comparative ability of seminiferous tubules and interstitial tissue of rat testes to synthesize androgens from progesterone-4-14C in vitro. Endocrinology 76, 646–656 (1965).
Dantchakoff, V.: Embryogénie expérimentale. Sur l’obtention expérimentale des free- martins chez le cobaye et sur la nature du facteur conditionnant leur histogenèse sexuelle. C.R. Acad. Sci. (Paris) 204, 195 (1937).
Dantchakoff, V.: Der Aufbau des Geschlechts beim höheren Wirbeltier. Jena: Fischer 1941.
Dawson, A.B.: A note on the staining of the skeleton of cleared specimens with alizarin red S. Stain Technol. 1, 123 (1926).
Joss, E.E., Sobel, E.H. and Zuppinger, K.A.: Skeletal maturation in rats with special reference to order and time of epiphyseal closure. Endocrinology 72, 117–122 (1963).
Dorfman, R.I.: The anti-androgenic activity of a phenanthrene derivative in the chick. Endocrinology 64, 463 (1959).
Dorfman, R.I.: A nonsteroidal androgen. Science 131, 1096 (1960).
Dorfman, R.I.: An anti-androgen assay using the castrated mouse. Proc. Soc. exp. Biol. (N.Y.) 111, 441–443 (1962).
Dorfman, R.I.: (Ed.). “Methods in Hormone Research”, vol. IIa “Bioassay”, 2nd Edition. New York-London: Academic Press 1969.
Dorfman, R.I.: Antiandrogens. In: James, Y.H.T. and Martini, L. “Hormonal Steroids”, Proceedings of the Third International Congress on Hormonal Steroids, Hamburg 1970. Excerpta Medica, Amsterdam 1971.
Dorfman, R.I., Dorfman, A.S.: A test for anti-androgens. Acta endocr. (Kbh.) 33, 308–316 (1960).
Dorfman, R.I., Forchielli, E., Gut, M.: Androgen biosynthesis and related studies. Recent Progr. Hormone Res. 19, 251–273 (1963).
Dorfman, R.I., Stevens, D.: Some biological properties of a perhydrophenanthrene derivative. Endocrinology 67, 394–406 (1960).
Ebling, F.J.: Sebaceous glands. I. The effects of sex hormones on the sebaceous glands of the female albino rat. J. Endocr. 5, 297–302 (1948).
Ebling, F.J.: Sebaceous glands: changes in sebaceous glands following implantation of oestradiol benzoate in female albino rat. J. Endocr. 7, 288–298 (1951).
Ebling, F.J.: Changes in the sebaceous glands and epidermis during the oestrous cycle of the albino rat. J. Endocr. 10, 147–154 (1954).
Ebling, F.J.: The action of testosterone and oestradiol on the sebaceous glands and epidermis of the rat. J. Embryol. exp. Morph. 5, 74–82 (1957).
Ebling, F.J.: The action of testosterone on the sebaceous glands and epidermis in castrated and hypophysectomized male rats. J. Endocr. 15, 297–306 (1957).
Ebling, F.J.: Hormonal control of the sebaceous gland in experimental animals. In: Montagna, W., Ellis, R.A. and Silver, A.F. (Eds.). “Advances in Biology of Skin”, vol. 4 “Sebaceous Glands,” pp. 200–219. Oxford Pergamon Press: 1963.
Ebling, F.J.: The action of an antiandrogenic steroid, 17α-methyl-B-nortestosterone, on sebum secretion in rats treated with testosterone. J. Endocr. 38, 181–185 (1967).
Ebling, F.J.: Steroid hormones and sebaceous secretion. In: Briggs, M.H. (Ed.). “Advances in Steroids”, vol. 2, p. Iff. New York-London: Academic Press 1970.
Ebling, F.J.: The effects of cyproterone acetate and oestradiol upon testosterone stimulated sebaceous activity in the rat. Acta endocr. (Kbh.) 72, 361–365 (1973).
Ebling, F.J., Skinner, J.: The measurement of sebum production in rats treated with testosterone and oestradiol. Brit. J. Derm. 79, 386–393 (1967).
Elger, W.: Die Rolle der fetalen Androgene in der Sexualdifferenzierung des Kaninchens und ihre Abgrenzimg gegen andere hormonale und somatische Faktoren durch Anwendung eines starken Antiandrogens. Arch. Anat. micr. Morph, exp. 55, 657–743 (1966).
