Abstract
Following the discovery of the androgens in the early nineteen thirties and the first demonstration of their anabolic effects in 1935, evidence rapidly accumulated to show that practically no tissue in the body was immune from possible androgen stimulation, whether assessed on histological or on biochemical criteria. Considering the diversity of the biochemical effects attributable to the androgens, it is not surprising that an equal diversity is to be seen in the experiments designed to study these effects. Arbitrarily, although with some justification on historical and biochemical grounds, these studies can be said to fall into two main groups.
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Abbreviations
- dihydrotestosterone (DHT):
-
5α-androstan-17β-ol-3-one
- testosterone:
-
androst-4-ene-17β-ol-3-one
- 3α-androstanediol:
-
5α-androstan-3α,17β-diol
- 3β-androstanediol:
-
5α-androstan-3β,17β-diol
- androstenedione:
-
androst-4-ene-3,17-dione
- androstanedione:
-
5α-androstan-3,17-dione
- androsterone:
-
5α-androstan-3α-ol-17-one
- dehydroepiandrosterone:
-
androstan-5-ene-3β-ol-17-one
- 17β-estradiol:
-
estra-1,3,5(10)-triene-3,17β-diol
- progesterone:
-
pregn-4-ene-3,20-dione
- cortisol (hydrocortisone):
-
pregn-4-ene-11β, 17α,21-triol-3,20-dione
- cyproterone:
-
pregn-4,6-diene-1,2α-methylene-6-chloro-17α-hydroxy-3,20-dione
- R 2956:
-
estra-5,9,11-triene-2α,2β,17β-trimethyl-17β-hydroxy-3-one
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Wagner, R.K., Hughes, A. (1974). Current Views on Androgen Receptors and Mechanism of Androgen Action. In: Androgens II and Antiandrogens / Androgene II und Antiandrogene. Handbuch der experimentellen Pharmakologie/Handbook of Experimental Pharmacology, vol 35 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80859-3_1
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