Abstract
The administration of glucose to anesthetized fed rats causes within 1 to 2 minutes the inactivation of phosphorylase; glycogen synthetase is activated only when and if the level of phosphorylase α has been taken down below a threshold value equal to approximately 10% of the total phosphorylase. The same conclusion has been reached in a study with anesthetized fed mice. These observations are adequately explained by the previously described stimulation of the phosphorylase phosphatase reaction by glucose and inhibition of synthetase phosphatase by phosphorylase α. In some experiments, insulin caused a partial inactivation of liver phosphorylase in the liver of normal rats, but more often was without effect. When effective in the diabetic animal, insulin produced the inactivation of glycogen phosphorylase and the activation of glycogen synthetase. Glucocorticoids displayed two effects: a greater activity of phosphorylase phosphatase and a decreased inhibition of synthetase phosphatase by phosphorylase α.
The mechanism is discussed by which glucokinase and glucose 6-phosphatase adapt their rate of reaction to that of glycogen synthetase and of glycogen phosphorylase when glycogen synthesis or degradation is greatly stimulated.
This work was supported by the Fonds de la Recherche Scientifique Médicale and by NIH Grant AM 9235. W. Stalmans and H. De Wulf are fellows of the NFWO; L. Hue is a fellow of the FNRS.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bailey, J. M., and Whelan, W. J., (1972), Biochem. Biophys. Res. Commun, 46, 191.
Beaufay, H., and de Duve, C., (1954)„ Bull. Soc. Chim. Biol, 36, 1525.
Berthet, J., Jacques, P., Hers, H. G., and de Duve, C., (1956), Biochim. Biophys. Acta, 20, 190.
Bishop, J. S., and Larner, J., (1967), J. Biol. Chem, 242, 1354.
Bishop, J. S., Goldberg, N. D., and Larner, J., (1971), Am. J. Physiol, 220, 499.
Bishop, J. S., Steele, R., Altszuler, N., Dunn, A., Bjerknes, C., and De Bodo, R. C., (1965), Am. J. Physiol, 208, 307.
de Barsy, Th., Stalmans, W., Laloux, M., De Wulf, H., and Hers, H. G., (1972), Biochem. Biophys. Res. Commun, 46, 183.
de Duve, C., (1956), in Ciba Foundation Colloquia on Endocrinology, Wolstenholme, G. E. W., and O’Connor, C. M., Ed., Churchill, London, p. 203.
De Wulf, H., (1971), The Control of Glycogen Metabolism in The Liver. Thesis, Louvain, Vander, 131 p.
Exton, J. H., Lewis, S. B., Ho, R. J., Robinson, G. A., and Park, C. R., (1971), Ann. N.Y. Acad. Sci, 185, 85.
Hers, H. G., De Wulf, H., and Stalmans, W., (1970), FEBS Letters, 12, 73.
Hue, L., and Hers, H. G., (1972), in Biochemistry of the Glycosidic Linkage PAABS
Symposium, Piras, R., and Pontis, H. G., Ed., Academic Press, New York, p. 681.
Jefferson, L. S., Exton, J. H., Butcher, R. W., Sutherland, E. W., and Park, C. R., (1968), J. BioZ. Chem, 243, 1031.
Katz, J., and Dunn, A., (1967), Biochemistry, 6, 1.
Nichols, W. K., and Goldberg, N. D., (1972), Biochim. Biophys. Acta, 279, 245.
Soskin, S., (1940), Endocrinology, 26, 297.
Soskin, S., and Levine, R., (1946), Carbohydrate Metabolism,University of Chicago Press, 315 p.
Stalmans, W., De Wulf, H., Lederer, B., and Hers, H. G.,(1970), Europ. J. Biochem., 15, 9.
Stalmans, W., De Wulf, H., and Hers, H. G., (1971), Europ. J. Biochem, 18, 582.
Stalmans, W., de Barsy, Th., Laloux, M., De Wulf, H., and Hers, H. G., (1972), in Metabolic Interconversion of Enzymes, Wieland, O., Heimreich, E., and Holzer, H., Ed., Berlin, Spring Verlag, p. 121.
Van den Berghe, G., (1971), quoted by De Wulf, H., (1971).
Vinuela, E., Salas, M., and Sols, A., (1963), J. Biol. Chem,238, PC1175.
Walsh, D. A., and Krebs, E. G., (1973), in The Enzymes, Boyer, P. D., Ed., Academic Press, New York, vol. 8, p. 555.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1974 Springer-Verlag Berlin · Heidelberg
About this paper
Cite this paper
Hers, H.G., Stalmans, W., De Wulf, H., Laloux, M., Hue, L. (1974). The Control of Glycogen Metabolism in the Liver. In: Metabolic Interconversion of Enzymes 1973. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80817-3_9
Download citation
DOI: https://doi.org/10.1007/978-3-642-80817-3_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-80819-7
Online ISBN: 978-3-642-80817-3
eBook Packages: Springer Book Archive