Elger, W., Neumann, F., Berswordt-Wallrabe, R. von: The influence of androgen antagonists and progestogens on the sex differentiation of different mammalian species. In: Hamburgh, M. and Barrington, E.J.W. (Eds.). “Hormones in Development”, chapt. 51, pp. 651–667. New York: Appleton-Century-Crofts, Educational Division, Meredith Corporation 1971.
Elger, W., Neumann, F., Steinbeck, H., Hahn, J.D.: The significance of hormones in mammalian sex differentiation as evidenced by experiments with synthetic androgens and antiandrogens. In: Gibian, H. and Plötz, E.J. (Eds.). “Mammalian Reproduction”, 21. Colloquium der Gesellschaft für Biologische Chemie, Mosbach/Baden - April 1970, pp. 33–44. Berlin-Heidelberg-New York: Springer 1970.
Elger, W., Steinbeck, H., Neumann, F.: Die Abdominal-Drüse des mongolischen Gerbils als Modell zur Untersuchung endokriner Einflüsse auf die Talgdrüsenfunktion. 13. Symp. Dtsch. Gesellschaft für Endokrinologie, Würzburg 1967. In: Klein, E. (Ed.). “Das Testosteron - Die Struma”, pp. 120–121. Berlin-Heidelberg-New York: Springer 1968.
Fang, S., Anderson, K.M., Liao, S.: Receptor proteins for androgens. On the role of specific proteins in selective retention of 17β-hydroxy-5α-androstan-3-one by rat ventral prostate in vivo and in vitro. J. biol. Chem. 244, 6584–6595 (1969).
Fang, S., Liao, S.: Antagonistic action of antiandrogens on the formation of a specific dihydrotestosterone-receptor protein complex in rat ventral prostate. Molec. Pharmacol. 5, 428–431 (1969).
Fang, S., Liao, S.: Androgen receptors. Steroid- and tissue-specific retention of a 17β- hydroxy-5α-androstan-3-one-protein complex by the cell nuclei of ventral prostate. J. biol. Chem. 246, 16–24 (1971).
Gallagher, T.F., Koch, F.C.: The quantitative assay for the testicular hormone by the comb-growth reaction. Second communication. J. Pharmacol, exp. Ther. 55, 97–117 (1935)
Gans, E., Jongh, S.E. de: The enhancing effect of progesterone on the production of an androgen in vitro. Acta physiol. pharmacol. neerl. 10, 135–143 (1961).
Geller, J., Damme, O. van, Garabieta, G., Loh, A., Rettfra, J., Scifter, E.: Effects of cyproterone acetate on 3H-testosterone uptake and enzyme synthesis by the ventral prostate of the rat. Endocrinology 84, 1330–1335 (1969).
Geller, J., Loh, A., Winograd, J.: Effect of cyproterone acetate on 3Htestosterone i uptake and enzyme synthesis by the ventral prostate of the rat. Excerpta med. (Amst.) Int. Congr. Ser. 157, Abstract No. 312 (1968).
Glenn, E.M., Gray, J.: Effect of various hormones on the growth and histology of the i gerbil (Meriones unguiculatus) abdominal sebaceous gland pad. Endocrinology 76, 115–123 (1965).
Greenwood, A.W., Blyth, J.S.S., Callow, R.K.: Quantitative studies on the response of the capon’s comb to androsterone. BiochemJ. 29, 1400–1413 (1935).
Hagen, A.A., Eik-Nes, K.B.: In vivo conversion of 17α-hydroxypregnenolone to 17α- hydroxyprogesterone by the canine testis. Fed. Proc. 22, 330 (Abstract) (1963).
Hamilton, J.B., Montagna, W.: Sebaceous glands of hamster; morphological effects of androgens on integumentary structures. Amer. J. Anat. 86, 191 (1950).
Hambierstein, J., Cupceancu, B.: Behandlung des Hirsutismus mit Cyproteronacetat. Dtsch. med. Wschr. 94, 829–834 (1969).
Haskin, D., Lasher, N., Rothman, S.: Some effects of ACTH, cortisone, progesterone and testosterone on sebaceous glands in white rat. J. invest. Derm. 20, 207 (1953).
Hertel, P., Kramer, M., Neumann, F.: Einfluß eines Antiandrogens (Cyproteronacetat) auf Knochenwachstum und Knochenreifung männlicher Ratten. Arzneimittel-Forsch. 19, 1777–1790 (1969).
