Immune Responsiveness in Acute Lymphocytic Leukemia Patients under Chemotherapy and Immunotherapy: A Preliminary Report
With increased survival and prolonged chemotherapy of acute lymphocytic leukemia there have arisen new complications of infection by viral fungal and protozoan organisms which have resulted in significant morbidity and mortality, probably directly related to the immunosuppressive effects of tumoricidal therapy. In assessing new drug regimens for ALL their propensity to cause immunosuppression and the consequences thereof must be evaluated along with the classical parameters of hematologic and organ toxicity and therapeutic effectiveness. We have established and rendered operational a multiphasic schema of immunological evaluation comprising both in vitro and in vivo tests of cellular immune responsiveness. We report here our early results of the immunologic evaluation of patients during 2 phases of a new protocol for the treatment of acute lymphocytic leukemia, ICIG # 9. For comparison, we report as well the preliminary results of the same battery of tests applied to a group of patients currently under treatment with immunostimulatory therapy for periods of 1–7 years.
KeywordsAcute Lymphocytic Leukemia Cellular Immune Responsiveness Tritiated Thymidine Pokeweed Mitogen Immunologic Evaluation
Acute lymphocytic leukemia
Counts per minute
Phosphate buffered saline
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