Hoffmann, W., Breuer, H.: Wirkung von l,2α-Methylen-6-chlor-Δ4’6-pregnadien- 17α-ol-3,20-dion (Cyproteron) auf die Biogenese von C19-Steroiden in Rattentestes. Acta endocr. (Kbh.) 57, 623–638 (1968).
Hoffmann, W., Breuer, H., Neumann, F.: Wirkung einer Behandlung mit einem Antiandrogen (Cyproteron) auf die Aktivität von Steroidenzymen bei der Ratte. Arzneimittel-Forsch. (Drug Res.) 18, 586–588 (1968).
Hooker, C.W., Pfeiffer, C.A.: Effects of sex hormones upon body growth, skin, hair and sebaceous glands in rat. Endocrinology 32, 69–76 (1943).
Huggins, C., Parson, F.M., Jensen, E.V.: Promotion of growth of preputial glands by steroids and the pituitary growth hormone. Endocrinology 57, 25–32 (1955).
Jones, E.L., Woodbury, L.: The effect of antiandrogens on the response of rat preputial glands to testosterone. J. invest. Derm. 43, 165–170 (1964).
Joss, E. E., Zuppinger, K. A., Sobel, E. H.: Effect of testosterone propionate and methyl testosterone on growth and skeletal maturation in rats. Endocrinology 72, 123–130 (1963).
Jost, A.: Gonadal hormones in the sex differentiation of the mammalian fetus. In: Haan, R.L. de and Ursprung, H. (Eds.). “Organogenesis”. New York: Holt, Rinehart and Winston 1965.
Jost, A.: Hormonal factors in the sex differentiation of the mammalian foetus. Phil. Trans. B259, 119–131 (1970).
Junkmann, K., Neumann, F.: Zum Wirkungsmechanismus von an Feten antimaskulin wirksamen Gestagenen. Acta endocr. (Kbh.) Suppl. 90, 139–154 (1964).
Korenchevsky, V., Dennison, M.: The effect on male rats of the simultaneous administration of male and female sexual hormones and the relation to the assay of the hormones. Biochem. J. 28, 1486–1499 (1934).
Läuppi, E., Studer, A.: Inhibition of experimental, testosterone-induced epidermis proliferation in the female rat by a synthetic phenanthrene derivative with antiandro- genic effect. Experientia (Basel) 15, 264–265 (1959).
Läuppi, E., Studer, A.: Additional studies on skin proliferation-inhibiting properties of a phenanthrene derivative (Ro 2–7239). Dermatologica (Basel) 120, 275–285 (1960).
Lapiere, C.: Modifications of the sebaceous glands by local application of sex hormones to the skin of mice. C.R. Soc. Biol. (Paris) 147, 1302–1306 (1953).
Lerner, L.J., Bianchi, A., Borman, A.: Α-norprogesterone, an androgen antagonist. Proc. Soc. exp. Biol. (N.Y.) 103, 172–175 (1960).
Lerner, L.J., Bianchi, A., Dzelzkalns, M.: A sensitive anti-androgen assay: antagonism of locally applied androgen by Α-norprogesterone inuncted on the chick comb. Acta endocr. (Kbh.) 44, 398–402 (1963).
Masson, G.: Spermatogenic activity of various steroids. Amer. J. med. Sci. 209, 324–327 (1945).
Nayfeh, S.N., Baggett, B.: Metabolism of progesterone by rat testicular homogenates. I. Isolation and identification of metabolites. Endocrinology 78, 460–470 (1966).
Neri, R.O., Casmer, C., Zeman, W.V., Fielder, F., Tabachnick, I.A.: Effects of an antiandrogen, SH 714 (6-chlor-Δ6-l,2α-methylen-17α-hydroxyprogesterone acetate, eyproterone acetate) on canine prostatic hyperplasia. Endocrinology 82, 311–317 (1968).
Neumann, F.: Methods for evaluating antisexual hormones. In: Mantegazza, P. and Piccini, F. (Eds.). “Methods in Drug Evaluation”. Proceedings of the International Symposium, Milan 1965, p. 548–573. Amsterdam: North-Holland 1966.
Neumann, F.: Chemische Konstitution und pharmakologische Wirkung. In: Junkmann, K. (Ed.). “Gestagene”, Handbuch der experimentellen Pharmakologie, vol. 22/1, chapt. VI, pp. 680–1025. Berlin-Heidelberg-New York: Springer 1968.
Neumann, F.: Use of eyproterone acetate in animal and clinical trials. IVth International Seminar on Reproductive Physiology and Sexual Endocrinology “Hormones and Antagonists”, Brussels: May 1972. Gynec. Invest. 2, 150–179 (1971/1972).
Neumann, F., Berswordt-Wallrabe, R. von: Effects of the androgen antagonist eyproterone acetate on the testicular structure, spermatogenesis and accessory sexual glands of testosterone-treated adult hypophysectomized rats. J. Endocr.35, 363–371 (1966).
Neumann, F., Berswordt-Wallrabe, R. von, Elger, W., Steinbeck, H.: Hormonhemmer - Untersuchungen mit Testosteron-Antagonisten. 18. Mosbacher Koll. d. Gesellschaft für Biologische Chemie “Wirkungsmechanismen der Hormone”, Mosbach 1967, p. 218–248. Berlin-Heidelberg-New York: Springer 1967.
Neumann, F., Berswordt-Wallrabe, R. von, Elger, W., Steinbeck, H., Hahn, J.D., Kramer, M.: Aspects of androgen-dependent events as studied by antiandrogens. Recent Progr. Hormone Res. 26, 337–410 (1970).
Neumann, F., Elger, W.: Proof of the activity of androgenic agents on the differentiation of the external genitalia, the mammary gland and the hypothalamic-pituitary system in rats. Proc. Und International Symposium on Steroid Hormones, “Androgens in Normal and Pathological Conditions”, Ghent 1965. Excerpta Med. Int. Congr. Ser. 101, 168–185 (1965).
Neumann, F., Elger, W.: The effect of a new antiandrogenic steroid, 6-ehloro-17- hydroxy-lα,2α-methylenepregnα-4,6-diene-3,20-dione acetate (eyproterone acetate) on the sebaceous glands of mice. J. invest. Derm. 46, 561–572 (1966).
Neumann, F., Elger, W.: Eine neue Methode zur Prüfung antiandrogen wirksamer Substanzen an weiblichen Ratten. Acta endocr. (Kbh.) 52, 54–62 (1966).
Neumann, F., Elger, W.: Der Einfluß von Antiandrogenen auf Differenzierungsvorgänge. I. Schering-Symposium on Endocrinology “Advances in the Biosciences”, Berlin 1967. Vieweg, Oxford: Pergamon Press 1969, pp. 80–107.
Neumann, F., Elger, W., Berswordt-Wallrabe, R. von, Kramer, M.: Restitution der akzessorischen Geschlechtsdrüsen nach Langzeitbehandlung mit einem Androgen- Antagonisten (Cyproteronacetat). Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 255, 236–244 (1966).
Neumann, F., Elger, W., Steinbeck, H.: Antagonisten der Sexualhormone (Anti- oestrogene, Antigestagene und Antiandrogene). Int. J. clin. Pharmacol. Ther. Toxic. 6, 475–488 (1968).
Neumann, F., Elger, W., Steinbeck, H., Berswordt-Wallrabe, R. von: Antiandrogene. In: Klein, E. (Ed.). “Das Testosteron - Die Struma”, p. 78–101. Berlin-Heidelberg-New York: Springer 1968.
Neumann, F., Hamada, H.: Intrauterine Feminisierung männlicher Rattenfeten durch das stark gestagen wirksame 6-chlor-Δ6-l,2-methylen-17α-hydroxy-progesteronacetat. 10. Symp. Dtsch. Ges. für Endokrinologie, Wien 1963, p. 301–304. Berfin-Göttingen- Heidelberg-New York: Springer 1964
Neumann, F., Junkmann, K.: A new method for determination of virilizing properties of steroids on the fetus. Endocrinology 73, 33–37 (1963).
Neumann, F., Kramer, M.: Antagonism of androgenic and antiandrogenic action on the rat fetus. Endocrinology 75, 428–433 (1964).
Neumann, F., Richter, K.-D., Günzel, P.: Wirkungen von Antiandrogenen. Zbl. Vet.-Med., Reihe A, 12, 171–188 (1965).
Neumann, F., Steinbeck, EL, Berswordt-Wallrabe, R. von: Untersuchungen zur spermatogenen Aktivität von Gestagenen. Endokrinologie 52, 54–62 (1967).
Neumann, F., Steinbeck, H., Elger, W.: Sexualdifferenzierung. 16. Symp. Dtsch. Gesellschaft für Endokrinologie, Ulm 1970, “Endokrinologie der Entwicklung und Reifung”, p. 58–82. Berlin-Heidelberg-New York: Springer 1970.
Neumann, F., Steinbeck, H., Elger, W., Berswordt-Wallrabe, R. von: Hoden: Morphologie und Funktion unter der Einwirkung von PMS und HCG bei gleichzeitiger Antiandrogenbehandlung. Acta endocr. (Kbh.) 57, 639–648 (1968).
Nikkari, T., Valavaara, M.: The production of sebum in young rats: effects of age, sex, hypophysectomy and treatment with somatotrophic hormone and sex hormones. J. Endocr. 43, 113–118 (1969).
Pfeiffer, C. A., Hooker, C. W., Kirschbaum, A.: Deposition of pigment in the sparrow’s bill in response to direct applications as a specific and quantitative test for androgen. Endocrinology 34, 389–399 (1944).
Randall, L.O., Selitto, J. J.: Anti-androgenic activity of a synthetic phenanthrene. Endocrinology 62, 693–695 (1958).
Ruzicka, L., Tschopp, E.: Über die künstliche Herstellung der physiologischen Wirkungen des männlichen Sexualhormons. Schweiz, med. Wschr. 49, 1118–1120 (1934).
Savard, K., Dorfman, R.I., Baggett, B., Engel, L.L.: Biosynthesis of androgens from progesterone by human testicular tissue in vitro. J. clin. Endocr. 16, 1629–1630 (1956).
Schenck, B., Neumann, F.: Einfluß von Sexualhormonen auf Knochenreifung und Knoehenwaehstum weiblicher Ratten. Arzneimittel-Forsch. (Drug Res.) 23, 887–907 (1973).
Segaloff, A., Gabbard, R.B.: Anti-androgenic activity of 17,17-dimethyl-18-nor- androst-13-enes. Steroids 4, 433–443 (1964).
Selye, H.: The pharmacology of steroid hormones and their derivatives. Rev. canad. Biol. 1, 578–632 (1942).
Selye, H.: Correlations between the chemical structure and the pharmacological actions of the steroids. Endocrinology 30, 437–453 (1942).
Selye, H., Albert, S.: Morphogenetic actions of various steroids in the castrate male rat. J. Pharmacol, exp. Ther. 76, 137–148 (1942).
Selye, H., Friedman, S.: The action of various steroid hormones on the testis. Endocrinology 28, 129–140 (1941).
Steinbeck, H., Mehring, M., Neumann, F.: Comparison of the effects of cyproterone, cyproterone acetate and estradiol on testicular function, accessory sexual glands and fertility in a long-term study on rats. J. Reprod. Fertil. 26, 65–76 (1971).
Stern, J.M., Eisenfeld, A.J.: Androgen accumulation and binding to macromolecules in seminal vesicles: inhibition by cyproterone. Science 166, 233–235 (1969).
Stern, J.M., Eisenfeld, A.J.: Distribution and metabolism of 3H-testosterone in castrated male rats, effects of cyproterone, progesterone and unlabeled testosterone. Endocrinology 88, 1117–1125 (1971).
Visser, J. de: The influence of androgenic, anabolic and progestational steroids on maintenance of testicular weight in hypophysectomized rats. Acta physiol. pharmacol. neerl. 13, 108–110 (1965).
Walsh, P.C., Korenman, S.G.: Action of antiandrogens: preservation of 5α-reductase activity and inhibition of chromatin-dihydrotestosterone complex formation. Clin. Res. 18, 126 (1970).
Walsh, P.C., Korenman, S.G.: Mechanism of androgenic action: effect of specific intracellular inhibitors. J. Urol. (Baltimore) 105, 850–857 (1971).
Wiechert, R., Steinbeck, H., Elger, W., Neumann, F.: Wirkungen und Struktur neuer antiandrogener Steroide. Arzneimittel-Forsch. (Drug Res.) 17, 1103–1116 (1967).
Zahler, H.: Über die androkinetische Wirkung des Progesterons und das Zustandkommen ihrer Verstärkung durch die gleichzeitige Zufuhr von Oestrogenen. Virchows Arch. path. Anat. 320, 374 (1951).
Zarate, A., Mahesh, V. B., Greenblatt, R. B.: Effect of an antiandrogen, 17α-methyl-B- nortestosterone, on acne and hirsutism. J. clin. Endocr. 26, 1394–1398 (1966).
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Neumann, F., Steinbeck, H. (1974). Antiandrogens. In: Androgens II and Antiandrogens / Androgene II und Antiandrogene. Handbuch der experimentellen Pharmakologie/Handbook of Experimental Pharmacology, vol 35 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80859-3_6
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